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The map label for this gene is cysS [H]

Identifier: 62390397

GI number: 62390397

Start: 1597713

End: 1598975

Strand: Reverse

Name: cysS [H]

Synonym: cg1709

Alternate gene names: 62390397

Gene position: 1598975-1597713 (Counterclockwise)

Preceding gene: 161486719

Following gene: 62390396

Centisome position: 48.71

GC content: 57.88

Gene sequence:

>1263_bases
ATGCAATCTTGGCCTACACCTGAAGTACCTGCTCTCGCTGGCACGCCTGTGCCTTTGGAATTGTTCGACACTGCAGATCA
GGAAGTACGCCTGGTTGAAACCCCACCTGCCGGATCCGACACACCGGTTGGCATGTACGTCTGTGGCATCACTCCCTACG
ACTCCACACACTTGGGGCACGCGGCGACATACCTCGCTTTCGATCTGATCTACCGCATCCTGCTGGACAATGATCACGAT
GTCCACTACGTCCAAAACATCACCGATGTCGATGACCCTCTGTTTGAACGCGCAGCCCGCGACGGCGTCGACTGGCGCGA
CCTCGGCACCAGCCAAATCAACCTCTTCCGCAGCGATATGGAAGCCCTGAGCATCATTCCGCCGAAGGACTACATCGGTG
CGATTGAGTCCATCGACGAAGTCATTGAGATGGTCAAGACGCTTCTCGACGAAGGCGCCGCGTACATCGTCGAGGACGCC
GAATATCCAGATGTCTACGCATCAATCAACGCCACAGACAAATTTGGCTACGAGTCCAATTACGACGCAGCGACCATGGC
TGAGTTCTTCGCAGAACGCGGCGGCGACCCAGAGCGTCCCGGCAAGAAAAACCCCATGGATGCCCTCCTGTGGCGCGCAG
CCCGCGAAGGTGAACCAAGCTGGGAATCCCCATTCGGCGCAGGTCGTCCTGGCTGGCACATCGAGTGTTCAGCAATCGCT
ACCAACCGCCTAGGACACAGCTTTGATATCCAAGGTGGCGGCTCTGACCTGATCTTCCCTCACCACGAGTTCTCCGCAGC
GCACGCCGAAGCAGCTCACGGTGTCGAGCGCATGGCTAAGCACTACGTCCACGCTGGCATGATATCCCAAGATGGCGTGA
AAATGTCCAAGTCTTTGGGCAACCTGGAATTTGTTTCCCGCCTCACCGCTGCAGGCCACGAGCCCGGCGCGATCCGCCTC
GGTGTTTTTGCCAACCATTACCGTGGCAACCGTGATTGGAACGCAGAGAGCCTCGCCACCGCAGAACAGCGTCTAGCAAC
CTGGCGTGAAGCAGCACGAGCTGCAACCAATAGGGAAGATGCCATTGCAGTTGTCGAGCAGCTTCGTGCACACCTATCTG
CTGACCTTGATACTCCCGGCGCGCTCGCCGCGGTAGATAATTGGGCAGCGGGTATCGACACCACGACCGATTCAAAAGAG
TTCACCGAGGTAGGAAACATCGTGGTCGCAGCCATTGATGCCCTCCTGGGCGTGCAGCTCTAG

Upstream 100 bases:

>100_bases
TAGGACGTGTCTCCGCGCTGAACTTGTGCAATGAGCCTGCACATAGCTTGCAAATAGCTTGTCGCGGAAATAATTACGGA
AAGAAGATAGAGTAAAACCC

Downstream 100 bases:

>100_bases
GAAATTTCAGGAACAATACATCTCATGACCATTCGCGCCACTTTCCAGCCTTCCGTAGATGAATTCATCTCCACTCTCGA
AGAGTTTGCAACAGGTTCAT

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: L-Cys:GlcN-Ins ligase; Mycothiol ligase; MSH ligase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MQSWPTPEVPALAGTPVPLELFDTADQEVRLVETPPAGSDTPVGMYVCGITPYDSTHLGHAATYLAFDLIYRILLDNDHD
VHYVQNITDVDDPLFERAARDGVDWRDLGTSQINLFRSDMEALSIIPPKDYIGAIESIDEVIEMVKTLLDEGAAYIVEDA
EYPDVYASINATDKFGYESNYDAATMAEFFAERGGDPERPGKKNPMDALLWRAAREGEPSWESPFGAGRPGWHIECSAIA
TNRLGHSFDIQGGGSDLIFPHHEFSAAHAEAAHGVERMAKHYVHAGMISQDGVKMSKSLGNLEFVSRLTAAGHEPGAIRL
GVFANHYRGNRDWNAESLATAEQRLATWREAARAATNREDAIAVVEQLRAHLSADLDTPGALAAVDNWAAGIDTTTDSKE
FTEVGNIVVAAIDALLGVQL

Sequences:

>Translated_420_residues
MQSWPTPEVPALAGTPVPLELFDTADQEVRLVETPPAGSDTPVGMYVCGITPYDSTHLGHAATYLAFDLIYRILLDNDHD
VHYVQNITDVDDPLFERAARDGVDWRDLGTSQINLFRSDMEALSIIPPKDYIGAIESIDEVIEMVKTLLDEGAAYIVEDA
EYPDVYASINATDKFGYESNYDAATMAEFFAERGGDPERPGKKNPMDALLWRAAREGEPSWESPFGAGRPGWHIECSAIA
TNRLGHSFDIQGGGSDLIFPHHEFSAAHAEAAHGVERMAKHYVHAGMISQDGVKMSKSLGNLEFVSRLTAAGHEPGAIRL
GVFANHYRGNRDWNAESLATAEQRLATWREAARAATNREDAIAVVEQLRAHLSADLDTPGALAAVDNWAAGIDTTTDSKE
FTEVGNIVVAAIDALLGVQL
>Mature_420_residues
MQSWPTPEVPALAGTPVPLELFDTADQEVRLVETPPAGSDTPVGMYVCGITPYDSTHLGHAATYLAFDLIYRILLDNDHD
VHYVQNITDVDDPLFERAARDGVDWRDLGTSQINLFRSDMEALSIIPPKDYIGAIESIDEVIEMVKTLLDEGAAYIVEDA
EYPDVYASINATDKFGYESNYDAATMAEFFAERGGDPERPGKKNPMDALLWRAAREGEPSWESPFGAGRPGWHIECSAIA
TNRLGHSFDIQGGGSDLIFPHHEFSAAHAEAAHGVERMAKHYVHAGMISQDGVKMSKSLGNLEFVSRLTAAGHEPGAIRL
GVFANHYRGNRDWNAESLATAEQRLATWREAARAATNREDAIAVVEQLRAHLSADLDTPGALAAVDNWAAGIDTTTDSKE
FTEVGNIVVAAIDALLGVQL

Specific function: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins [H]

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily [H]

Homologues:

Organism=Homo sapiens, GI13375695, Length=360, Percent_Identity=32.7777777777778, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI303304987, Length=235, Percent_Identity=35.3191489361702, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI21269877, Length=235, Percent_Identity=35.3191489361702, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI62240992, Length=235, Percent_Identity=35.3191489361702, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI10835051, Length=235, Percent_Identity=35.3191489361702, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1786737, Length=380, Percent_Identity=36.3157894736842, Blast_Score=229, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17509795, Length=258, Percent_Identity=30.6201550387597, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17509797, Length=258, Percent_Identity=30.6201550387597, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324082, Length=291, Percent_Identity=31.6151202749141, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI19922218, Length=312, Percent_Identity=35.8974358974359, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI19922364, Length=278, Percent_Identity=33.0935251798561, Blast_Score=148, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015803
- InterPro:   IPR017812
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01406 tRNA-synt_1e [H]

EC number: =6.3.1.13 [H]

Molecular weight: Translated: 45747; Mature: 45747

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSWPTPEVPALAGTPVPLELFDTADQEVRLVETPPAGSDTPVGMYVCGITPYDSTHLGH
CCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCHH
AATYLAFDLIYRILLDNDHDVHYVQNITDVDDPLFERAARDGVDWRDLGTSQINLFRSDM
HHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHH
EALSIIPPKDYIGAIESIDEVIEMVKTLLDEGAAYIVEDAEYPDVYASINATDKFGYESN
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCCCCCCCCC
YDAATMAEFFAERGGDPERPGKKNPMDALLWRAAREGEPSWESPFGAGRPGWHIECSAIA
CCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEH
TNRLGHSFDIQGGGSDLIFPHHEFSAAHAEAAHGVERMAKHYVHAGMISQDGVKMSKSLG
HCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCC
NLEFVSRLTAAGHEPGAIRLGVFANHYRGNRDWNAESLATAEQRLATWREAARAATNRED
CHHHHHHHHHCCCCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
AIAVVEQLRAHLSADLDTPGALAAVDNWAAGIDTTTDSKEFTEVGNIVVAAIDALLGVQL
HHHHHHHHHHHHCCCCCCCCCHHHHHCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQSWPTPEVPALAGTPVPLELFDTADQEVRLVETPPAGSDTPVGMYVCGITPYDSTHLGH
CCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCHH
AATYLAFDLIYRILLDNDHDVHYVQNITDVDDPLFERAARDGVDWRDLGTSQINLFRSDM
HHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHH
EALSIIPPKDYIGAIESIDEVIEMVKTLLDEGAAYIVEDAEYPDVYASINATDKFGYESN
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCCCCCCCCC
YDAATMAEFFAERGGDPERPGKKNPMDALLWRAAREGEPSWESPFGAGRPGWHIECSAIA
CCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEH
TNRLGHSFDIQGGGSDLIFPHHEFSAAHAEAAHGVERMAKHYVHAGMISQDGVKMSKSLG
HCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCC
NLEFVSRLTAAGHEPGAIRLGVFANHYRGNRDWNAESLATAEQRLATWREAARAATNRED
CHHHHHHHHHCCCCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
AIAVVEQLRAHLSADLDTPGALAAVDNWAAGIDTTTDSKEFTEVGNIVVAAIDALLGVQL
HHHHHHHHHHHHCCCCCCCCCHHHHHCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA