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The map label for this gene is catF [H]

Identifier: 66045961

GI number: 66045961

Start: 3306708

End: 3307970

Strand: Reverse

Name: catF [H]

Synonym: Psyr_2725

Alternate gene names: 66045961

Gene position: 3307970-3306708 (Counterclockwise)

Preceding gene: 66045962

Following gene: 66045960

Centisome position: 54.29

GC content: 65.16

Gene sequence:

>1263_bases
ATGAGTGGCAGCGGGCAGTATTCGGCATTCAGTGACGTGGCCATCGTCGATGCGGTGCGCACGCCCTGGGTGGATCTGGG
CGGTGCTCTGGCACCTGTCTCGCCCATCGATCTGGGTATCAAGGTCGGCCGCGAGGTTCTGGCGCGTGCCTCCATTCAGG
CGGATCAGGTCGACAGCGTACTGGCCGGTTCGATGGCGCAGGCCAGTTTCGATGCCTACCTGCTGCCCCGGCACATCGGC
CTGTACAGCGGCGTCGCGCACAGCGTTCCGGCATTGGGTGTGCAGCGTATCTGTGCCACCGGTTTCGAATTGTTGCGCCA
GGCCGCCTTGCACGTGGGCGAAGGCGGGCAGATGGCGCTGTGCGTCGCCGCCGAGTCCATGTCGCGCAACCCGATCGCGG
CCTATACCCACCGCAATGGCTTCTCGCTCGGTGCCGCTGTGCAGTTCAAGGATTTTCTCTGGGAAGCGCTGTATGACCCG
GCACCGGCGATGGACATGATCGCCACGGCAGACAACCTCGCAAGGCGTCATGGGTTGAGCCGTGAGGCGGTGGACCGCTA
TGCCTTGCTCAGCCATGAGCGGGCGCTGCAGTCGCAGGTTTCCGGCAAATGGACCGAGGAAATTGTCCCGGTCAGCAGCG
AGCGCTTTGCGCTGGAAGGCTATCAGCCGCGTAGCATCGAGTTGCCGCGAGGGGTTGAAGTGGTCGCGCAGGACAGCCAT
CCGCGTGCGACCCATCTGGCAGCGCTGTCGCGTCTGCGCGCCATTCACGCGAACGGGGTGCAGACCGCAGGCAATAGCTG
TGCGGTGGTCGATGGCGCGGCGGCGGCCCTGGTGGGGCGTGCTTCACAATCGACGAGACCGGTGTTGGCGCACCTGCTGG
CCAGCGCGGTGACGGGGGTGGCGCCAGAGTTCATGGGCATCGGCCCCGCACCTGCGATTCGCTTGCTGTTGCAGCGCAGC
GGGCTGGCGCTGAGCGATATTGGCCGACTGGAAATCAATGAAGCGCAGGCCGCTCAGGTTCTGGCGGTGGCACAAACCCT
AGAACTGGAACTGAAACTGGACCTCGAGCGGCTCAACTGTCTGGGTGGATCACTGGGCCTGGGTCACCCGTTGGCAGCCA
CCGGGCTACGTCTGGTCATGACCCTGGCCCGGCAACTGCGCGACGCGGGCCTGCGTTACGGTATCGCGGCAGCCTGCGTC
GGCGGCGGCCAGGGCATGGCGCTGCTGATCGAGAATCCCCATTATGTGTCCAACCGTGTCTAG

Upstream 100 bases:

>100_bases
GGTCGATCAACCAGCGCGCTGTTCTGCAGTGGCGCGCAGACAAGGTCGAAGCGCTGTACCGTGATCAGGATCCGGACAAG
CTCCGTGCCGAGCCCAAGGC

Downstream 100 bases:

>100_bases
CCAGGAAAATACCCGCAAATGCGACATTTTCCTGCTTCAAACGCTACCCCCCACGCAGGTCATCCTTTAGCGCTTGACCG
AATCGTGGCGAACAGTGAAT

Product: thiolase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSGSGQYSAFSDVAIVDAVRTPWVDLGGALAPVSPIDLGIKVGREVLARASIQADQVDSVLAGSMAQASFDAYLLPRHIG
LYSGVAHSVPALGVQRICATGFELLRQAALHVGEGGQMALCVAAESMSRNPIAAYTHRNGFSLGAAVQFKDFLWEALYDP
APAMDMIATADNLARRHGLSREAVDRYALLSHERALQSQVSGKWTEEIVPVSSERFALEGYQPRSIELPRGVEVVAQDSH
PRATHLAALSRLRAIHANGVQTAGNSCAVVDGAAAALVGRASQSTRPVLAHLLASAVTGVAPEFMGIGPAPAIRLLLQRS
GLALSDIGRLEINEAQAAQVLAVAQTLELELKLDLERLNCLGGSLGLGHPLAATGLRLVMTLARQLRDAGLRYGIAAACV
GGGQGMALLIENPHYVSNRV

Sequences:

>Translated_420_residues
MSGSGQYSAFSDVAIVDAVRTPWVDLGGALAPVSPIDLGIKVGREVLARASIQADQVDSVLAGSMAQASFDAYLLPRHIG
LYSGVAHSVPALGVQRICATGFELLRQAALHVGEGGQMALCVAAESMSRNPIAAYTHRNGFSLGAAVQFKDFLWEALYDP
APAMDMIATADNLARRHGLSREAVDRYALLSHERALQSQVSGKWTEEIVPVSSERFALEGYQPRSIELPRGVEVVAQDSH
PRATHLAALSRLRAIHANGVQTAGNSCAVVDGAAAALVGRASQSTRPVLAHLLASAVTGVAPEFMGIGPAPAIRLLLQRS
GLALSDIGRLEINEAQAAQVLAVAQTLELELKLDLERLNCLGGSLGLGHPLAATGLRLVMTLARQLRDAGLRYGIAAACV
GGGQGMALLIENPHYVSNRV
>Mature_419_residues
SGSGQYSAFSDVAIVDAVRTPWVDLGGALAPVSPIDLGIKVGREVLARASIQADQVDSVLAGSMAQASFDAYLLPRHIGL
YSGVAHSVPALGVQRICATGFELLRQAALHVGEGGQMALCVAAESMSRNPIAAYTHRNGFSLGAAVQFKDFLWEALYDPA
PAMDMIATADNLARRHGLSREAVDRYALLSHERALQSQVSGKWTEEIVPVSSERFALEGYQPRSIELPRGVEVVAQDSHP
RATHLAALSRLRAIHANGVQTAGNSCAVVDGAAAALVGRASQSTRPVLAHLLASAVTGVAPEFMGIGPAPAIRLLLQRSG
LALSDIGRLEINEAQAAQVLAVAQTLELELKLDLERLNCLGGSLGLGHPLAATGLRLVMTLARQLRDAGLRYGIAAACVG
GGQGMALLIENPHYVSNRV

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=406, Percent_Identity=34.7290640394089, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI148539872, Length=414, Percent_Identity=34.5410628019324, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4501853, Length=421, Percent_Identity=34.4418052256532, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI4557237, Length=410, Percent_Identity=28.780487804878, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI4504327, Length=447, Percent_Identity=29.7539149888143, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI194353979, Length=417, Percent_Identity=26.6187050359712, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI87082165, Length=410, Percent_Identity=35.8536585365854, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1788554, Length=411, Percent_Identity=36.2530413625304, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=36.2530413625304, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI48994986, Length=412, Percent_Identity=34.7087378640777, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1788683, Length=420, Percent_Identity=29.5238095238095, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI133906874, Length=407, Percent_Identity=38.8206388206388, Blast_Score=261, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17535921, Length=408, Percent_Identity=30.6372549019608, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI25147385, Length=405, Percent_Identity=26.9135802469136, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17551802, Length=437, Percent_Identity=27.4599542334096, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322031, Length=337, Percent_Identity=32.9376854599407, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6325229, Length=415, Percent_Identity=27.4698795180723, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17648125, Length=412, Percent_Identity=39.3203883495146, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24655093, Length=412, Percent_Identity=34.9514563106796, Blast_Score=205, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24640423, Length=412, Percent_Identity=27.1844660194175, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI17137578, Length=441, Percent_Identity=29.9319727891156, Blast_Score=131, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 44101; Mature: 43970

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGSGQYSAFSDVAIVDAVRTPWVDLGGALAPVSPIDLGIKVGREVLARASIQADQVDSV
CCCCCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
LAGSMAQASFDAYLLPRHIGLYSGVAHSVPALGVQRICATGFELLRQAALHVGEGGQMAL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
CVAAESMSRNPIAAYTHRNGFSLGAAVQFKDFLWEALYDPAPAMDMIATADNLARRHGLS
EEEEHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
REAVDRYALLSHERALQSQVSGKWTEEIVPVSSERFALEGYQPRSIELPRGVEVVAQDSH
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEECCCCCCCEECCCCCEEEECCCC
PRATHLAALSRLRAIHANGVQTAGNSCAVVDGAAAALVGRASQSTRPVLAHLLASAVTGV
CHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHC
APEFMGIGPAPAIRLLLQRSGLALSDIGRLEINEAQAAQVLAVAQTLELELKLDLERLNC
CHHHHCCCCHHHHHHHHHHCCCCHHCCCCEEECHHHHHHHHHHHHHHEEEEEECHHHHHH
LGGSLGLGHPLAATGLRLVMTLARQLRDAGLRYGIAAACVGGGQGMALLIENPHYVSNRV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCEEEEEECCCHHCCCC
>Mature Secondary Structure 
SGSGQYSAFSDVAIVDAVRTPWVDLGGALAPVSPIDLGIKVGREVLARASIQADQVDSV
CCCCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
LAGSMAQASFDAYLLPRHIGLYSGVAHSVPALGVQRICATGFELLRQAALHVGEGGQMAL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
CVAAESMSRNPIAAYTHRNGFSLGAAVQFKDFLWEALYDPAPAMDMIATADNLARRHGLS
EEEEHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
REAVDRYALLSHERALQSQVSGKWTEEIVPVSSERFALEGYQPRSIELPRGVEVVAQDSH
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEECCCCCCCEECCCCCEEEECCCC
PRATHLAALSRLRAIHANGVQTAGNSCAVVDGAAAALVGRASQSTRPVLAHLLASAVTGV
CHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHC
APEFMGIGPAPAIRLLLQRSGLALSDIGRLEINEAQAAQVLAVAQTLELELKLDLERLNC
CHHHHCCCCHHHHHHHHHHCCCCHHCCCCEEECHHHHHHHHHHHHHHEEEEEECHHHHHH
LGGSLGLGHPLAATGLRLVMTLARQLRDAGLRYGIAAACVGGGQGMALLIENPHYVSNRV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCEEEEEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]