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The map label for this gene is macA [H]

Identifier: 66045839

GI number: 66045839

Start: 3057159

End: 3058328

Strand: Direct

Name: macA [H]

Synonym: Psyr_2603

Alternate gene names: 66045839

Gene position: 3057159-3058328 (Clockwise)

Preceding gene: 66045836

Following gene: 66045840

Centisome position: 50.17

GC content: 56.15

Gene sequence:

>1170_bases
ATGGTCGGCTTTTTCCGGAAATTGAATGTCCGCAAAATCCTTTTGAGAATCGTCCTGATCGATCTGACGGTTTCGCTGGC
AGGCTATGCCTTCTATAAGGGCGCCAGCGGAGAAGAAGAGACTGCCTTTCTATCAGCCGCAGCAGAAGTTACGGACATTG
AGTACGCCGTATCCGCACAGGGTGTGCTTCAGGGGCGTAATCAAGTGGACGTTGGCGCCCAGGTTTCCGGGCAATTGCAG
TCCCTGAAAGTCAAACCAGGTGACCAGGTCAAAAAAAACCAGCTGTTGGCAGAGATCGATCCACTGCCCGCCAGAAATGC
TCTGCGCCAGGCGGTTGTCAAGATCGAACAACTCACGGCTGAGCGGGACGCGACACTGCACAGGTTGAAACTTGCCGAGT
CGAATGATCGTAGATATCAGGAATTGGGCGCTACGACGGCGGTTTCCAAAGCGGATCAGGACAAGGCCCGATTCGAGCTG
GAGACCCAACGCGCCAACCTGGTGTCGCTCACCGCACAATTACACACGGCCCGCGTGCAGGAAGAAGCCGCACGCATCAA
ACTCGACTACACACGAATCTTCGCACCAATGGATGGTCAGGTCCTCGCCATCGTCACTCAGGAGGGCCAGACAGTCATTG
CAGACCAGACGGCACCGGTCATTCTGAAGATGGCGCAACTCGACACCATGACCGTGAAGGCGCAGGTTTCCGAAGCCGAC
GTGCTCAAGATCAAACCCGGTCTTGCGATTTACTTCACTATCCCGGGCGATCCTGACACACGCTATAACGCCACCCTCAA
GGCGATCGAGCCGGGTCCTGTGGACGCTGCAAGCCAGACCGGAGCAACAGCCGAAAGCGGCAAAGCCGTCTTCTACAACG
CTCTTTTCGATGTCCTCAACCTTGAAAACCGCTTCTACATCAACATGACCGCTAACGTGCGAATTGTGCTGGAGGCGAAG
GAGGGCGTATTAACGATCCCTGTCGCCGCACTGGGTGATCGGCGGGACGACGGCACCTACAGTGTAAGGGTGCTGGGTGA
AGGTAACGAGGTCAGAACAGCCTACGTAGGGCCGGGTATCAATAACCAGGTCAGGGTCGAAATACGTTCGGGGCTTAAAG
CCGGCGACAGAGTGGTCATCGGAGAGCGGGGCGGTGTGGAAGGTGTTTAA

Upstream 100 bases:

>100_bases
GTATCGAAGTAGAGACTCTCATGTACGCCCTTTATTTAAGTGTTGATCCGTTGATTCATCCGAGATCCGGGACGCCCATT
GAGCGGGGAATACCGTGAGC

Downstream 100 bases:

>100_bases
GGGTAGGACGAGGATGTATTGGCAATAAGCGATCAAGGACAGTTTTCAGCCGACGTCAAATCGATAACGCACACCTTGCA
AGCGTCTGATCAATAAAATG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MVGFFRKLNVRKILLRIVLIDLTVSLAGYAFYKGASGEEETAFLSAAAEVTDIEYAVSAQGVLQGRNQVDVGAQVSGQLQ
SLKVKPGDQVKKNQLLAEIDPLPARNALRQAVVKIEQLTAERDATLHRLKLAESNDRRYQELGATTAVSKADQDKARFEL
ETQRANLVSLTAQLHTARVQEEAARIKLDYTRIFAPMDGQVLAIVTQEGQTVIADQTAPVILKMAQLDTMTVKAQVSEAD
VLKIKPGLAIYFTIPGDPDTRYNATLKAIEPGPVDAASQTGATAESGKAVFYNALFDVLNLENRFYINMTANVRIVLEAK
EGVLTIPVAALGDRRDDGTYSVRVLGEGNEVRTAYVGPGINNQVRVEIRSGLKAGDRVVIGERGGVEGV

Sequences:

>Translated_389_residues
MVGFFRKLNVRKILLRIVLIDLTVSLAGYAFYKGASGEEETAFLSAAAEVTDIEYAVSAQGVLQGRNQVDVGAQVSGQLQ
SLKVKPGDQVKKNQLLAEIDPLPARNALRQAVVKIEQLTAERDATLHRLKLAESNDRRYQELGATTAVSKADQDKARFEL
ETQRANLVSLTAQLHTARVQEEAARIKLDYTRIFAPMDGQVLAIVTQEGQTVIADQTAPVILKMAQLDTMTVKAQVSEAD
VLKIKPGLAIYFTIPGDPDTRYNATLKAIEPGPVDAASQTGATAESGKAVFYNALFDVLNLENRFYINMTANVRIVLEAK
EGVLTIPVAALGDRRDDGTYSVRVLGEGNEVRTAYVGPGINNQVRVEIRSGLKAGDRVVIGERGGVEGV
>Mature_389_residues
MVGFFRKLNVRKILLRIVLIDLTVSLAGYAFYKGASGEEETAFLSAAAEVTDIEYAVSAQGVLQGRNQVDVGAQVSGQLQ
SLKVKPGDQVKKNQLLAEIDPLPARNALRQAVVKIEQLTAERDATLHRLKLAESNDRRYQELGATTAVSKADQDKARFEL
ETQRANLVSLTAQLHTARVQEEAARIKLDYTRIFAPMDGQVLAIVTQEGQTVIADQTAPVILKMAQLDTMTVKAQVSEAD
VLKIKPGLAIYFTIPGDPDTRYNATLKAIEPGPVDAASQTGATAESGKAVFYNALFDVLNLENRFYINMTANVRIVLEAK
EGVLTIPVAALGDRRDDGTYSVRVLGEGNEVRTAYVGPGINNQVRVEIRSGLKAGDRVVIGERGGVEGV

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=331, Percent_Identity=44.7129909365559, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87082036, Length=337, Percent_Identity=29.3768545994065, Blast_Score=95, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42164; Mature: 42164

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGFFRKLNVRKILLRIVLIDLTVSLAGYAFYKGASGEEETAFLSAAAEVTDIEYAVSAQ
CCCCHHHCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHEEEEEEEECC
GVLQGRNQVDVGAQVSGQLQSLKVKPGDQVKKNQLLAEIDPLPARNALRQAVVKIEQLTA
HHHCCCCCEECCCEECCCEEEEEECCCCCHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHH
ERDATLHRLKLAESNDRRYQELGATTAVSKADQDKARFELETQRANLVSLTAQLHTARVQ
HHCCCEEEEEECCCCCHHHHHHCCHHHHCCCCCCHHEEEEECCCCCEEEEHHHHHHHHHH
EEAARIKLDYTRIFAPMDGQVLAIVTQEGQTVIADQTAPVILKMAQLDTMTVKAQVSEAD
HHHHEEEEEEEEEEECCCCCEEEEEECCCCEEEECCCCCEEEEEECCCEEEEEEECCCCE
VLKIKPGLAIYFTIPGDPDTRYNATLKAIEPGPVDAASQTGATAESGKAVFYNALFDVLN
EEEECCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHHHHC
LENRFYINMTANVRIVLEAKEGVLTIPVAALGDRRDDGTYSVRVLGEGNEVRTAYVGPGI
CCCEEEEEEECCEEEEEEECCCEEEEEHHHCCCCCCCCEEEEEEEECCCEEEEEEECCCC
NNQVRVEIRSGLKAGDRVVIGERGGVEGV
CCEEEEEEECCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MVGFFRKLNVRKILLRIVLIDLTVSLAGYAFYKGASGEEETAFLSAAAEVTDIEYAVSAQ
CCCCHHHCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHEEEEEEEECC
GVLQGRNQVDVGAQVSGQLQSLKVKPGDQVKKNQLLAEIDPLPARNALRQAVVKIEQLTA
HHHCCCCCEECCCEECCCEEEEEECCCCCHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHH
ERDATLHRLKLAESNDRRYQELGATTAVSKADQDKARFELETQRANLVSLTAQLHTARVQ
HHCCCEEEEEECCCCCHHHHHHCCHHHHCCCCCCHHEEEEECCCCCEEEEHHHHHHHHHH
EEAARIKLDYTRIFAPMDGQVLAIVTQEGQTVIADQTAPVILKMAQLDTMTVKAQVSEAD
HHHHEEEEEEEEEEECCCCCEEEEEECCCCEEEECCCCCEEEEEECCCEEEEEEECCCCE
VLKIKPGLAIYFTIPGDPDTRYNATLKAIEPGPVDAASQTGATAESGKAVFYNALFDVLN
EEEECCCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEHHHHHHHHC
LENRFYINMTANVRIVLEAKEGVLTIPVAALGDRRDDGTYSVRVLGEGNEVRTAYVGPGI
CCCEEEEEEECCEEEEEEECCCEEEEEHHHCCCCCCCCEEEEEEEECCCEEEEEEECCCC
NNQVRVEIRSGLKAGDRVVIGERGGVEGV
CCEEEEEEECCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]