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The map label for this gene is putP [H]

Identifier: 62390051

GI number: 62390051

Start: 1219496

End: 1221070

Strand: Reverse

Name: putP [H]

Synonym: cg1314

Alternate gene names: 62390051

Gene position: 1221070-1219496 (Counterclockwise)

Preceding gene: 62390058

Following gene: 62390050

Centisome position: 37.2

GC content: 50.67

Gene sequence:

>1575_bases
ATGAGCGATAACACCTGGTTCATCATAGCCATCGTTATCTATATGTTGGTGATGGTGCTCATCGGCTATTGGAGTTACCG
CAAGACAGAAAAATACGACGACTACATGCTCGCCGGCCGCGGGCTCAACCCTTTTGTTGCCGCAATGTCCGCAGGTGCCT
CAGATATGTCAGGTTGGCTGCTCATGGGTCTGCCCGGCGCGCTGTTTGTCACCGGCATGTCCGAGTTGTGGATCGCAGTC
GGACTCACCATTGGTGCATGGGCGAACTGGATGTGGGTGGCACCTCGTCTTCGTTCTTATTCCGAAATCTCGGCCAACTC
AATCACCCTGCCTTCATTCTTTGAGAACCGACTTCGCGATAAATCTCGCGCGCTTCGCATCATTGCAGCACTAATTATCA
TTGTGTTCTTCACCTTCTACATTTCTTCAGGCATGGTTGCTGGTGGAGTGTATTGGGAGTCCACGTTTGGTGGAGATTAT
CTACTCGGTATGGCCATTGTCGCAGGTGTGACAGTGCTGTATACCTTCATTGGAGGATTCCTTGCTGTGTCTTATACAGA
CGCAGTTCAGGGGACTATCATGTTCTTCTCGTTGATCATCGTGCCAGTCATGGCATATTTCGCACTGGCGAACCCCATGG
ATATTTGGAGCTTTGCAAACTCTAATGATTACGGCCCGCACACCGATGGAATTGGCAATCCCACCTACTTCTCCATGATC
AGTGGCATTTCTGCAGCAGCAATCATTGGTAACTTAGGTTGGGGTCTTGGATACTTCGGCCAGCCACACATTGTGGTTCG
TTTCATGGCACTTCGCACACCAGCTGAAGCAAAGCAAGGTCGTCGCATCGGTATTTCCTGGATGATAATCTGCCTGATTG
GTGCAACCTTTACCGCAATTATCTCCACAGTTTTCTTTGCACAAAACCCCGACGCCAACATCACTGACACAAGGGCTTAT
GAGTCCATCTTCCTAGATCTTGCCCGGATGCTGTTCCACCCATTGATCGCTGGACTTATTCTGACTGCTGTTCTCGCGGC
CATCATGTCTACCATGTCGTCACAGCTGCTGGTCACCGCATCTTCCCTGATTGAGGACCTGCTGAAGGTAGTTAAAAAGG
ACTCGCTGAGCGAACGCACCCTGATCATGCTGTCTCGTGCCACAGTCATCATTCTGGCGATCATTGCAGCAGCCATGGCT
ATTAACCCGTCTGATTCCATCCTCGGATTGGTGGGATTTGCGTGGGCAGGATTCGGCTCTGCATTTGGTCCGATCATACT
TGCTAGCCTTTATTGGAAGCGTCTCAACGCCGCCGGCGCTATCTCCGGCATGATTACTGGTGCTATTGTCTCCATCGCGT
GGGGTATGTCCCCACTAAGCGATACGTTGTATGAAATCATCCCAGGTTTCGCCTTGGCAACCATCGTGATGGTCGTTGTT
TCCCTCCTGACAAAGGAACCCTCCGAAGAAATCCTCAACGAGTTTGAAACCGCCAAGGATCTTGCTGCCGCTGTGGAATC
AAACGAGGATGTTGATTTCGCTGACGCAGCTCAGAAGCTTTCGAAAGAAAGTTAA

Upstream 100 bases:

>100_bases
GTATATTCAGACACCCACGTCGATTAGTGTTGTAGTTCACAGTGCTTATTTTTTATTTGTATCTTTGCACGTTTGTCCCC
TACCCAAAAGGAGAAACCTC

Downstream 100 bases:

>100_bases
GCCTTAGAGGGAACCAAACGCCAAGGCGATGAGTCTAACCCGAGTATGAAGAACTTTATTCGGGTACTCATCGCCTTTAG
TGTTTTCCTCTGTATATATA

Product: proline transport system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MSDNTWFIIAIVIYMLVMVLIGYWSYRKTEKYDDYMLAGRGLNPFVAAMSAGASDMSGWLLMGLPGALFVTGMSELWIAV
GLTIGAWANWMWVAPRLRSYSEISANSITLPSFFENRLRDKSRALRIIAALIIIVFFTFYISSGMVAGGVYWESTFGGDY
LLGMAIVAGVTVLYTFIGGFLAVSYTDAVQGTIMFFSLIIVPVMAYFALANPMDIWSFANSNDYGPHTDGIGNPTYFSMI
SGISAAAIIGNLGWGLGYFGQPHIVVRFMALRTPAEAKQGRRIGISWMIICLIGATFTAIISTVFFAQNPDANITDTRAY
ESIFLDLARMLFHPLIAGLILTAVLAAIMSTMSSQLLVTASSLIEDLLKVVKKDSLSERTLIMLSRATVIILAIIAAAMA
INPSDSILGLVGFAWAGFGSAFGPIILASLYWKRLNAAGAISGMITGAIVSIAWGMSPLSDTLYEIIPGFALATIVMVVV
SLLTKEPSEEILNEFETAKDLAAAVESNEDVDFADAAQKLSKES

Sequences:

>Translated_524_residues
MSDNTWFIIAIVIYMLVMVLIGYWSYRKTEKYDDYMLAGRGLNPFVAAMSAGASDMSGWLLMGLPGALFVTGMSELWIAV
GLTIGAWANWMWVAPRLRSYSEISANSITLPSFFENRLRDKSRALRIIAALIIIVFFTFYISSGMVAGGVYWESTFGGDY
LLGMAIVAGVTVLYTFIGGFLAVSYTDAVQGTIMFFSLIIVPVMAYFALANPMDIWSFANSNDYGPHTDGIGNPTYFSMI
SGISAAAIIGNLGWGLGYFGQPHIVVRFMALRTPAEAKQGRRIGISWMIICLIGATFTAIISTVFFAQNPDANITDTRAY
ESIFLDLARMLFHPLIAGLILTAVLAAIMSTMSSQLLVTASSLIEDLLKVVKKDSLSERTLIMLSRATVIILAIIAAAMA
INPSDSILGLVGFAWAGFGSAFGPIILASLYWKRLNAAGAISGMITGAIVSIAWGMSPLSDTLYEIIPGFALATIVMVVV
SLLTKEPSEEILNEFETAKDLAAAVESNEDVDFADAAQKLSKES
>Mature_523_residues
SDNTWFIIAIVIYMLVMVLIGYWSYRKTEKYDDYMLAGRGLNPFVAAMSAGASDMSGWLLMGLPGALFVTGMSELWIAVG
LTIGAWANWMWVAPRLRSYSEISANSITLPSFFENRLRDKSRALRIIAALIIIVFFTFYISSGMVAGGVYWESTFGGDYL
LGMAIVAGVTVLYTFIGGFLAVSYTDAVQGTIMFFSLIIVPVMAYFALANPMDIWSFANSNDYGPHTDGIGNPTYFSMIS
GISAAAIIGNLGWGLGYFGQPHIVVRFMALRTPAEAKQGRRIGISWMIICLIGATFTAIISTVFFAQNPDANITDTRAYE
SIFLDLARMLFHPLIAGLILTAVLAAIMSTMSSQLLVTASSLIEDLLKVVKKDSLSERTLIMLSRATVIILAIIAAAMAI
NPSDSILGLVGFAWAGFGSAFGPIILASLYWKRLNAAGAISGMITGAIVSIAWGMSPLSDTLYEIIPGFALATIVMVVVS
LLTKEPSEEILNEFETAKDLAAAVESNEDVDFADAAQKLSKES

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=504, Percent_Identity=46.2301587301587, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI109659836, Length=565, Percent_Identity=23.8938053097345, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI109659839, Length=583, Percent_Identity=23.156089193825, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI110835708, Length=594, Percent_Identity=22.7272727272727, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4507035, Length=408, Percent_Identity=23.0392156862745, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI4507031, Length=590, Percent_Identity=22.2033898305085, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI14140236, Length=588, Percent_Identity=24.1496598639456, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787251, Length=498, Percent_Identity=47.3895582329317, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1790503, Length=456, Percent_Identity=25.4385964912281, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI87082237, Length=461, Percent_Identity=26.2472885032538, Blast_Score=109, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17539284, Length=475, Percent_Identity=25.2631578947368, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221459584, Length=390, Percent_Identity=23.8461538461538, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24640370, Length=429, Percent_Identity=22.8438228438228, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 56648; Mature: 56517

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNTWFIIAIVIYMLVMVLIGYWSYRKTEKYDDYMLAGRGLNPFVAAMSAGASDMSGWL
CCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHCCCCCCCCEE
LMGLPGALFVTGMSELWIAVGLTIGAWANWMWVAPRLRSYSEISANSITLPSFFENRLRD
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCHHHCCCCCCCCHHHHHHHHHH
KSRALRIIAALIIIVFFTFYISSGMVAGGVYWESTFGGDYLLGMAIVAGVTVLYTFIGGF
HHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
LAVSYTDAVQGTIMFFSLIIVPVMAYFALANPMDIWSFANSNDYGPHTDGIGNPTYFSMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHH
SGISAAAIIGNLGWGLGYFGQPHIVVRFMALRTPAEAKQGRRIGISWMIICLIGATFTAI
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHH
ISTVFFAQNPDANITDTRAYESIFLDLARMLFHPLIAGLILTAVLAAIMSTMSSQLLVTA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLIEDLLKVVKKDSLSERTLIMLSRATVIILAIIAAAMAINPSDSILGLVGFAWAGFGS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCH
AFGPIILASLYWKRLNAAGAISGMITGAIVSIAWGMSPLSDTLYEIIPGFALATIVMVVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHH
SLLTKEPSEEILNEFETAKDLAAAVESNEDVDFADAAQKLSKES
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SDNTWFIIAIVIYMLVMVLIGYWSYRKTEKYDDYMLAGRGLNPFVAAMSAGASDMSGWL
CCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHCCCCCCCCEE
LMGLPGALFVTGMSELWIAVGLTIGAWANWMWVAPRLRSYSEISANSITLPSFFENRLRD
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCHHHCCCCCCCCHHHHHHHHHH
KSRALRIIAALIIIVFFTFYISSGMVAGGVYWESTFGGDYLLGMAIVAGVTVLYTFIGGF
HHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
LAVSYTDAVQGTIMFFSLIIVPVMAYFALANPMDIWSFANSNDYGPHTDGIGNPTYFSMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHH
SGISAAAIIGNLGWGLGYFGQPHIVVRFMALRTPAEAKQGRRIGISWMIICLIGATFTAI
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHH
ISTVFFAQNPDANITDTRAYESIFLDLARMLFHPLIAGLILTAVLAAIMSTMSSQLLVTA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLIEDLLKVVKKDSLSERTLIMLSRATVIILAIIAAAMAINPSDSILGLVGFAWAGFGS
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCH
AFGPIILASLYWKRLNAAGAISGMITGAIVSIAWGMSPLSDTLYEIIPGFALATIVMVVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHH
SLLTKEPSEEILNEFETAKDLAAAVESNEDVDFADAAQKLSKES
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]