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The map label for this gene is ppp [H]

Identifier: 62388940

GI number: 62388940

Start: 46666

End: 48021

Strand: Reverse

Name: ppp [H]

Synonym: cg0062

Alternate gene names: 62388940

Gene position: 48021-46666 (Counterclockwise)

Preceding gene: 62388941

Following gene: 62388939

Centisome position: 1.46

GC content: 54.94

Gene sequence:

>1356_bases
ATGTTGACACTTAAATATGCGGTGGCATCTGACCGAGGGTTAGTGCGCGGGAACAATGAGGATTCCGCTTACGCTGGCCC
GCATTTGTTGGCGCTGGCTGATGGTATGGGCGGCCATGCTGCTGGTGAGATCGCTTCCCAAACCATGATCAACCATTTGC
GTGCGCTTGATGTTGATCCTGGTGATAACGATATGTTGGCGCTGGTGGGCATGGTGGCAGGCGAAGCCAACGCGGCGATT
GCTGAGGGCATCGCCGAAGACCCGGCGCGCGACGGCATGGGCACTACGTTGACGGCGTTCATGTTTAACGGGCGTGACCT
GGCAATGTGCCACGTCGGCGATAGTCGTGGTTATGTGCTTCGCGACGATAAGTTGGTACAGGTTACAGTCGACGATACTT
TTGTGCAGTCGTTGGTCGCTGAGGGCAAGCTTGATCCAGAAGATGTTTCAACTCACCCTCAGCGTTCTTTGATTCTGAAG
GCTTACACCGGCCATCCTGTGGAGCCCACTCTGGAGCAATTCCCGGCCTTGCCTGGGGATCGTTTGTTGTTGTGCTCTGA
TGGTCTATCAGATCCGGTTACACACTCCACGATTGAAGAAACAGTGCGTGTAGGCACCCCGCAGGATGCGTCCACCAAGT
TGGTGGAGTTGGCGCTGCGTTCTGGCGGTCCGGACAATGTGACGGTCATTGTGGCCGATGTTGTAGAAGTCACCGAGGCG
GAAGCAGCAGCGGAAGCATCAGTGCCTGTCACGGCTGGTGCGCTCAATGGTGAGCAGCCTGAAGATCCGCGGCCTGATAC
CGCTGCGGGACGCGCTGCGGCGATCACACGGCGAGCTCAAGTGATTGATCCGGCACCAAAGATATCTGATGCTGGAACGG
AGGATATTCCCACAATTGAGGAGCCACCAGAGAAAAGTTCCAGCAAACTTGCGGTATTGATCGTAGCCCTGGTCATCCTC
ATCGGTGTAGTTGCCGCAGGATGGTGGGGCTACTCCCGTATTGACAGCACTTTTTACGTCGCGGTCAATGATGAGGAAGC
CATCACCGTGGAACACGGTGTGGATTACCGCATCTTTGGCAAGGATTTACATTCGCAATTCCAGGTGGCGTGCCTGAATG
AAGCTGGCACCTTGTCACTCAAGGAATCCTGTGAAAACGGTACGTCTTTCAAATTGGATGATTTACCGGCATCTGTTCGC
GGTAGTGTCGCAGGATTACCGTCTGGGTCGTATGACGAGGTCCAGGCGCAAATGCAACGGCTGGCTGCTCAAGCTTTGCC
AGTGTGCGTGAACTTAGAAGTAACAACCGGTGGCGATAGAAACGAACCCGGAGTCAATTGTAGGGAGGTCTCATGA

Upstream 100 bases:

>100_bases
ACGGCACTTTTGTCGGTGGTACGCGCATTGATCAGCCTGAGCAGATTGCGGTGGGCACGGATATCCGTATTGGTCGTACA
ACAGTGAGGCTTGTTCCCTG

Downstream 100 bases:

>100_bases
ACACGCTTGAACGATTAAAGCTTCGTCGCACGGAAATGTGGCTGCTGATACTTGCCACACTCGTTGTGTCGATCATGTTC
ATCAGCCTCGAGCTGGCCAT

Product: protein phosphatase

Products: NA

Alternate protein names: Mycobacterial Ser/Thr phosphatase; Mstp; Possible serine/threonine phosphatase Ppp [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MLTLKYAVASDRGLVRGNNEDSAYAGPHLLALADGMGGHAAGEIASQTMINHLRALDVDPGDNDMLALVGMVAGEANAAI
AEGIAEDPARDGMGTTLTAFMFNGRDLAMCHVGDSRGYVLRDDKLVQVTVDDTFVQSLVAEGKLDPEDVSTHPQRSLILK
AYTGHPVEPTLEQFPALPGDRLLLCSDGLSDPVTHSTIEETVRVGTPQDASTKLVELALRSGGPDNVTVIVADVVEVTEA
EAAAEASVPVTAGALNGEQPEDPRPDTAAGRAAAITRRAQVIDPAPKISDAGTEDIPTIEEPPEKSSSKLAVLIVALVIL
IGVVAAGWWGYSRIDSTFYVAVNDEEAITVEHGVDYRIFGKDLHSQFQVACLNEAGTLSLKESCENGTSFKLDDLPASVR
GSVAGLPSGSYDEVQAQMQRLAAQALPVCVNLEVTTGGDRNEPGVNCREVS

Sequences:

>Translated_451_residues
MLTLKYAVASDRGLVRGNNEDSAYAGPHLLALADGMGGHAAGEIASQTMINHLRALDVDPGDNDMLALVGMVAGEANAAI
AEGIAEDPARDGMGTTLTAFMFNGRDLAMCHVGDSRGYVLRDDKLVQVTVDDTFVQSLVAEGKLDPEDVSTHPQRSLILK
AYTGHPVEPTLEQFPALPGDRLLLCSDGLSDPVTHSTIEETVRVGTPQDASTKLVELALRSGGPDNVTVIVADVVEVTEA
EAAAEASVPVTAGALNGEQPEDPRPDTAAGRAAAITRRAQVIDPAPKISDAGTEDIPTIEEPPEKSSSKLAVLIVALVIL
IGVVAAGWWGYSRIDSTFYVAVNDEEAITVEHGVDYRIFGKDLHSQFQVACLNEAGTLSLKESCENGTSFKLDDLPASVR
GSVAGLPSGSYDEVQAQMQRLAAQALPVCVNLEVTTGGDRNEPGVNCREVS
>Mature_451_residues
MLTLKYAVASDRGLVRGNNEDSAYAGPHLLALADGMGGHAAGEIASQTMINHLRALDVDPGDNDMLALVGMVAGEANAAI
AEGIAEDPARDGMGTTLTAFMFNGRDLAMCHVGDSRGYVLRDDKLVQVTVDDTFVQSLVAEGKLDPEDVSTHPQRSLILK
AYTGHPVEPTLEQFPALPGDRLLLCSDGLSDPVTHSTIEETVRVGTPQDASTKLVELALRSGGPDNVTVIVADVVEVTEA
EAAAEASVPVTAGALNGEQPEDPRPDTAAGRAAAITRRAQVIDPAPKISDAGTEDIPTIEEPPEKSSSKLAVLIVALVIL
IGVVAAGWWGYSRIDSTFYVAVNDEEAITVEHGVDYRIFGKDLHSQFQVACLNEAGTLSLKESCENGTSFKLDDLPASVR
GSVAGLPSGSYDEVQAQMQRLAAQALPVCVNLEVTTGGDRNEPGVNCREVS

Specific function: The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (pknA, pknB, pknD, pknE and pknF) and the penicillin-binding protein PBPA [H]

COG id: COG0631

COG function: function code T; Serine/threonine protein phosphatase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential). Note=May be localized to the outside of the cell [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015655
- InterPro:   IPR001932
- InterPro:   IPR014045 [H]

Pfam domain/function: PF00481 PP2C [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 47403; Mature: 47403

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLKYAVASDRGLVRGNNEDSAYAGPHLLALADGMGGHAAGEIASQTMINHLRALDVDP
CEEEEEEECCCCCEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHEECCCC
GDNDMLALVGMVAGEANAAIAEGIAEDPARDGMGTTLTAFMFNGRDLAMCHVGDSRGYVL
CCCCCEEEEHHHCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCEEEEEEECCCCCEEE
RDDKLVQVTVDDTFVQSLVAEGKLDPEDVSTHPQRSLILKAYTGHPVEPTLEQFPALPGD
ECCEEEEEEECHHHHHHHHHCCCCCHHHCCCCCCCEEEEEECCCCCCCCHHHHCCCCCCC
RLLLCSDGLSDPVTHSTIEETVRVGTPQDASTKLVELALRSGGPDNVTVIVADVVEVTEA
EEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHH
EAAAEASVPVTAGALNGEQPEDPRPDTAAGRAAAITRRAQVIDPAPKISDAGTEDIPTIE
HHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
EPPEKSSSKLAVLIVALVILIGVVAAGWWGYSRIDSTFYVAVNDEEAITVEHGVDYRIFG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEECCCCEEEEECCCCEEEEC
KDLHSQFQVACLNEAGTLSLKESCENGTSFKLDDLPASVRGSVAGLPSGSYDEVQAQMQR
HHHCCCEEEEEECCCCCEEHHHHCCCCCCEEECCCCHHHCCCCCCCCCCCHHHHHHHHHH
LAAQALPVCVNLEVTTGGDRNEPGVNCREVS
HHHHHCCEEEEEEEECCCCCCCCCCCCEECC
>Mature Secondary Structure
MLTLKYAVASDRGLVRGNNEDSAYAGPHLLALADGMGGHAAGEIASQTMINHLRALDVDP
CEEEEEEECCCCCEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHEECCCC
GDNDMLALVGMVAGEANAAIAEGIAEDPARDGMGTTLTAFMFNGRDLAMCHVGDSRGYVL
CCCCCEEEEHHHCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCEEEEEEECCCCCEEE
RDDKLVQVTVDDTFVQSLVAEGKLDPEDVSTHPQRSLILKAYTGHPVEPTLEQFPALPGD
ECCEEEEEEECHHHHHHHHHCCCCCHHHCCCCCCCEEEEEECCCCCCCCHHHHCCCCCCC
RLLLCSDGLSDPVTHSTIEETVRVGTPQDASTKLVELALRSGGPDNVTVIVADVVEVTEA
EEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHH
EAAAEASVPVTAGALNGEQPEDPRPDTAAGRAAAITRRAQVIDPAPKISDAGTEDIPTIE
HHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
EPPEKSSSKLAVLIVALVILIGVVAAGWWGYSRIDSTFYVAVNDEEAITVEHGVDYRIFG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEECCCCEEEEECCCCEEEEC
KDLHSQFQVACLNEAGTLSLKESCENGTSFKLDDLPASVRGSVAGLPSGSYDEVQAQMQR
HHHCCCEEEEEECCCCCEEHHHHCCCCCCEEECCCCHHHCCCCCCCCCCCHHHHHHHHHH
LAAQALPVCVNLEVTTGGDRNEPGVNCREVS
HHHHHCCEEEEEEEECCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]