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The map label for this gene is map [H]

Identifier: 66045386

GI number: 66045386

Start: 2503827

End: 2504618

Strand: Direct

Name: map [H]

Synonym: Psyr_2146

Alternate gene names: 66045386

Gene position: 2503827-2504618 (Clockwise)

Preceding gene: 66045385

Following gene: 66045390

Centisome position: 41.09

GC content: 59.09

Gene sequence:

>792_bases
ATGAGCAGCGCTATCGGTATCAAGACCGAACAGGACCTCGTGCAGTTGCGCATAGCCGGCAGGCTGGCTGCCGATGTGCT
CGCGATGATCACGCCTTACGTCAAGGCTGGCGTCAGCACCGAAGCGCTCGACGACATCTGCAATGAATACATCGTCAAAG
AGCTGAAAGTGATTCCCGCGAATGTGGGTTATCACGGTTTTACCAAGACCACCTGCATCTCCCCGAATGCCGTAGTGTGC
CATGGCATACCTTCTGCCACCGATATCCTCAAGGAAGGCGATATCGTCAATATCGACGTTGCAGTGATCAAAGACGGCTG
GTACGGCGATACCAGCCGTATGTACCTGGTGGGTGAGGTCAGCCCGCTGGCCAGGCGTCTGGTCGAGACGACCTATGAGG
CAACTCGCGCCGGTATTCATGCCGTGCGTCCGGGGGCAACCCTGGGTGATATCGGTTACGCCATCCAGAGCGTCGCTCAT
CGCGAAGGCTTCAGCGTGGTACGTGAGTATTGCGGGCACGGTATCGGGCGCAAGTACCATGAAGAACCGCAGGTTCTGCA
CTATGGTGCGCAGGGCAAAGGCCTCAGGCTCAAACCGGGCATGGTGTTTACCATCGAGCCGATGATCAATGCGGGCAGGG
CGGGCACCCGGACGTTGCCGGATGGCTGGACGGTTCTGACCAGCGACCTCTCACTGTCTGCGCAGTGGGAGCATATGGTT
GCCGTCACCTCGACCGGTTTCGAGCTGCTGACGCCGTGGCCTGACGGTACGGGTGATTACCCGGCCATCTGA

Upstream 100 bases:

>100_bases
AGATGCTGATCCGTCTCGAAAATGCCGGTGAGACCGTGTTGACCGCTTCGAACTTCAACGTCTCGGAGCTTGCAGCTTCC
AGCCTGTCCAAGGCGGCCTC

Downstream 100 bases:

>100_bases
TCCAGTAGGGTCTGGCAATGTATATGAACAATGGCCTTTTCGAAGGCCATTGCTTTGTTGGAAAGGGCGATGCCTCAGGC
TTGTAGCGAAGACCTTCTCC

Product: peptidase M24A

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSSAIGIKTEQDLVQLRIAGRLAADVLAMITPYVKAGVSTEALDDICNEYIVKELKVIPANVGYHGFTKTTCISPNAVVC
HGIPSATDILKEGDIVNIDVAVIKDGWYGDTSRMYLVGEVSPLARRLVETTYEATRAGIHAVRPGATLGDIGYAIQSVAH
REGFSVVREYCGHGIGRKYHEEPQVLHYGAQGKGLRLKPGMVFTIEPMINAGRAGTRTLPDGWTVLTSDLSLSAQWEHMV
AVTSTGFELLTPWPDGTGDYPAI

Sequences:

>Translated_263_residues
MSSAIGIKTEQDLVQLRIAGRLAADVLAMITPYVKAGVSTEALDDICNEYIVKELKVIPANVGYHGFTKTTCISPNAVVC
HGIPSATDILKEGDIVNIDVAVIKDGWYGDTSRMYLVGEVSPLARRLVETTYEATRAGIHAVRPGATLGDIGYAIQSVAH
REGFSVVREYCGHGIGRKYHEEPQVLHYGAQGKGLRLKPGMVFTIEPMINAGRAGTRTLPDGWTVLTSDLSLSAQWEHMV
AVTSTGFELLTPWPDGTGDYPAI
>Mature_262_residues
SSAIGIKTEQDLVQLRIAGRLAADVLAMITPYVKAGVSTEALDDICNEYIVKELKVIPANVGYHGFTKTTCISPNAVVCH
GIPSATDILKEGDIVNIDVAVIKDGWYGDTSRMYLVGEVSPLARRLVETTYEATRAGIHAVRPGATLGDIGYAIQSVAHR
EGFSVVREYCGHGIGRKYHEEPQVLHYGAQGKGLRLKPGMVFTIEPMINAGRAGTRTLPDGWTVLTSDLSLSAQWEHMVA
VTSTGFELLTPWPDGTGDYPAI

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=250, Percent_Identity=43.2, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI40385867, Length=251, Percent_Identity=39.4422310756972, Blast_Score=185, Evalue=4e-47,
Organism=Escherichia coli, GI1786364, Length=260, Percent_Identity=58.4615384615385, Blast_Score=312, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI71996291, Length=256, Percent_Identity=40.234375, Blast_Score=187, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6323273, Length=250, Percent_Identity=40.8, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI21355531, Length=256, Percent_Identity=40.234375, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=37.9591836734694, Blast_Score=171, Evalue=3e-43,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28370; Mature: 28239

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAIGIKTEQDLVQLRIAGRLAADVLAMITPYVKAGVSTEALDDICNEYIVKELKVIPA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEC
NVGYHGFTKTTCISPNAVVCHGIPSATDILKEGDIVNIDVAVIKDGWYGDTSRMYLVGEV
CCCCCCCCCEEECCCCCEEEECCCCHHHHHHCCCEEEEEEEEEECCCCCCCCCEEEEECC
SPLARRLVETTYEATRAGIHAVRPGATLGDIGYAIQSVAHREGFSVVREYCGHGIGRKYH
CHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EEPQVLHYGAQGKGLRLKPGMVFTIEPMINAGRAGTRTLPDGWTVLTSDLSLSAQWEHMV
CCCCEEEECCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEE
AVTSTGFELLTPWPDGTGDYPAI
EEEECCCEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SSAIGIKTEQDLVQLRIAGRLAADVLAMITPYVKAGVSTEALDDICNEYIVKELKVIPA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEC
NVGYHGFTKTTCISPNAVVCHGIPSATDILKEGDIVNIDVAVIKDGWYGDTSRMYLVGEV
CCCCCCCCCEEECCCCCEEEECCCCHHHHHHCCCEEEEEEEEEECCCCCCCCCEEEEECC
SPLARRLVETTYEATRAGIHAVRPGATLGDIGYAIQSVAHREGFSVVREYCGHGIGRKYH
CHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EEPQVLHYGAQGKGLRLKPGMVFTIEPMINAGRAGTRTLPDGWTVLTSDLSLSAQWEHMV
CCCCEEEECCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEE
AVTSTGFELLTPWPDGTGDYPAI
EEEECCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]