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The map label for this gene is lldD [H]

Identifier: 66766459

GI number: 66766459

Start: 130905

End: 132065

Strand: Reverse

Name: lldD [H]

Synonym: XC_0110

Alternate gene names: 66766459

Gene position: 132065-130905 (Counterclockwise)

Preceding gene: 66766461

Following gene: 66766455

Centisome position: 2.57

GC content: 67.61

Gene sequence:

>1161_bases
ATGATCATTTCTGCCGCTTCCGATTACCGCGCCGCCGCCGAAGCCCGCTTGCCGCCGTTCCTGTTCCACTACATTGATGG
CGGCGCGTATGCCGAGCACACCTTGCGGCGCAATGTCTCGGACCTGGCGGATATCGCGTTGCGTCAGCGCGTGCTGCGCA
ATATGTCCGATCTCAGCCTGAGCACCGAGCTGTTCGGCGAGACGCTGGCGATGCCGGTGGCGCTGGCACCGGTGGGGCTC
ACCGGCATGTACGCACGCCGCGGCGAAGTGCAGGCCGCGCGTGCAGCCGCTGCGCGCGGCATTCCGTTCACGCTGTCCAC
GGTGTCGGTGTGCCCGATCGAGGAAGTGGCACCAGCGATCGACCGCCCGATGTGGTTCCAGCTGTATGTGCTCAAGGACC
GCGGCTTCATGCGCAACGCGCTGGAGCGCGCCAAGACCGCCGGGGTGACCACGCTGGTGTTCACGGTGGACATGCCCACG
CCCGGCGCGCGCTACCGCGATGCGCACTCGGGCATGAGCGGGCCTAACGCGTCGCTGCGGCGCATGCTGCAGGCGATGAC
GCACCCGCGCTGGGCGTGGGACGTGGGCCTGCTCGGCAAACCGCATGACCTGGGCAACATCTCCACCTACCGCGGCAGCC
CCACCGGATTGCAGGATTACATCGGCTGGCTGGCGGCCAATTTCGACCCCTCCATCTCGTGGAAGGACCTGGAATGGATC
CGCGAGTTCTGGACCGGGCCGATGGTGATCAAGGGCATCCTCGACCCGGAGGACGCACGCGACGCGGTGCGCTTCGGCGC
CGACGGCATCGTGGTGTCCAACCATGGCGGGCGCCAGCTCGATGGCGTGCTGTCCAGCGCGCGCGCATTGCCGGCGATTG
CCGATGCAGTGAAGGGCGAGCTGAAGATCCTGGCCGACTCGGGCATTCGCAGTGGGTTAGATGTGGTGCGCATGCTGGCG
CTGGGTGCCGATGCCGTATTGCTCGGCCGCGCGTTCGTCTACGCACTGGCCGCCGGCGGCCAGGCCGGCGTGGAAAACCT
GCTGACCCTGATCGAGCGCGAGATGCGCGTGGCGATGATCCTCACCGGCACGCATTCGGTGGCCGAGATCAGCGGCGACG
CGTTGAGCCGGGTAACGCGCGAGGCGGCGGTTGTGCCTTGA

Upstream 100 bases:

>100_bases
TGCATCGCTGTACACCCACGTGTGCGCGTTGGCCGCGACGGTTCGCGCCACGGGCGATCGTCTTACACTCTGAGGCTGCC
CCCGCCGCTCCCCGCCTTCG

Downstream 100 bases:

>100_bases
GGCTGGAAATTGGGGATTGGGGATTGGGGATTGGGAATCGGGAATCGGGAATCGGGAATCGGGAATCGTTAGAGCATCGC
GCGCGCACGGTTTTCGATGT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MIISAASDYRAAAEARLPPFLFHYIDGGAYAEHTLRRNVSDLADIALRQRVLRNMSDLSLSTELFGETLAMPVALAPVGL
TGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAIDRPMWFQLYVLKDRGFMRNALERAKTAGVTTLVFTVDMPT
PGARYRDAHSGMSGPNASLRRMLQAMTHPRWAWDVGLLGKPHDLGNISTYRGSPTGLQDYIGWLAANFDPSISWKDLEWI
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGELKILADSGIRSGLDVVRMLA
LGADAVLLGRAFVYALAAGGQAGVENLLTLIEREMRVAMILTGTHSVAEISGDALSRVTREAAVVP

Sequences:

>Translated_386_residues
MIISAASDYRAAAEARLPPFLFHYIDGGAYAEHTLRRNVSDLADIALRQRVLRNMSDLSLSTELFGETLAMPVALAPVGL
TGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAIDRPMWFQLYVLKDRGFMRNALERAKTAGVTTLVFTVDMPT
PGARYRDAHSGMSGPNASLRRMLQAMTHPRWAWDVGLLGKPHDLGNISTYRGSPTGLQDYIGWLAANFDPSISWKDLEWI
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGELKILADSGIRSGLDVVRMLA
LGADAVLLGRAFVYALAAGGQAGVENLLTLIEREMRVAMILTGTHSVAEISGDALSRVTREAAVVP
>Mature_386_residues
MIISAASDYRAAAEARLPPFLFHYIDGGAYAEHTLRRNVSDLADIALRQRVLRNMSDLSLSTELFGETLAMPVALAPVGL
TGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAIDRPMWFQLYVLKDRGFMRNALERAKTAGVTTLVFTVDMPT
PGARYRDAHSGMSGPNASLRRMLQAMTHPRWAWDVGLLGKPHDLGNISTYRGSPTGLQDYIGWLAANFDPSISWKDLEWI
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGELKILADSGIRSGLDVVRMLA
LGADAVLLGRAFVYALAAGGQAGVENLLTLIEREMRVAMILTGTHSVAEISGDALSRVTREAAVVP

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=365, Percent_Identity=36.4383561643836, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI54234014, Length=372, Percent_Identity=34.9462365591398, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI7705393, Length=372, Percent_Identity=34.9462365591398, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI1790033, Length=375, Percent_Identity=83.4666666666667, Blast_Score=654, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193208036, Length=370, Percent_Identity=34.0540540540541, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI32566217, Length=283, Percent_Identity=33.5689045936396, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323587, Length=389, Percent_Identity=30.0771208226221, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI78707188, Length=372, Percent_Identity=36.2903225806452, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI281363140, Length=372, Percent_Identity=36.2903225806452, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI78707190, Length=372, Percent_Identity=36.2903225806452, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41622; Mature: 41622

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISAASDYRAAAEARLPPFLFHYIDGGAYAEHTLRRNVSDLADIALRQRVLRNMSDLSL
CEECCCCCHHHHHHCCCCHHEEHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
STELFGETLAMPVALAPVGLTGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAI
HHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCEEECCEEECCHHHHHHHH
DRPMWFQLYVLKDRGFMRNALERAKTAGVTTLVFTVDMPTPGARYRDAHSGMSGPNASLR
CCCCEEEEEEEECCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHCCCCCCCHHHH
RMLQAMTHPRWAWDVGLLGKPHDLGNISTYRGSPTGLQDYIGWLAANFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGE
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
LKILADSGIRSGLDVVRMLALGADAVLLGRAFVYALAAGGQAGVENLLTLIEREMRVAMI
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEE
LTGTHSVAEISGDALSRVTREAAVVP
EECCCHHHHHCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIISAASDYRAAAEARLPPFLFHYIDGGAYAEHTLRRNVSDLADIALRQRVLRNMSDLSL
CEECCCCCHHHHHHCCCCHHEEHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
STELFGETLAMPVALAPVGLTGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAI
HHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCEEECCEEECCHHHHHHHH
DRPMWFQLYVLKDRGFMRNALERAKTAGVTTLVFTVDMPTPGARYRDAHSGMSGPNASLR
CCCCEEEEEEEECCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHCCCCCCCHHHH
RMLQAMTHPRWAWDVGLLGKPHDLGNISTYRGSPTGLQDYIGWLAANFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGE
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
LKILADSGIRSGLDVVRMLALGADAVLLGRAFVYALAAGGQAGVENLLTLIEREMRVAMI
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEE
LTGTHSVAEISGDALSRVTREAAVVP
EECCCHHHHHCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]