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The map label for this gene is panE [C]

Identifier: 66045314

GI number: 66045314

Start: 2419564

End: 2420535

Strand: Direct

Name: panE [C]

Synonym: Psyr_2074

Alternate gene names: 66045314

Gene position: 2419564-2420535 (Clockwise)

Preceding gene: 66045312

Following gene: 66045315

Centisome position: 39.71

GC content: 64.51

Gene sequence:

>972_bases
ATGAGTGTTGATTCCCGTGGTCCGCGCGTCGGCATCATTGGTACGGGTGCCATCGGTGGCTTTTACGGACTGATGCTGGC
GCGTGCCGGATACGATGTGCATTTTCTGCTGCGCAGCGAGTTTGACACGGTGGCGCGCGAAGGTTTGCAGGTCAAAAGCG
CCGTGCACGGCGAGCTGTCCCTCAAGCCCGTTCAGGCGTATCGCTCGGCGGCTGAAATGCCGCCTTGTGACTGGCTGCTG
GTCGGCACCAAGAGCACCGGCAATGCCGCGCTCGGTCCGATCATCCGTCAGGTGGCTGCGCCGAATGCCAGCGTGCTGCT
GTTGCAAAACGGCCTGGCTGTCGAAGACCAACTGCGTAACGTCCTGCCCGACAGCCTGCACATACTCGGCGGGCTGTGTT
TCGTCTGCGTCAACCGGGTTGCGCCCGGCGTCGTCGCCCATGAAGCCTTCGGTGCGGTCAGTGTCGGCTATCACAGCGGC
CCGGCGGACGATGAGGCGAGCCGCATGGCGGTCGTCGAAGCCTGCGCGGCCCTGTTCAAGACGGCCGGCATCGACGCGCC
GGTCATGGCCAATCTGCAGCAGGCCCGCTGGCAGAAGCTGGTCTGGAATGTGCCCTATAACGGGCTGTCGGCCTTGTTGC
AGACCAGTACCGGTCGATTGATGGCCGATCCTGACAGCCAGGCCTTGATCCGGGCGCTGATGGACGAGGTCGTGCAGGGG
GCCGAGGCCTGCGGGCACACCTTGCCGCCGGGTTTCGCGCAGCATCTGTTTACAGTGACCGAAAACATGCCGGATTACAG
GCCCAGCATGTACCACGACCTGGCCGAAAGACGCCCGCTGGAGCTGGACGCCATTTATGCCCGGCCCCTTGCGGCGGCGC
TTGCCGCCGGGTTTGACATGCCCCGCGTGCGGGCGCTTTATCAGGCACTGGCGTTCATCGATCGGGGCAACCGCCCGGCA
AGCAAGGAGTGA

Upstream 100 bases:

>100_bases
TGGCCAGGTCGTTGCCCGGGATGCGCTGCCTTATTGCAAGACAATCCGCTGCGACGGATAGTGTACGGCCGCAAATAGCG
AGACAGTCAAGGGAGAGGTC

Downstream 100 bases:

>100_bases
TTCATGACAGAAGCTGAAGACCATAAGCTGGTACTGGCGATTTCATCGCGCGCACTGTTCGATCTGCGCGACAGTCATGA
GGTGTACATGGCCGATGGCG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSVDSRGPRVGIIGTGAIGGFYGLMLARAGYDVHFLLRSEFDTVAREGLQVKSAVHGELSLKPVQAYRSAAEMPPCDWLL
VGTKSTGNAALGPIIRQVAAPNASVLLLQNGLAVEDQLRNVLPDSLHILGGLCFVCVNRVAPGVVAHEAFGAVSVGYHSG
PADDEASRMAVVEACAALFKTAGIDAPVMANLQQARWQKLVWNVPYNGLSALLQTSTGRLMADPDSQALIRALMDEVVQG
AEACGHTLPPGFAQHLFTVTENMPDYRPSMYHDLAERRPLELDAIYARPLAAALAAGFDMPRVRALYQALAFIDRGNRPA
SKE

Sequences:

>Translated_323_residues
MSVDSRGPRVGIIGTGAIGGFYGLMLARAGYDVHFLLRSEFDTVAREGLQVKSAVHGELSLKPVQAYRSAAEMPPCDWLL
VGTKSTGNAALGPIIRQVAAPNASVLLLQNGLAVEDQLRNVLPDSLHILGGLCFVCVNRVAPGVVAHEAFGAVSVGYHSG
PADDEASRMAVVEACAALFKTAGIDAPVMANLQQARWQKLVWNVPYNGLSALLQTSTGRLMADPDSQALIRALMDEVVQG
AEACGHTLPPGFAQHLFTVTENMPDYRPSMYHDLAERRPLELDAIYARPLAAALAAGFDMPRVRALYQALAFIDRGNRPA
SKE
>Mature_322_residues
SVDSRGPRVGIIGTGAIGGFYGLMLARAGYDVHFLLRSEFDTVAREGLQVKSAVHGELSLKPVQAYRSAAEMPPCDWLLV
GTKSTGNAALGPIIRQVAAPNASVLLLQNGLAVEDQLRNVLPDSLHILGGLCFVCVNRVAPGVVAHEAFGAVSVGYHSGP
ADDEASRMAVVEACAALFKTAGIDAPVMANLQQARWQKLVWNVPYNGLSALLQTSTGRLMADPDSQALIRALMDEVVQGA
EACGHTLPPGFAQHLFTVTENMPDYRPSMYHDLAERRPLELDAIYARPLAAALAAGFDMPRVRALYQALAFIDRGNRPAS
KE

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320057, Length=339, Percent_Identity=22.7138643067847, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 34528; Mature: 34397

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDSRGPRVGIIGTGAIGGFYGLMLARAGYDVHFLLRSEFDTVAREGLQVKSAVHGELS
CCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCHHHHHHCCCCC
LKPVQAYRSAAEMPPCDWLLVGTKSTGNAALGPIIRQVAAPNASVLLLQNGLAVEDQLRN
CHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHH
VLPDSLHILGGLCFVCVNRVAPGVVAHEAFGAVSVGYHSGPADDEASRMAVVEACAALFK
HCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHH
TAGIDAPVMANLQQARWQKLVWNVPYNGLSALLQTSTGRLMADPDSQALIRALMDEVVQG
HCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHH
AEACGHTLPPGFAQHLFTVTENMPDYRPSMYHDLAERRPLELDAIYARPLAAALAAGFDM
HHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
PRVRALYQALAFIDRGNRPASKE
HHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SVDSRGPRVGIIGTGAIGGFYGLMLARAGYDVHFLLRSEFDTVAREGLQVKSAVHGELS
CCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCHHHHHHCCCCC
LKPVQAYRSAAEMPPCDWLLVGTKSTGNAALGPIIRQVAAPNASVLLLQNGLAVEDQLRN
CHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHH
VLPDSLHILGGLCFVCVNRVAPGVVAHEAFGAVSVGYHSGPADDEASRMAVVEACAALFK
HCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHH
TAGIDAPVMANLQQARWQKLVWNVPYNGLSALLQTSTGRLMADPDSQALIRALMDEVVQG
HCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHH
AEACGHTLPPGFAQHLFTVTENMPDYRPSMYHDLAERRPLELDAIYARPLAAALAAGFDM
HHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
PRVRALYQALAFIDRGNRPASKE
HHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]