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The map label for this gene is thiC [H]

Identifier: 62390189

GI number: 62390189

Start: 1371341

End: 1373104

Strand: Reverse

Name: thiC [H]

Synonym: cg1476

Alternate gene names: 62390189

Gene position: 1373104-1371341 (Counterclockwise)

Preceding gene: 62390191

Following gene: 62390185

Centisome position: 41.83

GC content: 56.46

Gene sequence:

>1764_bases
ATGACGCCTACCCAAAATGAGATCCACCCGAAACATAGCTACTCCCCCATCCGCAAGGACGGTCTCGAGGTCCCGGAGAC
CGAAATCCGCCTCGATGACTCGCCAAGCGGCCCCAACGAACCCTTCCGCATCTACCGCACCCGTGGCCCAGAAACCAACC
CCAAGCAGGGACTTCCGCGGCTGCGCGAGTCATGGATCACCGCCCGCGGCGACGTTGCCACCTATCAGGGGCGCGAGCGT
TTGCTTATCGACGACGGCCGCTCGGCAATGCGTCGAGGTCAAGCTTCGGCTGAGTGGAAAGGCCAAAAACCAGCTCCTTT
GAAGGCGCTACCTGGCAAAAGAGTCACCCAAATGGCCTATGCACGTGCTGGCGTGATTACTCGTGAAATGGAGTTTGTAG
CGCTGCGCGAACACGTTGATGCGGAGTTTGTGCGCTCTGAGGTGGCGCGCGGTCGGGCCATTATTCCCAACAACGTCAAC
CACCCCGAATCTGAACCGATGATTATTGGTCGCAAATTTTTGACCAAAATCAACGCCAATATTGGCAATTCTGCGGTCAC
CTCTTCAATCGAGGAAGAGGTGTCCAAGCTGCAGTGGGCCACGCGCTGGGGTGCCGATACCGTGATGGATCTATCCACCG
GCGATGATATTCACACCACCCGCGAATGGATTATCCGCAACTCCCCCGTTCCTATCGGCACCGTCCCGATCTACCAAGCG
CTGGAAAAAGTAAATGGCGTGGCCGCAGACCTTAACTGGGAAGTATTCCGCGATACCATCATTGAGCAGTGTGAACAAGG
CGTGGACTATATGACCATCCACGCCGGCGTCCTGCTGGCTTATATCCCACTGACTACCCGTCGTGTCACCGGCATTGTCT
CCCGCGGCGGATCCATTATGGCCGGTTGGTGTCTGGCGCATCACCGCGAATCATTCCTCTACGAGCATTTCGACGAGCTG
TGCGAAATCTTTGCACAATATGACGTCGCATTCTCCCTCGGTGATGGCCTACGCCCCGGATCGCTTGCCGATGCCAACGA
CGCCGCGCAATTCGCCGAGCTGAAAACCATTGGTGAGCTCACCCAACGCGCCTGGGAATACGATGTACAAGTAATGGTCG
AAGGACCTGGACACGTGCCACTAAACATGATCCAGGAAAACAACGAGCTGGAACAAAAGTGGGCAGCGGACGCACCTTTT
TACACTCTTGGACCACTAGTTACCGACATCGCTCCAGGTTATGACCACATCACTTCTGCCATTGGTGCAGCTCACATCGC
CATGGGTGGCACCGCCATGCTGTGTTATGTCACCCCGAAAGAACACCTTGGCCTGCCCAACCGTGACGACGTCAAAACCG
GCGTAATCACCTACAAGCTCGCTGCCCACGCAGCAGATGTGGCCAAGGGTCATCCCGGCGCGCGTGCCTGGGACGACGCC
ATGAGTAAAGCGCGTTTTGAATTCCGTTGGAATGATCAGTTTGCGCTCTCCCTCGACCCCGACACTGCAATCGCTTATCA
CGACGAAACCCTGCCGGCAGAGCCTGCGAAAACCGCACACTTCTGTTCAATGTGTGGCCCGAAGTTCTGCTCCATGCGAA
TTAGCCAGGACATTCGCGATATGTTTGGCGATCAAATCGCGGAATTGGGGATGCCTGGGGTTGGGGATTCTTCTAGTGCT
GTTGCTTCTAGTGGGGCACGGGAGGGGATGGCTGAGAAATCCCGGGAATTTATTGCTGGTGGTGCGGAGGTTTATCGGCG
TTAG

Upstream 100 bases:

>100_bases
CACGGGCGCCCGAGCACGGGCTGAGATCGCGCTGATTGCTGCGCGAGCACCGTTTGAACCTGTCCGGTTAGCACCGGCGA
AGGAAGAGAGGAATGGTGCA

Downstream 100 bases:

>100_bases
ACAGAGCGATCCCAGATAGCCTCATATCGTTTTTCGACCAATGGCCAAATAATTTCCTGAACATCCTCCAATGTGGTGAC
GCCTTCCGCGAACTGCCCCC

Product: thiamine biosynthesis protein ThiC

Products: @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine!; 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

Alternate protein names: Hydroxymethylpyrimidine phosphate synthase; HMP-P synthase; HMP-phosphate synthase; HMPP synthase; Thiamine biosynthesis protein thiC [H]

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MTPTQNEIHPKHSYSPIRKDGLEVPETEIRLDDSPSGPNEPFRIYRTRGPETNPKQGLPRLRESWITARGDVATYQGRER
LLIDDGRSAMRRGQASAEWKGQKPAPLKALPGKRVTQMAYARAGVITREMEFVALREHVDAEFVRSEVARGRAIIPNNVN
HPESEPMIIGRKFLTKINANIGNSAVTSSIEEEVSKLQWATRWGADTVMDLSTGDDIHTTREWIIRNSPVPIGTVPIYQA
LEKVNGVAADLNWEVFRDTIIEQCEQGVDYMTIHAGVLLAYIPLTTRRVTGIVSRGGSIMAGWCLAHHRESFLYEHFDEL
CEIFAQYDVAFSLGDGLRPGSLADANDAAQFAELKTIGELTQRAWEYDVQVMVEGPGHVPLNMIQENNELEQKWAADAPF
YTLGPLVTDIAPGYDHITSAIGAAHIAMGGTAMLCYVTPKEHLGLPNRDDVKTGVITYKLAAHAADVAKGHPGARAWDDA
MSKARFEFRWNDQFALSLDPDTAIAYHDETLPAEPAKTAHFCSMCGPKFCSMRISQDIRDMFGDQIAELGMPGVGDSSSA
VASSGAREGMAEKSREFIAGGAEVYRR

Sequences:

>Translated_587_residues
MTPTQNEIHPKHSYSPIRKDGLEVPETEIRLDDSPSGPNEPFRIYRTRGPETNPKQGLPRLRESWITARGDVATYQGRER
LLIDDGRSAMRRGQASAEWKGQKPAPLKALPGKRVTQMAYARAGVITREMEFVALREHVDAEFVRSEVARGRAIIPNNVN
HPESEPMIIGRKFLTKINANIGNSAVTSSIEEEVSKLQWATRWGADTVMDLSTGDDIHTTREWIIRNSPVPIGTVPIYQA
LEKVNGVAADLNWEVFRDTIIEQCEQGVDYMTIHAGVLLAYIPLTTRRVTGIVSRGGSIMAGWCLAHHRESFLYEHFDEL
CEIFAQYDVAFSLGDGLRPGSLADANDAAQFAELKTIGELTQRAWEYDVQVMVEGPGHVPLNMIQENNELEQKWAADAPF
YTLGPLVTDIAPGYDHITSAIGAAHIAMGGTAMLCYVTPKEHLGLPNRDDVKTGVITYKLAAHAADVAKGHPGARAWDDA
MSKARFEFRWNDQFALSLDPDTAIAYHDETLPAEPAKTAHFCSMCGPKFCSMRISQDIRDMFGDQIAELGMPGVGDSSSA
VASSGAREGMAEKSREFIAGGAEVYRR
>Mature_586_residues
TPTQNEIHPKHSYSPIRKDGLEVPETEIRLDDSPSGPNEPFRIYRTRGPETNPKQGLPRLRESWITARGDVATYQGRERL
LIDDGRSAMRRGQASAEWKGQKPAPLKALPGKRVTQMAYARAGVITREMEFVALREHVDAEFVRSEVARGRAIIPNNVNH
PESEPMIIGRKFLTKINANIGNSAVTSSIEEEVSKLQWATRWGADTVMDLSTGDDIHTTREWIIRNSPVPIGTVPIYQAL
EKVNGVAADLNWEVFRDTIIEQCEQGVDYMTIHAGVLLAYIPLTTRRVTGIVSRGGSIMAGWCLAHHRESFLYEHFDELC
EIFAQYDVAFSLGDGLRPGSLADANDAAQFAELKTIGELTQRAWEYDVQVMVEGPGHVPLNMIQENNELEQKWAADAPFY
TLGPLVTDIAPGYDHITSAIGAAHIAMGGTAMLCYVTPKEHLGLPNRDDVKTGVITYKLAAHAADVAKGHPGARAWDDAM
SKARFEFRWNDQFALSLDPDTAIAYHDETLPAEPAKTAHFCSMCGPKFCSMRISQDIRDMFGDQIAELGMPGVGDSSSAV
ASSGAREGMAEKSREFIAGGAEVYRR

Specific function: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction [H]

COG id: COG0422

COG function: function code H; Thiamine biosynthesis protein ThiC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiC family [H]

Homologues:

Organism=Escherichia coli, GI1790427, Length=614, Percent_Identity=60.7491856677524, Blast_Score=732, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002817 [H]

Pfam domain/function: PF01964 ThiC [H]

EC number: NA

Molecular weight: Translated: 64821; Mature: 64690

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTQNEIHPKHSYSPIRKDGLEVPETEIRLDDSPSGPNEPFRIYRTRGPETNPKQGLPR
CCCCCCCCCCCCCCCCHHHCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCHHHCCHH
LRESWITARGDVATYQGRERLLIDDGRSAMRRGQASAEWKGQKPAPLKALPGKRVTQMAY
HHHHHHCCCCCEEEECCCCEEEEECCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
ARAGVITREMEFVALREHVDAEFVRSEVARGRAIIPNNVNHPESEPMIIGRKFLTKINAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEEHHHHHHHHCCC
IGNSAVTSSIEEEVSKLQWATRWGADTVMDLSTGDDIHTTREWIIRNSPVPIGTVPIYQA
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHEECCCCCCCCCHHHHH
LEKVNGVAADLNWEVFRDTIIEQCEQGVDYMTIHAGVLLAYIPLTTRRVTGIVSRGGSIM
HHHHCCEEECCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEE
AGWCLAHHRESFLYEHFDELCEIFAQYDVAFSLGDGLRPGSLADANDAAQFAELKTIGEL
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
TQRAWEYDVQVMVEGPGHVPLNMIQENNELEQKWAADAPFYTLGPLVTDIAPGYDHITSA
HHHHHCCCEEEEEECCCCCCHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHH
IGAAHIAMGGTAMLCYVTPKEHLGLPNRDDVKTGVITYKLAAHAADVAKGHPGARAWDDA
HHHHHHCCCCCEEEEEECCHHHCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCCHHHHHH
MSKARFEFRWNDQFALSLDPDTAIAYHDETLPAEPAKTAHFCSMCGPKFCSMRISQDIRD
HHHCEEEEEECCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHH
MFGDQIAELGMPGVGDSSSAVASSGAREGMAEKSREFIAGGAEVYRR
HHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TPTQNEIHPKHSYSPIRKDGLEVPETEIRLDDSPSGPNEPFRIYRTRGPETNPKQGLPR
CCCCCCCCCCCCCCCHHHCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCHHHCCHH
LRESWITARGDVATYQGRERLLIDDGRSAMRRGQASAEWKGQKPAPLKALPGKRVTQMAY
HHHHHHCCCCCEEEECCCCEEEEECCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
ARAGVITREMEFVALREHVDAEFVRSEVARGRAIIPNNVNHPESEPMIIGRKFLTKINAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCEEEHHHHHHHHCCC
IGNSAVTSSIEEEVSKLQWATRWGADTVMDLSTGDDIHTTREWIIRNSPVPIGTVPIYQA
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHEECCCCCCCCCHHHHH
LEKVNGVAADLNWEVFRDTIIEQCEQGVDYMTIHAGVLLAYIPLTTRRVTGIVSRGGSIM
HHHHCCEEECCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEE
AGWCLAHHRESFLYEHFDELCEIFAQYDVAFSLGDGLRPGSLADANDAAQFAELKTIGEL
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
TQRAWEYDVQVMVEGPGHVPLNMIQENNELEQKWAADAPFYTLGPLVTDIAPGYDHITSA
HHHHHCCCEEEEEECCCCCCHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHH
IGAAHIAMGGTAMLCYVTPKEHLGLPNRDDVKTGVITYKLAAHAADVAKGHPGARAWDDA
HHHHHHCCCCCEEEEEECCHHHCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCCHHHHHH
MSKARFEFRWNDQFALSLDPDTAIAYHDETLPAEPAKTAHFCSMCGPKFCSMRISQDIRD
HHHCEEEEEECCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHH
MFGDQIAELGMPGVGDSSSAVASSGAREGMAEKSREFIAGGAEVYRR
HHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ?; ?; 5'-phosphoribosyl-5-aminoimidazole [C]

Specific reaction: Synthesis of @AMIN06.txt*4-amino-2-methyl-5-hydroxymethylpyrimidine! 5'-phosphoribosyl-5-aminoimidazole = 4-amino-5-hydroxymethyl-2-methylpyrimidine-phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA