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The map label for this gene is norB [H]

Identifier: 62388970

GI number: 62388970

Start: 82118

End: 83569

Strand: Reverse

Name: norB [H]

Synonym: cg0103

Alternate gene names: 62388970

Gene position: 83569-82118 (Counterclockwise)

Preceding gene: 62388971

Following gene: 62388965

Centisome position: 2.55

GC content: 52.89

Gene sequence:

>1452_bases
ATGTCTTACACATCTTTTAAAGGCGATGATAAAGCCCTCATCGGCATAGTTTTATCAGTTCTCACATTTTGGCTTTTTGC
TCAGTCAACCCTAAATATCGGCCCAGATATGGCAACTGATTTAGGGATGAGCGATGGCACCATGAACATAGCTGTCGTGG
CCGCCGCGTTATTCTGTGGAACATTTATCGTCGCAGCCGGCGGCATCGCAGATGTCTTTGGCCGAGTACGAATCATGATG
ATTGGCAACATCCTTAACATCCTGGGATCTCTCCTCATCGCCACGGCAACGACTTCTTTAGCCACCCAAATGGTGATCAC
CGGCCGAGTTCTCCAAGGACTGGCAGCAGCGGCCATCATGTCTGCATCCCTAGCATTAGTTAAGACATATTGGTTAGGTA
CTGACCGCCAACGAGCAGTCTCCATTTGGTCCATTGGTTCATGGGGTGGCACCGGATTCTGCGCGCTTTTCGCGGGTCTT
GTTGTAGCAAGCCCCTTTGGTTGGAGAGGAATCTTCGCCCTCTGCGCGATCGTCTCCATCGTTGCTATTGCCCTTACCCG
CCACATCCCGGAATCCCGTCCGGCTCAATCCATTGGCATGCATTTGGATTGGAGTGGCATCATCGTTCTTGCCCTCAGTG
TTCTATCTCTTGAATTGTTTATTACCCAAGGTGAATCACTTGGCTGGACGCACTGGATGACCTGGACTCTCCTTGCCGTT
TCTTTGACATTTCTTGCAGTTTTCGTCTTCATTGAACGCATCGCCAGCTGGCCAGTTCTCGACTTCAACCTTTTCAAAGA
CCACGCCTTCAGCGGTGCGACCATCACCAACTTCATTATGAGCGCTACTGGCGGAGTAGTTGCCGTTGTCATGTGGGTTC
AGCAAATGGGATGGGGTGTCTCCCCAACAATCTCGGGACTCACCAGCATCGGCTTCGCAGCCTTTGTCATCCTTTTCATT
CGAGTTGGAGAAAAGGCCATGCAGAAAGTTGGCGCCCGAGCAGTGATCATCACCGCTGGCATCTTGGTAGCGACCGCGAC
CGCCCTCCTAATGATCACCGCGGTCAGCGAGTCAACGTACATCGTCATCTCCCTCGCCGGCTTCTCCCTTTATGGCCTTG
GCCTCGGACTCTTCGCCACCCCAGTCACCGATACTGCGCTTGGAACACTTCCCAAAGACCGTACCGGCGCTGGTGCAGGT
GTATTCAAGATGTCCTCTTCCCTCGGCGCAGCACTCGGCATCGCAATCTCCACTTCAGTGTTCCTCGCACTTCGCGACGG
CACCTCCATCAACTCCGACGTCGCACTCGCCGGAACAGTTTCACTTGGCATCAACGTTGTATTCGCAGCAACAGCCACCA
TCACCGCAGCAGTCCTTATTCCAAAAGCCGCTGGCAAAGTCTCACAAACCAGCATCACCCTTCCTGAGCCAGCTATCGCT
GTAAAAATCTAA

Upstream 100 bases:

>100_bases
TAAATTTTGTGGCACTCCCCACATTTCTATCAATCTATAGAAAGTATGACTTAAAGTCGATTTTGCAAGTTTCTATAGAT
TGATAGAAAAGGGAGTTTAG

Downstream 100 bases:

>100_bases
AACTTCACCAGGACAGATAAAGCTCGTACCTCCTCAAATAAAGAAGGTACGAGCTTTTTGCTTGTCGACGCTTGCCCCCA
GGCGCAGGTGCCACGTGCAC

Product: major facilitator superfamily permease

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MSYTSFKGDDKALIGIVLSVLTFWLFAQSTLNIGPDMATDLGMSDGTMNIAVVAAALFCGTFIVAAGGIADVFGRVRIMM
IGNILNILGSLLIATATTSLATQMVITGRVLQGLAAAAIMSASLALVKTYWLGTDRQRAVSIWSIGSWGGTGFCALFAGL
VVASPFGWRGIFALCAIVSIVAIALTRHIPESRPAQSIGMHLDWSGIIVLALSVLSLELFITQGESLGWTHWMTWTLLAV
SLTFLAVFVFIERIASWPVLDFNLFKDHAFSGATITNFIMSATGGVVAVVMWVQQMGWGVSPTISGLTSIGFAAFVILFI
RVGEKAMQKVGARAVIITAGILVATATALLMITAVSESTYIVISLAGFSLYGLGLGLFATPVTDTALGTLPKDRTGAGAG
VFKMSSSLGAALGIAISTSVFLALRDGTSINSDVALAGTVSLGINVVFAATATITAAVLIPKAAGKVSQTSITLPEPAIA
VKI

Sequences:

>Translated_483_residues
MSYTSFKGDDKALIGIVLSVLTFWLFAQSTLNIGPDMATDLGMSDGTMNIAVVAAALFCGTFIVAAGGIADVFGRVRIMM
IGNILNILGSLLIATATTSLATQMVITGRVLQGLAAAAIMSASLALVKTYWLGTDRQRAVSIWSIGSWGGTGFCALFAGL
VVASPFGWRGIFALCAIVSIVAIALTRHIPESRPAQSIGMHLDWSGIIVLALSVLSLELFITQGESLGWTHWMTWTLLAV
SLTFLAVFVFIERIASWPVLDFNLFKDHAFSGATITNFIMSATGGVVAVVMWVQQMGWGVSPTISGLTSIGFAAFVILFI
RVGEKAMQKVGARAVIITAGILVATATALLMITAVSESTYIVISLAGFSLYGLGLGLFATPVTDTALGTLPKDRTGAGAG
VFKMSSSLGAALGIAISTSVFLALRDGTSINSDVALAGTVSLGINVVFAATATITAAVLIPKAAGKVSQTSITLPEPAIA
VKI
>Mature_482_residues
SYTSFKGDDKALIGIVLSVLTFWLFAQSTLNIGPDMATDLGMSDGTMNIAVVAAALFCGTFIVAAGGIADVFGRVRIMMI
GNILNILGSLLIATATTSLATQMVITGRVLQGLAAAAIMSASLALVKTYWLGTDRQRAVSIWSIGSWGGTGFCALFAGLV
VASPFGWRGIFALCAIVSIVAIALTRHIPESRPAQSIGMHLDWSGIIVLALSVLSLELFITQGESLGWTHWMTWTLLAVS
LTFLAVFVFIERIASWPVLDFNLFKDHAFSGATITNFIMSATGGVVAVVMWVQQMGWGVSPTISGLTSIGFAAFVILFIR
VGEKAMQKVGARAVIITAGILVATATALLMITAVSESTYIVISLAGFSLYGLGLGLFATPVTDTALGTLPKDRTGAGAGV
FKMSSSLGAALGIAISTSVFLALRDGTSINSDVALAGTVSLGINVVFAATATITAAVLIPKAAGKVSQTSITLPEPAIAV
KI

Specific function: Multidrug efflux pump that acts independently of norA and is one of the factors that confers resistance against diverse quinolones and chemical compounds [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=405, Percent_Identity=24.9382716049383, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788710, Length=318, Percent_Identity=22.3270440251572, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323520, Length=245, Percent_Identity=24.8979591836735, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324954, Length=244, Percent_Identity=27.8688524590164, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50103; Mature: 49972

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTSFKGDDKALIGIVLSVLTFWLFAQSTLNIGPDMATDLGMSDGTMNIAVVAAALFCG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHH
TFIVAAGGIADVFGRVRIMMIGNILNILGSLLIATATTSLATQMVITGRVLQGLAAAAIM
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SASLALVKTYWLGTDRQRAVSIWSIGSWGGTGFCALFAGLVVASPFGWRGIFALCAIVSI
HHHHHHHHHHHCCCCCHHEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VAIALTRHIPESRPAQSIGMHLDWSGIIVLALSVLSLELFITQGESLGWTHWMTWTLLAV
HHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHH
SLTFLAVFVFIERIASWPVLDFNLFKDHAFSGATITNFIMSATGGVVAVVMWVQQMGWGV
HHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCC
SPTISGLTSIGFAAFVILFIRVGEKAMQKVGARAVIITAGILVATATALLMITAVSESTY
CHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHEECCCEE
IVISLAGFSLYGLGLGLFATPVTDTALGTLPKDRTGAGAGVFKMSSSLGAALGIAISTSV
EEEEECCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEE
FLALRDGTSINSDVALAGTVSLGINVVFAATATITAAVLIPKAAGKVSQTSITLPEPAIA
EEEEECCCCCCCCEEEEEEHHHCEEEEEEHHHHHHHHHEEECCCCCCCCCEEECCCCCEE
VKI
EEC
>Mature Secondary Structure 
SYTSFKGDDKALIGIVLSVLTFWLFAQSTLNIGPDMATDLGMSDGTMNIAVVAAALFCG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHH
TFIVAAGGIADVFGRVRIMMIGNILNILGSLLIATATTSLATQMVITGRVLQGLAAAAIM
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SASLALVKTYWLGTDRQRAVSIWSIGSWGGTGFCALFAGLVVASPFGWRGIFALCAIVSI
HHHHHHHHHHHCCCCCHHEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VAIALTRHIPESRPAQSIGMHLDWSGIIVLALSVLSLELFITQGESLGWTHWMTWTLLAV
HHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHH
SLTFLAVFVFIERIASWPVLDFNLFKDHAFSGATITNFIMSATGGVVAVVMWVQQMGWGV
HHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCC
SPTISGLTSIGFAAFVILFIRVGEKAMQKVGARAVIITAGILVATATALLMITAVSESTY
CHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHEECCCEE
IVISLAGFSLYGLGLGLFATPVTDTALGTLPKDRTGAGAGVFKMSSSLGAALGIAISTSV
EEEEECCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEE
FLALRDGTSINSDVALAGTVSLGINVVFAATATITAAVLIPKAAGKVSQTSITLPEPAIA
EEEEECCCCCCCCEEEEEEHHHCEEEEEEHHHHHHHHHEEECCCCCCCCCEEECCCCCEE
VKI
EEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA