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The map label for this gene is hlyB [H]

Identifier: 66045477

GI number: 66045477

Start: 2599432

End: 2601417

Strand: Direct

Name: hlyB [H]

Synonym: Psyr_2237

Alternate gene names: 66045477

Gene position: 2599432-2601417 (Clockwise)

Preceding gene: 66045476

Following gene: 66045478

Centisome position: 42.66

GC content: 60.78

Gene sequence:

>1986_bases
ATGACCATTCTTCAGCGAGTGATCGGTGGGTTTGCTGTGCTGGTGTTACTGCTGCTCGCCATGGCAGGTATCAGCTATCA
AAGCACCCATTCCATAAGCGATCGGATCAGCGTCATCACAGGGCAGTCCGCACCCTTGAGCAGGGCGGCGAGCGAGCTTT
ACGTGCATGTGCTGCGCGCCAACCAGGCACTGCTCGGGATTCTGGTCAGCACTGATCCCAAACAGATCGATGATGGCAAG
CAGCCGTTCAACGACAGCATGACCCGGTTCAATCAGTTGCTGGACAGCACGCCTGCCTACATTGGCGATCGTGCCGAACT
GCGCGACAACCTGAACCAGCAACGCCAACTGAGTGCGGCTTATGCCGAGCAGGCGCAGACGCTGATTGCCAGCCATCGAC
AGCACGTTCTGCAGGCACTTCAGAGCCGAGTGCTGCAGGGCTACAGCAGCAGTCAGGGCGCGCAACTGACCGGTTATCTT
CGTGACTATATTGCCCGCGAGCGCAACGCCGGCTCCGCCGAGACGGTGGCGGCGGGGGAAAAGCTGTTACTGGACGTCGG
CAAATCCTACGAAGGTCTGGCTGCCCATGCCGCCACACCGAATATTCAGACCTTGCAGCGCGTGCTCAACCTGCAGGATG
AGGTGATCAGCACCCGCACACGGGAGCTCATCGCAGCCGACCCGCGCGCCGGCCGGATTGCCAGCGTGATGGTCAACCGC
TTGCTGAACGACCTGACCGGCAGCGACGGCGTTTATCAGGCCTACAGGCAGGAAGCGGCACTCGCCGAGCAGGTCGACAA
ACAGCGCCAGGCAGCGGAAACCCGTCTTCAGGCAACGCTGGGCAAGATTGGCGAGTTCGGCAATCAGTCACTGGCGGTGG
CCAACGAGGCCAAGGCCGGGGCTGATTCGACGATTGCCACCAGCCTTAGCCTGTTGCTGATCGCCTGCCTGCTGGCCGTC
ATGGCGGCAGCAATCATCGGCACATGGGTCGCCTTCAGCCTTCGTCGCCCTCTGGCTGCGTTTCGCGAGGTTTTGAAGAC
GCTCACCAGTGGCGACATGCGGGTACGTTTCGACGTCAGCCGCCGCGATGAGTTTGGTGAGTTGGGGGGTTATCTCAATG
AATTCACCCAGTCGTTGCAACAGACGTTTCGTCAGCTGATCGGGTCGGCCGACACCCTGGCGCTGACCGCCAGCCAGAAC
GCGCAGATCAGTGAGCAGACTACCCGCGTGGTCGACGAGCAGAAGGATCGTCTCAACTCTGCCGCGTCAGCCATGAATGA
AATGGAAAGCACGGTCGAGGAAGTCGCCCGTCGGGCTCAGGACACTCGTGGCGCGGTGGACAGCACCAGTGAGTTGACCG
GGAAAGTGCAAAAGCGCGTGGCTGAGACCATCGTCAACATTCGCCAGCAGGCTGAGCAGGTCAACAAGGCGTCTGCGGTG
ACCGACGAGTTGCAGAAATACGGGCAGAACATCGACGGCATCGTCGACGCCATTCGCACCATTGCCGAACAGACCAACCT
GCTGGCGCTCAACGCAGCCATCGAAGCGGCGCGGGCTGGCGAGCAGGGCAGGGGCTTTGCGGTGGTGGCCGATGAGGTGC
GCTCGCTGGCCAGTCGCACCCAGACCTCCACCAGCGAGATCCAGGAAATGATCGGCCAGATGCAGAGCAAGATCCATTCG
GCGGTAGAGGTGATGAACGAAAGCCAGATCCAGTCCGACCATTGCGTGACACTGGCCTCCGGCGCTGATCAATTGCTGGT
GGAAATGGGCGAGGCGGTGGATGTGATTCGCGACATGAACATTCAGATCGCTGCGGCCACCGAACAGCAAAGCGCGACCG
TGCAGGAGACCAGTCGCATGGTCACGCACATCAACGATTCCGCCCAGCAGGCCGCCGACGGTGCCGAGCAATCGGCAATC
AGCAGTCAGGACCTGTCAAAAATGGCCAGGGATCAGCGCGAGCTGCTCCATCATTTCAGCGTTTAA

Upstream 100 bases:

>100_bases
CGGCCGACATTCTCTTTAGCGCTGCGATCATTTTCCGGACTGACGTTCTCCACGCGGGCCCGGATCAGATTCAGCGCAAT
AAAAATAAAAGAGGATAGCC

Downstream 100 bases:

>100_bases
CGCCCCGGGAGTCAGAACATGAAACAGTGGTTATCGATTTCCCTGAGTGCGAGCCTGCTGTTCGCTGGCCTGGCGCAGGC
GGCCACGCCGCTGATCGGTG

Product: histidine kinase, HAMP region: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MTILQRVIGGFAVLVLLLLAMAGISYQSTHSISDRISVITGQSAPLSRAASELYVHVLRANQALLGILVSTDPKQIDDGK
QPFNDSMTRFNQLLDSTPAYIGDRAELRDNLNQQRQLSAAYAEQAQTLIASHRQHVLQALQSRVLQGYSSSQGAQLTGYL
RDYIARERNAGSAETVAAGEKLLLDVGKSYEGLAAHAATPNIQTLQRVLNLQDEVISTRTRELIAADPRAGRIASVMVNR
LLNDLTGSDGVYQAYRQEAALAEQVDKQRQAAETRLQATLGKIGEFGNQSLAVANEAKAGADSTIATSLSLLLIACLLAV
MAAAIIGTWVAFSLRRPLAAFREVLKTLTSGDMRVRFDVSRRDEFGELGGYLNEFTQSLQQTFRQLIGSADTLALTASQN
AQISEQTTRVVDEQKDRLNSAASAMNEMESTVEEVARRAQDTRGAVDSTSELTGKVQKRVAETIVNIRQQAEQVNKASAV
TDELQKYGQNIDGIVDAIRTIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLASRTQTSTSEIQEMIGQMQSKIHS
AVEVMNESQIQSDHCVTLASGADQLLVEMGEAVDVIRDMNIQIAAATEQQSATVQETSRMVTHINDSAQQAADGAEQSAI
SSQDLSKMARDQRELLHHFSV

Sequences:

>Translated_661_residues
MTILQRVIGGFAVLVLLLLAMAGISYQSTHSISDRISVITGQSAPLSRAASELYVHVLRANQALLGILVSTDPKQIDDGK
QPFNDSMTRFNQLLDSTPAYIGDRAELRDNLNQQRQLSAAYAEQAQTLIASHRQHVLQALQSRVLQGYSSSQGAQLTGYL
RDYIARERNAGSAETVAAGEKLLLDVGKSYEGLAAHAATPNIQTLQRVLNLQDEVISTRTRELIAADPRAGRIASVMVNR
LLNDLTGSDGVYQAYRQEAALAEQVDKQRQAAETRLQATLGKIGEFGNQSLAVANEAKAGADSTIATSLSLLLIACLLAV
MAAAIIGTWVAFSLRRPLAAFREVLKTLTSGDMRVRFDVSRRDEFGELGGYLNEFTQSLQQTFRQLIGSADTLALTASQN
AQISEQTTRVVDEQKDRLNSAASAMNEMESTVEEVARRAQDTRGAVDSTSELTGKVQKRVAETIVNIRQQAEQVNKASAV
TDELQKYGQNIDGIVDAIRTIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLASRTQTSTSEIQEMIGQMQSKIHS
AVEVMNESQIQSDHCVTLASGADQLLVEMGEAVDVIRDMNIQIAAATEQQSATVQETSRMVTHINDSAQQAADGAEQSAI
SSQDLSKMARDQRELLHHFSV
>Mature_660_residues
TILQRVIGGFAVLVLLLLAMAGISYQSTHSISDRISVITGQSAPLSRAASELYVHVLRANQALLGILVSTDPKQIDDGKQ
PFNDSMTRFNQLLDSTPAYIGDRAELRDNLNQQRQLSAAYAEQAQTLIASHRQHVLQALQSRVLQGYSSSQGAQLTGYLR
DYIARERNAGSAETVAAGEKLLLDVGKSYEGLAAHAATPNIQTLQRVLNLQDEVISTRTRELIAADPRAGRIASVMVNRL
LNDLTGSDGVYQAYRQEAALAEQVDKQRQAAETRLQATLGKIGEFGNQSLAVANEAKAGADSTIATSLSLLLIACLLAVM
AAAIIGTWVAFSLRRPLAAFREVLKTLTSGDMRVRFDVSRRDEFGELGGYLNEFTQSLQQTFRQLIGSADTLALTASQNA
QISEQTTRVVDEQKDRLNSAASAMNEMESTVEEVARRAQDTRGAVDSTSELTGKVQKRVAETIVNIRQQAEQVNKASAVT
DELQKYGQNIDGIVDAIRTIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLASRTQTSTSEIQEMIGQMQSKIHSA
VEVMNESQIQSDHCVTLASGADQLLVEMGEAVDVIRDMNIQIAAATEQQSATVQETSRMVTHINDSAQQAADGAEQSAIS
SQDLSKMARDQRELLHHFSV

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=335, Percent_Identity=28.6567164179104, Blast_Score=112, Evalue=9e-26,
Organism=Escherichia coli, GI1788194, Length=348, Percent_Identity=28.448275862069, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1787690, Length=342, Percent_Identity=28.0701754385965, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1788195, Length=315, Percent_Identity=28.8888888888889, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1789453, Length=333, Percent_Identity=26.4264264264264, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 71613; Mature: 71482

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILQRVIGGFAVLVLLLLAMAGISYQSTHSISDRISVITGQSAPLSRAASELYVHVLRA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHH
NQALLGILVSTDPKQIDDGKQPFNDSMTRFNQLLDSTPAYIGDRAELRDNLNQQRQLSAA
CHHHHEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCCHHHHHHCHHHHHHHHHH
YAEQAQTLIASHRQHVLQALQSRVLQGYSSSQGAQLTGYLRDYIARERNAGSAETVAAGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
KLLLDVGKSYEGLAAHAATPNIQTLQRVLNLQDEVISTRTRELIAADPRAGRIASVMVNR
HHHHHHCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LLNDLTGSDGVYQAYRQEAALAEQVDKQRQAAETRLQATLGKIGEFGNQSLAVANEAKAG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHCCC
ADSTIATSLSLLLIACLLAVMAAAIIGTWVAFSLRRPLAAFREVLKTLTSGDMRVRFDVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECH
RRDEFGELGGYLNEFTQSLQQTFRQLIGSADTLALTASQNAQISEQTTRVVDEQKDRLNS
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
AASAMNEMESTVEEVARRAQDTRGAVDSTSELTGKVQKRVAETIVNIRQQAEQVNKASAV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDELQKYGQNIDGIVDAIRTIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLASRT
HHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHH
QTSTSEIQEMIGQMQSKIHSAVEVMNESQIQSDHCVTLASGADQLLVEMGEAVDVIRDMN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHCCC
IQIAAATEQQSATVQETSRMVTHINDSAQQAADGAEQSAISSQDLSKMARDQRELLHHFS
EEEEECCCHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
V
C
>Mature Secondary Structure 
TILQRVIGGFAVLVLLLLAMAGISYQSTHSISDRISVITGQSAPLSRAASELYVHVLRA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHH
NQALLGILVSTDPKQIDDGKQPFNDSMTRFNQLLDSTPAYIGDRAELRDNLNQQRQLSAA
CHHHHEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCCHHHHHHCHHHHHHHHHH
YAEQAQTLIASHRQHVLQALQSRVLQGYSSSQGAQLTGYLRDYIARERNAGSAETVAAGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
KLLLDVGKSYEGLAAHAATPNIQTLQRVLNLQDEVISTRTRELIAADPRAGRIASVMVNR
HHHHHHCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LLNDLTGSDGVYQAYRQEAALAEQVDKQRQAAETRLQATLGKIGEFGNQSLAVANEAKAG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHCCC
ADSTIATSLSLLLIACLLAVMAAAIIGTWVAFSLRRPLAAFREVLKTLTSGDMRVRFDVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECH
RRDEFGELGGYLNEFTQSLQQTFRQLIGSADTLALTASQNAQISEQTTRVVDEQKDRLNS
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
AASAMNEMESTVEEVARRAQDTRGAVDSTSELTGKVQKRVAETIVNIRQQAEQVNKASAV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDELQKYGQNIDGIVDAIRTIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLASRT
HHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHH
QTSTSEIQEMIGQMQSKIHSAVEVMNESQIQSDHCVTLASGADQLLVEMGEAVDVIRDMN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHCCC
IQIAAATEQQSATVQETSRMVTHINDSAQQAADGAEQSAISSQDLSKMARDQRELLHHFS
EEEEECCCHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]