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The map label for this gene is pat [H]

Identifier: 62389116

GI number: 62389116

Start: 232258

End: 233283

Strand: Reverse

Name: pat [H]

Synonym: cg0267

Alternate gene names: 62389116

Gene position: 233283-232258 (Counterclockwise)

Preceding gene: 62389118

Following gene: 62389115

Centisome position: 7.11

GC content: 56.04

Gene sequence:

>1026_bases
ATGATTAGAGCAGATTTGGCAACTATCCCTACTTATGTCCCTGGCCGTCGTCTTGTTGATGCTACGAAGTTATCTAGTAA
TGAAGTTAGTTTTTCCCCTCTCCCGGCAGCAGTTGATGCGGTGACGGAGGCTACTTGGGGGGCTAATCGGTACCCGGATA
TGGGTGCGGTTGAGCTCCGTGAGGCTCTTGCAGAGCATTTAGAGGTTGAGTTTGACCAGGTCACGGTAGGTTGCGGCTCG
TCTGCGCTGTGTCAACAGCTGGTTCAGGCAACGTGCGCTCAGGGCGATGAGGTCATTTTTCCATGGCGCAGCTTTGAGGC
TTATCCAATTTTCGCGCAGGTCGCGGGCGCCACTCCTGTTGCCATTCCGCTGACTGCTGATCAGAATCATGATCTTGATG
CGATGGCAGCCGCGATCACTGATAAGACCCGCCTCATTTTCATCTGCAACCCCAACAATCCTTCGGGCACCACCATCACC
CAGGCGCAGTTTGATAATTTCATGGAAAAGGTTCCAAACGATGTCGTTGTTGGGCTGGATGAGGCTTATTTTGAGTTCAA
CCGCGCGGACGACACCCCAGTTGCCACTGAGGAAATCCACCGCCACGACAACGTGATTGGTTTGCGCACGTTCTCCAAGG
CGTATGGCCTGGCGGGCTTGCGTGTTGGTTACGCCTTCGGAAACGCAGAGATCATCGCAGCGATGAATAAGGTGGCTATT
CCTTTCGCGGTGAATTCAGCAGCTCAGGCGGCAGCGCTTGCGAGTTTGAATTCTGCCGATGAGTTGATGGAACGGGTGGA
GGAAACCGTCGAAAAGCGTGATGCTGTGGTGTCAGCGCTTGGTGCTGCGCCGACGCAGGCCAATTTCGTCTGGCTGCCGG
GCGAGGGCGCCGCTGAGTTGGCGGCTAAATTGGCCGAGCACGGCATCGTGATTCGCGCGTTCCCCGAGGGTGCGCGCATT
TCGGTGACCAACGCCGAGGAAACTGACAAGCTGCTGCGCGCGTGGGAGGCCATCAATGCTGGGTAG

Upstream 100 bases:

>100_bases
ACCGATATGTTACAGTACCCCCTCTTGCTAAATTTCAGCAAACCTGCAGGTAAATGACTTAATCGGATGCGTGTCCATAG
GGGCTAGTACTGTGTAAATC

Downstream 100 bases:

>100_bases
TCTTTGGCGTTTTGCGGTGCGCACCGCAGCAGGCGCGGTGGCGTTGTGGGTGGTTATTAAGCTTATCGACGGCATCTCCC
TGAGTTTTCCCACCACACCT

Product: aminotransferase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MIRADLATIPTYVPGRRLVDATKLSSNEVSFSPLPAAVDAVTEATWGANRYPDMGAVELREALAEHLEVEFDQVTVGCGS
SALCQQLVQATCAQGDEVIFPWRSFEAYPIFAQVAGATPVAIPLTADQNHDLDAMAAAITDKTRLIFICNPNNPSGTTIT
QAQFDNFMEKVPNDVVVGLDEAYFEFNRADDTPVATEEIHRHDNVIGLRTFSKAYGLAGLRVGYAFGNAEIIAAMNKVAI
PFAVNSAAQAAALASLNSADELMERVEETVEKRDAVVSALGAAPTQANFVWLPGEGAAELAAKLAEHGIVIRAFPEGARI
SVTNAEETDKLLRAWEAINAG

Sequences:

>Translated_341_residues
MIRADLATIPTYVPGRRLVDATKLSSNEVSFSPLPAAVDAVTEATWGANRYPDMGAVELREALAEHLEVEFDQVTVGCGS
SALCQQLVQATCAQGDEVIFPWRSFEAYPIFAQVAGATPVAIPLTADQNHDLDAMAAAITDKTRLIFICNPNNPSGTTIT
QAQFDNFMEKVPNDVVVGLDEAYFEFNRADDTPVATEEIHRHDNVIGLRTFSKAYGLAGLRVGYAFGNAEIIAAMNKVAI
PFAVNSAAQAAALASLNSADELMERVEETVEKRDAVVSALGAAPTQANFVWLPGEGAAELAAKLAEHGIVIRAFPEGARI
SVTNAEETDKLLRAWEAINAG
>Mature_341_residues
MIRADLATIPTYVPGRRLVDATKLSSNEVSFSPLPAAVDAVTEATWGANRYPDMGAVELREALAEHLEVEFDQVTVGCGS
SALCQQLVQATCAQGDEVIFPWRSFEAYPIFAQVAGATPVAIPLTADQNHDLDAMAAAITDKTRLIFICNPNNPSGTTIT
QAQFDNFMEKVPNDVVVGLDEAYFEFNRADDTPVATEEIHRHDNVIGLRTFSKAYGLAGLRVGYAFGNAEIIAAMNKVAI
PFAVNSAAQAAALASLNSADELMERVEETVEKRDAVVSALGAAPTQANFVWLPGEGAAELAAKLAEHGIVIRAFPEGARI
SVTNAEETDKLLRAWEAINAG

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=358, Percent_Identity=26.536312849162, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786816, Length=265, Percent_Identity=28.6792452830189, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788722, Length=280, Percent_Identity=26.0714285714286, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788627, Length=247, Percent_Identity=26.7206477732794, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=355, Percent_Identity=24.7887323943662, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9

Molecular weight: Translated: 36450; Mature: 36450

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRADLATIPTYVPGRRLVDATKLSSNEVSFSPLPAAVDAVTEATWGANRYPDMGAVELR
CCCCCCCCCCCCCCCCCEEHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHH
EALAEHLEVEFDQVTVGCGSSALCQQLVQATCAQGDEVIFPWRSFEAYPIFAQVAGATPV
HHHHHHHCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEHEECCCCCCE
AIPLTADQNHDLDAMAAAITDKTRLIFICNPNNPSGTTITQAQFDNFMEKVPNDVVVGLD
EEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCEEEHHHHHHHHHHCCCCEEEECH
EAYFEFNRADDTPVATEEIHRHDNVIGLRTFSKAYGLAGLRVGYAFGNAEIIAAMNKVAI
HHHHCCCCCCCCCCHHHHHHHCCCEEEEEHHHHHHCCCCEEEEEEECCCCEEEEHHHEEE
PFAVNSAAQAAALASLNSADELMERVEETVEKRDAVVSALGAAPTQANFVWLPGEGAAEL
EEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHH
AAKLAEHGIVIRAFPEGARISVTNAEETDKLLRAWEAINAG
HHHHHHCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRADLATIPTYVPGRRLVDATKLSSNEVSFSPLPAAVDAVTEATWGANRYPDMGAVELR
CCCCCCCCCCCCCCCCCEEHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHH
EALAEHLEVEFDQVTVGCGSSALCQQLVQATCAQGDEVIFPWRSFEAYPIFAQVAGATPV
HHHHHHHCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEHEECCCCCCE
AIPLTADQNHDLDAMAAAITDKTRLIFICNPNNPSGTTITQAQFDNFMEKVPNDVVVGLD
EEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCEEEHHHHHHHHHHCCCCEEEECH
EAYFEFNRADDTPVATEEIHRHDNVIGLRTFSKAYGLAGLRVGYAFGNAEIIAAMNKVAI
HHHHCCCCCCCCCCHHHHHHHCCCEEEEEHHHHHHCCCCEEEEEEECCCCEEEEHHHEEE
PFAVNSAAQAAALASLNSADELMERVEETVEKRDAVVSALGAAPTQANFVWLPGEGAAEL
EEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHH
AAKLAEHGIVIRAFPEGARISVTNAEETDKLLRAWEAINAG
HHHHHHCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA