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The map label for this gene is iunH3 [H]

Identifier: 62390248

GI number: 62390248

Start: 1429688

End: 1430626

Strand: Reverse

Name: iunH3 [H]

Synonym: cg1543

Alternate gene names: 62390248

Gene position: 1430626-1429688 (Counterclockwise)

Preceding gene: 62390249

Following gene: 62390247

Centisome position: 43.58

GC content: 56.44

Gene sequence:

>939_bases
ATGACCACCAAGATCATCCTCGACTGCGATCCAGGACACGACGACGCTGTAGCCATGCTGCTCGCAGCCGGCAGCCCAGA
AATTGAACTGCTTGGAATCACCACGGTCGGCGGCAACCAGACCTTGGACAAGGTCACCCACAATACGCAGGTCGTAGCCA
CCATCGCTGATATCAATGCGCCCATCTACCGCGGTGTCACCCGACCATTGGTGCGCCCCGTTGAGGTAGCCGAAGATATC
CACGGCGATACCGGCATGGAAATCCACAAGTACGAACTGCCTGAACCAACCAAGCAGGTAGAAGACACCCACGCGGTGGA
TTTCATCATCGATACCATCATGAATAACGAGCCCGGCAGCGTAGCGCTGGTTCCCACCGGACCACTGACCAACATCGCGC
TGGCAGTCCGGAAAGAACCACGCATCGCCGAGCGAGTCAAGGAAGTTGTCCTCATGGGCGGGGGCTACCACGTAGGAAAC
TGGACCGCCGTAGCTGAATTCAACATCAAGATCGACCCCGAAGCAGCCCACATCGTATTCAACGAAAAGTGGCCACTGAC
TATGGTCGGCCTCGACCTTACCCACCAGGCGCTCGCAACACCTGAGATCGAAGCCAAGTTCAACGAGCTGGGCACCGACG
TCGCCGACTTCGTCGTCGCGCTTTTCGACGCTTTCCGCAAGAATTACCAGGACGCACAGGGTTTTGATAACCCACCAGTA
CACGACCCTTGTGCTGTTGCATACCTTGTTGACCCAACCGTATTCACCACCCGCAAAGCACCACTCGATGTGGAGCTGTA
CGGCGCACTCACCACAGGCATGACCGTTGCTGATTTCCGCGCACCGGCTCCAGCAGATTGCACCACCCAAGTAGCTGTTG
ACCTGGACTTTGATAAATTCTGGAACATGGTGATCGATGCAGTAAAGCGCATCGGATAG

Upstream 100 bases:

>100_bases
CCAGAATCAATCACCGATACAGTGGCAGCCAAAGTCCAGGCTGAAGAAGCCGCTCAAGCCGCCAGCTAAATCCACAAACT
GAACTAAGGAGTTTTACCCT

Downstream 100 bases:

>100_bases
ACCTGTTCACAAGGTTGTTAGAGGGCGTATCCGCACCTGATTGGTGAGGGTACGCCCTCCTTTTGTGGATATCGCTGCTA
GTGGACGTCGAAAAGCAAAA

Product: inosine-uridine preferring nucleoside hydrolase

Products: NA

Alternate protein names: Cytidine/uridine-specific hydrolase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTTKIILDCDPGHDDAVAMLLAAGSPEIELLGITTVGGNQTLDKVTHNTQVVATIADINAPIYRGVTRPLVRPVEVAEDI
HGDTGMEIHKYELPEPTKQVEDTHAVDFIIDTIMNNEPGSVALVPTGPLTNIALAVRKEPRIAERVKEVVLMGGGYHVGN
WTAVAEFNIKIDPEAAHIVFNEKWPLTMVGLDLTHQALATPEIEAKFNELGTDVADFVVALFDAFRKNYQDAQGFDNPPV
HDPCAVAYLVDPTVFTTRKAPLDVELYGALTTGMTVADFRAPAPADCTTQVAVDLDFDKFWNMVIDAVKRIG

Sequences:

>Translated_312_residues
MTTKIILDCDPGHDDAVAMLLAAGSPEIELLGITTVGGNQTLDKVTHNTQVVATIADINAPIYRGVTRPLVRPVEVAEDI
HGDTGMEIHKYELPEPTKQVEDTHAVDFIIDTIMNNEPGSVALVPTGPLTNIALAVRKEPRIAERVKEVVLMGGGYHVGN
WTAVAEFNIKIDPEAAHIVFNEKWPLTMVGLDLTHQALATPEIEAKFNELGTDVADFVVALFDAFRKNYQDAQGFDNPPV
HDPCAVAYLVDPTVFTTRKAPLDVELYGALTTGMTVADFRAPAPADCTTQVAVDLDFDKFWNMVIDAVKRIG
>Mature_311_residues
TTKIILDCDPGHDDAVAMLLAAGSPEIELLGITTVGGNQTLDKVTHNTQVVATIADINAPIYRGVTRPLVRPVEVAEDIH
GDTGMEIHKYELPEPTKQVEDTHAVDFIIDTIMNNEPGSVALVPTGPLTNIALAVRKEPRIAERVKEVVLMGGGYHVGNW
TAVAEFNIKIDPEAAHIVFNEKWPLTMVGLDLTHQALATPEIEAKFNELGTDVADFVVALFDAFRKNYQDAQGFDNPPVH
DPCAVAYLVDPTVFTTRKAPLDVELYGALTTGMTVADFRAPAPADCTTQVAVDLDFDKFWNMVIDAVKRIG

Specific function: Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides [H]

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family. RihB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788486, Length=306, Percent_Identity=43.1372549019608, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1786871, Length=312, Percent_Identity=39.1025641025641, Blast_Score=224, Evalue=4e-60,
Organism=Escherichia coli, GI1786213, Length=308, Percent_Identity=37.012987012987, Blast_Score=163, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI32565474, Length=191, Percent_Identity=37.696335078534, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17565698, Length=291, Percent_Identity=29.8969072164948, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320608, Length=327, Percent_Identity=34.8623853211009, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24641839, Length=290, Percent_Identity=30, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641837, Length=197, Percent_Identity=34.5177664974619, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24583915, Length=187, Percent_Identity=29.9465240641711, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015910
- InterPro:   IPR023186
- InterPro:   IPR001910
- InterPro:   IPR022977 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: =3.2.2.8 [H]

Molecular weight: Translated: 33923; Mature: 33792

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS01247 IUNH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKIILDCDPGHDDAVAMLLAAGSPEIELLGITTVGGNQTLDKVTHNTQVVATIADINA
CCEEEEEECCCCCCHHEEEEEECCCCCEEEEEEEEECCCCHHHHHCCCCEEEEEEECCCC
PIYRGVTRPLVRPVEVAEDIHGDTGMEIHKYELPEPTKQVEDTHAVDFIIDTIMNNEPGS
HHHHCCHHHHCCHHHHHHHCCCCCCCEEEEEECCCHHHHHCHHHHHHHHHHHHHCCCCCC
VALVPTGPLTNIALAVRKEPRIAERVKEVVLMGGGYHVGNWTAVAEFNIKIDPEAAHIVF
EEEEECCCCCCEEEEEECCCHHHHHHHHHEEECCCEEECCEEEEEEEEEEECCCEEEEEE
NEKWPLTMVGLDLTHQALATPEIEAKFNELGTDVADFVVALFDAFRKNYQDAQGFDNPPV
CCCCCEEEEECCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
HDPCAVAYLVDPTVFTTRKAPLDVELYGALTTGMTVADFRAPAPADCTTQVAVDLDFDKF
CCCEEEEEEECCCEEECCCCCCCEEEEEEHCCCCEEECCCCCCCCCCCEEEEEEECHHHH
WNMVIDAVKRIG
HHHHHHHHHHCC
>Mature Secondary Structure 
TTKIILDCDPGHDDAVAMLLAAGSPEIELLGITTVGGNQTLDKVTHNTQVVATIADINA
CEEEEEECCCCCCHHEEEEEECCCCCEEEEEEEEECCCCHHHHHCCCCEEEEEEECCCC
PIYRGVTRPLVRPVEVAEDIHGDTGMEIHKYELPEPTKQVEDTHAVDFIIDTIMNNEPGS
HHHHCCHHHHCCHHHHHHHCCCCCCCEEEEEECCCHHHHHCHHHHHHHHHHHHHCCCCCC
VALVPTGPLTNIALAVRKEPRIAERVKEVVLMGGGYHVGNWTAVAEFNIKIDPEAAHIVF
EEEEECCCCCCEEEEEECCCHHHHHHHHHEEECCCEEECCEEEEEEEEEEECCCEEEEEE
NEKWPLTMVGLDLTHQALATPEIEAKFNELGTDVADFVVALFDAFRKNYQDAQGFDNPPV
CCCCCEEEEECCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
HDPCAVAYLVDPTVFTTRKAPLDVELYGALTTGMTVADFRAPAPADCTTQVAVDLDFDKF
CCCEEEEEEECCCEEECCCCCCCEEEEEEHCCCCEEECCCCCCCCCCCEEEEEEECHHHH
WNMVIDAVKRIG
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA