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The map label for this gene is cpnA [H]

Identifier: 57652315

GI number: 57652315

Start: 2655607

End: 2656311

Strand: Direct

Name: cpnA [H]

Synonym: SACOL2594

Alternate gene names: 57652315

Gene position: 2655607-2656311 (Clockwise)

Preceding gene: 57652314

Following gene: 57652316

Centisome position: 94.53

GC content: 38.01

Gene sequence:

>705_bases
ATGACTAAAATTGTGTTAATCACAGGAGGCAATAAAGGGTTAGGCTATGCAAGTGCAGAGGCACTTAAAGCATTGGGTTA
CAAAGTTTATATAGGTTCTCGGAATGATGTAAGAGGACAACAAGCATCACAAAAATTAGGTGTTCATTATGTACAATTAG
ATGTTACAAGTGACTACTCAGTCAAAAATGCTTATAACATGATTGCTGAAAAAGAAGGCCGTCTTGATATCCTCATTAAC
AATGCAGGTATATCTGGTCAATTTTCAGCACCTTCCAAATTGACACCTCGTGACGTTGAAGAAGTATATCAAACGAATGT
ATTCGGTATCGTACGAATGATGAATACATTCGTCCCTCTCTTAGAAAAATCTGAACAACCTGTTGTCGTCAACGTATCAA
GTGGTTTAGGTTCATTTGGAATGGTTACAAACCCCGAAACAGCTGAATCTAAAGTGAATTCATTAGCTTATTGTTCGTCT
AAATCGGCAGTAACAATGCTAACGCTACAATACGCTAAAGGATTACCTAACATGCAAATCAATGCTGCTGATCCAGGCGC
TACAAATACTGATTTAGTTGGTGATTTTAGTAATAATTCCAAACACGTTTCTGAAGGAATCAAGCCAATCATTCAATTAG
CAACGATTGGTGCAGATGGCCCAACAGGTACATTTATTAATGGCGATGGAGAGATGCCTTGGTAG

Upstream 100 bases:

>100_bases
TCAACTAGTGTATTTGCCTTCCAAATAGAGCATCGCCATATTTCAATTGAAGCGTACAGAAATTATTTATTAAACATTTA
TTTAGATGAGGTGGGACGTA

Downstream 100 bases:

>100_bases
ATCAATTTTATGTTACAAACATTGAAATTAGAGGTATATAAAAAATGCTTCTGCAATAGATGCAATAAACATGCAATACA
ATATGGAGGCGAAGTAAATG

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTKIVLITGGNKGLGYASAEALKALGYKVYIGSRNDVRGQQASQKLGVHYVQLDVTSDYSVKNAYNMIAEKEGRLDILIN
NAGISGQFSAPSKLTPRDVEEVYQTNVFGIVRMMNTFVPLLEKSEQPVVVNVSSGLGSFGMVTNPETAESKVNSLAYCSS
KSAVTMLTLQYAKGLPNMQINAADPGATNTDLVGDFSNNSKHVSEGIKPIIQLATIGADGPTGTFINGDGEMPW

Sequences:

>Translated_234_residues
MTKIVLITGGNKGLGYASAEALKALGYKVYIGSRNDVRGQQASQKLGVHYVQLDVTSDYSVKNAYNMIAEKEGRLDILIN
NAGISGQFSAPSKLTPRDVEEVYQTNVFGIVRMMNTFVPLLEKSEQPVVVNVSSGLGSFGMVTNPETAESKVNSLAYCSS
KSAVTMLTLQYAKGLPNMQINAADPGATNTDLVGDFSNNSKHVSEGIKPIIQLATIGADGPTGTFINGDGEMPW
>Mature_233_residues
TKIVLITGGNKGLGYASAEALKALGYKVYIGSRNDVRGQQASQKLGVHYVQLDVTSDYSVKNAYNMIAEKEGRLDILINN
AGISGQFSAPSKLTPRDVEEVYQTNVFGIVRMMNTFVPLLEKSEQPVVVNVSSGLGSFGMVTNPETAESKVNSLAYCSSK
SAVTMLTLQYAKGLPNMQINAADPGATNTDLVGDFSNNSKHVSEGIKPIIQLATIGADGPTGTFINGDGEMPW

Specific function: Reduces cyclopentanol to cyclopentanone. The enzyme also shows considerable activity toward cyclohexanol [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI10190746, Length=237, Percent_Identity=31.6455696202532, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI4502599, Length=278, Percent_Identity=28.7769784172662, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI4504503, Length=205, Percent_Identity=34.1463414634146, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI186928839, Length=202, Percent_Identity=30.1980198019802, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI193804850, Length=207, Percent_Identity=28.5024154589372, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI225579078, Length=205, Percent_Identity=28.2926829268293, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI31542939, Length=231, Percent_Identity=26.4069264069264, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI7657478, Length=203, Percent_Identity=29.064039408867, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI44680136, Length=199, Percent_Identity=29.6482412060301, Blast_Score=64, Evalue=1e-10,
Organism=Homo sapiens, GI44680133, Length=199, Percent_Identity=29.6482412060301, Blast_Score=64, Evalue=1e-10,
Organism=Homo sapiens, GI17738292, Length=199, Percent_Identity=29.6482412060301, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1787335, Length=202, Percent_Identity=27.2277227722772, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787820, Length=138, Percent_Identity=28.2608695652174, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17558006, Length=223, Percent_Identity=28.6995515695067, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538182, Length=211, Percent_Identity=29.8578199052133, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17505416, Length=150, Percent_Identity=34, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193207563, Length=209, Percent_Identity=28.2296650717703, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558994, Length=211, Percent_Identity=30.3317535545024, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=202, Percent_Identity=26.7326732673267, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45554248, Length=207, Percent_Identity=30.4347826086957, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24640117, Length=207, Percent_Identity=30.4347826086957, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573296, Length=201, Percent_Identity=28.8557213930348, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161076371, Length=201, Percent_Identity=29.3532338308458, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28571387, Length=209, Percent_Identity=27.7511961722488, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24586328, Length=210, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17737361, Length=206, Percent_Identity=28.6407766990291, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921754, Length=203, Percent_Identity=27.5862068965517, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641232, Length=204, Percent_Identity=30.8823529411765, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28571526, Length=202, Percent_Identity=29.7029702970297, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.163 [H]

Molecular weight: Translated: 24932; Mature: 24800

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIVLITGGNKGLGYASAEALKALGYKVYIGSRNDVRGQQASQKLGVHYVQLDVTSDYS
CEEEEEEECCCCCCCCHHHHHHHHCCEEEEECCCCCCCCHHHHHHHCEEEEEEEECCCCC
VKNAYNMIAEKEGRLDILINNAGISGQFSAPSKLTPRDVEEVYQTNVFGIVRMMNTFVPL
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEKSEQPVVVNVSSGLGSFGMVTNPETAESKVNSLAYCSSKSAVTMLTLQYAKGLPNMQI
HCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHEEECCCCCEEEEEEHHHCCCCCCEE
NAADPGATNTDLVGDFSNNSKHVSEGIKPIIQLATIGADGPTGTFINGDGEMPW
ECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHEECCCCCCCCEECCCCCCCC
>Mature Secondary Structure 
TKIVLITGGNKGLGYASAEALKALGYKVYIGSRNDVRGQQASQKLGVHYVQLDVTSDYS
EEEEEEECCCCCCCCHHHHHHHHCCEEEEECCCCCCCCHHHHHHHCEEEEEEEECCCCC
VKNAYNMIAEKEGRLDILINNAGISGQFSAPSKLTPRDVEEVYQTNVFGIVRMMNTFVPL
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEKSEQPVVVNVSSGLGSFGMVTNPETAESKVNSLAYCSSKSAVTMLTLQYAKGLPNMQI
HCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHEEECCCCCEEEEEEHHHCCCCCCEE
NAADPGATNTDLVGDFSNNSKHVSEGIKPIIQLATIGADGPTGTFINGDGEMPW
ECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHEECCCCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12406764 [H]