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The map label for this gene is aldH [H]

Identifier: 62389352

GI number: 62389352

Start: 475485

End: 477047

Strand: Reverse

Name: aldH [H]

Synonym: cg0535

Alternate gene names: 62389352

Gene position: 477047-475485 (Counterclockwise)

Preceding gene: 62389353

Following gene: 62389351

Centisome position: 14.53

GC content: 56.11

Gene sequence:

>1563_bases
ATGATCACCGCAACCGCACTGCATGGGTGTTCACTGATTGATGGCGAGTGGGTCGCTGGAAAAAATGGTGAGATTACAGG
ATTCGATCCGCGCACCAATGCGAGTCTGAACCCTTCCTACTCTTTAGCAAACAGCGCACAGCTGCGCGCCGCCACAACAT
CGGCGAAGCGAGCTTTTGAAAGCTACCGACTCACTACTCCAGAGGTTAGAGCAGATTTCCTGGATTCCATCGCTGACAAC
ATCGATGCGCTATCCGGCGAGATCGTGCAACGGGCGAGCCTGGAGACAGGTTTGGGAACTACCCGACTCACAGGCGAAGT
AGCCCGCACCAGCAACCAGCTCCGCCTGTTTGCAGAAACCGTGAGAAGCGGACAGTTCCACCGAGTACGCATTGAACGAG
GACCGCGGATTGATCTTCGCCAGCGTCAGGTTCCGTTGGGACCAGTCGCGGTATTCGGGGCAAGCAACTTCCCCGTCGCT
TTCTCTACTGCTGGTGGCGATACAGCATCAGCGTTGGCTGCAGGCTGCCCTGTGGTTTTTAAGGCGCATAATGCGCACCC
TGGAACAGCTGAGCTCGTCGGGCAAGCGGTGCGGGGAGCCGTCGAAAAGCATGAGTTTGATGCTGGTGTGTTTAACCTTG
TCTACGGCCGTGGCGTGGAAATTGGCCAGGAGCTGGCTGCGGATCCGAATATCACGGCAATCGGTTTTACCGGTTCACGC
CAGGGTGGTTTGGCACTGTCACAGACTGCGTTTAGCCGCCCAGTTCCCGTTCCAGTCTTTGCAGAAATGAGTGCCACCAA
CCCTGTGTTCGTCTTCCCCGGCGCGCTGGCGGATTTGGATGCATCGAGTTCCTTGGCTGAGGCGTTTACCGCTTCCGTCA
CCGGCAGTTCCGGGCAATTGTGCACCAAGCCTGGCCTCGTTTTCATCCCGCGCGGTGTTGTTGGTGATGCTTTTGTGGCG
CTCGTAGCAGCCAAATTTAAAGAAACCACGGGTCAAACGATGCTCACGCAAGGCATCGCTCAGGCATGGCAGCGCGGAGT
CGACAACCTTGCAGCACAGCCAAGTGTAAAAATCCTCGCCCAAGGCACCCCCGGAGATGGAGAGAACGCGCCGGGCCCGG
TGGTGTTTGAAAGTGATGTGCAGGCGTTGCTAAATAATGTGGTGTTGCAGGAAGAAATCTTCGGTGCGGCATCGCTGGTG
GTGCGTTATGATTCCCCGGATCAACTCCACCAAGTAGCCAATTCACTCGAGGGACAATTAACAGCCACGATCCACGCATC
CCAGGATGATTTCCAGGAAGTCTCGAAACTTATCCCCCTCTTGGAGGATCTCGCGGGCCGTGTTCTTTACGGCGGCTGGC
CAACGGGTGTGGAAGTTGGGCACACGGTTATCCATGGAGGCCCTTATCCGGCGACCTCAAATGCGCAGTCGACAAGTGTT
GGAACCCTGGCAATCGAGAGATTTATGCGCCCGGTTTCTTATCAAACTTTCCCGGCTGAGCTGCTTCCAGATCCAGTTTC
TGAGGCGAATAAATGGGCTGTACCTCGGGAAATAGACCGTTAA

Upstream 100 bases:

>100_bases
CACCACTGCGTAACCTTTCCGAGCAAGATATCGCGGACCTGTCGGATTTGCTTGCCACCTCTGGCGCAGGTTCCTACCGC
CTTCCAGTTGAGGTGAAAGC

Downstream 100 bases:

>100_bases
TAGCTGGTCTTTACATTTGCCAGAAAGCTCCGACGAAACCCCAATAGTTGACACGGAAACTAATTCATTCTAGCTTTAGT
GACCATGTCAACTACCAGGG

Product: ketoglutarate semialdehyde dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MITATALHGCSLIDGEWVAGKNGEITGFDPRTNASLNPSYSLANSAQLRAATTSAKRAFESYRLTTPEVRADFLDSIADN
IDALSGEIVQRASLETGLGTTRLTGEVARTSNQLRLFAETVRSGQFHRVRIERGPRIDLRQRQVPLGPVAVFGASNFPVA
FSTAGGDTASALAAGCPVVFKAHNAHPGTAELVGQAVRGAVEKHEFDAGVFNLVYGRGVEIGQELAADPNITAIGFTGSR
QGGLALSQTAFSRPVPVPVFAEMSATNPVFVFPGALADLDASSSLAEAFTASVTGSSGQLCTKPGLVFIPRGVVGDAFVA
LVAAKFKETTGQTMLTQGIAQAWQRGVDNLAAQPSVKILAQGTPGDGENAPGPVVFESDVQALLNNVVLQEEIFGAASLV
VRYDSPDQLHQVANSLEGQLTATIHASQDDFQEVSKLIPLLEDLAGRVLYGGWPTGVEVGHTVIHGGPYPATSNAQSTSV
GTLAIERFMRPVSYQTFPAELLPDPVSEANKWAVPREIDR

Sequences:

>Translated_520_residues
MITATALHGCSLIDGEWVAGKNGEITGFDPRTNASLNPSYSLANSAQLRAATTSAKRAFESYRLTTPEVRADFLDSIADN
IDALSGEIVQRASLETGLGTTRLTGEVARTSNQLRLFAETVRSGQFHRVRIERGPRIDLRQRQVPLGPVAVFGASNFPVA
FSTAGGDTASALAAGCPVVFKAHNAHPGTAELVGQAVRGAVEKHEFDAGVFNLVYGRGVEIGQELAADPNITAIGFTGSR
QGGLALSQTAFSRPVPVPVFAEMSATNPVFVFPGALADLDASSSLAEAFTASVTGSSGQLCTKPGLVFIPRGVVGDAFVA
LVAAKFKETTGQTMLTQGIAQAWQRGVDNLAAQPSVKILAQGTPGDGENAPGPVVFESDVQALLNNVVLQEEIFGAASLV
VRYDSPDQLHQVANSLEGQLTATIHASQDDFQEVSKLIPLLEDLAGRVLYGGWPTGVEVGHTVIHGGPYPATSNAQSTSV
GTLAIERFMRPVSYQTFPAELLPDPVSEANKWAVPREIDR
>Mature_520_residues
MITATALHGCSLIDGEWVAGKNGEITGFDPRTNASLNPSYSLANSAQLRAATTSAKRAFESYRLTTPEVRADFLDSIADN
IDALSGEIVQRASLETGLGTTRLTGEVARTSNQLRLFAETVRSGQFHRVRIERGPRIDLRQRQVPLGPVAVFGASNFPVA
FSTAGGDTASALAAGCPVVFKAHNAHPGTAELVGQAVRGAVEKHEFDAGVFNLVYGRGVEIGQELAADPNITAIGFTGSR
QGGLALSQTAFSRPVPVPVFAEMSATNPVFVFPGALADLDASSSLAEAFTASVTGSSGQLCTKPGLVFIPRGVVGDAFVA
LVAAKFKETTGQTMLTQGIAQAWQRGVDNLAAQPSVKILAQGTPGDGENAPGPVVFESDVQALLNNVVLQEEIFGAASLV
VRYDSPDQLHQVANSLEGQLTATIHASQDDFQEVSKLIPLLEDLAGRVLYGGWPTGVEVGHTVIHGGPYPATSNAQSTSV
GTLAIERFMRPVSYQTFPAELLPDPVSEANKWAVPREIDR

Specific function: Catalyzes the oxidation of long-chain aliphatic aldehydes to acids. May be implicated in controlling luminescence as it catalyzes the oxidation of the fatty aldehyde substrate for the light-emitting reaction [H]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI12007648, Length=441, Percent_Identity=24.0362811791383, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI4507229, Length=365, Percent_Identity=24.1095890410959, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI153266822, Length=442, Percent_Identity=24.6606334841629, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI25777721, Length=370, Percent_Identity=22.972972972973, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI115387104, Length=437, Percent_Identity=22.6544622425629, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI21614513, Length=417, Percent_Identity=25.1798561151079, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1788042, Length=457, Percent_Identity=28.2275711159737, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789015, Length=450, Percent_Identity=26.6666666666667, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1787558, Length=504, Percent_Identity=26.5873015873016, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87081896, Length=424, Percent_Identity=28.7735849056604, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1787684, Length=426, Percent_Identity=26.9953051643192, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787715, Length=437, Percent_Identity=26.7734553775744, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786504, Length=451, Percent_Identity=26.1640798226164, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87082295, Length=436, Percent_Identity=24.7706422018349, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1787250, Length=387, Percent_Identity=26.3565891472868, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562198, Length=422, Percent_Identity=24.8815165876777, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25143874, Length=410, Percent_Identity=22.4390243902439, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI133930964, Length=327, Percent_Identity=26.9113149847095, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25143876, Length=410, Percent_Identity=22.4390243902439, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71995606, Length=377, Percent_Identity=27.8514588859416, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71995613, Length=421, Percent_Identity=26.3657957244656, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115534176, Length=322, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17534119, Length=453, Percent_Identity=23.6203090507726, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319478, Length=438, Percent_Identity=24.6575342465753, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320917, Length=437, Percent_Identity=24.9427917620137, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6323822, Length=317, Percent_Identity=28.7066246056782, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281362580, Length=455, Percent_Identity=25.7142857142857, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI62472918, Length=455, Percent_Identity=25.7142857142857, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI62472926, Length=455, Percent_Identity=25.7142857142857, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI62472936, Length=455, Percent_Identity=25.7142857142857, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21356737, Length=455, Percent_Identity=25.7142857142857, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24650465, Length=432, Percent_Identity=24.537037037037, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24666674, Length=322, Percent_Identity=25.776397515528, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.4 [H]

Molecular weight: Translated: 54716; Mature: 54716

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITATALHGCSLIDGEWVAGKNGEITGFDPRTNASLNPSYSLANSAQLRAATTSAKRAFE
CEEEEEECCCEEECCCEEECCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
SYRLTTPEVRADFLDSIADNIDALSGEIVQRASLETGLGTTRLTGEVARTSNQLRLFAET
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHCCHHHHHHHHH
VRSGQFHRVRIERGPRIDLRQRQVPLGPVAVFGASNFPVAFSTAGGDTASALAAGCPVVF
HHCCCEEEEEECCCCCCCHHHCCCCCCCEEEECCCCCCEEEECCCCCHHHHHHHCCCEEE
KAHNAHPGTAELVGQAVRGAVEKHEFDAGVFNLVYGRGVEIGQELAADPNITAIGFTGSR
EECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHCCCCCEEEEEECCCC
QGGLALSQTAFSRPVPVPVFAEMSATNPVFVFPGALADLDASSSLAEAFTASVTGSSGQL
CCCEEEEHHHCCCCCCCCEEEECCCCCCEEECCCCHHCCCCCHHHHHHHHHEECCCCCCE
CTKPGLVFIPRGVVGDAFVALVAAKFKETTGQTMLTQGIAQAWQRGVDNLAAQPSVKILA
ECCCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
QGTPGDGENAPGPVVFESDVQALLNNVVLQEEIFGAASLVVRYDSPDQLHQVANSLEGQL
ECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHCCCEE
TATIHASQDDFQEVSKLIPLLEDLAGRVLYGGWPTGVEVGHTVIHGGPYPATSNAQSTSV
EEEEECCHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHCCEEEECCCCCCCCCCCCCCH
GTLAIERFMRPVSYQTFPAELLPDPVSEANKWAVPREIDR
HHHHHHHHHHHCCCCCCCHHHCCCCHHHCCCCCCCHHCCC
>Mature Secondary Structure
MITATALHGCSLIDGEWVAGKNGEITGFDPRTNASLNPSYSLANSAQLRAATTSAKRAFE
CEEEEEECCCEEECCCEEECCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
SYRLTTPEVRADFLDSIADNIDALSGEIVQRASLETGLGTTRLTGEVARTSNQLRLFAET
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHCCHHHHHHHHH
VRSGQFHRVRIERGPRIDLRQRQVPLGPVAVFGASNFPVAFSTAGGDTASALAAGCPVVF
HHCCCEEEEEECCCCCCCHHHCCCCCCCEEEECCCCCCEEEECCCCCHHHHHHHCCCEEE
KAHNAHPGTAELVGQAVRGAVEKHEFDAGVFNLVYGRGVEIGQELAADPNITAIGFTGSR
EECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHCCCCCEEEEEECCCC
QGGLALSQTAFSRPVPVPVFAEMSATNPVFVFPGALADLDASSSLAEAFTASVTGSSGQL
CCCEEEEHHHCCCCCCCCEEEECCCCCCEEECCCCHHCCCCCHHHHHHHHHEECCCCCCE
CTKPGLVFIPRGVVGDAFVALVAAKFKETTGQTMLTQGIAQAWQRGVDNLAAQPSVKILA
ECCCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
QGTPGDGENAPGPVVFESDVQALLNNVVLQEEIFGAASLVVRYDSPDQLHQVANSLEGQL
ECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHCCCEE
TATIHASQDDFQEVSKLIPLLEDLAGRVLYGGWPTGVEVGHTVIHGGPYPATSNAQSTSV
EEEEECCHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHCCEEEECCCCCCCCCCCCCCH
GTLAIERFMRPVSYQTFPAELLPDPVSEANKWAVPREIDR
HHHHHHHHHHHCCCCCCCHHHCCCCHHHCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8527447; 10903148 [H]