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The map label for this gene is aroB

Identifier: 62185306

GI number: 62185306

Start: 803276

End: 804415

Strand: Direct

Name: aroB

Synonym: CAB693

Alternate gene names: 62185306

Gene position: 803276-804415 (Clockwise)

Preceding gene: 62185305

Following gene: 62185307

Centisome position: 70.19

GC content: 39.3

Gene sequence:

>1140_bases
ATGATCGAAAACTTGATTTCTCATCCTCATCATATCAAACTTGTGGGAGACTTCTTCAATAAAAAGTTATTTTCTTCCAT
ATCTACAGATCATCCGCTTGTCATCCTTACCGATGTTCAAGTTGCTAAAGAAATTCTCCCTCCTATTGTAGATTTTATAC
ATTCTTTAGACTATACGGTCGTTCCTTTATCCTTTCCTTCCGGAGAGAAAAATAAAACATGGGAAACTTTCATTTCCCTA
CAGAATCAGCTCATAGATCACGATATTCCTTTGGGTTCTACCATGATAGGTATTGGGGGTGGTGTAGTTTTAGACATGGT
AGGATTTCTCGCTTCTACATATTGCCGGGGCATTCCGCTATTCCTAGTCCCCACAACAATGACGGCAATGATAGATGCTT
GTATAGGAGGAAAAAATGGTATTAATCTACGTGGACTAAAAAATCGCTTGGGGACTTTCTATCTCCCGCAAGATGTCTGG
ATATGCCCTGAGTTCTTATCAACATTACCTAAGAAAGAGTGGCTCTACGGAATTTCCGAAGCGATAAAACACGGATGTAT
CGCTGATGCCTCTATCTGGGAGTTTCTTCATAACTACGGCGACATGCTATTTTCTTCTCGGGAAATTCTTAGTGAATTTA
TCAAAAGAAACTGCCTTGTTAAAGCCGCCATTGTTGCTAAAGACCCTCATGATCAACATCTAAGAAAAATACTCAATTTC
GGTCATACAATTGCACACGCTATAGAAACATTATCCCAAGGCTGTCTCCCCCACGGATTGGCAGTAAGCGTAGGCATGAT
GATAGAAACAAAAATCTCCCTAGAATCAGGAATCATGAAGAATCCTGCTCTGCTAGAACAATTACACCATCTATCTAAAC
GCTTCCATTTGCCTACAACTCTTGAAGAACTACGCGATCTTATTCCTCAACATCTTCATCATGAATTTTACGATCCTGAA
AATATCATCCATGCTCTTGGCTATGACAAAAAAAACCTCTCCAAAAAAGCCATCAGAATGGTTATGATGGAAGATGCAGG
CAAGGCAACTTCATGTAATGGCATCTATTGTACAGTGCCAAAAATGGCTATCCTTTATGAAATTCTAAAAAGTGAATGCT
ATGCTATGTGCAACAATTAG

Upstream 100 bases:

>100_bases
GTCATGATCCCTGTGTTACTATAAGAGCTGTAGGTGTCGTAGAAGCCATGGTAAATCTTGTCCTAGCTGATTTGTTATTA
CAACAACGATGTGCGAGACT

Downstream 100 bases:

>100_bases
TGGGCCTACGTTTGCTGAAGCTAAACAGCAACTTTTACACTCCTTACCTCTAGTCGATAGTATAGAGTTACGCATTGATT
GTCTTTTATCCCTGTCTTCA

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MIENLISHPHHIKLVGDFFNKKLFSSISTDHPLVILTDVQVAKEILPPIVDFIHSLDYTVVPLSFPSGEKNKTWETFISL
QNQLIDHDIPLGSTMIGIGGGVVLDMVGFLASTYCRGIPLFLVPTTMTAMIDACIGGKNGINLRGLKNRLGTFYLPQDVW
ICPEFLSTLPKKEWLYGISEAIKHGCIADASIWEFLHNYGDMLFSSREILSEFIKRNCLVKAAIVAKDPHDQHLRKILNF
GHTIAHAIETLSQGCLPHGLAVSVGMMIETKISLESGIMKNPALLEQLHHLSKRFHLPTTLEELRDLIPQHLHHEFYDPE
NIIHALGYDKKNLSKKAIRMVMMEDAGKATSCNGIYCTVPKMAILYEILKSECYAMCNN

Sequences:

>Translated_379_residues
MIENLISHPHHIKLVGDFFNKKLFSSISTDHPLVILTDVQVAKEILPPIVDFIHSLDYTVVPLSFPSGEKNKTWETFISL
QNQLIDHDIPLGSTMIGIGGGVVLDMVGFLASTYCRGIPLFLVPTTMTAMIDACIGGKNGINLRGLKNRLGTFYLPQDVW
ICPEFLSTLPKKEWLYGISEAIKHGCIADASIWEFLHNYGDMLFSSREILSEFIKRNCLVKAAIVAKDPHDQHLRKILNF
GHTIAHAIETLSQGCLPHGLAVSVGMMIETKISLESGIMKNPALLEQLHHLSKRFHLPTTLEELRDLIPQHLHHEFYDPE
NIIHALGYDKKNLSKKAIRMVMMEDAGKATSCNGIYCTVPKMAILYEILKSECYAMCNN
>Mature_379_residues
MIENLISHPHHIKLVGDFFNKKLFSSISTDHPLVILTDVQVAKEILPPIVDFIHSLDYTVVPLSFPSGEKNKTWETFISL
QNQLIDHDIPLGSTMIGIGGGVVLDMVGFLASTYCRGIPLFLVPTTMTAMIDACIGGKNGINLRGLKNRLGTFYLPQDVW
ICPEFLSTLPKKEWLYGISEAIKHGCIADASIWEFLHNYGDMLFSSREILSEFIKRNCLVKAAIVAKDPHDQHLRKILNF
GHTIAHAIETLSQGCLPHGLAVSVGMMIETKISLESGIMKNPALLEQLHHLSKRFHLPTTLEELRDLIPQHLHHEFYDPE
NIIHALGYDKKNLSKKAIRMVMMEDAGKATSCNGIYCTVPKMAILYEILKSECYAMCNN

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=358, Percent_Identity=29.3296089385475, Blast_Score=138, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6320332, Length=321, Percent_Identity=30.5295950155763, Blast_Score=147, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_CHLAB (Q5L5F1)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_220091.1
- ProteinModelPortal:   Q5L5F1
- SMR:   Q5L5F1
- GeneID:   3337260
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB693
- HOGENOM:   HBG632303
- OMA:   LESGIMK
- ProtClustDB:   PRK00002
- BioCyc:   CABO218497:CAB693-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 42485; Mature: 42485

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIENLISHPHHIKLVGDFFNKKLFSSISTDHPLVILTDVQVAKEILPPIVDFIHSLDYTV
CCCCHHCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEE
VPLSFPSGEKNKTWETFISLQNQLIDHDIPLGSTMIGIGGGVVLDMVGFLASTYCRGIPL
EEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCE
FLVPTTMTAMIDACIGGKNGINLRGLKNRLGTFYLPQDVWICPEFLSTLPKKEWLYGISE
EEEHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEECCCCCEECHHHHHHCCHHHHHHHHHH
AIKHGCIADASIWEFLHNYGDMLFSSREILSEFIKRNCLVKAAIVAKDPHDQHLRKILNF
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GHTIAHAIETLSQGCLPHGLAVSVGMMIETKISLESGIMKNPALLEQLHHLSKRFHLPTT
HHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEHHHHHCCCCCHHHHHHHHHHHHHCCCCHH
LEELRDLIPQHLHHEFYDPENIIHALGYDKKNLSKKAIRMVMMEDAGKATSCNGIYCTVP
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECH
KMAILYEILKSECYAMCNN
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIENLISHPHHIKLVGDFFNKKLFSSISTDHPLVILTDVQVAKEILPPIVDFIHSLDYTV
CCCCHHCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEE
VPLSFPSGEKNKTWETFISLQNQLIDHDIPLGSTMIGIGGGVVLDMVGFLASTYCRGIPL
EEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCE
FLVPTTMTAMIDACIGGKNGINLRGLKNRLGTFYLPQDVWICPEFLSTLPKKEWLYGISE
EEEHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEECCCCCEECHHHHHHCCHHHHHHHHHH
AIKHGCIADASIWEFLHNYGDMLFSSREILSEFIKRNCLVKAAIVAKDPHDQHLRKILNF
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GHTIAHAIETLSQGCLPHGLAVSVGMMIETKISLESGIMKNPALLEQLHHLSKRFHLPTT
HHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEHHHHHCCCCCHHHHHHHHHHHHHCCCCHH
LEELRDLIPQHLHHEFYDPENIIHALGYDKKNLSKKAIRMVMMEDAGKATSCNGIYCTVP
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECH
KMAILYEILKSECYAMCNN
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA