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The map label for this gene is alsR [H]

Identifier: 66044022

GI number: 66044022

Start: 872972

End: 873892

Strand: Direct

Name: alsR [H]

Synonym: Psyr_0767

Alternate gene names: 66044022

Gene position: 872972-873892 (Clockwise)

Preceding gene: 66044018

Following gene: 66044023

Centisome position: 14.33

GC content: 62.65

Gene sequence:

>921_bases
ATGATTGATTTGAAATTGATGCGTCAGTACGTGGTGGTCGCTGAAACCTTGAATTTTCGCAAGGCCGCGCAGCGCTTGAA
CATGTCACAGCCGCCCCTGAGCGTTGCGATTCGTCGTCTGGAAGAATGCCTGGGTGTGCAGTTGTTGCAGCGCAGTACGC
GCTCCACGCAACTGACCGCCGCGGGCGTGGTGTTTCTGGCCGAGGCTCGGCAGACGCTGCTGCAGGCCGAACGGGCCTGC
GAAATGGCACGTCGCTCAGCGGCAGGCATGCTCGGCACGATTCGCCTGGGCTTTGTCGACAGCGTGGTCGATGGTTTGCT
GCCGGCGCTGCTGCGTCGCTATCAGGCAGCGAACCCGAACGTCGATATTCAACTGCAGGAGGCCACCCCACCCGAGCAGC
TTGAAGGCCTGCGCAATGAGCGGCTGGACGTCGGCATTCTGGTATTGCCGGTCATCGACCCGGGCACTATTCATATCGAG
CCGCTGTTCGAGGACCGCATGGTCGCGGTGCTGCCGCAGGATCATCCCTTGGCCGAGCAGACATCCATCGGTCTTGCGGC
GTTGGCAGACCAATCCTGGATTCTGTTCGCCCCGCATCATGGCCCGGGCATGCACTCGCACATTCTGCTGGCCTGCGCCA
GTGCAGGCTTTACCCCTCGGGTCGTGCAACAGCCTCGCCAGATGCAGACCACGGCCGCGCTGGTCGCCGGAGGAATGGGT
GTGGCGCTCATGCCGCAGCGCTATGCCCGACGTCAGCCTGGGCGGCTGGCGTGTCGGGAGATAACTGGGCCAGGCACACC
TGTTGCCTATGTGCTGGCGCTGGCGTATCGCGAGTTGTCTCCGTGTGCGCAGTCATTGCGCGAAGTGATCATGGAGCTGG
TTCAGTCGCCGGCGTTCAGGCTGTCGTCCGCTGAGTCATGA

Upstream 100 bases:

>100_bases
AGCGATCTCGCCCCTAGCCGTTGAACCATGAAGTATGTGCAACGCTCATTTATTTGTAACATACTAATTTGATAGCTCAT
TGATACTAAAAAAATATCAG

Downstream 100 bases:

>100_bases
CGCCGTCGCCTCAACTCGGGCCGGAACCCGCAACTCGCCCCTCCCGGCAGGTGCCGGTTCAAATGCACTGAACGCCTTGC
AACGGCCTGACTCCAAATCT

Product: regulatory protein, LysR:LysR, substrate-binding

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIDLKLMRQYVVVAETLNFRKAAQRLNMSQPPLSVAIRRLEECLGVQLLQRSTRSTQLTAAGVVFLAEARQTLLQAERAC
EMARRSAAGMLGTIRLGFVDSVVDGLLPALLRRYQAANPNVDIQLQEATPPEQLEGLRNERLDVGILVLPVIDPGTIHIE
PLFEDRMVAVLPQDHPLAEQTSIGLAALADQSWILFAPHHGPGMHSHILLACASAGFTPRVVQQPRQMQTTAALVAGGMG
VALMPQRYARRQPGRLACREITGPGTPVAYVLALAYRELSPCAQSLREVIMELVQSPAFRLSSAES

Sequences:

>Translated_306_residues
MIDLKLMRQYVVVAETLNFRKAAQRLNMSQPPLSVAIRRLEECLGVQLLQRSTRSTQLTAAGVVFLAEARQTLLQAERAC
EMARRSAAGMLGTIRLGFVDSVVDGLLPALLRRYQAANPNVDIQLQEATPPEQLEGLRNERLDVGILVLPVIDPGTIHIE
PLFEDRMVAVLPQDHPLAEQTSIGLAALADQSWILFAPHHGPGMHSHILLACASAGFTPRVVQQPRQMQTTAALVAGGMG
VALMPQRYARRQPGRLACREITGPGTPVAYVLALAYRELSPCAQSLREVIMELVQSPAFRLSSAES
>Mature_306_residues
MIDLKLMRQYVVVAETLNFRKAAQRLNMSQPPLSVAIRRLEECLGVQLLQRSTRSTQLTAAGVVFLAEARQTLLQAERAC
EMARRSAAGMLGTIRLGFVDSVVDGLLPALLRRYQAANPNVDIQLQEATPPEQLEGLRNERLDVGILVLPVIDPGTIHIE
PLFEDRMVAVLPQDHPLAEQTSIGLAALADQSWILFAPHHGPGMHSHILLACASAGFTPRVVQQPRQMQTTAALVAGGMG
VALMPQRYARRQPGRLACREITGPGTPVAYVLALAYRELSPCAQSLREVIMELVQSPAFRLSSAES

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=292, Percent_Identity=34.5890410958904, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI2367136, Length=253, Percent_Identity=35.1778656126482, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1788887, Length=295, Percent_Identity=34.2372881355932, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1790399, Length=244, Percent_Identity=29.9180327868852, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI157672245, Length=249, Percent_Identity=31.3253012048193, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI145693105, Length=243, Percent_Identity=27.1604938271605, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1788297, Length=302, Percent_Identity=27.4834437086093, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787601, Length=201, Percent_Identity=31.3432835820896, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1788748, Length=245, Percent_Identity=25.7142857142857, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87081904, Length=182, Percent_Identity=28.021978021978, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789506, Length=225, Percent_Identity=22.6666666666667, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787530, Length=235, Percent_Identity=25.531914893617, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787589, Length=154, Percent_Identity=35.0649350649351, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788296, Length=242, Percent_Identity=25.2066115702479, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789639, Length=262, Percent_Identity=26.7175572519084, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786713, Length=185, Percent_Identity=31.3513513513514, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790208, Length=291, Percent_Identity=25.7731958762887, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788481, Length=192, Percent_Identity=29.1666666666667, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33419; Mature: 33419

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLKLMRQYVVVAETLNFRKAAQRLNMSQPPLSVAIRRLEECLGVQLLQRSTRSTQLTA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AGVVFLAEARQTLLQAERACEMARRSAAGMLGTIRLGFVDSVVDGLLPALLRRYQAANPN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VDIQLQEATPPEQLEGLRNERLDVGILVLPVIDPGTIHIEPLFEDRMVAVLPQDHPLAEQ
EEEEEECCCCHHHHHHHHHCCCCEEEEEEEEECCCEEEEEECCCCCEEEECCCCCCCCHH
TSIGLAALADQSWILFAPHHGPGMHSHILLACASAGFTPRVVQQPRQMQTTAALVAGGMG
HCCCHHEECCCCEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHCCCC
VALMPQRYARRQPGRLACREITGPGTPVAYVLALAYRELSPCAQSLREVIMELVQSPAFR
CEECCHHHHCCCCCCEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LSSAES
CCCCCC
>Mature Secondary Structure
MIDLKLMRQYVVVAETLNFRKAAQRLNMSQPPLSVAIRRLEECLGVQLLQRSTRSTQLTA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AGVVFLAEARQTLLQAERACEMARRSAAGMLGTIRLGFVDSVVDGLLPALLRRYQAANPN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VDIQLQEATPPEQLEGLRNERLDVGILVLPVIDPGTIHIEPLFEDRMVAVLPQDHPLAEQ
EEEEEECCCCHHHHHHHHHCCCCEEEEEEEEECCCEEEEEECCCCCEEEECCCCCCCCHH
TSIGLAALADQSWILFAPHHGPGMHSHILLACASAGFTPRVVQQPRQMQTTAALVAGGMG
HCCCHHEECCCCEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHCCCC
VALMPQRYARRQPGRLACREITGPGTPVAYVLALAYRELSPCAQSLREVIMELVQSPAFR
CEECCHHHHCCCCCCEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LSSAES
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]