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The map label for this gene is ubiB [C]

Identifier: 66766759

GI number: 66766759

Start: 487595

End: 489319

Strand: Reverse

Name: ubiB [C]

Synonym: XC_0417

Alternate gene names: 66766759

Gene position: 489319-487595 (Counterclockwise)

Preceding gene: 66766762

Following gene: 162017110

Centisome position: 9.5

GC content: 67.88

Gene sequence:

>1725_bases
ATGGCCTTGAGCCCCAACGACCCGCACCGCACACCGGCTCAGGCCACGCACCCGGCCGACAACGCCGTGGTCGGCGGCAT
GAGCCGACGGACGCAGATCCTGCGCCTGTTGCTGCGGTACCGCGGGTCGGGCGTGTTTGCCGGCATGAGCCTGGACCCGG
CGGCGGTCAACGAATACGAAGTGCCCGCCGAAGGCACGCCGGACCAGTTCGTTGCCGACCTGGAAGCGCTAGGCCCCACC
TTCGTCAAACTCGGCCAGATGCTCTCCACCCGCCCGGACATCGTGCCGCCTGAGTTCGCCACCGCGCTGGAGCGCATGCA
GGAGAACACCAGCTCGGTGCCGGTGGAGCGCATCCGCCAGATCATCGAAGAAGAGCTCGGCGTGGCGGTCAACAAGGCGT
TCTCGCATTTCGACCCGGTGCCGCTGGGCTGCGCCTCGCTGGCGCAGGTGCATCGCGCCGCCCTGCGTGACGGCACGCCG
GTGGCGATCAAGGTGCAAAAACCCGAAGTCGCCGCGCAGGTGCGCTCGGACCTGGACGTGCTCAAAAGCTTCGCCAACGC
CGCCGACCGCCTCACCGGCATCGGCCGCCGCGTGCGCTTTGCCGACTGGCTGGGCGAGTTCGGCAAGACCCTGCGCGCCG
AACTCAACTACGAGGCCGAGGCCGAGACCCTGGTGCGTTTTGGCGAACACCTCAAGCCGTTCCCCTTGCTATGGGTGCCG
CAGCCGGTGTGGGACCTCAGCAGCCGCAAGGTGCTGACCATGCAGCTGGCCGAAGGCGTGCGCGTGGACAAGATCTCCGG
CCTGCGCCGCACCGAGCAGCCGATGGACGAGTTGGCCGCGGCCCTGGTCAAGGGCTACCTGGACCAGATGTTCGTGCATG
GCGAAATCCATGCCGACCCGCACCCGGGCAACCTGCGGGTGATGCCCGACGGCCGCCTGGCCATCTTCGACCTGGGCATG
GTGGCGCACGTGCCACCGCGCCTGCGCGAGCGCCTGCTCAAATTGCTGTTTGCCGCCGTGGACGGCCGTGGCGAAGAAGT
CGCCGAGGAAACCATCGCGCTCAGCACGCGCCTGGAGGACTACGACGAGGAGCGCTACCTGCGCGAAACCGGGCAGATGA
TTGCCCGCTACGCCGCACACGACGCCACCTCCGAGGGCCGCGTGGTGCTGGACCTGGTGCGCATTGCCACCGCCACCGGC
CTGCGCACCCCGCCGGAGCTGAGCCTGCTCGGCAAGACCTTGCTGAACCTGGAAGGCGTGTGCCGCGCGCTGTCGCCGGC
ATTGGACACCCGCCGCATCGTCGAACGCCACCTGCAGCACGTGATGCGCGCACGCCTGAAGAAGTCGATGTCGGCGGCCA
ACCTGGCCAGCGAAGCCATGGAATTGCAGCACCTGCTGCGCGAAGGCCCGCGCCGCATGTCCGACATCCTCTCGCTGGTG
GCCGAAAACCGCATGCAGATGCGTGTGACCGGGCTGGAAGAGTCGCACCTGATGGAAAGCCTGCAGAAGATCGCCAACCG
CGTCGCCGCCGGCATCGTCACCGCCGCGCTGATCATGGCGTCCTCGCAGATGATGCGGATCGAGACCGGTCTCAAGCTCT
GGGGCTACCCCGCGATTGCGATGGTGCTGTTTCTGCTCGGCGTGTTCCTGGGCCTGGGTATCGTGCTCAGTGCGCTGGTC
TTCGACCGCCGCGTGCGCGCACGTGAGGAACGTGGGCACCGGTAA

Upstream 100 bases:

>100_bases
CGGCAGCAGCGGTACGCCCACCCCGTTCGCAGGGCCGGGCGCGGATTCACCACACGACGACCCGGCGCTGGCCACACTCG
GGCGCTCAACACACCCGGAG

Downstream 100 bases:

>100_bases
CGCGGGATGGTTGGTGCCTGCTGCTTGTGCGCCTGTTCTTCGTTAGGCGTTCGACGCCGCATATGGGCGGTGGCAGTGGC
GTTGAAGTCAAAGGTGTCTG

Product: ABC transporter substrate binding protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MALSPNDPHRTPAQATHPADNAVVGGMSRRTQILRLLLRYRGSGVFAGMSLDPAAVNEYEVPAEGTPDQFVADLEALGPT
FVKLGQMLSTRPDIVPPEFATALERMQENTSSVPVERIRQIIEEELGVAVNKAFSHFDPVPLGCASLAQVHRAALRDGTP
VAIKVQKPEVAAQVRSDLDVLKSFANAADRLTGIGRRVRFADWLGEFGKTLRAELNYEAEAETLVRFGEHLKPFPLLWVP
QPVWDLSSRKVLTMQLAEGVRVDKISGLRRTEQPMDELAAALVKGYLDQMFVHGEIHADPHPGNLRVMPDGRLAIFDLGM
VAHVPPRLRERLLKLLFAAVDGRGEEVAEETIALSTRLEDYDEERYLRETGQMIARYAAHDATSEGRVVLDLVRIATATG
LRTPPELSLLGKTLLNLEGVCRALSPALDTRRIVERHLQHVMRARLKKSMSAANLASEAMELQHLLREGPRRMSDILSLV
AENRMQMRVTGLEESHLMESLQKIANRVAAGIVTAALIMASSQMMRIETGLKLWGYPAIAMVLFLLGVFLGLGIVLSALV
FDRRVRAREERGHR

Sequences:

>Translated_574_residues
MALSPNDPHRTPAQATHPADNAVVGGMSRRTQILRLLLRYRGSGVFAGMSLDPAAVNEYEVPAEGTPDQFVADLEALGPT
FVKLGQMLSTRPDIVPPEFATALERMQENTSSVPVERIRQIIEEELGVAVNKAFSHFDPVPLGCASLAQVHRAALRDGTP
VAIKVQKPEVAAQVRSDLDVLKSFANAADRLTGIGRRVRFADWLGEFGKTLRAELNYEAEAETLVRFGEHLKPFPLLWVP
QPVWDLSSRKVLTMQLAEGVRVDKISGLRRTEQPMDELAAALVKGYLDQMFVHGEIHADPHPGNLRVMPDGRLAIFDLGM
VAHVPPRLRERLLKLLFAAVDGRGEEVAEETIALSTRLEDYDEERYLRETGQMIARYAAHDATSEGRVVLDLVRIATATG
LRTPPELSLLGKTLLNLEGVCRALSPALDTRRIVERHLQHVMRARLKKSMSAANLASEAMELQHLLREGPRRMSDILSLV
AENRMQMRVTGLEESHLMESLQKIANRVAAGIVTAALIMASSQMMRIETGLKLWGYPAIAMVLFLLGVFLGLGIVLSALV
FDRRVRAREERGHR
>Mature_573_residues
ALSPNDPHRTPAQATHPADNAVVGGMSRRTQILRLLLRYRGSGVFAGMSLDPAAVNEYEVPAEGTPDQFVADLEALGPTF
VKLGQMLSTRPDIVPPEFATALERMQENTSSVPVERIRQIIEEELGVAVNKAFSHFDPVPLGCASLAQVHRAALRDGTPV
AIKVQKPEVAAQVRSDLDVLKSFANAADRLTGIGRRVRFADWLGEFGKTLRAELNYEAEAETLVRFGEHLKPFPLLWVPQ
PVWDLSSRKVLTMQLAEGVRVDKISGLRRTEQPMDELAAALVKGYLDQMFVHGEIHADPHPGNLRVMPDGRLAIFDLGMV
AHVPPRLRERLLKLLFAAVDGRGEEVAEETIALSTRLEDYDEERYLRETGQMIARYAAHDATSEGRVVLDLVRIATATGL
RTPPELSLLGKTLLNLEGVCRALSPALDTRRIVERHLQHVMRARLKKSMSAANLASEAMELQHLLREGPRRMSDILSLVA
ENRMQMRVTGLEESHLMESLQKIANRVAAGIVTAALIMASSQMMRIETGLKLWGYPAIAMVLFLLGVFLGLGIVLSALVF
DRRVRAREERGHR

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=228, Percent_Identity=35.9649122807018, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI41393593, Length=278, Percent_Identity=32.0143884892086, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI217035081, Length=183, Percent_Identity=36.6120218579235, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI34147522, Length=277, Percent_Identity=27.7978339350181, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI27363457, Length=293, Percent_Identity=27.3037542662116, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI217416386, Length=388, Percent_Identity=24.2268041237113, Blast_Score=96, Evalue=9e-20,
Organism=Escherichia coli, GI2367309, Length=379, Percent_Identity=31.1345646437995, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17559152, Length=266, Percent_Identity=29.6992481203008, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32565180, Length=297, Percent_Identity=29.96632996633, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323282, Length=291, Percent_Identity=26.4604810996564, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6325148, Length=260, Percent_Identity=26.5384615384615, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6321319, Length=290, Percent_Identity=25.5172413793103, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI22024280, Length=261, Percent_Identity=31.8007662835249, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI18859849, Length=243, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24662575, Length=268, Percent_Identity=26.1194029850746, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63557; Mature: 63425

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSPNDPHRTPAQATHPADNAVVGGMSRRTQILRLLLRYRGSGVFAGMSLDPAAVNEYE
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCC
VPAEGTPDQFVADLEALGPTFVKLGQMLSTRPDIVPPEFATALERMQENTSSVPVERIRQ
CCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
IIEEELGVAVNKAFSHFDPVPLGCASLAQVHRAALRDGTPVAIKVQKPEVAAQVRSDLDV
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHH
LKSFANAADRLTGIGRRVRFADWLGEFGKTLRAELNYEAEAETLVRFGEHLKPFPLLWVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECC
QPVWDLSSRKVLTMQLAEGVRVDKISGLRRTEQPMDELAAALVKGYLDQMFVHGEIHADP
CCCCCCCCCCEEHHHHHCCCCHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHCCEEECCC
HPGNLRVMPDGRLAIFDLGMVAHVPPRLRERLLKLLFAAVDGRGEEVAEETIALSTRLED
CCCCEEECCCCCEEEEECCHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
YDEERYLRETGQMIARYAAHDATSEGRVVLDLVRIATATGLRTPPELSLLGKTLLNLEGV
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
CRALSPALDTRRIVERHLQHVMRARLKKSMSAANLASEAMELQHLLREGPRRMSDILSLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
AENRMQMRVTGLEESHLMESLQKIANRVAAGIVTAALIMASSQMMRIETGLKLWGYPAIA
HHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHH
MVLFLLGVFLGLGIVLSALVFDRRVRAREERGHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALSPNDPHRTPAQATHPADNAVVGGMSRRTQILRLLLRYRGSGVFAGMSLDPAAVNEYE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCC
VPAEGTPDQFVADLEALGPTFVKLGQMLSTRPDIVPPEFATALERMQENTSSVPVERIRQ
CCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
IIEEELGVAVNKAFSHFDPVPLGCASLAQVHRAALRDGTPVAIKVQKPEVAAQVRSDLDV
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHH
LKSFANAADRLTGIGRRVRFADWLGEFGKTLRAELNYEAEAETLVRFGEHLKPFPLLWVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECC
QPVWDLSSRKVLTMQLAEGVRVDKISGLRRTEQPMDELAAALVKGYLDQMFVHGEIHADP
CCCCCCCCCCEEHHHHHCCCCHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHCCEEECCC
HPGNLRVMPDGRLAIFDLGMVAHVPPRLRERLLKLLFAAVDGRGEEVAEETIALSTRLED
CCCCEEECCCCCEEEEECCHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
YDEERYLRETGQMIARYAAHDATSEGRVVLDLVRIATATGLRTPPELSLLGKTLLNLEGV
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
CRALSPALDTRRIVERHLQHVMRARLKKSMSAANLASEAMELQHLLREGPRRMSDILSLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
AENRMQMRVTGLEESHLMESLQKIANRVAAGIVTAALIMASSQMMRIETGLKLWGYPAIA
HHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHH
MVLFLLGVFLGLGIVLSALVFDRRVRAREERGHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]