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The map label for this gene is fadI [H]

Identifier: 66043912

GI number: 66043912

Start: 732804

End: 734081

Strand: Direct

Name: fadI [H]

Synonym: Psyr_0645

Alternate gene names: 66043912

Gene position: 732804-734081 (Clockwise)

Preceding gene: 66043905

Following gene: 66043913

Centisome position: 12.03

GC content: 64.79

Gene sequence:

>1278_bases
ATGACGCATCCTCGTCGGGTCGCCATCGTCGGCGGTAACCGCATTCCGTTCGCGCGCTCCAATGGCCCTTATGCCAAGGC
CAGCAATCAGGACATGCTCACGGCTGCTCTGGAAGGGCTGATCGAGCGCTTCAATCTGCATGGGCTGCGCATGGGCGAGG
TGGTGACGGGCGCGGTGCTCAAGCACTCCAGAGACTTCAACCTGACCCGCGAATGCGTGCTCGGCTCGCGGCTCTCGGCA
CAGACCCCGGCTTACGACATTCAGCAAGCGTGCGGTACGGGGCTGGAAGCGGCGTTGCTGGTGGCCAACAAGATCGCTCT
GGGGCAGATCGAGTGCGGCATTGCCGGTGGCGTGGACACCACGTCCGATGCCCCGATCGGCGTCAACGAGGGGCTGCGCA
AGATCCTGCTGCAGGTAAACCGCAGCAAGACGCCCGGTGACAAGCTCAAGGCTCTGATGCAGTTGCGTCCACACCACCTC
AAACCGGAGCTGCCGCGTAACGGCGAGCCACGCACGCGCTTGTCGATGGGCCAGCATTGCGAGCTGATGGCGCAGACCTG
GGGCATAGAGCGCGGGCCGCAGGATCAACTGGCGCTCGAGAGCCATCTGAAAATGGCCGCGGCCTACGCCGAGGGCTGGC
AGGATGATTTGATGACGCCGTATCTGGGGCTGATCCGTGACAACAACCTGCGTCCGGACCTGACGATTGAAAAGCTGGCC
AGCCTCAAGCCCGCGTTCGAGCGCAGCGCCAAGGGCACCTTGTCGGCGGGCAATTCGACACCGCTGACCGATGGCGCATC
GGTGGTGTTGCTGGCCAGCGAGGAGTGGGCTCGCGAGCGGGGCCTGCCGGTGCTGGCCTACTGGCGCGACGGCGAGGCCG
CAGCGGTGGATTTCGTCAACGGTGCAGAAGGGCTGCTGATGGCGCCGGTCTACGCCGTTCCGCGTCTGCTGGCCCGCAAT
GGCCTGACCCTTCAGGACTTCGATTACTACGAAATCCATGAAGCCTTCGCCGCGCAGGTGCTGTGTACCCTCAAGGCCTG
GGAAGACGCCGACTACTGCAAGACCCGCCTAGGGCTGGACGCGCCGCTGGGGTCGATTGATCGCAGCAAACTGAACGTCA
AGGGCAGCTCACTGGCTGCCGGCCACCCGTTCGCCGCGACCGGAGGCCGCATCGTCGCCAATCTGGCCAAGCTGCTGGAT
GCGGCAGGCAGCGGACGTGGATTGATTTCCATCTGTGCCGCAGGCGGCCAGGGCGTGACGGCGATTCTGGAGCGTTAG

Upstream 100 bases:

>100_bases
CTCCTGAAGTCGGGGTTCAAAGGAATGGACCACGGTGGCATGACGTTTGTTCTTGCGATCGACACGGCTCATTCATTCGC
TTGAAGAAAGGGAGTTTTCC

Downstream 100 bases:

>100_bases
GCAAATGCTGGGGTCATGGGCATAATCCACAACTGACTTACGCAGAGCATGGGCACTATCGCGGTCTACCTGACGACTAT
CGTTCCTCACGCTCCTGCGT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTHPRRVAIVGGNRIPFARSNGPYAKASNQDMLTAALEGLIERFNLHGLRMGEVVTGAVLKHSRDFNLTRECVLGSRLSA
QTPAYDIQQACGTGLEAALLVANKIALGQIECGIAGGVDTTSDAPIGVNEGLRKILLQVNRSKTPGDKLKALMQLRPHHL
KPELPRNGEPRTRLSMGQHCELMAQTWGIERGPQDQLALESHLKMAAAYAEGWQDDLMTPYLGLIRDNNLRPDLTIEKLA
SLKPAFERSAKGTLSAGNSTPLTDGASVVLLASEEWARERGLPVLAYWRDGEAAAVDFVNGAEGLLMAPVYAVPRLLARN
GLTLQDFDYYEIHEAFAAQVLCTLKAWEDADYCKTRLGLDAPLGSIDRSKLNVKGSSLAAGHPFAATGGRIVANLAKLLD
AAGSGRGLISICAAGGQGVTAILER

Sequences:

>Translated_425_residues
MTHPRRVAIVGGNRIPFARSNGPYAKASNQDMLTAALEGLIERFNLHGLRMGEVVTGAVLKHSRDFNLTRECVLGSRLSA
QTPAYDIQQACGTGLEAALLVANKIALGQIECGIAGGVDTTSDAPIGVNEGLRKILLQVNRSKTPGDKLKALMQLRPHHL
KPELPRNGEPRTRLSMGQHCELMAQTWGIERGPQDQLALESHLKMAAAYAEGWQDDLMTPYLGLIRDNNLRPDLTIEKLA
SLKPAFERSAKGTLSAGNSTPLTDGASVVLLASEEWARERGLPVLAYWRDGEAAAVDFVNGAEGLLMAPVYAVPRLLARN
GLTLQDFDYYEIHEAFAAQVLCTLKAWEDADYCKTRLGLDAPLGSIDRSKLNVKGSSLAAGHPFAATGGRIVANLAKLLD
AAGSGRGLISICAAGGQGVTAILER
>Mature_424_residues
THPRRVAIVGGNRIPFARSNGPYAKASNQDMLTAALEGLIERFNLHGLRMGEVVTGAVLKHSRDFNLTRECVLGSRLSAQ
TPAYDIQQACGTGLEAALLVANKIALGQIECGIAGGVDTTSDAPIGVNEGLRKILLQVNRSKTPGDKLKALMQLRPHHLK
PELPRNGEPRTRLSMGQHCELMAQTWGIERGPQDQLALESHLKMAAAYAEGWQDDLMTPYLGLIRDNNLRPDLTIEKLAS
LKPAFERSAKGTLSAGNSTPLTDGASVVLLASEEWARERGLPVLAYWRDGEAAAVDFVNGAEGLLMAPVYAVPRLLARNG
LTLQDFDYYEIHEAFAAQVLCTLKAWEDADYCKTRLGLDAPLGSIDRSKLNVKGSSLAAGHPFAATGGRIVANLAKLLDA
AGSGRGLISICAAGGQGVTAILER

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=36.4705882352941, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI4501853, Length=433, Percent_Identity=29.5612009237875, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI148539872, Length=429, Percent_Identity=27.7389277389277, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI167614485, Length=431, Percent_Identity=28.538283062645, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI4557237, Length=435, Percent_Identity=27.1264367816092, Blast_Score=138, Evalue=8e-33,
Organism=Escherichia coli, GI1788683, Length=425, Percent_Identity=38.5882352941176, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI87082165, Length=432, Percent_Identity=31.712962962963, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1788554, Length=432, Percent_Identity=30.0925925925926, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI48994986, Length=434, Percent_Identity=28.3410138248848, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1787663, Length=436, Percent_Identity=29.3577981651376, Blast_Score=129, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=35.1415094339623, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17535921, Length=430, Percent_Identity=26.2790697674419, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI133906874, Length=427, Percent_Identity=27.8688524590164, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI25147385, Length=432, Percent_Identity=24.0740740740741, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322031, Length=433, Percent_Identity=32.1016166281755, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=440, Percent_Identity=27.9545454545455, Blast_Score=143, Evalue=6e-35,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=36.9158878504673, Blast_Score=264, Evalue=7e-71,
Organism=Drosophila melanogaster, GI24655093, Length=434, Percent_Identity=27.6497695852535, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24640423, Length=434, Percent_Identity=25.8064516129032, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI17648125, Length=431, Percent_Identity=28.7703016241299, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 45530; Mature: 45399

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPRRVAIVGGNRIPFARSNGPYAKASNQDMLTAALEGLIERFNLHGLRMGEVVTGAVL
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHH
KHSRDFNLTRECVLGSRLSAQTPAYDIQQACGTGLEAALLVANKIALGQIECGIAGGVDT
HCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHEECEEEECCCCCCCC
TSDAPIGVNEGLRKILLQVNRSKTPGDKLKALMQLRPHHLKPELPRNGEPRTRLSMGQHC
CCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCHH
ELMAQTWGIERGPQDQLALESHLKMAAAYAEGWQDDLMTPYLGLIRDNNLRPDLTIEKLA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHH
SLKPAFERSAKGTLSAGNSTPLTDGASVVLLASEEWARERGLPVLAYWRDGEAAAVDFVN
HCCHHHHHCCCCEEECCCCCCCCCCCCEEEEECHHHHHHCCCEEEEEEECCCEEEEEECC
GAEGLLMAPVYAVPRLLARNGLTLQDFDYYEIHEAFAAQVLCTLKAWEDADYCKTRLGLD
CCCCCEECHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
APLGSIDRSKLNVKGSSLAAGHPFAATGGRIVANLAKLLDAAGSGRGLISICAAGGQGVT
CCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHH
AILER
HHHCC
>Mature Secondary Structure 
THPRRVAIVGGNRIPFARSNGPYAKASNQDMLTAALEGLIERFNLHGLRMGEVVTGAVL
CCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHH
KHSRDFNLTRECVLGSRLSAQTPAYDIQQACGTGLEAALLVANKIALGQIECGIAGGVDT
HCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHEECEEEECCCCCCCC
TSDAPIGVNEGLRKILLQVNRSKTPGDKLKALMQLRPHHLKPELPRNGEPRTRLSMGQHC
CCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCHH
ELMAQTWGIERGPQDQLALESHLKMAAAYAEGWQDDLMTPYLGLIRDNNLRPDLTIEKLA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHH
SLKPAFERSAKGTLSAGNSTPLTDGASVVLLASEEWARERGLPVLAYWRDGEAAAVDFVN
HCCHHHHHCCCCEEECCCCCCCCCCCCEEEEECHHHHHHCCCEEEEEEECCCEEEEEECC
GAEGLLMAPVYAVPRLLARNGLTLQDFDYYEIHEAFAAQVLCTLKAWEDADYCKTRLGLD
CCCCCEECHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
APLGSIDRSKLNVKGSSLAAGHPFAATGGRIVANLAKLLDAAGSGRGLISICAAGGQGVT
CCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHH
AILER
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA