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The map label for this gene is accC [H]

Identifier: 66766866

GI number: 66766866

Start: 623239

End: 624606

Strand: Reverse

Name: accC [H]

Synonym: XC_0527

Alternate gene names: 66766866

Gene position: 624606-623239 (Counterclockwise)

Preceding gene: 66766867

Following gene: 66766863

Centisome position: 12.13

GC content: 64.55

Gene sequence:

>1368_bases
ATGCTCGATAAAGTCGTCATTGCCAACCGAGGTGAAATCGCGCTGCGCATCCTGCGCGCGTGCCACACGCTCGGCATCCG
CACGGTCGCGGTGCACTCCACGGTCGACCGTAACCTCAAGCACGTGGCCATGGCCGACGAGTCGGTGTGTATCGGCCCGG
CCGCGTCCAGCGACAGTTACCTCAACATCCCGGCGCTGATCGCCGCGGCCGAGGTCACCGACGCGCAGGCCATCCACCCC
GGCTACGGGTTTCTCTCGGAAAACGCCGATTTTGCCGAGCGGGTGGAAGAATCCGGCTTCATCTTCATCGGCCCCAAGGC
CGACACCATCCGCCTGATGGGCGACAAGGTCGAGGCGATCCGCGCGATGAAGGCCGCCGGCGTACCGTGCGTGCCCGGCT
CGGGCGGCCCGCTGGGCGATGACATCGTGGCCAACACCAAGATCGCGCGCGAAATCGGCTACCCGGTGATCATCAAGGCC
GCCGGTGGCGGCGGTGGACGCGGCATGCGCGTGGTGCATTCGGAGGCCGCGCTGAAGGCGGCGATCGAAACCACCAAGTC
CGAAGCAAAGGCCGCTTTCAGCAACGATCAGGTCTACATGGAGAAGTTCCTGGAGAACCCACGCCATGTGGAAATCCAGG
TGCTTGCCGATGGCCAGGGCAACGCCATCCATCTGGGCGAGCGCGATTGCTCGATGCAGCGCCGTCACCAGAAAGTGGTG
GAAGAAGCGCCGGCACCGGGCATCAGCGAAGAACTGCGCGCTGAGATCGGCAAGGTCTGCGTGGATGCGTGCATCCGCAT
CGGTTACCGCGGCGCGGGCACCTTCGAATTCCTGTTCGAAGGCGGCCGGTTCTACTTCATCGAAATGAACACGCGTATCC
AGGTGGAACACCCGGTGACCGAGCGCATCACCGGCATCGACCTGGTGTGCGAGCAGCTGCGCATCGCCGCCGGCCACAAG
CTGAGCATCAAGCAGAGCGACATCGTGCTGCGCGGGCATGCGATCGAGTGCCGCATCAACGCCGAAGACCCGGAAACCTT
CATGCCCAACCCGGGCCTGATCACCGCCTTCCATCCGCCGGGTGGCCCGGGCGTGCGCGTGGATACGCACATCTATGCCG
GCTACAAGGTGCCGCCGAACTACGACTCGATGATCGGCAAGCTGATCGTGCACGGCCCGGACCGCGAGACCGCGATCGCG
CGCATGCGCGTGGCGCTGAGCGAGATGGTGGTGGACGGCATCAAGACCAACATCCCGCTGCAGCAGCGCATCATGCGCGA
CAAGGGCTTCCAGGCCGGTGGGCAGAACATCCACTACCTGGAAAAGCGACTGGCCGAACGCAAGAACAAGTCGATCGCGC
TGGTCTGA

Upstream 100 bases:

>100_bases
GGTGTTCGCCAAGCTCACTGCACTGATGAACGCCCTACGCAGACGTGGAGCCGCCTGATGCCCGCATCTACCCATTCCCC
ATTCCCGACTCCCTATTCCC

Downstream 100 bases:

>100_bases
TCGCAGTAGCGCTGGCCAAGAAAAAGGCGGGTAAACCCGCCTTTTTCGTGTCTACGTGTGCGCTGGGAGCGTAGTGTTCA
AACTACAGGGCCGCGGCATT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MLDKVVIANRGEIALRILRACHTLGIRTVAVHSTVDRNLKHVAMADESVCIGPAASSDSYLNIPALIAAAEVTDAQAIHP
GYGFLSENADFAERVEESGFIFIGPKADTIRLMGDKVEAIRAMKAAGVPCVPGSGGPLGDDIVANTKIAREIGYPVIIKA
AGGGGGRGMRVVHSEAALKAAIETTKSEAKAAFSNDQVYMEKFLENPRHVEIQVLADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGISEELRAEIGKVCVDACIRIGYRGAGTFEFLFEGGRFYFIEMNTRIQVEHPVTERITGIDLVCEQLRIAAGHK
LSIKQSDIVLRGHAIECRINAEDPETFMPNPGLITAFHPPGGPGVRVDTHIYAGYKVPPNYDSMIGKLIVHGPDRETAIA
RMRVALSEMVVDGIKTNIPLQQRIMRDKGFQAGGQNIHYLEKRLAERKNKSIALV

Sequences:

>Translated_455_residues
MLDKVVIANRGEIALRILRACHTLGIRTVAVHSTVDRNLKHVAMADESVCIGPAASSDSYLNIPALIAAAEVTDAQAIHP
GYGFLSENADFAERVEESGFIFIGPKADTIRLMGDKVEAIRAMKAAGVPCVPGSGGPLGDDIVANTKIAREIGYPVIIKA
AGGGGGRGMRVVHSEAALKAAIETTKSEAKAAFSNDQVYMEKFLENPRHVEIQVLADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGISEELRAEIGKVCVDACIRIGYRGAGTFEFLFEGGRFYFIEMNTRIQVEHPVTERITGIDLVCEQLRIAAGHK
LSIKQSDIVLRGHAIECRINAEDPETFMPNPGLITAFHPPGGPGVRVDTHIYAGYKVPPNYDSMIGKLIVHGPDRETAIA
RMRVALSEMVVDGIKTNIPLQQRIMRDKGFQAGGQNIHYLEKRLAERKNKSIALV
>Mature_455_residues
MLDKVVIANRGEIALRILRACHTLGIRTVAVHSTVDRNLKHVAMADESVCIGPAASSDSYLNIPALIAAAEVTDAQAIHP
GYGFLSENADFAERVEESGFIFIGPKADTIRLMGDKVEAIRAMKAAGVPCVPGSGGPLGDDIVANTKIAREIGYPVIIKA
AGGGGGRGMRVVHSEAALKAAIETTKSEAKAAFSNDQVYMEKFLENPRHVEIQVLADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGISEELRAEIGKVCVDACIRIGYRGAGTFEFLFEGGRFYFIEMNTRIQVEHPVTERITGIDLVCEQLRIAAGHK
LSIKQSDIVLRGHAIECRINAEDPETFMPNPGLITAFHPPGGPGVRVDTHIYAGYKVPPNYDSMIGKLIVHGPDRETAIA
RMRVALSEMVVDGIKTNIPLQQRIMRDKGFQAGGQNIHYLEKRLAERKNKSIALV

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=50.2272727272727, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=48.3069977426637, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=48.3069977426637, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=48.3069977426637, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=46.6517857142857, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=46.6517857142857, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=46.6517857142857, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=30.0589390962672, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=30.0589390962672, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=30.0589390962672, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=30.0589390962672, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=30.0589390962672, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI134142062, Length=516, Percent_Identity=29.6511627906977, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=76.1261261261261, Blast_Score=676, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=187, Percent_Identity=26.2032085561497, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=47.4040632054176, Blast_Score=403, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=435, Percent_Identity=48.735632183908, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17562816, Length=453, Percent_Identity=43.7086092715232, Blast_Score=342, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI133931226, Length=502, Percent_Identity=28.6852589641434, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=526, Percent_Identity=28.8973384030418, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71997163, Length=526, Percent_Identity=28.8973384030418, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319685, Length=433, Percent_Identity=44.1108545034642, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=44.8660714285714, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=45.5357142857143, Blast_Score=331, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6324343, Length=538, Percent_Identity=29.7397769516729, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6323863, Length=460, Percent_Identity=31.304347826087, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=45.413870246085, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=47.4157303370787, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=47.4157303370787, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=47.4157303370787, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=47.4157303370787, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=47.4157303370787, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=47.4157303370787, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=47.4157303370787, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=47.4157303370787, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=47.4157303370787, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=47.4157303370787, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=45.0980392156863, Blast_Score=345, Evalue=5e-95,
Organism=Drosophila melanogaster, GI161076409, Length=504, Percent_Identity=29.5634920634921, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24586458, Length=504, Percent_Identity=29.5634920634921, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI161076407, Length=504, Percent_Identity=29.5634920634921, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24586460, Length=504, Percent_Identity=29.5634920634921, Blast_Score=216, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49365; Mature: 49365

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKVVIANRGEIALRILRACHTLGIRTVAVHSTVDRNLKHVAMADESVCIGPAASSDSY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECHHHCCCEEEEECCCCEEECCCCCCCCE
LNIPALIAAAEVTDAQAIHPGYGFLSENADFAERVEESGFIFIGPKADTIRLMGDKVEAI
ECCHHHEEEHHCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCHHHHH
RAMKAAGVPCVPGSGGPLGDDIVANTKIAREIGYPVIIKAAGGGGGRGMRVVHSEAALKA
HHHHHCCCCCCCCCCCCCCCCHHCCCHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AIETTKSEAKAAFSNDQVYMEKFLENPRHVEIQVLADGQGNAIHLGERDCSMQRRHQKVV
HHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGISEELRAEIGKVCVDACIRIGYRGAGTFEFLFEGGRFYFIEMNTRIQVEHPVT
HHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEEECCEEEECCCHH
ERITGIDLVCEQLRIAAGHKLSIKQSDIVLRGHAIECRINAEDPETFMPNPGLITAFHPP
HHHCCHHHHHHHHHHHCCCEEEEECCCEEEECEEEEEEECCCCCCCCCCCCCEEEEECCC
GGPGVRVDTHIYAGYKVPPNYDSMIGKLIVHGPDRETAIARMRVALSEMVVDGIKTNIPL
CCCCCEEEEEEEECEECCCCHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCH
QQRIMRDKGFQAGGQNIHYLEKRLAERKNKSIALV
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEECC
>Mature Secondary Structure
MLDKVVIANRGEIALRILRACHTLGIRTVAVHSTVDRNLKHVAMADESVCIGPAASSDSY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECHHHCCCEEEEECCCCEEECCCCCCCCE
LNIPALIAAAEVTDAQAIHPGYGFLSENADFAERVEESGFIFIGPKADTIRLMGDKVEAI
ECCHHHEEEHHCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCHHHHH
RAMKAAGVPCVPGSGGPLGDDIVANTKIAREIGYPVIIKAAGGGGGRGMRVVHSEAALKA
HHHHHCCCCCCCCCCCCCCCCHHCCCHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AIETTKSEAKAAFSNDQVYMEKFLENPRHVEIQVLADGQGNAIHLGERDCSMQRRHQKVV
HHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGISEELRAEIGKVCVDACIRIGYRGAGTFEFLFEGGRFYFIEMNTRIQVEHPVT
HHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEEECCEEEECCCHH
ERITGIDLVCEQLRIAAGHKLSIKQSDIVLRGHAIECRINAEDPETFMPNPGLITAFHPP
HHHCCHHHHHHHHHHHCCCEEEEECCCEEEECEEEEEEECCCCCCCCCCCCCEEEEECCC
GGPGVRVDTHIYAGYKVPPNYDSMIGKLIVHGPDRETAIARMRVALSEMVVDGIKTNIPL
CCCCCEEEEEEEECEECCCCHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCH
QQRIMRDKGFQAGGQNIHYLEKRLAERKNKSIALV
HHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]