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The map label for this gene is ptpA

Identifier: 57652100

GI number: 57652100

Start: 2002584

End: 2003048

Strand: Direct

Name: ptpA

Synonym: SACOL1939

Alternate gene names: 57652100

Gene position: 2002584-2003048 (Clockwise)

Preceding gene: 57652096

Following gene: 57652101

Centisome position: 71.28

GC content: 33.98

Gene sequence:

>465_bases
ATGGTAGATGTAGCATTTGTCTGTCTTGGCAATATATGTCGTTCTCCAATGGCAGAAGCAATCATGCGACAAAGACTTAA
AGACAGAAATATTCATGATATTAAAGTACATTCAAGAGGTACTGGTAGCTGGAATTTAGGAGAGCCACCTCATGAAGGTA
CACAAAAAATTCTCAACAAACACAATATTCCATTTGATGGCATGATTAGTGAATTATTCGAAGCGACAGATGATTTTGAT
TACATTGTGGCTATGGATCAAAGTAACGTTGATAATATTAAATCTATCAATCCTAATCTTAAGGGACAATTGTTCAAACT
GTTAGAATTTAGTAATATGGAAGAGAGTGATGTACCAGATCCATACTACACGAATAATTTTGAAGGTGTATACGACATGG
TATTATCATCTTGTGATAATTTAATAGACTACATCGTAAAAGATGCAAATTTGAAAGAGGGGTAG

Upstream 100 bases:

>100_bases
CAATTTAATAAACTTTAATAGAATTTTATATAATCTGCTTTCTTATTGTTTAAAGTCGCTATAAAATGGGGATATAACTA
CATAGTTTGGAGGAATCAAA

Downstream 100 bases:

>100_bases
TTTTTTATGGAAAATAAATTTGTTCCTGGTATTTTAATTGGTGCCGTAATTGGTGGTGCAATTAGTTTAGCTGATAAATC
TACACGTCAAGCTTTAGTTC

Product: phosphotyrosine protein phosphatase

Products: NA

Alternate protein names: Phosphotyrosine phosphatase A; PTPase A

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MVDVAFVCLGNICRSPMAEAIMRQRLKDRNIHDIKVHSRGTGSWNLGEPPHEGTQKILNKHNIPFDGMISELFEATDDFD
YIVAMDQSNVDNIKSINPNLKGQLFKLLEFSNMEESDVPDPYYTNNFEGVYDMVLSSCDNLIDYIVKDANLKEG

Sequences:

>Translated_154_residues
MVDVAFVCLGNICRSPMAEAIMRQRLKDRNIHDIKVHSRGTGSWNLGEPPHEGTQKILNKHNIPFDGMISELFEATDDFD
YIVAMDQSNVDNIKSINPNLKGQLFKLLEFSNMEESDVPDPYYTNNFEGVYDMVLSSCDNLIDYIVKDANLKEG
>Mature_154_residues
MVDVAFVCLGNICRSPMAEAIMRQRLKDRNIHDIKVHSRGTGSWNLGEPPHEGTQKILNKHNIPFDGMISELFEATDDFD
YIVAMDQSNVDNIKSINPNLKGQLFKLLEFSNMEESDVPDPYYTNNFEGVYDMVLSSCDNLIDYIVKDANLKEG

Specific function: Dephosphorylates the phosphotyrosine-containing proteins

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family

Homologues:

Organism=Homo sapiens, GI4757714, Length=147, Percent_Identity=34.0136054421769, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI6005988, Length=147, Percent_Identity=34.0136054421769, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI87081812, Length=136, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325330, Length=131, Percent_Identity=35.1145038167939, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI78711846, Length=158, Percent_Identity=34.8101265822785, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI78706770, Length=159, Percent_Identity=36.4779874213836, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI78706772, Length=159, Percent_Identity=36.4779874213836, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI78706766, Length=142, Percent_Identity=31.6901408450704, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI78706768, Length=142, Percent_Identity=31.6901408450704, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI78706764, Length=128, Percent_Identity=32.8125, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24648069, Length=149, Percent_Identity=29.5302013422819, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTPA_STAA3 (Q2FFL4)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_494514.1
- HSSP:   Q9PN39
- ProteinModelPortal:   Q2FFL4
- SMR:   Q2FFL4
- STRING:   Q2FFL4
- EnsemblBacteria:   EBSTAT00000036327
- GeneID:   3913409
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_1862
- eggNOG:   COG0394
- GeneTree:   EBGT00050000025091
- HOGENOM:   HBG730979
- OMA:   VDSAGTH
- ProtClustDB:   CLSK885622
- InterPro:   IPR000106
- InterPro:   IPR017867
- PANTHER:   PTHR11717
- PRINTS:   PR00719
- SMART:   SM00226

Pfam domain/function: PF01451 LMWPc; SSF52788 Tyr_Pase_low_mol_wt

EC number: =3.1.3.48

Molecular weight: Translated: 17491; Mature: 17491

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 14-14 ACT_SITE 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDVAFVCLGNICRSPMAEAIMRQRLKDRNIHDIKVHSRGTGSWNLGEPPHEGTQKILNK
CCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHH
HNIPFDGMISELFEATDDFDYIVAMDQSNVDNIKSINPNLKGQLFKLLEFSNMEESDVPD
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCC
PYYTNNFEGVYDMVLSSCDNLIDYIVKDANLKEG
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVDVAFVCLGNICRSPMAEAIMRQRLKDRNIHDIKVHSRGTGSWNLGEPPHEGTQKILNK
CCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHH
HNIPFDGMISELFEATDDFDYIVAMDQSNVDNIKSINPNLKGQLFKLLEFSNMEESDVPD
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCC
PYYTNNFEGVYDMVLSSCDNLIDYIVKDANLKEG
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA