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The map label for this gene is ilvD [H]

Identifier: 66043736

GI number: 66043736

Start: 508137

End: 509984

Strand: Direct

Name: ilvD [H]

Synonym: Psyr_0469

Alternate gene names: 66043736

Gene position: 508137-509984 (Clockwise)

Preceding gene: 66043728

Following gene: 66043745

Centisome position: 8.34

GC content: 63.15

Gene sequence:

>1848_bases
ATGCCTGATTACCGCTCGAAAACCTCCACCCACGGCCGCAACATGGCCGGCGCCCGTGCCCTGTGGCGCGCCACGGGCAT
GAAGGACGAAGACTTTAAGAAACCGATCATTGCCATTGCCAACTCCTTCACCCAGTTCGTACCGGGCCACGTCCACCTCA
AGGACATGGGCCAGCTGGTCGCGCGTGAAGTCGAACGCGCCGGTGGCGTGGCCAAGGAATTCAACACCATTGCGGTCGAC
GACGGCATCGCCATGGGCCACGACGGCATGCTCTATTCGCTGCCGAGCCGCGAGATCATTGCCGACTCGGTCGAGTACAT
GGTCAACGCGCATTGCGCCGACGCCATCGTGTGCATTTCCAACTGCGACAAGATCACCCCCGGCATGCTGATGGCGTCGT
TGCGCCTGAACATTCCGGTGATCTTCGTCTCCGGCGGGCCGATGGAAGCGGGCAAGACCAAACTGGCCAGCCACGGCCTG
GATCTGGTCGATGCGATGGTCATCGCCGCCGACTCGACAGCCAGTGACGAAAAAGTCGCCGAGTATGAGCGCAGCGCCTG
TCCGACCTGCGGGTCGTGTTCCGGCATGTTCACCGCCAACTCGATGAACTGCCTGACCGAGGCACTGGGCCTGGCCCTGC
CGGGCAACGGTTCCGCACTCGCCACCCACAGCGACCGCGAGCAACTGTTCCTGCAGGCCGGCCGCACCATCGTTGACCTG
TGCCGTCAGTACTACAAGGAAAACGATGATTCGGTGTTGCCGCGCAACATCGCCAACTTCAAGGCGTTCGAGAACGCCAT
GACGCTGGACATCGCCATGGGCGGTTCGACCAACACCATCCTGCACTTGCTGGCAGCGGCCCAGGAAGCCGAGATCGACT
TCGACCTGCGCCACATCGACCATCTTTCGCGCAAGGTGCCGCAGCTGTGCAAGGTCGCGCCGAATATCCAGAAGTACCAC
ATGGAAGACGTGCACCGCGCAGGCGGGATCTTCAGCATCCTCGGCGAGCTGGCGCGTGGCGGTCTGCTGCACACCGACCT
GCCCACCGTACACAGCAAGACCCTGGCTGAAGGCATCGCCAAATGGGACATCACCCAGACTGACGACGAAGCCGTGCACA
CCTTCTTCAAGGCAGGCCCGGCGGGCATCCCGACGCAGACCGCGTTCAGCCAGTCGACCCGCTGGGAAAGCCTGGATGAC
GACCGTGAAAACGGCTGCATCCGCAGCGTCCAGCACGCCTATTCGCAAGAAGGTGGCCTGGCCGTGCTATACGGCAACAT
CGCCCTGGACGGCTGCGTGGTGAAAACCGCCGGTGTCGACGAGTCGATCCACGTCTTCGAAGGCAGCGCGAAGATCTTCG
AAAGCCAGGACAGCGCGGTACGCGGGATTCTCGCAGACGAAGTCAAAGCGGGCGACATCGTGATCATCCGCTACGAAGGC
CCGAAAGGCGGCCCGGGCATGCAGGAAATGCTCTACCCGACGTCCTACCTGAAGTCCAAGGGGCTGGGCAAGGATTGCGC
GCTGCTGACTGACGGCCGTTTCTCGGGCGGTACGTCCGGCCTGTCCATCGGCCACGCCTCGCCGGAAGCGGCGGCAGGTG
GCGCGATCGGTCTGGTGCGCGACGGTGACAAGGTGCTGATCGACATCCCCAATCGCTCGATCAACCTGCTGATCGACGAT
GCCGAGATGGCCGAGCGTCGCACCGAACAGGACAAGAAAGGCTGGAAGCCTGTCGAGTCGCGTCCGCGCAAAGTGACCAC
CGCCCTCAAGGCCTACGCCCTGCTGGCGACCAGCGCCGACAAGGGCGCCGTGCGTGACAAGGCGTTGCTGGACAAACTGG
TGCCTTGA

Upstream 100 bases:

>100_bases
TTCGGTTTCTTCGCTGCCTGCGGTCACTGCCGCTGGTCCGCGACGTCAATAGAAGCTCACTCCCTTCCTGATTCAGCCTT
ATTTTTGCCGGAGTGCTCCA

Downstream 100 bases:

>100_bases
TCCGCATCGGTAGAAGGTAAAAGCAAAAGCCCGGCAGAGATGCCGGGCTTTTTGCTGCGTTTGAAAAAGCAGCGCTTACT
TGCGGTCGGCAATCACCCCG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MPDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDMGQLVAREVERAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLASHGL
DLVDAMVIAADSTASDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSALATHSDREQLFLQAGRTIVDL
CRQYYKENDDSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEIDFDLRHIDHLSRKVPQLCKVAPNIQKYH
MEDVHRAGGIFSILGELARGGLLHTDLPTVHSKTLAEGIAKWDITQTDDEAVHTFFKAGPAGIPTQTAFSQSTRWESLDD
DRENGCIRSVQHAYSQEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDSAVRGILADEVKAGDIVIIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKDCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVRDGDKVLIDIPNRSINLLIDD
AEMAERRTEQDKKGWKPVESRPRKVTTALKAYALLATSADKGAVRDKALLDKLVP

Sequences:

>Translated_615_residues
MPDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDMGQLVAREVERAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLASHGL
DLVDAMVIAADSTASDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSALATHSDREQLFLQAGRTIVDL
CRQYYKENDDSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEIDFDLRHIDHLSRKVPQLCKVAPNIQKYH
MEDVHRAGGIFSILGELARGGLLHTDLPTVHSKTLAEGIAKWDITQTDDEAVHTFFKAGPAGIPTQTAFSQSTRWESLDD
DRENGCIRSVQHAYSQEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDSAVRGILADEVKAGDIVIIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKDCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVRDGDKVLIDIPNRSINLLIDD
AEMAERRTEQDKKGWKPVESRPRKVTTALKAYALLATSADKGAVRDKALLDKLVP
>Mature_614_residues
PDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDMGQLVAREVERAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLASHGLD
LVDAMVIAADSTASDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSALATHSDREQLFLQAGRTIVDLC
RQYYKENDDSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEIDFDLRHIDHLSRKVPQLCKVAPNIQKYHM
EDVHRAGGIFSILGELARGGLLHTDLPTVHSKTLAEGIAKWDITQTDDEAVHTFFKAGPAGIPTQTAFSQSTRWESLDDD
RENGCIRSVQHAYSQEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDSAVRGILADEVKAGDIVIIRYEGP
KGGPGMQEMLYPTSYLKSKGLGKDCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVRDGDKVLIDIPNRSINLLIDDA
EMAERRTEQDKKGWKPVESRPRKVTTALKAYALLATSADKGAVRDKALLDKLVP

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=615, Percent_Identity=73.6585365853659, Blast_Score=942, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=495, Percent_Identity=32.3232323232323, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1786464, Length=519, Percent_Identity=30.8285163776493, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1788157, Length=537, Percent_Identity=28.4916201117318, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6322476, Length=608, Percent_Identity=38.1578947368421, Blast_Score=365, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65992; Mature: 65861

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHH
AREVERAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHEEEEC
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLASHGLDLVDAMVIAADSTASDEKVA
CCCCCCHHHHHHHEECCCEEEEEECCCCCCCHHHHHHCCHHHHHHHHEECCCCCCHHHHH
EYERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSALATHSDREQLFLQAGRTIVDL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCEEEECCHHHHHHHHHCCHHHHH
CRQYYKENDDSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEIDFDLRHID
HHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHH
HLSRKVPQLCKVAPNIQKYHMEDVHRAGGIFSILGELARGGLLHTDLPTVHSKTLAEGIA
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCEEECCCCHHHHHHHHHHHH
KWDITQTDDEAVHTFFKAGPAGIPTQTAFSQSTRWESLDDDRENGCIRSVQHAYSQEGGL
HCCCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCHHCHHHHHHHHHHCCCCCE
AVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDSAVRGILADEVKAGDIVIIRYEG
EEEECCEEECCEEEEECCCCCCEEEEECCHHHHCCCCHHHHHHHHHCCCCCCEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKDCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVR
CCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
DGDKVLIDIPNRSINLLIDDAEMAERRTEQDKKGWKPVESRPRKVTTALKAYALLATSAD
CCCEEEEECCCCCEEEEEECHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHEECCC
KGAVRDKALLDKLVP
CCCHHHHHHHHHHCC
>Mature Secondary Structure 
PDYRSKTSTHGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDMGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHH
AREVERAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHEEEEC
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLASHGLDLVDAMVIAADSTASDEKVA
CCCCCCHHHHHHHEECCCEEEEEECCCCCCCHHHHHHCCHHHHHHHHEECCCCCCHHHHH
EYERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSALATHSDREQLFLQAGRTIVDL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCEEEECCHHHHHHHHHCCHHHHH
CRQYYKENDDSVLPRNIANFKAFENAMTLDIAMGGSTNTILHLLAAAQEAEIDFDLRHID
HHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHH
HLSRKVPQLCKVAPNIQKYHMEDVHRAGGIFSILGELARGGLLHTDLPTVHSKTLAEGIA
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCEEECCCCHHHHHHHHHHHH
KWDITQTDDEAVHTFFKAGPAGIPTQTAFSQSTRWESLDDDRENGCIRSVQHAYSQEGGL
HCCCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCHHCHHHHHHHHHHCCCCCE
AVLYGNIALDGCVVKTAGVDESIHVFEGSAKIFESQDSAVRGILADEVKAGDIVIIRYEG
EEEECCEEECCEEEEECCCCCCEEEEECCHHHHCCCCHHHHHHHHHCCCCCCEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKDCALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVR
CCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
DGDKVLIDIPNRSINLLIDDAEMAERRTEQDKKGWKPVESRPRKVTTALKAYALLATSAD
CCCEEEEECCCCCEEEEEECHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHEECCC
KGAVRDKALLDKLVP
CCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA