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The map label for this gene is ubiA

Identifier: 66766745

GI number: 66766745

Start: 464606

End: 465511

Strand: Reverse

Name: ubiA

Synonym: XC_0402

Alternate gene names: 66766745

Gene position: 465511-464606 (Counterclockwise)

Preceding gene: 66766747

Following gene: 66766743

Centisome position: 9.04

GC content: 67.33

Gene sequence:

>906_bases
ATGAGCAAGCAAGGTTTCAAGAACGTGCCCATGGCCCCTGCGCTGACGTGGCCAGAGCGCCTGGGACAGTATTGGAAGTT
GGTCCGTGGTGACCGCCCGATCGGCAGCCTGCTGCTGCTCTGGCCCACCTGGTGGGCGCTGTGGCTGGCGGCCGGGGGCC
TGCCGCCGTTGTGGACCTTGTTCGTGTTCACCGCTGGCGTCTGGCTGACCCGTTCGGCCGGCTGCGTGATCAACGACTAC
GCCGACCGCTGGCTGGATCCGCACGTAGAGCGCACAAAGTCGCGTCCGCTCGCCACCGGCGCGGTCTCCGGCCGCGAGGC
GCTGTGGGTGTTCGTGGTGTTGATGCTGGTCGCCTTCGCGCTGGTGCTCAGCCTCAACTGGCTGACCGTGGCGCTGAGCG
TGCCCGGCCTGTTTCTGGCCGCCAGCTATCCCTATCTGAAGCGCCACACCCATCTGCCGCAGGTATACCTGGGCATGGCG
TTCGGCTGGGGCATCCCGATGGGCTTCGCCGCCGTGCAGGGCAGCGTGCCGCTGCTGGCCTGGCTGCTATACGCCGCCAA
CATCCTCTGGGCCACCGCCTACGACACCTGGTATGCCATGGTCGACCGCGAGGACGACCTCCGCATGGGCAGCAAGTCCA
CCGCCATCCTGTTCGGCCGTTACGACCTGATCGCGCAAGGCGTGCTGTATGCGCTGATGTTCGCGGCCCTGGTGCTGGTG
GGCTTGCGCGCCGGCCTCAGCATCGCTTACTGGGCTGGGCTGGGCATCGCAGCGCTGCTGGTGGCCTACGAATTCCACAT
CGCGCGCCACCGCGAACGCGGCCCCTGCTTCCGCGCCTTCCTGCATAACAACTGGGTAGGCCTGGCGATCTTCGTCGGCA
TCGCCGCGTCGCTGGCGTTGCGCTAG

Upstream 100 bases:

>100_bases
TGAAAACCCACTTCAAAAGCGCGCCCAACCGCAGCCAACAGCGACGTCCACACCATCAAGCGCATGACCGCGGCCAAGCG
GCGCTGCTACCCTTTGCAGC

Downstream 100 bases:

>100_bases
CGGGTAGATGCGCTAATCGCGCCGCGCGTTAAGCCCGCAGGGGCCGCGAAGACACAGGTTGCCCGCCACTGGTGTGCGCC
TTGGAGCGCCCGCGCAGCAA

Product: 4-hydroxybenzoate octaprenyltransferase

Products: NA

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSKQGFKNVPMAPALTWPERLGQYWKLVRGDRPIGSLLLLWPTWWALWLAAGGLPPLWTLFVFTAGVWLTRSAGCVINDY
ADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFALVLSLNWLTVALSVPGLFLAASYPYLKRHTHLPQVYLGMA
FGWGIPMGFAAVQGSVPLLAWLLYAANILWATAYDTWYAMVDREDDLRMGSKSTAILFGRYDLIAQGVLYALMFAALVLV
GLRAGLSIAYWAGLGIAALLVAYEFHIARHRERGPCFRAFLHNNWVGLAIFVGIAASLALR

Sequences:

>Translated_301_residues
MSKQGFKNVPMAPALTWPERLGQYWKLVRGDRPIGSLLLLWPTWWALWLAAGGLPPLWTLFVFTAGVWLTRSAGCVINDY
ADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFALVLSLNWLTVALSVPGLFLAASYPYLKRHTHLPQVYLGMA
FGWGIPMGFAAVQGSVPLLAWLLYAANILWATAYDTWYAMVDREDDLRMGSKSTAILFGRYDLIAQGVLYALMFAALVLV
GLRAGLSIAYWAGLGIAALLVAYEFHIARHRERGPCFRAFLHNNWVGLAIFVGIAASLALR
>Mature_300_residues
SKQGFKNVPMAPALTWPERLGQYWKLVRGDRPIGSLLLLWPTWWALWLAAGGLPPLWTLFVFTAGVWLTRSAGCVINDYA
DRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFALVLSLNWLTVALSVPGLFLAASYPYLKRHTHLPQVYLGMAF
GWGIPMGFAAVQGSVPLLAWLLYAANILWATAYDTWYAMVDREDDLRMGSKSTAILFGRYDLIAQGVLYALMFAALVLVG
LRAGLSIAYWAGLGIAALLVAYEFHIARHRERGPCFRAFLHNNWVGLAIFVGIAASLALR

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=281, Percent_Identity=37.0106761565836, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1790473, Length=279, Percent_Identity=55.9139784946236, Blast_Score=303, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI17553718, Length=305, Percent_Identity=36.0655737704918, Blast_Score=174, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI32565247, Length=305, Percent_Identity=34.7540983606557, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17553720, Length=365, Percent_Identity=30.4109589041096, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32565245, Length=161, Percent_Identity=42.8571428571429, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI32565243, Length=160, Percent_Identity=42.5, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324370, Length=300, Percent_Identity=33, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI21355567, Length=274, Percent_Identity=38.3211678832117, Blast_Score=184, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_XANC8 (Q4UZN6)

Other databases:

- EMBL:   CP000050
- RefSeq:   YP_241507.1
- STRING:   Q4UZN6
- GeneID:   3381599
- GenomeReviews:   CP000050_GR
- KEGG:   xcb:XC_0402
- eggNOG:   COG0382
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- PhylomeDB:   Q4UZN6
- ProtClustDB:   PRK12848
- BioCyc:   XCAM314565:XC_0402-MONOMER
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33437; Mature: 33306

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12e3f200)-; HASH(0xe3836f8)-; HASH(0x124c0a94)-; HASH(0x11be149c)-; HASH(0x12ef2834)-; HASH(0x13478134)-; HASH(0x12d321d4)-; HASH(0x1346af50)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQGFKNVPMAPALTWPERLGQYWKLVRGDRPIGSLLLLWPTWWALWLAAGGLPPLWTL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
FVFTAGVWLTRSAGCVINDYADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFA
HHHHHHHHHHCCCCCEEEHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LVLSLNWLTVALSVPGLFLAASYPYLKRHTHLPQVYLGMAFGWGIPMGFAAVQGSVPLLA
HHHHHHHHHHHHHCCHHHHHCCCHHHHHHCCCCHHHHHHHHHCCCCHHHHHHCCCHHHHH
WLLYAANILWATAYDTWYAMVDREDDLRMGSKSTAILFGRYDLIAQGVLYALMFAALVLV
HHHHHHHHHHHHHHHHHHHEECCCHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
GLRAGLSIAYWAGLGIAALLVAYEFHIARHRERGPCFRAFLHNNWVGLAIFVGIAASLAL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHC
R
H
>Mature Secondary Structure 
SKQGFKNVPMAPALTWPERLGQYWKLVRGDRPIGSLLLLWPTWWALWLAAGGLPPLWTL
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
FVFTAGVWLTRSAGCVINDYADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFA
HHHHHHHHHHCCCCCEEEHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LVLSLNWLTVALSVPGLFLAASYPYLKRHTHLPQVYLGMAFGWGIPMGFAAVQGSVPLLA
HHHHHHHHHHHHHCCHHHHHCCCHHHHHHCCCCHHHHHHHHHCCCCHHHHHHCCCHHHHH
WLLYAANILWATAYDTWYAMVDREDDLRMGSKSTAILFGRYDLIAQGVLYALMFAALVLV
HHHHHHHHHHHHHHHHHHHEECCCHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
GLRAGLSIAYWAGLGIAALLVAYEFHIARHRERGPCFRAFLHNNWVGLAIFVGIAASLAL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHC
R
H

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA