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The map label for this gene is lpxD [H]

Identifier: 66044601

GI number: 66044601

Start: 1533763

End: 1534818

Strand: Direct

Name: lpxD [H]

Synonym: Psyr_1353

Alternate gene names: 66044601

Gene position: 1533763-1534818 (Clockwise)

Preceding gene: 66044600

Following gene: 66044602

Centisome position: 25.17

GC content: 57.58

Gene sequence:

>1056_bases
ATGAGCATAACCATCAAGCTCGGCCAGTTGGCCGAGTTCCTTGGTGCCACGTTACGTGGCGACAAGGATATCGAAATCAC
CGGGCTGGCCACTTTGCAAGAGGCCGGCCCTGGTCAAGTCAGTTTCCTGGCAAATCCCAAGTACCGTAAATTGCTGGTCG
ATACCCAGGCCACTGCCGTGCTGCTCAAACCTGCAGACGCCGACGGTTACGCCGGTAATGCGCTGGTGGTTCCTGATACT
TATCTGGCCTACGCACGCATTTCGCATTTTTTCGATCCCAAGCCTAAAAGTAGCGCAGGCGTTCATCCGACGGCAGTGAT
TGCCGCAGATGCACTGATTGATCCTGCTGCCAGCATTGGCGCTTTTGCTGTGATCGAGAGCGGTGTGCGCATTGCAGCAG
GTGTCACCATCGGTGCTCACTGCTTCATCGGCGCTCGCTGCGAGATCGGTGAAGGCGGCTGGCTGGCCCCGCGGGTAACG
CTTTACCACGATGTGCGCATTGGCAAGCGCGTGGTCATCCAGTCGGGTGCTGTGCTGGGTGGCGAAGGCTTTGGCTTTGC
CCAGGATAAAGGTATCTACCACAAGGTTGCACAGATCGGTGGCGTCACCCTCGGTGATGACGTCGAGGTTGGCGTCAATA
CGGCGATCGATCGCGGTGCACTGGCTGACACGCGCATCGGCAATGGCGTGAAACTGGATAACCAGATTCAGATTGCTCAC
AACGTTCAGATTGGCGACCACACGGCGATGGCTGCGTGTGTCGGCATTTCCGGAAGCACCAAAATCGGCAAGCATTGCAT
GCTGGCTGGAGGTGTCGGTCTGGTGGGGCATATCGAGATTTGCGATGGCGTTTTCATCACCGGCATGACGATGGTGACGC
ATTCCATCACCGAGCCGGGTTCGTACTCGTCCGGTACGGCCATGCAGCCGGCCGCCGAGTGGCGCAAGAGTGCAGCTCGT
CTGCGCAAGATCGATGATATGGCGCGACGTCTGCAAAAGCTTGAAAAGGCCATAGAGACGGTGACCTGCGCTGATAATCG
CTCATCTGATGGCTGA

Upstream 100 bases:

>100_bases
GTTTCGACCTGGTCTTCGAGCGCGGTGCGGTGATCGACGTCAAGCCACAGTATGACGTGACTCGCCAGGTCATCGAGCGC
ATGAACCAGCTGAAGTAACC

Downstream 100 bases:

>100_bases
TACCTTTTTAATATCAAGCGTGCTCAGTCGATAAACTGCCTCCTTGATGTAGAGGGGTGCTGCGCAGTCGCGACGCACTC
CTAATCTTTACTACAGGCTT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSITIKLGQLAEFLGATLRGDKDIEITGLATLQEAGPGQVSFLANPKYRKLLVDTQATAVLLKPADADGYAGNALVVPDT
YLAYARISHFFDPKPKSSAGVHPTAVIAADALIDPAASIGAFAVIESGVRIAAGVTIGAHCFIGARCEIGEGGWLAPRVT
LYHDVRIGKRVVIQSGAVLGGEGFGFAQDKGIYHKVAQIGGVTLGDDVEVGVNTAIDRGALADTRIGNGVKLDNQIQIAH
NVQIGDHTAMAACVGISGSTKIGKHCMLAGGVGLVGHIEICDGVFITGMTMVTHSITEPGSYSSGTAMQPAAEWRKSAAR
LRKIDDMARRLQKLEKAIETVTCADNRSSDG

Sequences:

>Translated_351_residues
MSITIKLGQLAEFLGATLRGDKDIEITGLATLQEAGPGQVSFLANPKYRKLLVDTQATAVLLKPADADGYAGNALVVPDT
YLAYARISHFFDPKPKSSAGVHPTAVIAADALIDPAASIGAFAVIESGVRIAAGVTIGAHCFIGARCEIGEGGWLAPRVT
LYHDVRIGKRVVIQSGAVLGGEGFGFAQDKGIYHKVAQIGGVTLGDDVEVGVNTAIDRGALADTRIGNGVKLDNQIQIAH
NVQIGDHTAMAACVGISGSTKIGKHCMLAGGVGLVGHIEICDGVFITGMTMVTHSITEPGSYSSGTAMQPAAEWRKSAAR
LRKIDDMARRLQKLEKAIETVTCADNRSSDG
>Mature_350_residues
SITIKLGQLAEFLGATLRGDKDIEITGLATLQEAGPGQVSFLANPKYRKLLVDTQATAVLLKPADADGYAGNALVVPDTY
LAYARISHFFDPKPKSSAGVHPTAVIAADALIDPAASIGAFAVIESGVRIAAGVTIGAHCFIGARCEIGEGGWLAPRVTL
YHDVRIGKRVVIQSGAVLGGEGFGFAQDKGIYHKVAQIGGVTLGDDVEVGVNTAIDRGALADTRIGNGVKLDNQIQIAHN
VQIGDHTAMAACVGISGSTKIGKHCMLAGGVGLVGHIEICDGVFITGMTMVTHSITEPGSYSSGTAMQPAAEWRKSAARL
RKIDDMARRLQKLEKAIETVTCADNRSSDG

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=336, Percent_Identity=50.8928571428571, Blast_Score=333, Evalue=8e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36543; Mature: 36412

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITIKLGQLAEFLGATLRGDKDIEITGLATLQEAGPGQVSFLANPKYRKLLVDTQATAV
CEEEEEHHHHHHHHHHHHCCCCCEEEEEEEEHHCCCCCEEEEEECCCEEEEEEECCCEEE
LLKPADADGYAGNALVVPDTYLAYARISHFFDPKPKSSAGVHPTAVIAADALIDPAASIG
EEEECCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCHHEEEHHHHHCCHHHHH
AFAVIESGVRIAAGVTIGAHCFIGARCEIGEGGWLAPRVTLYHDVRIGKRVVIQSGAVLG
HHHHHHCCCEEEEEEEEECEEEEECEEEECCCCCCCCEEEEEEECCCCCEEEEECCCEEC
GEGFGFAQDKGIYHKVAQIGGVTLGDDVEVGVNTAIDRGALADTRIGNGVKLDNQIQIAH
CCCCCCCCCCCHHHHHHHHCCEEECCCCEECCCCCCCCCCCCCCCCCCCEEECCEEEEEE
NVQIGDHTAMAACVGISGSTKIGKHCMLAGGVGLVGHIEICDGVFITGMTMVTHSITEPG
EEEECCCCEEEEEEECCCCCCCCCEEEEECCCCEEEEEEECCCEEEHHHHHHHCCCCCCC
SYSSGTAMQPAAEWRKSAARLRKIDDMARRLQKLEKAIETVTCADNRSSDG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCC
>Mature Secondary Structure 
SITIKLGQLAEFLGATLRGDKDIEITGLATLQEAGPGQVSFLANPKYRKLLVDTQATAV
EEEEEHHHHHHHHHHHHCCCCCEEEEEEEEHHCCCCCEEEEEECCCEEEEEEECCCEEE
LLKPADADGYAGNALVVPDTYLAYARISHFFDPKPKSSAGVHPTAVIAADALIDPAASIG
EEEECCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCCCCCCCHHEEEHHHHHCCHHHHH
AFAVIESGVRIAAGVTIGAHCFIGARCEIGEGGWLAPRVTLYHDVRIGKRVVIQSGAVLG
HHHHHHCCCEEEEEEEEECEEEEECEEEECCCCCCCCEEEEEEECCCCCEEEEECCCEEC
GEGFGFAQDKGIYHKVAQIGGVTLGDDVEVGVNTAIDRGALADTRIGNGVKLDNQIQIAH
CCCCCCCCCCCHHHHHHHHCCEEECCCCEECCCCCCCCCCCCCCCCCCCEEECCEEEEEE
NVQIGDHTAMAACVGISGSTKIGKHCMLAGGVGLVGHIEICDGVFITGMTMVTHSITEPG
EEEECCCCEEEEEEECCCCCCCCCEEEEECCCCEEEEEEECCCEEEHHHHHHHCCCCCCC
SYSSGTAMQPAAEWRKSAARLRKIDDMARRLQKLEKAIETVTCADNRSSDG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA