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The map label for this gene is czcD [H]

Identifier: 57652168

GI number: 57652168

Start: 2198604

End: 2199584

Strand: Direct

Name: czcD [H]

Synonym: SACOL2138

Alternate gene names: 57652168

Gene position: 2198604-2199584 (Clockwise)

Preceding gene: 57652167

Following gene: 57652169

Centisome position: 78.26

GC content: 33.23

Gene sequence:

>981_bases
ATGTCTCATTCACATCATCATCATGACCATATGCATAGTCATGTAACTACAAATAATAAGAAAGTATTGTTTATATCGTT
TTTAATAATCGGTCTATATATGTTTATCGAAATCATCGGCGGTCTCCTTGCTAACAGCTTGGCATTACTATCTGACGGTA
TCCATATGTTTAGCGACACATTCTCATTAGGTGTTGCACTTGTCGCATTTATTTATGCTGAAAAGAATGCCACAACTACA
AAAACATTTGGTTATAAACGTTTCGAAGTACTCGCAGCGTTATTTAACGGTGTAACGCTTTTTGTAATAAGTATTTTGAT
TGTTTTTGAAGCGATTAAACGTTTCTTTGTTCCTTCTGAAGTTCAATCAAAAGAAATGTTAATCATTAGTATTATCGGTT
TAATTGTCAATATCGTTGTTGCATTCTTTATGTTTAAAGGCGGCGACACTTCACACAATTTAAATATGCGTGGTGCTTTT
CTACATGTTATCGGAGACTTATTAGGTTCAGTTGGCGCCATTACTGCAGCTATTTTAATTTGGGCATTTGGATGGACAAT
CGCCGATCCTATCGCAAGTATTTTAGTTTCCGTTATTATTTTAAAAAGTGCTTGGGGTATCACAAAATCTTCAATTAACA
TTTTAATGGAAGGCACACCAAGTGATGTTGATATAGATGAAGTTATAACTACTATTAAAAAGGATTCACGAATACAAAGT
GTGCATGATTGCCATGTTTGGACAATTTCAAATGATATGAATGCATTGAGTTGTCATGTTGTTGTAGACCATACATTGAC
AATGAAAGAATGTGAATTATTATTAGAAAACATTGAGCATGATTTATTACATTTAAATATTCACCATATGACTATTCAAT
TAGAAACGCCTAATCACAAACATGATGAATCGATTATATGTTCAGGAACACATAGTCATTCACATAACCATCATGCTCAT
CATCACGCGCATGTACATTAA

Upstream 100 bases:

>100_bases
GGCCAATCAATGATTTATTCATTAGATGACATCCACGTAGCAACTATGTTAAAGCAAGCCATACATCACGCGAATCATCC
TAAAGAAAGTGGGTTATAAT

Downstream 100 bases:

>100_bases
TAATTTTAACCTACTGCCATTGCATCGATTAAACTTTTCAATGGCAGTAGGTTTTTTATGTCTTTATGGCGACTTGTTTG
GTCTTTGATGATGCAATGTT

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALVAFIYAEKNATTT
KTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAF
LHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQS
VHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAH
HHAHVH

Sequences:

>Translated_326_residues
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALVAFIYAEKNATTT
KTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAF
LHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQS
VHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAH
HHAHVH
>Mature_325_residues
SHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALVAFIYAEKNATTTK
TFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFL
HVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSV
HDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHH
HAHVH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=327, Percent_Identity=28.4403669724771, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI21361112, Length=336, Percent_Identity=27.3809523809524, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI20070323, Length=319, Percent_Identity=28.2131661442006, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI21359890, Length=321, Percent_Identity=27.4143302180685, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI289803013, Length=285, Percent_Identity=28.4210526315789, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI289803009, Length=285, Percent_Identity=28.4210526315789, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI289803007, Length=285, Percent_Identity=28.4210526315789, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI289803003, Length=285, Percent_Identity=28.4210526315789, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI64762489, Length=288, Percent_Identity=28.4722222222222, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI14210520, Length=237, Percent_Identity=27.4261603375527, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI52351208, Length=192, Percent_Identity=31.25, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI222080086, Length=137, Percent_Identity=32.1167883211679, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI40255009, Length=137, Percent_Identity=32.1167883211679, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI52352803, Length=124, Percent_Identity=37.0967741935484, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1786966, Length=288, Percent_Identity=43.0555555555556, Blast_Score=191, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI193210990, Length=316, Percent_Identity=29.746835443038, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17555794, Length=325, Percent_Identity=30.7692307692308, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17555796, Length=327, Percent_Identity=30.5810397553517, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32564488, Length=324, Percent_Identity=30.5555555555556, Blast_Score=141, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6320411, Length=191, Percent_Identity=34.0314136125654, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324892, Length=134, Percent_Identity=39.5522388059701, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323899, Length=139, Percent_Identity=38.1294964028777, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24656728, Length=337, Percent_Identity=27.299703264095, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24656724, Length=337, Percent_Identity=27.299703264095, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24656720, Length=337, Percent_Identity=27.299703264095, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24656715, Length=337, Percent_Identity=27.299703264095, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21357035, Length=337, Percent_Identity=27.299703264095, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24583858, Length=333, Percent_Identity=25.5255255255255, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645863, Length=141, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585900, Length=144, Percent_Identity=31.9444444444444, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24585898, Length=144, Percent_Identity=31.9444444444444, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24585896, Length=144, Percent_Identity=31.9444444444444, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19921672, Length=144, Percent_Identity=31.9444444444444, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24584409, Length=162, Percent_Identity=30.8641975308642, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574430, Length=162, Percent_Identity=30.8641975308642, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36267; Mature: 36135

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDT
CCCCCCCHHHHHHCEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FSLGVALVAFIYAEKNATTTKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSE
HHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
VQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHH
VHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHK
HHCEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHCCHHHEEEEEEEEEEEEECCCCC
HDESIICSGTHSHSHNHHAHHHAHVH
CCCCEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDT
CCCCCCHHHHHHCEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FSLGVALVAFIYAEKNATTTKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSE
HHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
VQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHH
VHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHK
HHCEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHCCHHHEEEEEEEEEEEEECCCCC
HDESIICSGTHSHSHNHHAHHHAHVH
CCCCEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]