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The map label for this gene is zot [H]

Identifier: 59713759

GI number: 59713759

Start: 659901

End: 661085

Strand: Reverse

Name: zot [H]

Synonym: VF_A0576

Alternate gene names: 59713759

Gene position: 661085-659901 (Counterclockwise)

Preceding gene: 59713760

Following gene: 59713758

Centisome position: 49.69

GC content: 39.66

Gene sequence:

>1185_bases
ATGAGTATCTTTGTTCATCATGGCGCGCCTGGCTCTTATAAAACATCGGGAGCACTCTGGCTTAGGCTTCTTCCTGCGAT
TAAATCAGGCCGTCCTATAGTTACTAATATCCGTGGTTTAAAGCTAGGGGTTATCGCTAAACACCTTGGTATTAATGAAT
CGGATATTGTTTTTATTTTTGTAGACACGGACCATCCTAATGGCCGTATTCATCTTGCTAAGTTTTGGCATTGGGCACCT
AAAGATGCGTTTATTTTTATTGATGAATGCGGTCGAATTTGGTCGCCTAAATTAACTATGGCCAACCTAAAAGCTCTTGA
TACACCTTCAGATTTAGTCGAAGAAGGGCGTCCAGAAACTTTTGAGGTAGCATTTGATATGCATCGTCACCATGGTTGGG
ATATTTGCCTCACAACACCGAATATTAGCAAGGTTCATGGAATGATACGTGACGCTGCGGAAATTGGTTATAGGCACTTT
AACCGCGCCACAATGGGTCTAGGAGCTAAATTTACCTTAACAACCCATGATGCTACCAATTCAGGCTTACAAGACTCTCA
CGCTACAACCAGAGAGATTAAAAAAGTACCTAAGTACGTTTTTAAAATGTATCAGAGCACAACAACGGGCAAGGCTAGGG
ATACGTTAGCTGGTACGCCTTTCTGGAAAGACAGAAAAATAGTTATCCTGTCACTTTTCATTATAAGTTTGTTCTCTTAT
TCATTTTATGGTCTTTATGATAATGAGTTAATTACAGGGGGAAATTATGAAAAACAGGTTTCAACAAATGAGCAAAGCAC
CATTACTTCTACTCAAGTTCCTAGTCATTCGCTGCCTAGCTTTTGTGTTCGTGGGATTTGCTTTCAAGATAACAGCGTCA
CTTATGATGGGGGGAATTATCAGATAGTGAATCAATTCCCTGATTTAGAATACAAGGGCATTTTTGCCACTGGCTTTGAT
AAGTTCAAAGGCTTAACGGTGTATTTTGAATCACAGCAAGGCTCTGTACCAACTGAGCTTTTTAATTACAGTTACCGTTA
TTCGGTGCTTTCAATGCCTGATTATAATGAGTTTTTAGTCTTTGATAAGATAAGACAGTTAGCCTTAATAGCTCCAGTTC
GTCGGGGTGCGCCGATTAAATCAGAGAAAGACGATTCATTGATTAATGTCTCGAGTGTTTTTTAA

Upstream 100 bases:

>100_bases
CACAATATAGTGGCATTCTGTTTTACCTTGGTTTAGATAAAGTATTTGCTATTTTAATTCAGGCTCTATTAACTCGCTTT
TCACTTCAGGTTTTTAAATT

Downstream 100 bases:

>100_bases
TAAGCTCGATTTTTATGGATTCGCTGAGCGTAGCGAACCTAATCTATAAAAATGAGTAAGGATAACAAAATGGTTCAATG
TATTTATAGAAATGGGCGTT

Product: zona occludens toxin

Products: NA

Alternate protein names: Zonular occludens toxin; Zot [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSIFVHHGAPGSYKTSGALWLRLLPAIKSGRPIVTNIRGLKLGVIAKHLGINESDIVFIFVDTDHPNGRIHLAKFWHWAP
KDAFIFIDECGRIWSPKLTMANLKALDTPSDLVEEGRPETFEVAFDMHRHHGWDICLTTPNISKVHGMIRDAAEIGYRHF
NRATMGLGAKFTLTTHDATNSGLQDSHATTREIKKVPKYVFKMYQSTTTGKARDTLAGTPFWKDRKIVILSLFIISLFSY
SFYGLYDNELITGGNYEKQVSTNEQSTITSTQVPSHSLPSFCVRGICFQDNSVTYDGGNYQIVNQFPDLEYKGIFATGFD
KFKGLTVYFESQQGSVPTELFNYSYRYSVLSMPDYNEFLVFDKIRQLALIAPVRRGAPIKSEKDDSLINVSSVF

Sequences:

>Translated_394_residues
MSIFVHHGAPGSYKTSGALWLRLLPAIKSGRPIVTNIRGLKLGVIAKHLGINESDIVFIFVDTDHPNGRIHLAKFWHWAP
KDAFIFIDECGRIWSPKLTMANLKALDTPSDLVEEGRPETFEVAFDMHRHHGWDICLTTPNISKVHGMIRDAAEIGYRHF
NRATMGLGAKFTLTTHDATNSGLQDSHATTREIKKVPKYVFKMYQSTTTGKARDTLAGTPFWKDRKIVILSLFIISLFSY
SFYGLYDNELITGGNYEKQVSTNEQSTITSTQVPSHSLPSFCVRGICFQDNSVTYDGGNYQIVNQFPDLEYKGIFATGFD
KFKGLTVYFESQQGSVPTELFNYSYRYSVLSMPDYNEFLVFDKIRQLALIAPVRRGAPIKSEKDDSLINVSSVF
>Mature_393_residues
SIFVHHGAPGSYKTSGALWLRLLPAIKSGRPIVTNIRGLKLGVIAKHLGINESDIVFIFVDTDHPNGRIHLAKFWHWAPK
DAFIFIDECGRIWSPKLTMANLKALDTPSDLVEEGRPETFEVAFDMHRHHGWDICLTTPNISKVHGMIRDAAEIGYRHFN
RATMGLGAKFTLTTHDATNSGLQDSHATTREIKKVPKYVFKMYQSTTTGKARDTLAGTPFWKDRKIVILSLFIISLFSYS
FYGLYDNELITGGNYEKQVSTNEQSTITSTQVPSHSLPSFCVRGICFQDNSVTYDGGNYQIVNQFPDLEYKGIFATGFDK
FKGLTVYFESQQGSVPTELFNYSYRYSVLSMPDYNEFLVFDKIRQLALIAPVRRGAPIKSEKDDSLINVSSVF

Specific function: Increases the permeability of the small intestine mucosa by affecting the structure of intercellular tight junctions (zonula occludens) [H]

COG id: COG4128

COG function: function code R; Zonula occludens toxin

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008900 [H]

Pfam domain/function: PF05707 Zot [H]

EC number: NA

Molecular weight: Translated: 44440; Mature: 44309

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFVHHGAPGSYKTSGALWLRLLPAIKSGRPIVTNIRGLKLGVIAKHLGINESDIVFIF
CEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCEEEEEEHHHCCCCCCCEEEEE
VDTDHPNGRIHLAKFWHWAPKDAFIFIDECGRIWSPKLTMANLKALDTPSDLVEEGRPET
EECCCCCCEEEEEEEEEECCCCCEEEEECCCCCCCCCEEEECCEECCCCHHHHHCCCCCE
FEVAFDMHRHHGWDICLTTPNISKVHGMIRDAAEIGYRHFNRATMGLGAKFTLTTHDATN
EEEEEEHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEEECCCCC
SGLQDSHATTREIKKVPKYVFKMYQSTTTGKARDTLAGTPFWKDRKIVILSLFIISLFSY
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
SFYGLYDNELITGGNYEKQVSTNEQSTITSTQVPSHSLPSFCVRGICFQDNSVTYDGGNY
HEEEEECCEEEECCCCCCEECCCCCCEEEECCCCCCCCCHHHHCCEEECCCEEEECCCCE
QIVNQFPDLEYKGIFATGFDKFKGLTVYFESQQGSVPTELFNYSYRYSVLSMPDYNEFLV
EEEECCCCCCCCEEEEECHHHHCCEEEEEECCCCCCCHHHHCCEEEEEEEECCCCCHHHH
FDKIRQLALIAPVRRGAPIKSEKDDSLINVSSVF
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure 
SIFVHHGAPGSYKTSGALWLRLLPAIKSGRPIVTNIRGLKLGVIAKHLGINESDIVFIF
EEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCEEEEEEHHHCCCCCCCEEEEE
VDTDHPNGRIHLAKFWHWAPKDAFIFIDECGRIWSPKLTMANLKALDTPSDLVEEGRPET
EECCCCCCEEEEEEEEEECCCCCEEEEECCCCCCCCCEEEECCEECCCCHHHHHCCCCCE
FEVAFDMHRHHGWDICLTTPNISKVHGMIRDAAEIGYRHFNRATMGLGAKFTLTTHDATN
EEEEEEHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEEEEECCCCC
SGLQDSHATTREIKKVPKYVFKMYQSTTTGKARDTLAGTPFWKDRKIVILSLFIISLFSY
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
SFYGLYDNELITGGNYEKQVSTNEQSTITSTQVPSHSLPSFCVRGICFQDNSVTYDGGNY
HEEEEECCEEEECCCCCCEECCCCCCEEEECCCCCCCCCHHHHCCEEECCCEEEECCCCE
QIVNQFPDLEYKGIFATGFDKFKGLTVYFESQQGSVPTELFNYSYRYSVLSMPDYNEFLV
EEEECCCCCCCCEEEEECHHHHCCEEEEEECCCCCCCHHHHCCEEEEEEEECCCCCHHHH
FDKIRQLALIAPVRRGAPIKSEKDDSLINVSSVF
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1730472; 10952301; 2052603 [H]