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The map label for this gene is fadA [H]

Identifier: 57652489

GI number: 57652489

Start: 248158

End: 249342

Strand: Reverse

Name: fadA [H]

Synonym: SACOL0211

Alternate gene names: 57652489

Gene position: 249342-248158 (Counterclockwise)

Preceding gene: 57652490

Following gene: 57652486

Centisome position: 8.88

GC content: 43.38

Gene sequence:

>1185_bases
ATGCAAGAAGCATACATTGTAGCTTATGGGCGTTCAGCCGCAGCGAAAGCAAAGCAAGGCGCATTATTCCACGAAAGACC
TGATGATGTCGCAGCCAAAGTATTACAAGGCGTATTGAAACGTATTGACGGAAAATTCAATAAGAATATGATTGAAGATG
TCATTGTTGGTACGGCTTTTCCAGAAGGATTACAAGGCCAAAACATTGCACGAACGATTGCATTGCGTGCGGGATTATCT
GACACGGTACCGGGTCAAACAGTGAATCGCTACTGCTCATCAGGATTACAAACCATCGCGATTGCAGCCAATCAAATTAT
GGCTGGTCAAGGAGATATACTTGTAGCTGGTGGCGTTGAATTGATGAGTGCCGTACCAATGGGTGGCAACGAGCCCACAA
ACAATCCAACCTTACAATATGATGATATAGGTGCGTCATATCCTATGGGTTTAACTGCTGAAAATGTAGCATCCCAATTT
GACGTATCACGCGAAGATCAAGATGCTTATGCTGTCAGAAGTCATCAACGTGCCTATGACGCACAACGTGATGGTCGGTT
CAAAGATGAAATTATTCCAATACAAGTAAACTCAGTTGAATATACAAACGCAGGACCAAAAGTACACACAAATATCTTTG
ACCAAGATGAATTTATACGCCCTGACACCACGATGGAGGCATTAGCCAAATTACGTACAGTATTTAAAGCTGACGGCACT
GTGACTGCAGGAACATCTGCCCCACTTTCTGATGGTGCAGGATTTGTAGTTTTAATGTCTGGAGATAAAGTGAAAGAACT
CGGCGTGACACCTATTGCACGATTCGTTGGTTTTAAGGCAGTAGGCGTTGACCCGAAAATTATGGGTATTGGGCCTGCAT
ATGCGATTCCTGAAGTATTGTCACTCAGCAATCTATCTGTTGAAGACATTGATTTGATCGAATTGAACGAAGCATTTGCT
TCTCAAACGATTGCATCTATTAAAGAAGTAGGTCTAGATATATCACGTACGAATGTGAATGGTGGCGCTATTGCTTTAGG
TCATCCATTAGGTGCTACAGGCGCAATGTTAACCGCGCGTTTACTTAATGAAATGGGTAGACGTCCCGATAGCCGTTACG
GCATGGTTACGATGTGTATTGGTGTCGGCATGGGTGCAGCTGCTATATTTGAATATGTGCGTTAG

Upstream 100 bases:

>100_bases
TACTAAAATCTAAAAAATCATATGAAAGAATTGCACATATGTTAAAAACTGGTAAGCCATTACGTAATTAAAAGATAGTC
ATTAAGAGAGGATGATAACC

Downstream 100 bases:

>100_bases
AATGGTTGATTTTGGATGAAGCGGATTCGTTTTGTTATTGAATGAAGTAGGCTGAAGTTGAAGCCAGTTGAAGTTGAAGC
GGGTTGAAGCAATTTCGTTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLS
DTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQF
DVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFA
SQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR

Sequences:

>Translated_394_residues
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLS
DTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQF
DVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFA
SQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
>Mature_394_residues
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRAGLS
DTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQF
DVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNEAFA
SQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=43.9897698209719, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI167614485, Length=360, Percent_Identity=40.8333333333333, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI148539872, Length=387, Percent_Identity=39.5348837209302, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4557237, Length=354, Percent_Identity=36.7231638418079, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4504327, Length=412, Percent_Identity=33.9805825242718, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI194353979, Length=240, Percent_Identity=35.8333333333333, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=41.8491484184915, Blast_Score=277, Evalue=9e-76,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=42.3173803526448, Blast_Score=277, Evalue=9e-76,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=40.0990099009901, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI87082165, Length=355, Percent_Identity=40.2816901408451, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1788683, Length=412, Percent_Identity=32.7669902912621, Blast_Score=177, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI133906874, Length=357, Percent_Identity=40.3361344537815, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=31.2342569269521, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17535921, Length=354, Percent_Identity=34.7457627118644, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=394, Percent_Identity=28.9340101522843, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=321, Percent_Identity=27.4143302180685, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322031, Length=405, Percent_Identity=40.2469135802469, Blast_Score=262, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=31.3106796116505, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=39.8514851485149, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17648125, Length=356, Percent_Identity=41.5730337078652, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24640423, Length=356, Percent_Identity=35.6741573033708, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17137578, Length=412, Percent_Identity=33.7378640776699, Blast_Score=199, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41805; Mature: 41805

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAF
CCCCEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
PEGLQGQNIARTIALRAGLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVE
CCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHEEEHHHHHHCCCCCCEEEECCHH
LMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQFDVSREDQDAYAVRSHQRAYD
HHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
AQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
HHHCCCCCCCEEEEEECCEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIPEVL
EECCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHCCEEECCCCEEEECCCHHHHHHHH
SLSNLSVEDIDLIELNEAFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTAR
HHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCHHHHHHHH
LLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
HHHHHCCCCCCCCCHHHEEHHCCCCHHHHHHHHC
>Mature Secondary Structure
MQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAF
CCCCEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
PEGLQGQNIARTIALRAGLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVE
CCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHEEEHHHHHHCCCCCCEEEECCHH
LMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQFDVSREDQDAYAVRSHQRAYD
HHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHH
AQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKADGT
HHHCCCCCCCEEEEEECCEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
VTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIPEVL
EECCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHCCEEECCCCEEEECCCHHHHHHHH
SLSNLSVEDIDLIELNEAFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTAR
HHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCHHHHHHHH
LLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
HHHHHCCCCCCCCCHHHEEHHCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]