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The map label for this gene is lysS [H]

Identifier: 66044559

GI number: 66044559

Start: 1488289

End: 1489791

Strand: Direct

Name: lysS [H]

Synonym: Psyr_1311

Alternate gene names: 66044559

Gene position: 1488289-1489791 (Clockwise)

Preceding gene: 66044558

Following gene: 66044560

Centisome position: 24.42

GC content: 60.01

Gene sequence:

>1503_bases
ATGAGCGACCAACAACTCGACCCGCAAGCCCTGCAACAGGAAGAAAACACCCTGATCGCCTTGCGCAAGGAAAAGCTTGC
TGCAGGCCGTGCCAAGGGTCAGGCCTTCCCCAATGACTTCCGCCGCGACAGCTACTGCAATGACCTGCAGAAACAGTACG
TCGACAAGACCAAGGAAGAACTGGCAGAGGCAGCGATTCCGGTCAAGGTTGCCGGTCGCATCATGCTCAACCGTGGCTCG
TTCATGGTGATCCAGGACATGACCGGGCGCATCCAGGTCTATGTCAACCGCAAGACCCTGCCCGAAGAAACCCTGGCCGA
GGTGAAAACCTGGGATCTGGGCGACATCATCGCCGCCGAAGGTACCCTGGCACGCTCCGGCAAGGGCGACCTGTACGTCG
AGATGACCAGCGTTCGCCTGCTGACCAAGTCCTTGCGTCCGCTGCCCGACAAGCACCACGGCCTGACCGACACCGAACAG
CGCTACCGTCAGCGTTACGTCGACCTGATCGTCAACGAGGAAGTGCGTGAGACCTTCCGCGTGCGTTCGCAGGTCATCGC
TCACATCCGCAGCTTCCTGATGAAGCGCGACTTCCTCGAAGTCGAAACGCCGATGCTGCAGACCATTCCGGGCGGCGCGG
CGGCCAAGCCGTTCGAAACCCACCACAACGCGCTGGACATGGAAATGTTCCTGCGTATCGCCCCGGAGCTGTACCTCAAG
CGTCTGGTGGTCGGTGGTTTCGAGAAGGTCTTCGAGATCAATCGCAACTTCCGTAACGAAGGTGTTTCGACCCGGCACAA
CCCCGAGTTCACCATGCTCGAGTTCTACCAGGCCTACGCCGATTACGAAGACAACATGGACCTCACCGAGGAACTGTTCC
GCGAACTGGCGCAACTGGTTCTGGGCAGCACCGATGTGCCTTATGGCGACAAGGTGTTCCACTTCGGCGAACCGTTCGTG
CGCCTGTCGGTGTTCGACTCGATCCTCAAGTACAACCCTGAGCTGACCGTTGCCGACCTGCAGGACATCGACAAGGCGCG
CGCCATTGCGAAAAAGGCCGGTGCCAAGGTGCTGGGCTTCGAAGGCCTGGGCAAATTGCAGGTGATGATTTTCGAAGAGC
TGGTCGAGCACAAGCTGGAACAGCCGCACTTCATCACCCAGTACCCGTTTGAAGTGTCGCCGCTGGCGCGTCGCAACGAC
GAAAACCCGAACGTCACCGACCGTTTCGAGCTGTTCATCGGTGGTCGCGAAATCGCCAATGCCTACTCCGAGCTCAACGA
CGCCGAAGATCAGGCCGAACGCTTCCAGGCTCAGGTGGCCGACAAGGATGCCGGTGACGACGAAGCCATGCACTACGACG
CCGACTTCGTTCGTGCGCTGGAGTACGGCATGCCGCCGACGGCAGGCGAGGGGATCGGTATCGATCGGTTGGTGATGTTG
CTCACCGACTCGCCGTCGATTCGCGACGTGATCCTCTTCCCGCACATGCGCCCGCAAGCGTAA

Upstream 100 bases:

>100_bases
CCTGATCGCGAGCCTCAAGCAAGGGCTGTAAACCGTCAGCCGACACCTCAAGTCCCTCGTCGCCAGGCGAGGGCGAACCT
GTGATGGAATATTTAAAGAC

Downstream 100 bases:

>100_bases
CCAGTGGAAAAACAGCCGCCTTCAATGGGCGGCTTTTTTTTAAGTGTTTTTCAGATCGACTCATTTCAGAGCGACTTATA
AGGAAGCTGTCGTGACGATT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MSDQQLDPQALQQEENTLIALRKEKLAAGRAKGQAFPNDFRRDSYCNDLQKQYVDKTKEELAEAAIPVKVAGRIMLNRGS
FMVIQDMTGRIQVYVNRKTLPEETLAEVKTWDLGDIIAAEGTLARSGKGDLYVEMTSVRLLTKSLRPLPDKHHGLTDTEQ
RYRQRYVDLIVNEEVRETFRVRSQVIAHIRSFLMKRDFLEVETPMLQTIPGGAAAKPFETHHNALDMEMFLRIAPELYLK
RLVVGGFEKVFEINRNFRNEGVSTRHNPEFTMLEFYQAYADYEDNMDLTEELFRELAQLVLGSTDVPYGDKVFHFGEPFV
RLSVFDSILKYNPELTVADLQDIDKARAIAKKAGAKVLGFEGLGKLQVMIFEELVEHKLEQPHFITQYPFEVSPLARRND
ENPNVTDRFELFIGGREIANAYSELNDAEDQAERFQAQVADKDAGDDEAMHYDADFVRALEYGMPPTAGEGIGIDRLVML
LTDSPSIRDVILFPHMRPQA

Sequences:

>Translated_500_residues
MSDQQLDPQALQQEENTLIALRKEKLAAGRAKGQAFPNDFRRDSYCNDLQKQYVDKTKEELAEAAIPVKVAGRIMLNRGS
FMVIQDMTGRIQVYVNRKTLPEETLAEVKTWDLGDIIAAEGTLARSGKGDLYVEMTSVRLLTKSLRPLPDKHHGLTDTEQ
RYRQRYVDLIVNEEVRETFRVRSQVIAHIRSFLMKRDFLEVETPMLQTIPGGAAAKPFETHHNALDMEMFLRIAPELYLK
RLVVGGFEKVFEINRNFRNEGVSTRHNPEFTMLEFYQAYADYEDNMDLTEELFRELAQLVLGSTDVPYGDKVFHFGEPFV
RLSVFDSILKYNPELTVADLQDIDKARAIAKKAGAKVLGFEGLGKLQVMIFEELVEHKLEQPHFITQYPFEVSPLARRND
ENPNVTDRFELFIGGREIANAYSELNDAEDQAERFQAQVADKDAGDDEAMHYDADFVRALEYGMPPTAGEGIGIDRLVML
LTDSPSIRDVILFPHMRPQA
>Mature_499_residues
SDQQLDPQALQQEENTLIALRKEKLAAGRAKGQAFPNDFRRDSYCNDLQKQYVDKTKEELAEAAIPVKVAGRIMLNRGSF
MVIQDMTGRIQVYVNRKTLPEETLAEVKTWDLGDIIAAEGTLARSGKGDLYVEMTSVRLLTKSLRPLPDKHHGLTDTEQR
YRQRYVDLIVNEEVRETFRVRSQVIAHIRSFLMKRDFLEVETPMLQTIPGGAAAKPFETHHNALDMEMFLRIAPELYLKR
LVVGGFEKVFEINRNFRNEGVSTRHNPEFTMLEFYQAYADYEDNMDLTEELFRELAQLVLGSTDVPYGDKVFHFGEPFVR
LSVFDSILKYNPELTVADLQDIDKARAIAKKAGAKVLGFEGLGKLQVMIFEELVEHKLEQPHFITQYPFEVSPLARRNDE
NPNVTDRFELFIGGREIANAYSELNDAEDQAERFQAQVADKDAGDDEAMHYDADFVRALEYGMPPTAGEGIGIDRLVMLL
TDSPSIRDVILFPHMRPQA

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=527, Percent_Identity=40.4174573055028, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI194272210, Length=527, Percent_Identity=40.4174573055028, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI45439306, Length=356, Percent_Identity=23.876404494382, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI40789249, Length=292, Percent_Identity=23.2876712328767, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790571, Length=483, Percent_Identity=62.7329192546584, Blast_Score=621, Evalue=1e-179,
Organism=Escherichia coli, GI1789256, Length=503, Percent_Identity=61.0337972166998, Blast_Score=619, Evalue=1e-178,
Organism=Escherichia coli, GI87082379, Length=321, Percent_Identity=31.4641744548287, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788173, Length=333, Percent_Identity=26.7267267267267, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17535925, Length=516, Percent_Identity=40.6976744186046, Blast_Score=353, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17535927, Length=516, Percent_Identity=40.6976744186046, Blast_Score=352, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI71994340, Length=500, Percent_Identity=41.6, Blast_Score=352, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI17551876, Length=489, Percent_Identity=23.9263803680982, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI32566633, Length=240, Percent_Identity=26.25, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320242, Length=461, Percent_Identity=42.5162689804772, Blast_Score=347, Evalue=4e-96,
Organism=Saccharomyces cerevisiae, GI6324256, Length=411, Percent_Identity=35.036496350365, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6323011, Length=346, Percent_Identity=28.6127167630058, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6325153, Length=225, Percent_Identity=28, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24640851, Length=483, Percent_Identity=42.6501035196687, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24640849, Length=483, Percent_Identity=42.6501035196687, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI17136276, Length=327, Percent_Identity=24.1590214067278, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24584738, Length=241, Percent_Identity=29.045643153527, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 57092; Mature: 56960

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQQLDPQALQQEENTLIALRKEKLAAGRAKGQAFPNDFRRDSYCNDLQKQYVDKTKEE
CCCCCCCHHHHHHCCCCEEEEHHHHHHHCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHH
LAEAAIPVKVAGRIMLNRGSFMVIQDMTGRIQVYVNRKTLPEETLAEVKTWDLGDIIAAE
HHHHCCCCEECCEEEEECCCEEEEEECCCEEEEEECCCCCCHHHHHHHCCCCCCCHHCCC
GTLARSGKGDLYVEMTSVRLLTKSLRPLPDKHHGLTDTEQRYRQRYVDLIVNEEVRETFR
CCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHH
VRSQVIAHIRSFLMKRDFLEVETPMLQTIPGGAAAKPFETHHNALDMEMFLRIAPELYLK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHH
RLVVGGFEKVFEINRNFRNEGVSTRHNPEFTMLEFYQAYADYEDNMDLTEELFRELAQLV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LGSTDVPYGDKVFHFGEPFVRLSVFDSILKYNPELTVADLQDIDKARAIAKKAGAKVLGF
HCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCEEEEC
EGLGKLQVMIFEELVEHKLEQPHFITQYPFEVSPLARRNDENPNVTDRFELFIGGREIAN
CCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHCCCCCCCCCCEEEEEECCHHHHH
AYSELNDAEDQAERFQAQVADKDAGDDEAMHYDADFVRALEYGMPPTAGEGIGIDRLVML
HHHHHCCHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCCCHHHEEEE
LTDSPSIRDVILFPHMRPQA
EECCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
SDQQLDPQALQQEENTLIALRKEKLAAGRAKGQAFPNDFRRDSYCNDLQKQYVDKTKEE
CCCCCCHHHHHHCCCCEEEEHHHHHHHCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHH
LAEAAIPVKVAGRIMLNRGSFMVIQDMTGRIQVYVNRKTLPEETLAEVKTWDLGDIIAAE
HHHHCCCCEECCEEEEECCCEEEEEECCCEEEEEECCCCCCHHHHHHHCCCCCCCHHCCC
GTLARSGKGDLYVEMTSVRLLTKSLRPLPDKHHGLTDTEQRYRQRYVDLIVNEEVRETFR
CCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHH
VRSQVIAHIRSFLMKRDFLEVETPMLQTIPGGAAAKPFETHHNALDMEMFLRIAPELYLK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHH
RLVVGGFEKVFEINRNFRNEGVSTRHNPEFTMLEFYQAYADYEDNMDLTEELFRELAQLV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LGSTDVPYGDKVFHFGEPFVRLSVFDSILKYNPELTVADLQDIDKARAIAKKAGAKVLGF
HCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCEEEEC
EGLGKLQVMIFEELVEHKLEQPHFITQYPFEVSPLARRNDENPNVTDRFELFIGGREIAN
CCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHCCCCCCCCCCEEEEEECCHHHHH
AYSELNDAEDQAERFQAQVADKDAGDDEAMHYDADFVRALEYGMPPTAGEGIGIDRLVML
HHHHHCCHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCCCHHHEEEE
LTDSPSIRDVILFPHMRPQA
EECCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA