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The map label for this gene is uvrA [H]

Identifier: 62389974

GI number: 62389974

Start: 1133598

End: 1135940

Strand: Reverse

Name: uvrA [H]

Synonym: cg1234

Alternate gene names: 62389974

Gene position: 1135940-1133598 (Counterclockwise)

Preceding gene: 62389976

Following gene: 62389973

Centisome position: 34.6

GC content: 54.8

Gene sequence:

>2343_bases
ATGCAAAAAGCTGATTCCCATGATTGGATTTCGGTCCACGGTGCGAATGAAAACAACCTCAAAAATGTGTCGGTGCGCAT
CCCTAAAAGGCGTCTCACCGTGTTCACGGGTGTGTCGGGATCTGGCAAGTCCTCGCTGGTGTTCGGCACAATTGCTGCGG
AATCACGCCGGTTGATCAACGAAACCTATAGCACTTTTGTGCAAGGTTTCATGCCGTCGATGGCAAGGCCCGATGTTGAC
CATTTGGAAGGCATCACCACGGCGATCATCGTCGATCAGGAGCAGATGGGCGCAAACCCACGGTCTACGGTGGGTACCGC
AACTGATGCCACCGCGATGTTGCGCATTTTGTTTTCCCGAATCGCGGAACCTAACGCGGGTGGCCCGGGAGCTTATTCCT
TCAACGTCCCCTCTGTTTCCGCATCCGGCGCCATCACGGTGGAAAAGGGCGGAAACACCAAGCGGGAGAAAGCTACCTTC
AAACGCACGGGTGGCATGTGCCCAGCGTGCGAGGGCATGGGCAGGGCCTCAGACATCGACCTCAAAGAGCTTTTCGACGC
CTCCCTCTCCCTCAACGACGGCGCCCTGACCATCCCCGGTTACACCCCAGGTGGATGGAGTTATCGGATGTATTCAGAAT
CGGGCCTTTTTGATGCTGCCAAGCCTATTAAGGATTTCACCGACGAAGAACGCCACAACTTCCTTTATCTTGAGCCCACC
AAGATGAAGATCGCTGGCATCAACATGACCTATGAGGGTCTTATCCCCCGCATTCAGAAATCCATGTTGTCTAAGGATCG
CGAAGGCATGCAGAAGCATATTCGTGCGTTCGTGGATCGAGCGGTTACCTTCATTCCTTGCCCTGCGTGTGGTGGAACTC
GATTAGCGCCACATGCCTTGGAGTCCAAGATCAATGGCAAAAACATCGCTGAGTTGTGCGCGATGGAGGTCCGTGATTTG
GCCAAGTGGATCAAAACGGTGGAAGCCCCCTCGGTTGCTCCCCTGCTCACCGCACTGACTGAAACCCTGGATAACTTCGT
GGAGATCGGTTTGGGCTATATCCAACTCGATCGCCCCGCTGGCACGTTGTCTGGTGGTGAGGCACAGCGCACCAAGATGA
TCCGCCATTTGGGCTCTGCATTGACTGACGTCACCTATGTTTTTGATGAACCCACCGCCGGTTTGCACGCCTACGACATT
GAACGCATGAACAAGTTGCTGCTCGATCTTCGCGATAAAGGCAATACCGTTTTAGTCGTGGAGCACAAGCCGGAAACCAT
CGCCATTGCAGATCATGTGGTGGACCTTGGGCCAGGTGCAGGCGCGGGTGGAGGTGAAATTCGGTTTGAGGGGAGCGTCG
ACAAGCTTAAAGACAGCGACACCGTGACTGGCCTCCATTTTAATGACCGGGCGTCATTGAAGGAATCCGTGCGTGCGCCG
CATGGCGCCCTGGAGATCCGCGGGGCCGATCGAAATAATTTGAACAATGTGGATGTCGATATTCCGCTCGGCGTGTTCAC
GGCGATTTCCGGCGTTGCAGGTTCGGGTAAGTCCTCGTTGATTCATGAGATTCCGCGTGATGAGTCGGTTGTGTTTGTCG
ATCAAACCGCAATCCACGGTTCTAATCGTTCCAATCCTGCGACATATACAGGCATGCTGGATTCGATTCGCAAGGCTTTT
GCCAAGGCCAATGATGTGAAACCGGCGCTGTTCTCCCCCAATTCTGAAGGCGCGTGCCCAAACTGTAAGGGCGCCGGCTC
GGTCTATGTCGATTTGGGCATGATGGCTGGGGTATCTTCGCCGTGTGAGGTGTGCGAGGGCAAGCGTTTTGATGAGTCCG
TGTTGGACTACCACTTTGGTGGCAAGGACATCGCAGACGTGTTGGGGCTGTCGGCTGCCAATGCGTATGAGTTTTTCGCG
GCGAAAGATTCAAAGATTTTGCCTGCGGCAAAGATCGCAAAGAGGCTTGTCGACGTCGGCCTCGGCTACATCACCCTCGG
CCAGCCGCTCACCACGTTGTCCGGCGGTGAACGCCAGCGTTTGAAGCTCGCCACCCACATGGCAGACAAGGCCACCACCT
TTATTTTGGATGAGCCCACCACAGGCCTGCACCTCGCTGATGTGAAAACCTTGCTGGATCTTTTTGATCAACTGGTTGAT
GACGGCAAGTCTGTCATCGTCATCGAACACCACCTCGGCGTGCTCGCTCACGCTGACCACATCATTGATGTCGGCCCTGG
TGCAGGTTCTGATGGTGGCTCGATTGTATTCGAGGGCAGCCCCGCGGAACTCATCAAAACTGATACTCCAACAGGACGCC
ACCTTAAAGCTTATGTAGATTAG

Upstream 100 bases:

>100_bases
TGTTTTAGCCATGGACCCCATACTAGGGAGAGTTTTGTTTTGGTGCTAGAAAAGGTTCACCAAGCGCGAACAGGCCTATG
CAAACGGTACGATATGACAC

Downstream 100 bases:

>100_bases
TTTCTTATGGAAAACCCTGGTGATCTCGGCGCTATGCCACAGTACGGTTTTGAGCATATTTCGATGCTCATCACCGCTGT
GGTTTTAGCGATTCTTGTCG

Product: excinuclease ATPase subunit-UvrA-like protein

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 780; Mature: 780

Protein sequence:

>780_residues
MQKADSHDWISVHGANENNLKNVSVRIPKRRLTVFTGVSGSGKSSLVFGTIAAESRRLINETYSTFVQGFMPSMARPDVD
HLEGITTAIIVDQEQMGANPRSTVGTATDATAMLRILFSRIAEPNAGGPGAYSFNVPSVSASGAITVEKGGNTKREKATF
KRTGGMCPACEGMGRASDIDLKELFDASLSLNDGALTIPGYTPGGWSYRMYSESGLFDAAKPIKDFTDEERHNFLYLEPT
KMKIAGINMTYEGLIPRIQKSMLSKDREGMQKHIRAFVDRAVTFIPCPACGGTRLAPHALESKINGKNIAELCAMEVRDL
AKWIKTVEAPSVAPLLTALTETLDNFVEIGLGYIQLDRPAGTLSGGEAQRTKMIRHLGSALTDVTYVFDEPTAGLHAYDI
ERMNKLLLDLRDKGNTVLVVEHKPETIAIADHVVDLGPGAGAGGGEIRFEGSVDKLKDSDTVTGLHFNDRASLKESVRAP
HGALEIRGADRNNLNNVDVDIPLGVFTAISGVAGSGKSSLIHEIPRDESVVFVDQTAIHGSNRSNPATYTGMLDSIRKAF
AKANDVKPALFSPNSEGACPNCKGAGSVYVDLGMMAGVSSPCEVCEGKRFDESVLDYHFGGKDIADVLGLSAANAYEFFA
AKDSKILPAAKIAKRLVDVGLGYITLGQPLTTLSGGERQRLKLATHMADKATTFILDEPTTGLHLADVKTLLDLFDQLVD
DGKSVIVIEHHLGVLAHADHIIDVGPGAGSDGGSIVFEGSPAELIKTDTPTGRHLKAYVD

Sequences:

>Translated_780_residues
MQKADSHDWISVHGANENNLKNVSVRIPKRRLTVFTGVSGSGKSSLVFGTIAAESRRLINETYSTFVQGFMPSMARPDVD
HLEGITTAIIVDQEQMGANPRSTVGTATDATAMLRILFSRIAEPNAGGPGAYSFNVPSVSASGAITVEKGGNTKREKATF
KRTGGMCPACEGMGRASDIDLKELFDASLSLNDGALTIPGYTPGGWSYRMYSESGLFDAAKPIKDFTDEERHNFLYLEPT
KMKIAGINMTYEGLIPRIQKSMLSKDREGMQKHIRAFVDRAVTFIPCPACGGTRLAPHALESKINGKNIAELCAMEVRDL
AKWIKTVEAPSVAPLLTALTETLDNFVEIGLGYIQLDRPAGTLSGGEAQRTKMIRHLGSALTDVTYVFDEPTAGLHAYDI
ERMNKLLLDLRDKGNTVLVVEHKPETIAIADHVVDLGPGAGAGGGEIRFEGSVDKLKDSDTVTGLHFNDRASLKESVRAP
HGALEIRGADRNNLNNVDVDIPLGVFTAISGVAGSGKSSLIHEIPRDESVVFVDQTAIHGSNRSNPATYTGMLDSIRKAF
AKANDVKPALFSPNSEGACPNCKGAGSVYVDLGMMAGVSSPCEVCEGKRFDESVLDYHFGGKDIADVLGLSAANAYEFFA
AKDSKILPAAKIAKRLVDVGLGYITLGQPLTTLSGGERQRLKLATHMADKATTFILDEPTTGLHLADVKTLLDLFDQLVD
DGKSVIVIEHHLGVLAHADHIIDVGPGAGSDGGSIVFEGSPAELIKTDTPTGRHLKAYVD
>Mature_780_residues
MQKADSHDWISVHGANENNLKNVSVRIPKRRLTVFTGVSGSGKSSLVFGTIAAESRRLINETYSTFVQGFMPSMARPDVD
HLEGITTAIIVDQEQMGANPRSTVGTATDATAMLRILFSRIAEPNAGGPGAYSFNVPSVSASGAITVEKGGNTKREKATF
KRTGGMCPACEGMGRASDIDLKELFDASLSLNDGALTIPGYTPGGWSYRMYSESGLFDAAKPIKDFTDEERHNFLYLEPT
KMKIAGINMTYEGLIPRIQKSMLSKDREGMQKHIRAFVDRAVTFIPCPACGGTRLAPHALESKINGKNIAELCAMEVRDL
AKWIKTVEAPSVAPLLTALTETLDNFVEIGLGYIQLDRPAGTLSGGEAQRTKMIRHLGSALTDVTYVFDEPTAGLHAYDI
ERMNKLLLDLRDKGNTVLVVEHKPETIAIADHVVDLGPGAGAGGGEIRFEGSVDKLKDSDTVTGLHFNDRASLKESVRAP
HGALEIRGADRNNLNNVDVDIPLGVFTAISGVAGSGKSSLIHEIPRDESVVFVDQTAIHGSNRSNPATYTGMLDSIRKAF
AKANDVKPALFSPNSEGACPNCKGAGSVYVDLGMMAGVSSPCEVCEGKRFDESVLDYHFGGKDIADVLGLSAANAYEFFA
AKDSKILPAAKIAKRLVDVGLGYITLGQPLTTLSGGERQRLKLATHMADKATTFILDEPTTGLHLADVKTLLDLFDQLVD
DGKSVIVIEHHLGVLAHADHIIDVGPGAGSDGGSIVFEGSPAELIKTDTPTGRHLKAYVD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=684, Percent_Identity=34.5029239766082, Blast_Score=357, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 83437; Mature: 83437

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKADSHDWISVHGANENNLKNVSVRIPKRRLTVFTGVSGSGKSSLVFGTIAAESRRLIN
CCCCCCCCEEEEECCCCCCCCEEEEEECCEEEEEEECCCCCCCCEEEEEEHHHHHHHHHH
ETYSTFVQGFMPSMARPDVDHLEGITTAIIVDQEQMGANPRSTVGTATDATAMLRILFSR
HHHHHHHHHHCCCCCCCCHHHHCCCEEEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHH
IAEPNAGGPGAYSFNVPSVSASGAITVEKGGNTKREKATFKRTGGMCPACEGMGRASDID
HCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
LKELFDASLSLNDGALTIPGYTPGGWSYRMYSESGLFDAAKPIKDFTDEERHNFLYLEPT
HHHHHCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCHHHHHHHHCCCHHHCCEEEEECC
KMKIAGINMTYEGLIPRIQKSMLSKDREGMQKHIRAFVDRAVTFIPCPACGGTRLAPHAL
EEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCHHHH
ESKINGKNIAELCAMEVRDLAKWIKTVEAPSVAPLLTALTETLDNFVEIGLGYIQLDRPA
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GTLSGGEAQRTKMIRHLGSALTDVTYVFDEPTAGLHAYDIERMNKLLLDLRDKGNTVLVV
CCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEE
EHKPETIAIADHVVDLGPGAGAGGGEIRFEGSVDKLKDSDTVTGLHFNDRASLKESVRAP
ECCCCEEEEEHHHEECCCCCCCCCCEEEECCCHHHCCCCCCEEEEEECCHHHHHHHHCCC
HGALEIRGADRNNLNNVDVDIPLGVFTAISGVAGSGKSSLIHEIPRDESVVFVDQTAIHG
CCEEEEECCCCCCCCCEEEECCHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEEEEECC
SNRSNPATYTGMLDSIRKAFAKANDVKPALFSPNSEGACPNCKGAGSVYVDLGMMAGVSS
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCEEEEEEHHHHCCCC
PCEVCEGKRFDESVLDYHFGGKDIADVLGLSAANAYEFFAAKDSKILPAAKIAKRLVDVG
CHHHHCCCCCCHHHHHHCCCCHHHHHHHCCCCCCHHHEEECCCCCCCCHHHHHHHHHHHC
LGYITLGQPLTTLSGGERQRLKLATHMADKATTFILDEPTTGLHLADVKTLLDLFDQLVD
CCEEECCCCHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHH
DGKSVIVIEHHLGVLAHADHIIDVGPGAGSDGGSIVFEGSPAELIKTDTPTGRHLKAYVD
CCCEEEEEECCCCCCEECCCEEECCCCCCCCCCEEEECCCCHHEEECCCCCCCCEEEECC
>Mature Secondary Structure
MQKADSHDWISVHGANENNLKNVSVRIPKRRLTVFTGVSGSGKSSLVFGTIAAESRRLIN
CCCCCCCCEEEEECCCCCCCCEEEEEECCEEEEEEECCCCCCCCEEEEEEHHHHHHHHHH
ETYSTFVQGFMPSMARPDVDHLEGITTAIIVDQEQMGANPRSTVGTATDATAMLRILFSR
HHHHHHHHHHCCCCCCCCHHHHCCCEEEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHH
IAEPNAGGPGAYSFNVPSVSASGAITVEKGGNTKREKATFKRTGGMCPACEGMGRASDID
HCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
LKELFDASLSLNDGALTIPGYTPGGWSYRMYSESGLFDAAKPIKDFTDEERHNFLYLEPT
HHHHHCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCHHHHHHHHCCCHHHCCEEEEECC
KMKIAGINMTYEGLIPRIQKSMLSKDREGMQKHIRAFVDRAVTFIPCPACGGTRLAPHAL
EEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCHHHH
ESKINGKNIAELCAMEVRDLAKWIKTVEAPSVAPLLTALTETLDNFVEIGLGYIQLDRPA
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GTLSGGEAQRTKMIRHLGSALTDVTYVFDEPTAGLHAYDIERMNKLLLDLRDKGNTVLVV
CCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEE
EHKPETIAIADHVVDLGPGAGAGGGEIRFEGSVDKLKDSDTVTGLHFNDRASLKESVRAP
ECCCCEEEEEHHHEECCCCCCCCCCEEEECCCHHHCCCCCCEEEEEECCHHHHHHHHCCC
HGALEIRGADRNNLNNVDVDIPLGVFTAISGVAGSGKSSLIHEIPRDESVVFVDQTAIHG
CCEEEEECCCCCCCCCEEEECCHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEEEEECC
SNRSNPATYTGMLDSIRKAFAKANDVKPALFSPNSEGACPNCKGAGSVYVDLGMMAGVSS
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCEEEEEEHHHHCCCC
PCEVCEGKRFDESVLDYHFGGKDIADVLGLSAANAYEFFAAKDSKILPAAKIAKRLVDVG
CHHHHCCCCCCHHHHHHCCCCHHHHHHHCCCCCCHHHEEECCCCCCCCHHHHHHHHHHHC
LGYITLGQPLTTLSGGERQRLKLATHMADKATTFILDEPTTGLHLADVKTLLDLFDQLVD
CCEEECCCCHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHH
DGKSVIVIEHHLGVLAHADHIIDVGPGAGSDGGSIVFEGSPAELIKTDTPTGRHLKAYVD
CCCEEEEEECCCCCCEECCCEEECCCCCCCCCCEEEECCCCHHEEECCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8675016 [H]