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The map label for this gene is pbuX [H]

Identifier: 57652646

GI number: 57652646

Start: 460970

End: 462238

Strand: Direct

Name: pbuX [H]

Synonym: SACOL0459

Alternate gene names: 57652646

Gene position: 460970-462238 (Clockwise)

Preceding gene: 57652645

Following gene: 57652647

Centisome position: 16.41

GC content: 35.78

Gene sequence:

>1269_bases
ATGAAAAATTTAATCCTAAGTGTTCAACATCTTTTAGCTATGTACGCAGGTGCTATCTTAGTTCCAATCATTGTTGGTAC
AAGTTTGAAGTTTACACCTGAACAAATCGCTTACTTAGTTACAGTAGATATATTTATGTGTGGGGTTGCCACATTTTTAC
AAGCCAATAAAGTAACAGGAACAGGATTACCAATCGTTCTTGGATGTACATTCACGGCTGTTGCGCCCATGATTTTAATT
GGTCAAACGAAAGGAATAGATGTACTTTATGGTTCGCTATTTTTATCAGGGATATTAGTTATTATCATCGCGCCTTTCTT
TTCACATCTTGTAAAATTCTTCCCACCAGTAGTAACGGGTAGTGTTGTTACTATCATTGGTATCAATTTAATGCCAGTAG
CAATGAATTACTTAGCTGGAGGTCAAGGTGCAAAGGACTATGGAGATGTTAAGAACATTTTGTTAGGTTTAATGACATTA
ATCATTATTCTTCTTTTACAAAGATTCACAACTGGATTTATTAAGAGTATTGCCATATTAATTGGACTCGTTTTAGGAAC
GATAGGTGCTGGCTTACTTGGGATGGTCGATATTAATCAAGTCAATCATGCCGGTTGGTTAGGCATCCCAGTGCCGTTTA
GATTCTCTGGATTTAGCTTTGATGTGACATCGACGTTAGTGTTCTTTATTGTAGCTATCGTTAGTTTAATTGAGTCGACA
GGTGTCTATCATGCGTTAAGTGAAATTACCGGTAAGAAGTTAGAAAGAAAAGATTTTCGTAAAGGTTATACTGCGGAAGG
TCTAGCGATAGTGTTAGGTTCTATATTCAATTCATTTCCGTATACAGCCTATTCGCAAAATGTAGGACTTGTTTCTTTAT
CCGGCGCTAAGAAAAACAATGTTATATACGGCATGGTCGTGTTATTACTTATATGTGGTTGTATACCTAAGCTTGGCGCA
TTAGCAAATATCATACCGCTACCTGTGTTAGGCGGTGCGATGATAGCTATGTTTGGCATGGTAATGGCATATGGTGTTAG
TATATTAGGACATATCGATTTTAAAAATCAAAACAATTTATTAATTATCGCTGTATCAGTAGGATTAGGTACTGGTATAA
GCGCTGTACCACAAGCATTTAAAGGTTTAGGTGAACAATTTGCATGGTTGACTCAAAACGGAATTGTTTTAGGCGCAATC
TCTGCAATTATTCTTAATTTCTTTTTTAATGGAATAAAGTATAAACAAACGGAAGAAAATGTGAAATAA

Upstream 100 bases:

>100_bases
ATGGGCATCAACGTTTAGAAGAAGCAGGTTTAACAGTTTCTTCTCTCTGCAAGGTTGCTTCACTAGAAGGAAACAAAGTG
ACATTGGTGGGAGAAGAATA

Downstream 100 bases:

>100_bases
TATAACTAATTAATTTGAAAAATGGAGGCTGTTTTTAATGTGGGAAAGTAAATTTGCAAAAGAATCATTAACGTTTGATG
ATGTGTTATTAATTCCAGCA

Product: xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILI
GQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTL
IIILLLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFIVAIVSLIEST
GVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLLICGCIPKLGA
LANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAI
SAIILNFFFNGIKYKQTEENVK

Sequences:

>Translated_422_residues
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILI
GQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTL
IIILLLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFIVAIVSLIEST
GVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLLICGCIPKLGA
LANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAI
SAIILNFFFNGIKYKQTEENVK
>Mature_422_residues
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILI
GQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTL
IIILLLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFIVAIVSLIEST
GVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLLICGCIPKLGA
LANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAI
SAIILNFFFNGIKYKQTEENVK

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=438, Percent_Identity=23.2876712328767, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI40316845, Length=438, Percent_Identity=23.2876712328767, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI44680145, Length=169, Percent_Identity=26.6272189349112, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI44680143, Length=169, Percent_Identity=26.6272189349112, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87082181, Length=427, Percent_Identity=38.1733021077283, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI87082178, Length=438, Percent_Identity=31.5068493150685, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI1790087, Length=431, Percent_Identity=29.6983758700696, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1788843, Length=437, Percent_Identity=27.2311212814645, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87081818, Length=391, Percent_Identity=28.1329923273657, Blast_Score=128, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17558856, Length=227, Percent_Identity=27.7533039647577, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17542262, Length=173, Percent_Identity=26.5895953757225, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21356175, Length=174, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44804; Mature: 44804

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TGLPIVLGCTFTAVAPMILIGQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTG
CCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
SVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTLIIILLLQRFTTGFIKSIAIL
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFIVAIVSLIEST
HHHHHHHHCCHHHHHEECCCCCCCCEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHC
GVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNN
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEECCCCCCC
VIYGMVVLLLICGCIPKLGALANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCE
LIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAISAIILNFFFNGIKYKQTEEN
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
VK
CC
>Mature Secondary Structure
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TGLPIVLGCTFTAVAPMILIGQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTG
CCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
SVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTLIIILLLQRFTTGFIKSIAIL
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFIVAIVSLIEST
HHHHHHHHCCHHHHHEECCCCCCCCEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHC
GVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNN
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEECCCCCCC
VIYGMVVLLLICGCIPKLGALANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCE
LIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAISAIILNFFFNGIKYKQTEEN
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
VK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]