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The map label for this gene is bccA [H]

Identifier: 66043767

GI number: 66043767

Start: 542495

End: 544228

Strand: Direct

Name: bccA [H]

Synonym: Psyr_0500

Alternate gene names: 66043767

Gene position: 542495-544228 (Clockwise)

Preceding gene: 66043766

Following gene: 66043770

Centisome position: 8.9

GC content: 64.88

Gene sequence:

>1734_bases
ATGAAAAAGGTTCTGATAGCCAATCGTGGCGAAATTGCCGTTCGTATTGCCCGTGCCTGCCGTGACTACGGAGTCGCCTC
GGTGGCGGTGTACGCCGATGCCGATATCGACGCGCTGCACGTGCGTCAGGCCGATGAGGCCTACGGACTGCAGGGCGAGC
GCCCGACCGACACCTACCTGAACATCGAAAAGCTGCTGGCGGTTGCCGCGCGTGCCGGTGCCGACGCGGTTCACCCAGGC
TACGGCTTCCTCTCGGAGCGCGCCGAATTCGCCCGCGCGGTGATCGACGCCGGTCTGATCTGGATCGGCCCCGATCCTGC
GACCATCGACGCACTGGGCGACAAGGTCCAGGCCCGACGTATCGCCCTGAAAGTCGGCGCACCCCTGGTGGCCGGTACGG
AAGACCCGGTAAACGATGCCTCTGAGGTGGTCGCATTTGCCGAGCAGCACGGCCTGCCGATTGCCATCAAGGCTGCCTTT
GGCGGCGGTGGGCGCGGCCTGAAAGTCGCCTGGAAGCTCGATGAAGTCAGCGAGCTGTACGAATCTGCAGTGCGTGAGGC
GTTGACCGCGTTCGGTCGTGGCGAGTGCTTCGTCGAGCGCTTCCTGGATCGCCCACGGCACATCGAAGCGCAGATCATCG
CCGACCGTCATGGCCGGGTGGTTGTGGTCGGCACCCGTGACTGCTCGTTGCAGCGTCGCAACCAGAAGCTGATCGAAGAA
GCGCCAGCGCCTTATCTGAATGACGAACTGCGCCAGCGCATTCACGAGTCGGCCCGCGCGGTCTGCGCCGAAGCGGGCTA
TGTCGGTGCCGGTACGGTGGAGTTCCTGCTCAGCGGCGATGGCACCCTGTCGTTCCTGGAGGTCAACACGCGCTTGCAGG
TCGAACACCCGGTGACGGAAGAAACCAGCGGTGTGGACCTGGTCATCGAACAACTTCGCGTCGCCGACGGCCTGCCGCTG
TCGTTCGATGGCACGCCTGTGCCGCGCGGTCACAGCTTTGAATTCCGCATCAATGCCGAAGACGCGGGCAACGGCTTTCT
GCCGACGCCGGGGTCTATCACTTTATTTCAGCCGCCGTCCGGTCCGGGCGTGCGTCTGGACACCGGCGTGGCAGAAGGCT
CACGGGTTTCACCAAACTTCGACTCGATGATCGCCAAGCTGATCGTCACCGGCGCCACCCGCGAACAGGCCATCAGCCGC
GCCCGCCGTGCGCTGGCCGAGTTCAAGGTGGAAGGCGTGGCCACCGTGCTGCCGTTCCACCGGGCGGTCATGGACCATGC
CGACTTCACCGCGGCCAATACCTTCGCCGTCCACACCCGCTGGATCGAAACCGACTTCGCCGAGCACGTCACCATCGCCC
CACGCAACGCAGAGCCGGTCGATCCCGGCGTGTTGCGCACCTTCGTTGAAATCGACGGCAAACGCCACGAACTGGGCCTG
CCTGCTGAGCTGCTGGCCGGCATGAGCCTGAACGCTGCCGCCCCGGCTGACGCCAGCCAGCCAGTCGCCGATGCCCCGGA
CCCGCACGCCGTGCTGACGCCGGTAGCGGGCAACCTGCATGCCTGGGCGGTTGAAGACGGTGCGACGGTAGAAAAGGGAC
AGGTGATCGCCATCATGGAGGCGATGAAGATGGAAACATCGATACTGGCACCGTGTGCCGGAACCGTGCAGATCGGCAAG
GAGCCTGGGGGGTATCTGGAGGCGAAGGTGGTGATTGGGCGGGTTGAGGCCTGA

Upstream 100 bases:

>100_bases
ACAAGGCCGGGCAGATTCCGGTCAATGCCCGCATTCGCTTCAACCCGCTGAGCGCCTTCGAGCCAGTGCGCCCCGCCACT
TCAGACGAGACCAAGAACAG

Downstream 100 bases:

>100_bases
TTTGATCGTTAATGTGCGTCAGCCGCGTGGGGGCGGCTGACGCACACTGTCAGTCTTCTCAATCCAGCCGCAACTCAGGC
GGCTCGGGCGCATCCTTGGT

Product: carbamoyl-phosphate synthase subunit L

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MKKVLIANRGEIAVRIARACRDYGVASVAVYADADIDALHVRQADEAYGLQGERPTDTYLNIEKLLAVAARAGADAVHPG
YGFLSERAEFARAVIDAGLIWIGPDPATIDALGDKVQARRIALKVGAPLVAGTEDPVNDASEVVAFAEQHGLPIAIKAAF
GGGGRGLKVAWKLDEVSELYESAVREALTAFGRGECFVERFLDRPRHIEAQIIADRHGRVVVVGTRDCSLQRRNQKLIEE
APAPYLNDELRQRIHESARAVCAEAGYVGAGTVEFLLSGDGTLSFLEVNTRLQVEHPVTEETSGVDLVIEQLRVADGLPL
SFDGTPVPRGHSFEFRINAEDAGNGFLPTPGSITLFQPPSGPGVRLDTGVAEGSRVSPNFDSMIAKLIVTGATREQAISR
ARRALAEFKVEGVATVLPFHRAVMDHADFTAANTFAVHTRWIETDFAEHVTIAPRNAEPVDPGVLRTFVEIDGKRHELGL
PAELLAGMSLNAAAPADASQPVADAPDPHAVLTPVAGNLHAWAVEDGATVEKGQVIAIMEAMKMETSILAPCAGTVQIGK
EPGGYLEAKVVIGRVEA

Sequences:

>Translated_577_residues
MKKVLIANRGEIAVRIARACRDYGVASVAVYADADIDALHVRQADEAYGLQGERPTDTYLNIEKLLAVAARAGADAVHPG
YGFLSERAEFARAVIDAGLIWIGPDPATIDALGDKVQARRIALKVGAPLVAGTEDPVNDASEVVAFAEQHGLPIAIKAAF
GGGGRGLKVAWKLDEVSELYESAVREALTAFGRGECFVERFLDRPRHIEAQIIADRHGRVVVVGTRDCSLQRRNQKLIEE
APAPYLNDELRQRIHESARAVCAEAGYVGAGTVEFLLSGDGTLSFLEVNTRLQVEHPVTEETSGVDLVIEQLRVADGLPL
SFDGTPVPRGHSFEFRINAEDAGNGFLPTPGSITLFQPPSGPGVRLDTGVAEGSRVSPNFDSMIAKLIVTGATREQAISR
ARRALAEFKVEGVATVLPFHRAVMDHADFTAANTFAVHTRWIETDFAEHVTIAPRNAEPVDPGVLRTFVEIDGKRHELGL
PAELLAGMSLNAAAPADASQPVADAPDPHAVLTPVAGNLHAWAVEDGATVEKGQVIAIMEAMKMETSILAPCAGTVQIGK
EPGGYLEAKVVIGRVEA
>Mature_577_residues
MKKVLIANRGEIAVRIARACRDYGVASVAVYADADIDALHVRQADEAYGLQGERPTDTYLNIEKLLAVAARAGADAVHPG
YGFLSERAEFARAVIDAGLIWIGPDPATIDALGDKVQARRIALKVGAPLVAGTEDPVNDASEVVAFAEQHGLPIAIKAAF
GGGGRGLKVAWKLDEVSELYESAVREALTAFGRGECFVERFLDRPRHIEAQIIADRHGRVVVVGTRDCSLQRRNQKLIEE
APAPYLNDELRQRIHESARAVCAEAGYVGAGTVEFLLSGDGTLSFLEVNTRLQVEHPVTEETSGVDLVIEQLRVADGLPL
SFDGTPVPRGHSFEFRINAEDAGNGFLPTPGSITLFQPPSGPGVRLDTGVAEGSRVSPNFDSMIAKLIVTGATREQAISR
ARRALAEFKVEGVATVLPFHRAVMDHADFTAANTFAVHTRWIETDFAEHVTIAPRNAEPVDPGVLRTFVEIDGKRHELGL
PAELLAGMSLNAAAPADASQPVADAPDPHAVLTPVAGNLHAWAVEDGATVEKGQVIAIMEAMKMETSILAPCAGTVQIGK
EPGGYLEAKVVIGRVEA

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=451, Percent_Identity=44.5676274944568, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=451, Percent_Identity=44.5676274944568, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=451, Percent_Identity=44.5676274944568, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=43.5955056179775, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI65506442, Length=434, Percent_Identity=41.4746543778802, Blast_Score=345, Evalue=9e-95,
Organism=Homo sapiens, GI189095269, Length=434, Percent_Identity=41.4746543778802, Blast_Score=345, Evalue=9e-95,
Organism=Homo sapiens, GI295821183, Length=434, Percent_Identity=41.4746543778802, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI38679977, Length=511, Percent_Identity=29.9412915851272, Blast_Score=212, Evalue=7e-55,
Organism=Homo sapiens, GI38679967, Length=511, Percent_Identity=29.9412915851272, Blast_Score=212, Evalue=7e-55,
Organism=Homo sapiens, GI38679960, Length=511, Percent_Identity=29.9412915851272, Blast_Score=212, Evalue=7e-55,
Organism=Homo sapiens, GI38679971, Length=511, Percent_Identity=29.9412915851272, Blast_Score=212, Evalue=8e-55,
Organism=Homo sapiens, GI38679974, Length=511, Percent_Identity=29.9412915851272, Blast_Score=212, Evalue=8e-55,
Organism=Homo sapiens, GI134142062, Length=512, Percent_Identity=30.2734375, Blast_Score=205, Evalue=8e-53,
Organism=Escherichia coli, GI1789654, Length=436, Percent_Identity=45.8715596330275, Blast_Score=355, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=44.8888888888889, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71987519, Length=437, Percent_Identity=43.4782608695652, Blast_Score=352, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI17567343, Length=450, Percent_Identity=41.3333333333333, Blast_Score=346, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI133931226, Length=494, Percent_Identity=29.3522267206478, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI71997168, Length=445, Percent_Identity=30.561797752809, Blast_Score=188, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=453, Percent_Identity=30.6843267108168, Blast_Score=187, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319695, Length=436, Percent_Identity=43.1192660550459, Blast_Score=350, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6321376, Length=436, Percent_Identity=44.2660550458716, Blast_Score=346, Evalue=6e-96,
Organism=Saccharomyces cerevisiae, GI6319685, Length=432, Percent_Identity=41.8981481481481, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6324343, Length=531, Percent_Identity=29.0018832391714, Blast_Score=197, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6323863, Length=461, Percent_Identity=29.7180043383948, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI281363050, Length=435, Percent_Identity=47.1264367816092, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652224, Length=435, Percent_Identity=47.1264367816092, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652222, Length=435, Percent_Identity=47.1264367816092, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652220, Length=435, Percent_Identity=47.1264367816092, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652218, Length=435, Percent_Identity=47.1264367816092, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652212, Length=435, Percent_Identity=47.1264367816092, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652210, Length=435, Percent_Identity=47.1264367816092, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652214, Length=435, Percent_Identity=47.1264367816092, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19921944, Length=435, Percent_Identity=47.1264367816092, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652216, Length=435, Percent_Identity=47.1264367816092, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24651757, Length=449, Percent_Identity=42.5389755011136, Blast_Score=352, Evalue=4e-97,
Organism=Drosophila melanogaster, GI24651759, Length=411, Percent_Identity=41.8491484184915, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24586458, Length=510, Percent_Identity=28.8235294117647, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI161076409, Length=510, Percent_Identity=28.8235294117647, Blast_Score=189, Evalue=6e-48,
Organism=Drosophila melanogaster, GI161076407, Length=510, Percent_Identity=28.8235294117647, Blast_Score=189, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24586460, Length=510, Percent_Identity=28.8235294117647, Blast_Score=189, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 61566; Mature: 61566

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLIANRGEIAVRIARACRDYGVASVAVYADADIDALHVRQADEAYGLQGERPTDTYL
CCCEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCHHHCCCCCCCCCHHHH
NIEKLLAVAARAGADAVHPGYGFLSERAEFARAVIDAGLIWIGPDPATIDALGDKVQARR
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHCCHHHHHE
IALKVGAPLVAGTEDPVNDASEVVAFAEQHGLPIAIKAAFGGGGRGLKVAWKLDEVSELY
EEEEECCCEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEHHHHHHHH
ESAVREALTAFGRGECFVERFLDRPRHIEAQIIADRHGRVVVVGTRDCSLQRRNQKLIEE
HHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHH
APAPYLNDELRQRIHESARAVCAEAGYVGAGTVEFLLSGDGTLSFLEVNTRLQVEHPVTE
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCEEEEECCCCC
ETSGVDLVIEQLRVADGLPLSFDGTPVPRGHSFEFRINAEDAGNGFLPTPGSITLFQPPS
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCC
GPGVRLDTGVAEGSRVSPNFDSMIAKLIVTGATREQAISRARRALAEFKVEGVATVLPFH
CCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RAVMDHADFTAANTFAVHTRWIETDFAEHVTIAPRNAEPVDPGVLRTFVEIDGKRHELGL
HHHHHCCCCCCCCEEEEEEEEECCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCCCC
PAELLAGMSLNAAAPADASQPVADAPDPHAVLTPVAGNLHAWAVEDGATVEKGQVIAIME
CHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCEECCCCEEEEHH
AMKMETSILAPCAGTVQIGKEPGGYLEAKVVIGRVEA
HHHHHHHHCCCCCCEEEECCCCCCEEEEEEEEEEECC
>Mature Secondary Structure
MKKVLIANRGEIAVRIARACRDYGVASVAVYADADIDALHVRQADEAYGLQGERPTDTYL
CCCEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCHHHCCCCCCCCCHHHH
NIEKLLAVAARAGADAVHPGYGFLSERAEFARAVIDAGLIWIGPDPATIDALGDKVQARR
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHCCHHHHHE
IALKVGAPLVAGTEDPVNDASEVVAFAEQHGLPIAIKAAFGGGGRGLKVAWKLDEVSELY
EEEEECCCEEECCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEHHHHHHHH
ESAVREALTAFGRGECFVERFLDRPRHIEAQIIADRHGRVVVVGTRDCSLQRRNQKLIEE
HHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHH
APAPYLNDELRQRIHESARAVCAEAGYVGAGTVEFLLSGDGTLSFLEVNTRLQVEHPVTE
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCEEEEECCCCC
ETSGVDLVIEQLRVADGLPLSFDGTPVPRGHSFEFRINAEDAGNGFLPTPGSITLFQPPS
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCC
GPGVRLDTGVAEGSRVSPNFDSMIAKLIVTGATREQAISRARRALAEFKVEGVATVLPFH
CCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RAVMDHADFTAANTFAVHTRWIETDFAEHVTIAPRNAEPVDPGVLRTFVEIDGKRHELGL
HHHHHCCCCCCCCEEEEEEEEECCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCCCC
PAELLAGMSLNAAAPADASQPVADAPDPHAVLTPVAGNLHAWAVEDGATVEKGQVIAIME
CHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCEECCCCEEEEHH
AMKMETSILAPCAGTVQIGKEPGGYLEAKVVIGRVEA
HHHHHHHHCCCCCCEEEECCCCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002 [H]