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The map label for this gene is yfhM [H]

Identifier: 62389194

GI number: 62389194

Start: 311896

End: 312891

Strand: Reverse

Name: yfhM [H]

Synonym: cg0358

Alternate gene names: 62389194

Gene position: 312891-311896 (Counterclockwise)

Preceding gene: 62389195

Following gene: 62389189

Centisome position: 9.53

GC content: 60.34

Gene sequence:

>996_bases
ATGGCCTTTTTTAGCTTTTCGACGTCTCCCCTCACCCGCCTCATCCCCGGCAGCCGCTCCAAAGCCACAGGCGCCAAACG
GCGCCTGAGCAGCACAATCGCGTCGATTGAACGCTCCCCCGGCATCATTGCCCTAGACGGACCGTTCACCCACGATCACG
TCTCCGTACGTGGCATTCGCCTCCATTTAGCAGAGGCAGGCTCCCCCACCAAACCCCTGGTTCTTCTGATCCACGGGGCT
TTCGGCGGTTGGTACGACTACCGCGAAGTCATCGGCCCACTCGCAGATGCCGGCTTCCACGTCGCCGCCATCGATCTACG
CGGCTACGGCATGTCCGACAAACCCCCAACAGGCTACGACCTCCGCCACGCAGCCGGAGAACTCAGCAGCGTTATCGCAG
CTCTCGGCCACGATGACGCACTTCTTGTCGGCTCCGACACCGGCGCCAGCATCGCCTGGGCTATCGCTTCCATGTACCCC
GAACGGGTCCGCGGCCTAATTTCCCTCGGCGCGATCCACCCCCTTGACATGCGACGCGCCATCCGACGAAAACCCCACCT
ACACGTCTCTGACCTCAGCCGACTTGCTCCTTTTCGGTTGCCCTCATTCCTGCATAACCTCTTCCACTTCGGAATCACCA
GCGAAGCTCGACGTGAGATCGTCAACAACACGTCCTCGTCCTACCAGCGCAGCAACGCATTCACAGAGACAGTGCTCCTC
CGCAAAAAAGCACTATCGATCGACCACACCATCACCCCGATCATCCGCACCAACCGCTACCTCGTTGGGTCGATCCCCAG
CAAAACAGTCTCCGCACCGGTGTGGCTGCTCAGAACCAACACTCGACGCTGGGAACATCTAGCCAATACTGCGCGCACTC
GAACGACAGGGCCATTCACCACCATCGCGATCCCCGGCGGCTACGAACTCCCCTACCTCGAGAACCCTTCCGAATTTGCA
GCAACCATCGCAGAGTTCGCGCGCACCACGTTTTAA

Upstream 100 bases:

>100_bases
CCGAGAAGCTGGAGAAGGCCAACAAGCGTGGCCTCTACACCTCCGCGTCCTTCCACAGCCCCGGCGCCATCACTGGCGAC
CACTAAAAAAGGAGACTTCG

Downstream 100 bases:

>100_bases
GCACTGTGGCTGAGGCGCTGCTGCTCATTTGGCGTCAGAAGGTCGCATGATTTTGGCGTGAATTAGTGGTTTTTCCCTGG
TTTTACCCCGGCGCATTGAC

Product: hydrolase or acyltransferase

Products: glycol

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MAFFSFSTSPLTRLIPGSRSKATGAKRRLSSTIASIERSPGIIALDGPFTHDHVSVRGIRLHLAEAGSPTKPLVLLIHGA
FGGWYDYREVIGPLADAGFHVAAIDLRGYGMSDKPPTGYDLRHAAGELSSVIAALGHDDALLVGSDTGASIAWAIASMYP
ERVRGLISLGAIHPLDMRRAIRRKPHLHVSDLSRLAPFRLPSFLHNLFHFGITSEARREIVNNTSSSYQRSNAFTETVLL
RKKALSIDHTITPIIRTNRYLVGSIPSKTVSAPVWLLRTNTRRWEHLANTARTRTTGPFTTIAIPGGYELPYLENPSEFA
ATIAEFARTTF

Sequences:

>Translated_331_residues
MAFFSFSTSPLTRLIPGSRSKATGAKRRLSSTIASIERSPGIIALDGPFTHDHVSVRGIRLHLAEAGSPTKPLVLLIHGA
FGGWYDYREVIGPLADAGFHVAAIDLRGYGMSDKPPTGYDLRHAAGELSSVIAALGHDDALLVGSDTGASIAWAIASMYP
ERVRGLISLGAIHPLDMRRAIRRKPHLHVSDLSRLAPFRLPSFLHNLFHFGITSEARREIVNNTSSSYQRSNAFTETVLL
RKKALSIDHTITPIIRTNRYLVGSIPSKTVSAPVWLLRTNTRRWEHLANTARTRTTGPFTTIAIPGGYELPYLENPSEFA
ATIAEFARTTF
>Mature_330_residues
AFFSFSTSPLTRLIPGSRSKATGAKRRLSSTIASIERSPGIIALDGPFTHDHVSVRGIRLHLAEAGSPTKPLVLLIHGAF
GGWYDYREVIGPLADAGFHVAAIDLRGYGMSDKPPTGYDLRHAAGELSSVIAALGHDDALLVGSDTGASIAWAIASMYPE
RVRGLISLGAIHPLDMRRAIRRKPHLHVSDLSRLAPFRLPSFLHNLFHFGITSEARREIVNNTSSSYQRSNAFTETVLLR
KKALSIDHTITPIIRTNRYLVGSIPSKTVSAPVWLLRTNTRRWEHLANTARTRTTGPFTTIAIPGGYELPYLENPSEFAA
TIAEFARTTF

Specific function: 3-hydroxyphenylpropionate degradation. [C]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI218777837, Length=176, Percent_Identity=33.5227272727273, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI27597073, Length=155, Percent_Identity=34.8387096774194, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI218777840, Length=112, Percent_Identity=36.6071428571429, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI13376164, Length=112, Percent_Identity=36.6071428571429, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17554012, Length=131, Percent_Identity=38.1679389312977, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.3.2.3

Molecular weight: Translated: 36258; Mature: 36127

Theoretical pI: Translated: 10.68; Mature: 10.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFFSFSTSPLTRLIPGSRSKATGAKRRLSSTIASIERSPGIIALDGPFTHDHVSVRGIR
CCEEECCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEE
LHLAEAGSPTKPLVLLIHGAFGGWYDYREVIGPLADAGFHVAAIDLRGYGMSDKPPTGYD
EEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCC
LRHAAGELSSVIAALGHDDALLVGSDTGASIAWAIASMYPERVRGLISLGAIHPLDMRRA
HHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHH
IRRKPHLHVSDLSRLAPFRLPSFLHNLFHFGITSEARREIVNNTSSSYQRSNAFTETVLL
HHHCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
RKKALSIDHTITPIIRTNRYLVGSIPSKTVSAPVWLLRTNTRRWEHLANTARTRTTGPFT
HHHHHCCCCCCCCCEECCCEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCEE
TIAIPGGYELPYLENPSEFAATIAEFARTTF
EEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AFFSFSTSPLTRLIPGSRSKATGAKRRLSSTIASIERSPGIIALDGPFTHDHVSVRGIR
CEEECCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEE
LHLAEAGSPTKPLVLLIHGAFGGWYDYREVIGPLADAGFHVAAIDLRGYGMSDKPPTGYD
EEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCC
LRHAAGELSSVIAALGHDDALLVGSDTGASIAWAIASMYPERVRGLISLGAIHPLDMRRA
HHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHH
IRRKPHLHVSDLSRLAPFRLPSFLHNLFHFGITSEARREIVNNTSSSYQRSNAFTETVLL
HHHCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
RKKALSIDHTITPIIRTNRYLVGSIPSKTVSAPVWLLRTNTRRWEHLANTARTRTTGPFT
HHHHHCCCCCCCCCEECCCEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCEE
TIAIPGGYELPYLENPSEFAATIAEFARTTF
EEEECCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; epoxide

Specific reaction: H2O + an epoxide = a glycol

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]