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The map label for this gene is macA [H]

Identifier: 66045853

GI number: 66045853

Start: 3172404

End: 3173561

Strand: Direct

Name: macA [H]

Synonym: Psyr_2617

Alternate gene names: 66045853

Gene position: 3172404-3173561 (Clockwise)

Preceding gene: 66045852

Following gene: 66045854

Centisome position: 52.06

GC content: 59.07

Gene sequence:

>1158_bases
ATGAAAAAGTTGAAGTTTCGCAAAGTGCTCATCGTTGTCGTGTTGTTGGTTCTGGCAGCGGGTATTGCCTACAGCGTCCA
GTCCCCGGAAAAGGCTCCGGAGTACCTGACTGCCAAGGTCGAACGCACCGATATCGAAAACTCGGTGCTGGCCAGCGGGG
TGCTGCAGGGCATCAAGCAGGTTGACGTCGGCGCGCAGGTCTCGGGCCAGCTCAAGTCTTTGAAGGTCAATCTGGGCGAC
AAGGTCAAACAGGGTCAGTGGCTGGCGGAAATCGATCCCGTGGTGCTGCAGAACACGCTGCGCCAGTCGCAGGTCAACGA
ACAGAACCTGATCGCCCAGAAGGATGCGGCTGTCGCACAGCTCAAGGACGCCAAAGCCATTTACCAGCGCTACAAGCAAC
TGCGTGCGGATGATGCGATCTCGCAAAAGGACTTCGATACGGCGCAATCGGACTTCGAGGTCCGGAGTGCCAACCTGCGG
TCGCTGGAAGCCCAGGTGCGCGACGCAAGAATCCAGATCGAGACCGCCAGGATCAACCTGGGCTACACCCGTATCGTCGC
GCCGATCAGTGGTGATGTGGTGGGTATCGTGACGCAGGAAGGTCAGACTGTGATCGCCAGCCAACTGACACCGGTGATTC
TCAAATTGGCGGATCTGGACACCATGACCGTCAAGGCTCAGGTCTCCGAGGCCGACGTGATTCATATCACCCCCGGGCAA
GAGGTGTATTTCACCATCCTCGGCGATGCCGAAAAACGCTATTACGCCAAGCTGAAAGGCACGGAGCCAGCGCCGCAAAA
CTTCCTTGATGCGCAATCCAGCACCGCCAGCAAACCGAACAGTGCGGTGTTCTACAACGCATTGTTCGACGTCCCCAACC
CTGATCACCGCCTGCGTATTTCGATGACCGCCCAAGTGCATATCGTGCGTGAAAAGGCCAAGGACGTGTTGACTGTCCCT
GTTGCGGCCCTGGGCGACAAGAATGGCGACGGCAGCTTCCCGGTGCGTGTGGTGGACGCGCAGGGCCAGGCCCAGAGCCG
CAATGTGCAGACCGGCATCAACAACAACGTGCGGGTCGAGATCAAGAGTGGCCTTGCCGAGGGTGACCAGGTGGTGATCG
GTGAACCGTCGGCTACACCAGCAGCAGCGGGGGCCTGA

Upstream 100 bases:

>100_bases
ACGGCATCTGGCGAACTGGTGGCTACCCCATGAATAACGTCGTTTCTTCAAGCCCGGCGGCTGATCGCCGGGTCAATCCT
CAACACATTCGTGGCTTTCT

Downstream 100 bases:

>100_bases
CCATGAGTCGAGCTCTTCTGGAACTCAACGGTGTCACCCGTCGTTTCGTCGCCGGCGAAAAGGACTTCATCGCGCTTAAT
GACATCAACCTCACGATCAA

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKKLKFRKVLIVVVLLVLAAGIAYSVQSPEKAPEYLTAKVERTDIENSVLASGVLQGIKQVDVGAQVSGQLKSLKVNLGD
KVKQGQWLAEIDPVVLQNTLRQSQVNEQNLIAQKDAAVAQLKDAKAIYQRYKQLRADDAISQKDFDTAQSDFEVRSANLR
SLEAQVRDARIQIETARINLGYTRIVAPISGDVVGIVTQEGQTVIASQLTPVILKLADLDTMTVKAQVSEADVIHITPGQ
EVYFTILGDAEKRYYAKLKGTEPAPQNFLDAQSSTASKPNSAVFYNALFDVPNPDHRLRISMTAQVHIVREKAKDVLTVP
VAALGDKNGDGSFPVRVVDAQGQAQSRNVQTGINNNVRVEIKSGLAEGDQVVIGEPSATPAAAGA

Sequences:

>Translated_385_residues
MKKLKFRKVLIVVVLLVLAAGIAYSVQSPEKAPEYLTAKVERTDIENSVLASGVLQGIKQVDVGAQVSGQLKSLKVNLGD
KVKQGQWLAEIDPVVLQNTLRQSQVNEQNLIAQKDAAVAQLKDAKAIYQRYKQLRADDAISQKDFDTAQSDFEVRSANLR
SLEAQVRDARIQIETARINLGYTRIVAPISGDVVGIVTQEGQTVIASQLTPVILKLADLDTMTVKAQVSEADVIHITPGQ
EVYFTILGDAEKRYYAKLKGTEPAPQNFLDAQSSTASKPNSAVFYNALFDVPNPDHRLRISMTAQVHIVREKAKDVLTVP
VAALGDKNGDGSFPVRVVDAQGQAQSRNVQTGINNNVRVEIKSGLAEGDQVVIGEPSATPAAAGA
>Mature_385_residues
MKKLKFRKVLIVVVLLVLAAGIAYSVQSPEKAPEYLTAKVERTDIENSVLASGVLQGIKQVDVGAQVSGQLKSLKVNLGD
KVKQGQWLAEIDPVVLQNTLRQSQVNEQNLIAQKDAAVAQLKDAKAIYQRYKQLRADDAISQKDFDTAQSDFEVRSANLR
SLEAQVRDARIQIETARINLGYTRIVAPISGDVVGIVTQEGQTVIASQLTPVILKLADLDTMTVKAQVSEADVIHITPGQ
EVYFTILGDAEKRYYAKLKGTEPAPQNFLDAQSSTASKPNSAVFYNALFDVPNPDHRLRISMTAQVHIVREKAKDVLTVP
VAALGDKNGDGSFPVRVVDAQGQAQSRNVQTGINNNVRVEIKSGLAEGDQVVIGEPSATPAAAGA

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=386, Percent_Identity=45.3367875647668, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI87082036, Length=331, Percent_Identity=26.2839879154079, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789665, Length=390, Percent_Identity=26.1538461538462, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789929, Length=308, Percent_Identity=25.3246753246753, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41616; Mature: 41616

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLKFRKVLIVVVLLVLAAGIAYSVQSPEKAPEYLTAKVERTDIENSVLASGVLQGIKQ
CCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHH
VDVGAQVSGQLKSLKVNLGDKVKQGQWLAEIDPVVLQNTLRQSQVNEQNLIAQKDAAVAQ
HCCCCCCCCCEEEEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LKDAKAIYQRYKQLRADDAISQKDFDTAQSDFEVRSANLRSLEAQVRDARIQIETARINL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHCCEEEEEEEEEEEC
GYTRIVAPISGDVVGIVTQEGQTVIASQLTPVILKLADLDTMTVKAQVSEADVIHITPGQ
CEEEEEEECCCCEEEEEECCCCEEEHHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCCC
EVYFTILGDAEKRYYAKLKGTEPAPQNFLDAQSSTASKPNSAVFYNALFDVPNPDHRLRI
EEEEEEECCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEEE
SMTAQVHIVREKAKDVLTVPVAALGDKNGDGSFPVRVVDAQGQAQSRNVQTGINNNVRVE
EEEEEEEEEEHHCCCEEEECHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEE
IKSGLAEGDQVVIGEPSATPAAAGA
EECCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKKLKFRKVLIVVVLLVLAAGIAYSVQSPEKAPEYLTAKVERTDIENSVLASGVLQGIKQ
CCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHH
VDVGAQVSGQLKSLKVNLGDKVKQGQWLAEIDPVVLQNTLRQSQVNEQNLIAQKDAAVAQ
HCCCCCCCCCEEEEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LKDAKAIYQRYKQLRADDAISQKDFDTAQSDFEVRSANLRSLEAQVRDARIQIETARINL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHCCEEEEEEEEEEEC
GYTRIVAPISGDVVGIVTQEGQTVIASQLTPVILKLADLDTMTVKAQVSEADVIHITPGQ
CEEEEEEECCCCEEEEEECCCCEEEHHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCCC
EVYFTILGDAEKRYYAKLKGTEPAPQNFLDAQSSTASKPNSAVFYNALFDVPNPDHRLRI
EEEEEEECCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCEEEE
SMTAQVHIVREKAKDVLTVPVAALGDKNGDGSFPVRVVDAQGQAQSRNVQTGINNNVRVE
EEEEEEEEEEHHCCCEEEECHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEE
IKSGLAEGDQVVIGEPSATPAAAGA
EECCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]