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The map label for this gene is entC [H]

Identifier: 62390178

GI number: 62390178

Start: 1361632

End: 1362762

Strand: Reverse

Name: entC [H]

Synonym: cg1462

Alternate gene names: 62390178

Gene position: 1362762-1361632 (Counterclockwise)

Preceding gene: 62390180

Following gene: 62390173

Centisome position: 41.51

GC content: 58.53

Gene sequence:

>1131_bases
ATGTCTGCCCACCGCAACCCCTCTGCCCCCAACACCGCCCCAGATTTCCTCTTATCCAGAGGCCACGGGTCTGTGCGCAC
CCAAGGATCAAAAGAAGTATTCACCGATCCCTGGGAGGCAGTAGACGCCCTTAAACAAGGGCGCGTAGCCATGGTGGTGG
GTGCTTTGCCCTTCGAACGGGACAAACCAGCAGCACTGACTGTCCCAGAACACATCATCCGCGAAGACGGCCCCCTAGAA
CCTCACGCCTACTACAGGTTTGGACCAGGCTCAGTACTGCACGCCAGCGTCGCAGGAATTGATCCCTCACCGATTGAGCA
TTTACGACGCGTCAATGCAGCCATCAATACCATCAACAACACTGTCCTGAACAAAGTTGTGCTCGCGCGCGCCGTGGACA
TCTCCTTCGAGCCACCCGTTGATCCCCTGCTGGTGGCCGCACGTTTGATTGATAACTCCCACAACAAGGACGGTTTCATC
GCCGACCTGACCCCTGCAGGCCCAGACTTTGCAGGCCACATGCTGGTTGGATCCTCCCCGGAGGTGTTAATCAAACGCCA
AGGTTCCACCATCACCGCATACCCACTGGCCGGCTCCGCACCACGGCTTGCCGATCCAGTGCGCGATGAAGCCCAAGGAC
AAAACCTCCTGGCCAGCGCCAAAAACCTAGAAGAACACTCCTACGTGGTCAACCACCTGCGCACCATCCTGGAACCACTG
TGCTCACAATTCGACGCCCCAACAGTTCCTGAACTGACCAAAACCAACGAAATGTGGCACCTCGCAACACCCATCGTTGG
CACCCTCAAGTACCCACACATCACCGCACTAGAACTAGCCATCCGCACACACCCCACCCCCGCGATCTGTGGCACCCCCA
CCGACGCCGCCGAAGCCCTCATCATCGAAGCGGAATCCCCCCGAAACTTCTACGCCGGAGCAGTCGGCTGGTGTGACTCC
ACCGGAGACGGCGAATACATGGTAGCCATCCGCTGCGCCGAAGTATCCGAAGACGGAACCTGGGCCAGAGCATGGGCAGG
CGGAGGCATCGTCGCCGAATCAGACGCCCAAGAAGAGTTTGATGAAACCACCGCGAAGCTCCAAACCATCATGCGCTCGC
TTGGTTTGTGA

Upstream 100 bases:

>100_bases
CAGAAACGAACACGAACATCAGTCATGCAGGCCATGTTAATAGCCCGCACCCACCGCCCGCGCGTTTACCCCAGTTCTAC
TGGGATTAGAATGGCTAACC

Downstream 100 bases:

>100_bases
GATGTGGTCTTAAAACACCGACTTCACGTGAGCTGACTTCTCACGCTCAACTTCTCGTGGGCAGACTGCACTCCGGATTC
CGGGCTTTCACTACTGATGT

Product: isochorismate synthase

Products: NA

Alternate protein names: Isochorismate mutase [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MSAHRNPSAPNTAPDFLLSRGHGSVRTQGSKEVFTDPWEAVDALKQGRVAMVVGALPFERDKPAALTVPEHIIREDGPLE
PHAYYRFGPGSVLHASVAGIDPSPIEHLRRVNAAINTINNTVLNKVVLARAVDISFEPPVDPLLVAARLIDNSHNKDGFI
ADLTPAGPDFAGHMLVGSSPEVLIKRQGSTITAYPLAGSAPRLADPVRDEAQGQNLLASAKNLEEHSYVVNHLRTILEPL
CSQFDAPTVPELTKTNEMWHLATPIVGTLKYPHITALELAIRTHPTPAICGTPTDAAEALIIEAESPRNFYAGAVGWCDS
TGDGEYMVAIRCAEVSEDGTWARAWAGGGIVAESDAQEEFDETTAKLQTIMRSLGL

Sequences:

>Translated_376_residues
MSAHRNPSAPNTAPDFLLSRGHGSVRTQGSKEVFTDPWEAVDALKQGRVAMVVGALPFERDKPAALTVPEHIIREDGPLE
PHAYYRFGPGSVLHASVAGIDPSPIEHLRRVNAAINTINNTVLNKVVLARAVDISFEPPVDPLLVAARLIDNSHNKDGFI
ADLTPAGPDFAGHMLVGSSPEVLIKRQGSTITAYPLAGSAPRLADPVRDEAQGQNLLASAKNLEEHSYVVNHLRTILEPL
CSQFDAPTVPELTKTNEMWHLATPIVGTLKYPHITALELAIRTHPTPAICGTPTDAAEALIIEAESPRNFYAGAVGWCDS
TGDGEYMVAIRCAEVSEDGTWARAWAGGGIVAESDAQEEFDETTAKLQTIMRSLGL
>Mature_375_residues
SAHRNPSAPNTAPDFLLSRGHGSVRTQGSKEVFTDPWEAVDALKQGRVAMVVGALPFERDKPAALTVPEHIIREDGPLEP
HAYYRFGPGSVLHASVAGIDPSPIEHLRRVNAAINTINNTVLNKVVLARAVDISFEPPVDPLLVAARLIDNSHNKDGFIA
DLTPAGPDFAGHMLVGSSPEVLIKRQGSTITAYPLAGSAPRLADPVRDEAQGQNLLASAKNLEEHSYVVNHLRTILEPLC
SQFDAPTVPELTKTNEMWHLATPIVGTLKYPHITALELAIRTHPTPAICGTPTDAAEALIIEAESPRNFYAGAVGWCDST
GDGEYMVAIRCAEVSEDGTWARAWAGGGIVAESDAQEEFDETTAKLQTIMRSLGL

Specific function: Might be involved in the biosynthesis of menaquinone. Converts chorismate to isochorismate [H]

COG id: COG1169

COG function: function code HQ; Isochorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786809, Length=337, Percent_Identity=35.6083086053413, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI87082077, Length=277, Percent_Identity=30.6859205776173, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1787518, Length=213, Percent_Identity=32.3943661971831, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788114, Length=204, Percent_Identity=29.9019607843137, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320935, Length=209, Percent_Identity=33.0143540669856, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR015890
- InterPro:   IPR004561 [H]

Pfam domain/function: PF00425 Chorismate_bind [H]

EC number: =5.4.4.2 [H]

Molecular weight: Translated: 40373; Mature: 40242

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAHRNPSAPNTAPDFLLSRGHGSVRTQGSKEVFTDPWEAVDALKQGRVAMVVGALPFER
CCCCCCCCCCCCCHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCC
DKPAALTVPEHIIREDGPLEPHAYYRFGPGSVLHASVAGIDPSPIEHLRRVNAAINTINN
CCCCEEECCHHHHCCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
TVLNKVVLARAVDISFEPPVDPLLVAARLIDNSHNKDGFIADLTPAGPDFAGHMLVGSSP
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEECCCC
EVLIKRQGSTITAYPLAGSAPRLADPVRDEAQGQNLLASAKNLEEHSYVVNHLRTILEPL
CEEEEECCCEEEEECCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
CSQFDAPTVPELTKTNEMWHLATPIVGTLKYPHITALELAIRTHPTPAICGTPTDAAEAL
HHHCCCCCCCCCCCCCCEEEECCCHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEE
IIEAESPRNFYAGAVGWCDSTGDGEYMVAIRCAEVSEDGTWARAWAGGGIVAESDAQEEF
EEECCCCCCEECCEEECCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCEEECCCCHHHH
DETTAKLQTIMRSLGL
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAHRNPSAPNTAPDFLLSRGHGSVRTQGSKEVFTDPWEAVDALKQGRVAMVVGALPFER
CCCCCCCCCCCCHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCC
DKPAALTVPEHIIREDGPLEPHAYYRFGPGSVLHASVAGIDPSPIEHLRRVNAAINTINN
CCCCEEECCHHHHCCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
TVLNKVVLARAVDISFEPPVDPLLVAARLIDNSHNKDGFIADLTPAGPDFAGHMLVGSSP
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEEEECCCC
EVLIKRQGSTITAYPLAGSAPRLADPVRDEAQGQNLLASAKNLEEHSYVVNHLRTILEPL
CEEEEECCCEEEEECCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
CSQFDAPTVPELTKTNEMWHLATPIVGTLKYPHITALELAIRTHPTPAICGTPTDAAEAL
HHHCCCCCCCCCCCCCCEEEECCCHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEE
IIEAESPRNFYAGAVGWCDSTGDGEYMVAIRCAEVSEDGTWARAWAGGGIVAESDAQEEF
EEECCCCCCEECCEEECCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCEEECCCCHHHH
DETTAKLQTIMRSLGL
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]