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The map label for this gene is abcA [H]

Identifier: 66043878

GI number: 66043878

Start: 701307

End: 702011

Strand: Direct

Name: abcA [H]

Synonym: Psyr_0611

Alternate gene names: 66043878

Gene position: 701307-702011 (Clockwise)

Preceding gene: 66043877

Following gene: 66043879

Centisome position: 11.51

GC content: 50.5

Gene sequence:

>705_bases
ATGAGTCGCGTCGTCATCAAGGCAGAAAACCTCACCAAACAGTTTGTTCTGCGCCACAACAGGGGCGGTTTGAAGAAGAG
GTTTCTCGGGCTGTTTGACGCTCGATATCGTGAACGTGCCGAAACATTCACGGCAGTCAGCGATGTATCGTTCACCTTGC
ACAAAGGCGAGTCGCTTGCACTGGTGGGGCATAACGGTTCAGGTAAAAGTACCTTGTTGCAACTGGTTTCACGCATTCTT
TTGCCGACCAGTGGGCGTCTGACCAGCGTGGGCCGGGTAGCACCGCTAATCGAAATAGGGGTGGGTTTTCACCCTGAACT
GACCGGCGAGGAAAATATCTACCTCAATGCCAGTCTGTTTGGATTGAGTAACAAGGAAGTGCGTTCGCGCTTTAATGAAA
TTGTCGATTTTTCCGGGTTGGGAAACTTCATCGATACACCGGTAAAGAACTATTCGTCTGGCATGTACATGAGGCTGGGT
TTTTCAGTCGCCGTTCATGTCGAGCCTCAGACATTACTGGCTGACGAAGTACTTGCGGTAGGTGACGAAGACTTCAAGCG
CAAATGCCACGAACGAATTCGCATGATGCAGGATGACGGGATGGCCTTGATTCTTGTTACCCACGCAGTAGAAGAAGGTA
AAGAGTTTTGCCAGCGTTACTTGACGCTTGAGCGTGGCCTGATGACCGAGCACGGTTATTACTGA

Upstream 100 bases:

>100_bases
CAGAGCCCCGTGATCTGCTGCTGTGCGTGTTCATGGGCGCCGCGTCGCTGCTGGTGGGGTTGTTCATGTTCAGGAAGGTG
GACAGCGTGGTGGAGTATTT

Downstream 100 bases:

>100_bases
TTCATTGTTTCGCGATGCCATGCTTCCAGTCAACTTGGCCATCACTCAATTCATAAAGGTATTTCCATGTTGCAAATTAT
CGTTCCGATGGCCGGGGCCG

Product: ABC transporter

Products: ADP; phosphate; putrescine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MSRVVIKAENLTKQFVLRHNRGGLKKRFLGLFDARYRERAETFTAVSDVSFTLHKGESLALVGHNGSGKSTLLQLVSRIL
LPTSGRLTSVGRVAPLIEIGVGFHPELTGEENIYLNASLFGLSNKEVRSRFNEIVDFSGLGNFIDTPVKNYSSGMYMRLG
FSVAVHVEPQTLLADEVLAVGDEDFKRKCHERIRMMQDDGMALILVTHAVEEGKEFCQRYLTLERGLMTEHGYY

Sequences:

>Translated_234_residues
MSRVVIKAENLTKQFVLRHNRGGLKKRFLGLFDARYRERAETFTAVSDVSFTLHKGESLALVGHNGSGKSTLLQLVSRIL
LPTSGRLTSVGRVAPLIEIGVGFHPELTGEENIYLNASLFGLSNKEVRSRFNEIVDFSGLGNFIDTPVKNYSSGMYMRLG
FSVAVHVEPQTLLADEVLAVGDEDFKRKCHERIRMMQDDGMALILVTHAVEEGKEFCQRYLTLERGLMTEHGYY
>Mature_233_residues
SRVVIKAENLTKQFVLRHNRGGLKKRFLGLFDARYRERAETFTAVSDVSFTLHKGESLALVGHNGSGKSTLLQLVSRILL
PTSGRLTSVGRVAPLIEIGVGFHPELTGEENIYLNASLFGLSNKEVRSRFNEIVDFSGLGNFIDTPVKNYSSGMYMRLGF
SVAVHVEPQTLLADEVLAVGDEDFKRKCHERIRMMQDDGMALILVTHAVEEGKEFCQRYLTLERGLMTEHGYY

Specific function: Influences the expression of the surface array protein gene (vapA). May have both regulatory and transport activities [H]

COG id: COG1134

COG function: function code GM; ABC-type polysaccharide/polyol phosphate transport system, ATPase component

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI31657092, Length=206, Percent_Identity=29.6116504854369, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI27477115, Length=204, Percent_Identity=28.921568627451, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI153792144, Length=198, Percent_Identity=26.2626262626263, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI6005701, Length=219, Percent_Identity=27.8538812785388, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI105990541, Length=216, Percent_Identity=27.3148148148148, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI27881501, Length=194, Percent_Identity=25.7731958762887, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI30795238, Length=194, Percent_Identity=25.7731958762887, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI27262624, Length=206, Percent_Identity=25.7281553398058, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI27262626, Length=206, Percent_Identity=25.7281553398058, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI116734710, Length=217, Percent_Identity=26.2672811059908, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI150417984, Length=199, Percent_Identity=25.1256281407035, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI27436953, Length=209, Percent_Identity=25.3588516746411, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI87081791, Length=199, Percent_Identity=29.1457286432161, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI87081782, Length=222, Percent_Identity=27.4774774774775, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787089, Length=207, Percent_Identity=26.5700483091787, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788450, Length=202, Percent_Identity=25.7425742574257, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786319, Length=198, Percent_Identity=26.7676767676768, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87081709, Length=200, Percent_Identity=24.5, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790467, Length=197, Percent_Identity=27.9187817258883, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789032, Length=246, Percent_Identity=23.1707317073171, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1786703, Length=205, Percent_Identity=30.2439024390244, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786398, Length=212, Percent_Identity=25.9433962264151, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787029, Length=203, Percent_Identity=27.0935960591133, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI48995001, Length=198, Percent_Identity=26.2626262626263, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788761, Length=197, Percent_Identity=27.9187817258883, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1789873, Length=197, Percent_Identity=27.9187817258883, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789593, Length=208, Percent_Identity=25.9615384615385, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87081834, Length=250, Percent_Identity=26.8, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI48994943, Length=204, Percent_Identity=26.4705882352941, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1786563, Length=178, Percent_Identity=27.5280898876405, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787370, Length=198, Percent_Identity=23.7373737373737, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790525, Length=205, Percent_Identity=26.8292682926829, Blast_Score=60, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17565586, Length=186, Percent_Identity=27.4193548387097, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71983510, Length=199, Percent_Identity=28.1407035175879, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71983523, Length=199, Percent_Identity=28.1407035175879, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71983516, Length=199, Percent_Identity=28.1407035175879, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17510237, Length=199, Percent_Identity=26.1306532663317, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115533608, Length=196, Percent_Identity=23.9795918367347, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI116007184, Length=207, Percent_Identity=27.0531400966184, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221500365, Length=207, Percent_Identity=27.0531400966184, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643674, Length=202, Percent_Identity=24.2574257425743, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 26258; Mature: 26126

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVVIKAENLTKQFVLRHNRGGLKKRFLGLFDARYRERAETFTAVSDVSFTLHKGESLA
CCEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCEEE
LVGHNGSGKSTLLQLVSRILLPTSGRLTSVGRVAPLIEIGVGFHPELTGEENIYLNASLF
EEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEE
GLSNKEVRSRFNEIVDFSGLGNFIDTPVKNYSSGMYMRLGFSVAVHVEPQTLLADEVLAV
CCCCHHHHHHHHHHHHHCCCCHHHCCCHHHCCCCEEEEEEEEEEEEECCHHHHHHHHHHC
GDEDFKRKCHERIRMMQDDGMALILVTHAVEEGKEFCQRYLTLERGLMTEHGYY
CCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SRVVIKAENLTKQFVLRHNRGGLKKRFLGLFDARYRERAETFTAVSDVSFTLHKGESLA
CEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCEEE
LVGHNGSGKSTLLQLVSRILLPTSGRLTSVGRVAPLIEIGVGFHPELTGEENIYLNASLF
EEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEE
GLSNKEVRSRFNEIVDFSGLGNFIDTPVKNYSSGMYMRLGFSVAVHVEPQTLLADEVLAV
CCCCHHHHHHHHHHHHHCCCCHHHCCCHHHCCCCEEEEEEEEEEEEECCHHHHHHHHHHC
GDEDFKRKCHERIRMMQDDGMALILVTHAVEEGKEFCQRYLTLERGLMTEHGYY
CCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; putrescine [Periplasm]; H2O [C]

Specific reaction: ATP + putrescine [Periplasm] + H2O = ADP + phosphate + putrescine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8491726 [H]