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The map label for this gene is trpC [H]

Identifier: 66044011

GI number: 66044011

Start: 860916

End: 861716

Strand: Direct

Name: trpC [H]

Synonym: Psyr_0756

Alternate gene names: 66044011

Gene position: 860916-861716 (Clockwise)

Preceding gene: 66044007

Following gene: 66044018

Centisome position: 14.13

GC content: 52.68

Gene sequence:

>801_bases
ATGAGTGATATTCTAAACAAAATAAAACATTACAAACTTCAGGAAATAGAGGCGGCGAAAGCTGACTTGCCATTCAGCCG
CCTCGAACAGCGTGCCCTCGAACAGTCCAGCCCACGCGGTTTTTATAAAGCACTGAAAGCAAAAGAGCAGCAGGGTCTGA
TCGGCTTGATTGCAGAAATAAAAAAAGCCAGTCCATCAAAAGGTCTGATTCGCGAAGACTTCAACCCTCCTGAACTGGCG
AAGGCTTACGAAACCGGTGGCGCTGCCTGTTTATCCGTTCTGACCGACACGCCAAGCTTCCAGGGCTCGCCGCAGTTTCT
CATTGACGCGCGAAACGCTTGCGCCCTTCCTGTGTTACGAAAAGACTTCATGTTTGATACGTATCAGGTGTATGAGGCAC
GTGCCTGGGGCGCGGACTGCATATTGCTGATCATGGCTTCATTGAGTGATGACCTGGCTGCCGAACTTGAAAGTGCTGCC
ATGACGCTGGGGATGGACGTCCTTGTGGAAGTGCATGACGAACATGAAATGGAGCGTGCGCTGAAACTGTCTTCCCCGCT
GCTCGGCGTCAATAATCGCAACCTGCATACCTTCGAAGTAGACCTCGGCACAAGCGAGCGACTGGCATCCATGGTGCCCG
CAGGCAAACTGCTGGTCGGCGAAAGTGGTATCGGCAACCATAATGATTGCCTGCGACTCAAGAAGTCCGGCATCACTACC
TTTCTGGTCGGCGAAAGCCTGATGCGCAAAGAAGATGTTGTGGCGGCGACAAGAACACTGCTGACCGGCAGTGCGGACTG
A

Upstream 100 bases:

>100_bases
TAGTCTGGTTTGACTTTTGCTAGAGGGCAAGAATCAGCGTTCTTGCGTCAAGCACACAGGAATTAATGTAATAAACTGCC
CGCTAATATGAGTGACTGTC

Downstream 100 bases:

>100_bases
CACGTATCAAGCTCCCGGGTCAGAGGGGCGGTTGTGCGTTCCTCTGATGCAGCCTGCGGATATTCCGGACGTAAGCAGTT
GTTTGCTCTGAATGCTATGG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSDILNKIKHYKLQEIEAAKADLPFSRLEQRALEQSSPRGFYKALKAKEQQGLIGLIAEIKKASPSKGLIREDFNPPELA
KAYETGGAACLSVLTDTPSFQGSPQFLIDARNACALPVLRKDFMFDTYQVYEARAWGADCILLIMASLSDDLAAELESAA
MTLGMDVLVEVHDEHEMERALKLSSPLLGVNNRNLHTFEVDLGTSERLASMVPAGKLLVGESGIGNHNDCLRLKKSGITT
FLVGESLMRKEDVVAATRTLLTGSAD

Sequences:

>Translated_266_residues
MSDILNKIKHYKLQEIEAAKADLPFSRLEQRALEQSSPRGFYKALKAKEQQGLIGLIAEIKKASPSKGLIREDFNPPELA
KAYETGGAACLSVLTDTPSFQGSPQFLIDARNACALPVLRKDFMFDTYQVYEARAWGADCILLIMASLSDDLAAELESAA
MTLGMDVLVEVHDEHEMERALKLSSPLLGVNNRNLHTFEVDLGTSERLASMVPAGKLLVGESGIGNHNDCLRLKKSGITT
FLVGESLMRKEDVVAATRTLLTGSAD
>Mature_265_residues
SDILNKIKHYKLQEIEAAKADLPFSRLEQRALEQSSPRGFYKALKAKEQQGLIGLIAEIKKASPSKGLIREDFNPPELAK
AYETGGAACLSVLTDTPSFQGSPQFLIDARNACALPVLRKDFMFDTYQVYEARAWGADCILLIMASLSDDLAAELESAAM
TLGMDVLVEVHDEHEMERALKLSSPLLGVNNRNLHTFEVDLGTSERLASMVPAGKLLVGESGIGNHNDCLRLKKSGITTF
LVGESLMRKEDVVAATRTLLTGSAD

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=263, Percent_Identity=39.1634980988593, Blast_Score=167, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=221, Percent_Identity=42.5339366515837, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29041; Mature: 28909

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILNKIKHYKLQEIEAAKADLPFSRLEQRALEQSSPRGFYKALKAKEQQGLIGLIAEI
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHH
KKASPSKGLIREDFNPPELAKAYETGGAACLSVLTDTPSFQGSPQFLIDARNACALPVLR
HHCCCCCCCHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHH
KDFMFDTYQVYEARAWGADCILLIMASLSDDLAAELESAAMTLGMDVLVEVHDEHEMERA
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHH
LKLSSPLLGVNNRNLHTFEVDLGTSERLASMVPAGKLLVGESGIGNHNDCLRLKKSGITT
HHHCCCEECCCCCCEEEEEEECCCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCEE
FLVGESLMRKEDVVAATRTLLTGSAD
EEHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SDILNKIKHYKLQEIEAAKADLPFSRLEQRALEQSSPRGFYKALKAKEQQGLIGLIAEI
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHH
KKASPSKGLIREDFNPPELAKAYETGGAACLSVLTDTPSFQGSPQFLIDARNACALPVLR
HHCCCCCCCHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHH
KDFMFDTYQVYEARAWGADCILLIMASLSDDLAAELESAAMTLGMDVLVEVHDEHEMERA
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHH
LKLSSPLLGVNNRNLHTFEVDLGTSERLASMVPAGKLLVGESGIGNHNDCLRLKKSGITT
HHHCCCEECCCCCCEEEEEEECCCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCEE
FLVGESLMRKEDVVAATRTLLTGSAD
EEHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA