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The map label for this gene is uvrC

Identifier: 62185404

GI number: 62185404

Start: 929360

End: 931174

Strand: Direct

Name: uvrC

Synonym: CAB799

Alternate gene names: 62185404

Gene position: 929360-931174 (Clockwise)

Preceding gene: 62185403

Following gene: 62185406

Centisome position: 81.21

GC content: 39.23

Gene sequence:

>1815_bases
ATGCGTGTAGAGGATTTTACTCCGAAACTGATTCCGGCATCTCCAGGTGTTTATCTCATGAAAGACAGCTCTGGAGAAGT
ATTGTATATCGGGAAAGCAAAAAACTTACGCAATCGCATAAGCACCTACTTTCGCAAAGACGGGGATTCTAGAGAAAGAA
TTCCTTTTCTCATGAAAAAAACAACAGACATAGAAACAATTTTAGTTTCTAATGAAACGGAGGCTTTTCTTTTAGAGAAC
AACCTAATAAAAAAGTATCATCCGAAATACAATGTTCTTTTAAAAGACGATAAAACCTTTTTTTGCCTAGCCATATCTCT
GACTCATCTTTGGCCGAAAATAGATGTTGTTCGTACTAAAGCAGTTACTTCTTCGAAAAAGCAGATCATTTTTGGTCCGT
ATGTGAGTGCAGAAGCCTGTCGCACACTTTTAGAAGTTATCAGTCAGTGGTTCCCTTTGCGCACCTGTTCTAACCGTGAA
TTTGCTTCAAGAAAACGTCCGTGTATTCTTTATGAGATGAAACGCTGTTTAGCACCTTGTGTGAACTTATGTTCTCATGA
GGAATATGAACAAACTTTAGATAAGGCCGTGTTATTTTTAAAAGGCCAAATCTCGGAAATCGTCCAAGATTTAGAGAAGT
CTATCGAGAAAGCCTCTAAAGAACAAAAATTTGAACAAGCAGGGATGTATTACCGGACATTAAAACTGATCCAACAAGCT
ATGGAAAAACAGCATGTAGAGAAATTCCATTTTCAAAATATAGATGCTATTGGTCTCTATCGAAAATACCAAAAGACTGT
TATCACTGTATTAACAATCCGTTCTGGGAAGTTACTCGGAGCGCGTCATTTCCCGTTTTCAGAAAATGCTCAAGAAGATG
CCGATGTGCTTTCCTCTTTTATATTGCAGTACTATACAAACCAACCTCAAACGCCTAAAGAAATTCTTACTCCTATTCCG
CTAAATATTCCTGATCTTCCGTCTTTATTAAATAAAGATACCCCGCCACAGCTACGTTCTCCAAAAACCGGTTATGGTAG
AGAATTGCTCAACTTAGCCAAAAATAATGCTCAGGTGCATGCAGAGACAACTATACAATCCTCGGCACTACCTTATGAGG
AGTTGAAGAAAATTCTGAAATCTCCTGATTATCCTTACCGTATAGAGTGTTATGATAATGCGCATCTACAAGGATCTCAT
GCTGTTGGCGTATACATTGTCTATGAAAACGACGCCTTGTCTCCCAAAGACTACAGGACATTCTCTATTTCCTCTTCTGC
TTATAATGACTTAGCTGCTTTCCATGAGGTGTTATCTCGTAGGTTTATCTCGCTCACTTCATCTATTCCCGATATGATTC
TTATCGATGGAGGGCGCACGCAATACGCACAAGCAAAGAAAACATTAAAAGAACTCAATCTTACAGGGATTCAAGTTGTT
TCCATAGCTAAGGAAGCAGGCAACCACAGCGGCTCATTAAAAAACGAAAAACTATTTTGTGATACGTTTCCCCAAGGAGT
GCTACTCCCTCCCACATCAAAGCTATTGCAATTTTTCCAGAAACTTAGGGATGAGGCACATAGATTTGCGCTCAGTAGGC
ATCGAAAAAAGCGTCACAAAGACTTCTTATTACCCAAAGAAAAGATTCCCGGAATTGGCGAGATCAAAAGAAAACGTTTA
TTACAAAAATTTAAAAGCTGGGAACAAGTTATGAAAGCTTCCCAGGGAGAGCTGGAAGCTATCCCTGGGCTCACGAAAAA
AGACATTCAACATGTGCTGGCTAAGCAAGCTGAAGATACGTATCTAGAAGACTGA

Upstream 100 bases:

>100_bases
GATATCGAGAGCGCAACAGATCTTACGTCAATTAGAAGGCCCGGAAGCGACTTCTAAACAACCTCAAGAAAAAGAGCTGC
AGCTCACATTGTTTTAAATC

Downstream 100 bases:

>100_bases
ACAGTGGCTTACTCTTCAACTTCTTCTTTTATCTCCTCTAAAAAGTCCTCTGCTGAGGGTAAATCTGCTACACATAATTC
TTCTATTTCATCCTCTGACT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MRVEDFTPKLIPASPGVYLMKDSSGEVLYIGKAKNLRNRISTYFRKDGDSRERIPFLMKKTTDIETILVSNETEAFLLEN
NLIKKYHPKYNVLLKDDKTFFCLAISLTHLWPKIDVVRTKAVTSSKKQIIFGPYVSAEACRTLLEVISQWFPLRTCSNRE
FASRKRPCILYEMKRCLAPCVNLCSHEEYEQTLDKAVLFLKGQISEIVQDLEKSIEKASKEQKFEQAGMYYRTLKLIQQA
MEKQHVEKFHFQNIDAIGLYRKYQKTVITVLTIRSGKLLGARHFPFSENAQEDADVLSSFILQYYTNQPQTPKEILTPIP
LNIPDLPSLLNKDTPPQLRSPKTGYGRELLNLAKNNAQVHAETTIQSSALPYEELKKILKSPDYPYRIECYDNAHLQGSH
AVGVYIVYENDALSPKDYRTFSISSSAYNDLAAFHEVLSRRFISLTSSIPDMILIDGGRTQYAQAKKTLKELNLTGIQVV
SIAKEAGNHSGSLKNEKLFCDTFPQGVLLPPTSKLLQFFQKLRDEAHRFALSRHRKKRHKDFLLPKEKIPGIGEIKRKRL
LQKFKSWEQVMKASQGELEAIPGLTKKDIQHVLAKQAEDTYLED

Sequences:

>Translated_604_residues
MRVEDFTPKLIPASPGVYLMKDSSGEVLYIGKAKNLRNRISTYFRKDGDSRERIPFLMKKTTDIETILVSNETEAFLLEN
NLIKKYHPKYNVLLKDDKTFFCLAISLTHLWPKIDVVRTKAVTSSKKQIIFGPYVSAEACRTLLEVISQWFPLRTCSNRE
FASRKRPCILYEMKRCLAPCVNLCSHEEYEQTLDKAVLFLKGQISEIVQDLEKSIEKASKEQKFEQAGMYYRTLKLIQQA
MEKQHVEKFHFQNIDAIGLYRKYQKTVITVLTIRSGKLLGARHFPFSENAQEDADVLSSFILQYYTNQPQTPKEILTPIP
LNIPDLPSLLNKDTPPQLRSPKTGYGRELLNLAKNNAQVHAETTIQSSALPYEELKKILKSPDYPYRIECYDNAHLQGSH
AVGVYIVYENDALSPKDYRTFSISSSAYNDLAAFHEVLSRRFISLTSSIPDMILIDGGRTQYAQAKKTLKELNLTGIQVV
SIAKEAGNHSGSLKNEKLFCDTFPQGVLLPPTSKLLQFFQKLRDEAHRFALSRHRKKRHKDFLLPKEKIPGIGEIKRKRL
LQKFKSWEQVMKASQGELEAIPGLTKKDIQHVLAKQAEDTYLED
>Mature_604_residues
MRVEDFTPKLIPASPGVYLMKDSSGEVLYIGKAKNLRNRISTYFRKDGDSRERIPFLMKKTTDIETILVSNETEAFLLEN
NLIKKYHPKYNVLLKDDKTFFCLAISLTHLWPKIDVVRTKAVTSSKKQIIFGPYVSAEACRTLLEVISQWFPLRTCSNRE
FASRKRPCILYEMKRCLAPCVNLCSHEEYEQTLDKAVLFLKGQISEIVQDLEKSIEKASKEQKFEQAGMYYRTLKLIQQA
MEKQHVEKFHFQNIDAIGLYRKYQKTVITVLTIRSGKLLGARHFPFSENAQEDADVLSSFILQYYTNQPQTPKEILTPIP
LNIPDLPSLLNKDTPPQLRSPKTGYGRELLNLAKNNAQVHAETTIQSSALPYEELKKILKSPDYPYRIECYDNAHLQGSH
AVGVYIVYENDALSPKDYRTFSISSSAYNDLAAFHEVLSRRFISLTSSIPDMILIDGGRTQYAQAKKTLKELNLTGIQVV
SIAKEAGNHSGSLKNEKLFCDTFPQGVLLPPTSKLLQFFQKLRDEAHRFALSRHRKKRHKDFLLPKEKIPGIGEIKRKRL
LQKFKSWEQVMKASQGELEAIPGLTKKDIQHVLAKQAEDTYLED

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=602, Percent_Identity=34.0531561461794, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1788037, Length=191, Percent_Identity=29.3193717277487, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_CHLAB (Q5L553)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_220189.1
- ProteinModelPortal:   Q5L553
- GeneID:   3338240
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB799
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q5L553
- ProtClustDB:   PRK00558
- BioCyc:   CABO218497:CAB799-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69265; Mature: 69265

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVEDFTPKLIPASPGVYLMKDSSGEVLYIGKAKNLRNRISTYFRKDGDSRERIPFLMKK
CCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHC
TTDIETILVSNETEAFLLENNLIKKYHPKYNVLLKDDKTFFCLAISLTHLWPKIDVVRTK
CCCEEEEEECCCCCEEEECCCCHHHHCCCEEEEEECCCEEEEEEEHHHHHCCCHHHHHHH
AVTSSKKQIIFGPYVSAEACRTLLEVISQWFPLRTCSNREFASRKRPCILYEMKRCLAPC
HHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHH
VNLCSHEEYEQTLDKAVLFLKGQISEIVQDLEKSIEKASKEQKFEQAGMYYRTLKLIQQA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEKQHVEKFHFQNIDAIGLYRKYQKTVITVLTIRSGKLLGARHFPFSENAQEDADVLSSF
HHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEEECCCEECCCCCCCCCCCHHHHHHHHHH
ILQYYTNQPQTPKEILTPIPLNIPDLPSLLNKDTPPQLRSPKTGYGRELLNLAKNNAQVH
HHHHHCCCCCCHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEE
AETTIQSSALPYEELKKILKSPDYPYRIECYDNAHLQGSHAVGVYIVYENDALSPKDYRT
EEHHHHCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCEE
FSISSSAYNDLAAFHEVLSRRFISLTSSIPDMILIDGGRTQYAQAKKTLKELNLTGIQVV
EEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHH
SIAKEAGNHSGSLKNEKLFCDTFPQGVLLPPTSKLLQFFQKLRDEAHRFALSRHRKKRHK
HHHHHHCCCCCCCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFLLPKEKIPGIGEIKRKRLLQKFKSWEQVMKASQGELEAIPGLTKKDIQHVLAKQAEDT
HCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHCCC
YLED
CCCC
>Mature Secondary Structure
MRVEDFTPKLIPASPGVYLMKDSSGEVLYIGKAKNLRNRISTYFRKDGDSRERIPFLMKK
CCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHC
TTDIETILVSNETEAFLLENNLIKKYHPKYNVLLKDDKTFFCLAISLTHLWPKIDVVRTK
CCCEEEEEECCCCCEEEECCCCHHHHCCCEEEEEECCCEEEEEEEHHHHHCCCHHHHHHH
AVTSSKKQIIFGPYVSAEACRTLLEVISQWFPLRTCSNREFASRKRPCILYEMKRCLAPC
HHHCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHH
VNLCSHEEYEQTLDKAVLFLKGQISEIVQDLEKSIEKASKEQKFEQAGMYYRTLKLIQQA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEKQHVEKFHFQNIDAIGLYRKYQKTVITVLTIRSGKLLGARHFPFSENAQEDADVLSSF
HHHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEEECCCEECCCCCCCCCCCHHHHHHHHHH
ILQYYTNQPQTPKEILTPIPLNIPDLPSLLNKDTPPQLRSPKTGYGRELLNLAKNNAQVH
HHHHHCCCCCCHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEE
AETTIQSSALPYEELKKILKSPDYPYRIECYDNAHLQGSHAVGVYIVYENDALSPKDYRT
EEHHHHCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCEE
FSISSSAYNDLAAFHEVLSRRFISLTSSIPDMILIDGGRTQYAQAKKTLKELNLTGIQVV
EEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHH
SIAKEAGNHSGSLKNEKLFCDTFPQGVLLPPTSKLLQFFQKLRDEAHRFALSRHRKKRHK
HHHHHHCCCCCCCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFLLPKEKIPGIGEIKRKRLLQKFKSWEQVMKASQGELEAIPGLTKKDIQHVLAKQAEDT
HCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHCCC
YLED
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA