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The map label for this gene is hemL2 [H]

Identifier: 57652083

GI number: 57652083

Start: 1984853

End: 1986142

Strand: Direct

Name: hemL2 [H]

Synonym: SACOL1922

Alternate gene names: 57652083

Gene position: 1984853-1986142 (Clockwise)

Preceding gene: 57650650

Following gene: 57652084

Centisome position: 70.65

GC content: 36.67

Gene sequence:

>1290_bases
ATGAATTTTAGTGAAAGTGAACGTTTACAACAACTTTCAAACGAATATATTCTAGGCGGTGTCAATTCCCCTTCTCGTTC
TTATAAAGCTGTAGGAGGCGGTGCACCTGTTGTTATGAAAGAAGGACACGGTGCATATTTATATGATGTCGATGGCAATA
AATTTATTGATTACCTTCAAGCATACGGTCCAATTATTACGGGGCATGCACATCCTCATATTACTAAAGCAATTCAAGAA
CAAGCTGCTAAAGGTGTTTTATTTGGTACACCGACTGAATTAGAAATTGAATTCAGCAAAAAATTACGTGATGCAATTCC
ATCTCTTGAGAAAATTCGCTTTGTAAATTCTGGAACAGAAGCAGTCATGACAACAATTCGTGTTGCACGTGCATATACTA
AAAGAAATAAAATTATAAAATTTGCTGGATCTTATCATGGCCATTCTGATTTAGTATTGGTTGCAGCAGGTAGCGGCCCA
TCTCAGCTCGGTTCTCCAGACTCAGCTGGTGTTCCAGAAAGCGTCGCACGTGAAGTCATTACTGTACCTTTCAATGATAT
TAACGCCTATAAAGAAGCAATTGAATTTTGGGGTGATGAAATTGCCGCAGTATTAGTAGAACCAATTGTTGGTAACTTTG
GAATGGTAATGCCTCAACCTGGATTTTTAGAAGAGGTTAATGAAATTTCACATAACAATGGGACCCTAGTGATTTATGAT
GAAGTAATTACTGCATTCCGTTTCCATTACGGTGCCGCTCAAGATTTATTAGGTGTTATCCCTGATTTAACTGCATTTGG
TAAAATTGTTGGCGGTGGTTTACCAATTGGAGGCTATGGTGGACGTCAAGATATTATGGAACAAGTAGCACCTCTAGGAC
CTGCATATCAAGCTGGTACAATGGCTGGTAACCCGTTATCTATGAAAGCAGGTATTGCATTACTCGAAGTACTAGAACAA
GACGGTGTTTATGAAAAATTAGACAGCTTAGGCCAACAACTAGAAGAAGGTTTACTTAAATTAATCGAAAAACATAATAT
CACAGCTACAATTAATCGTATTTATGGATCTTTAACATTGTACTTTACAGATGAAAAAGTCACACATTATGATCAAGTTG
AACATTCTGACGGCGAAGCGTTCGGTAAATTTTTCAAATTAATGTTAAATCAAGGTATCAATTTAGCACCTTCTAAGTTT
GAAGCTTGGTTCTTAACAACTGAACATACAGAAGAAGATATTAAACAAACTTTAAAAGCTGCAGACTATGCTTTTAGTCA
AATGAAATAA

Upstream 100 bases:

>100_bases
TGTTCTCCTTTTTGCAACATATAATCACCTTTTTCTTCATTATAATAATTTTATGATACGATATTAGATGAAAATATTAA
ATTAAAAGAGGTTGATATAA

Downstream 100 bases:

>100_bases
CTTTTAAGGAAGTATATTTTTAATTGAATTAAAATAAAGCAAATGCTCACATAGTAGATTCATTTTATATCGTTAACTAT
TAACGTTTAACTTGATATGT

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1 [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MNFSESERLQQLSNEYILGGVNSPSRSYKAVGGGAPVVMKEGHGAYLYDVDGNKFIDYLQAYGPIITGHAHPHITKAIQE
QAAKGVLFGTPTELEIEFSKKLRDAIPSLEKIRFVNSGTEAVMTTIRVARAYTKRNKIIKFAGSYHGHSDLVLVAAGSGP
SQLGSPDSAGVPESVAREVITVPFNDINAYKEAIEFWGDEIAAVLVEPIVGNFGMVMPQPGFLEEVNEISHNNGTLVIYD
EVITAFRFHYGAAQDLLGVIPDLTAFGKIVGGGLPIGGYGGRQDIMEQVAPLGPAYQAGTMAGNPLSMKAGIALLEVLEQ
DGVYEKLDSLGQQLEEGLLKLIEKHNITATINRIYGSLTLYFTDEKVTHYDQVEHSDGEAFGKFFKLMLNQGINLAPSKF
EAWFLTTEHTEEDIKQTLKAADYAFSQMK

Sequences:

>Translated_429_residues
MNFSESERLQQLSNEYILGGVNSPSRSYKAVGGGAPVVMKEGHGAYLYDVDGNKFIDYLQAYGPIITGHAHPHITKAIQE
QAAKGVLFGTPTELEIEFSKKLRDAIPSLEKIRFVNSGTEAVMTTIRVARAYTKRNKIIKFAGSYHGHSDLVLVAAGSGP
SQLGSPDSAGVPESVAREVITVPFNDINAYKEAIEFWGDEIAAVLVEPIVGNFGMVMPQPGFLEEVNEISHNNGTLVIYD
EVITAFRFHYGAAQDLLGVIPDLTAFGKIVGGGLPIGGYGGRQDIMEQVAPLGPAYQAGTMAGNPLSMKAGIALLEVLEQ
DGVYEKLDSLGQQLEEGLLKLIEKHNITATINRIYGSLTLYFTDEKVTHYDQVEHSDGEAFGKFFKLMLNQGINLAPSKF
EAWFLTTEHTEEDIKQTLKAADYAFSQMK
>Mature_429_residues
MNFSESERLQQLSNEYILGGVNSPSRSYKAVGGGAPVVMKEGHGAYLYDVDGNKFIDYLQAYGPIITGHAHPHITKAIQE
QAAKGVLFGTPTELEIEFSKKLRDAIPSLEKIRFVNSGTEAVMTTIRVARAYTKRNKIIKFAGSYHGHSDLVLVAAGSGP
SQLGSPDSAGVPESVAREVITVPFNDINAYKEAIEFWGDEIAAVLVEPIVGNFGMVMPQPGFLEEVNEISHNNGTLVIYD
EVITAFRFHYGAAQDLLGVIPDLTAFGKIVGGGLPIGGYGGRQDIMEQVAPLGPAYQAGTMAGNPLSMKAGIALLEVLEQ
DGVYEKLDSLGQQLEEGLLKLIEKHNITATINRIYGSLTLYFTDEKVTHYDQVEHSDGEAFGKFFKLMLNQGINLAPSKF
EAWFLTTEHTEEDIKQTLKAADYAFSQMK

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=321, Percent_Identity=33.0218068535826, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI13994255, Length=354, Percent_Identity=26.8361581920904, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI37574042, Length=360, Percent_Identity=26.6666666666667, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI24119277, Length=341, Percent_Identity=27.5659824046921, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI284507298, Length=237, Percent_Identity=33.7552742616034, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI226442709, Length=319, Percent_Identity=27.8996865203762, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI226442705, Length=360, Percent_Identity=25.8333333333333, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1786349, Length=427, Percent_Identity=47.0725995316159, Blast_Score=427, Evalue=1e-121,
Organism=Escherichia coli, GI1789016, Length=338, Percent_Identity=32.8402366863905, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI145693181, Length=430, Percent_Identity=29.0697674418605, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788044, Length=338, Percent_Identity=30.4733727810651, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1789759, Length=328, Percent_Identity=28.6585365853659, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1787560, Length=362, Percent_Identity=27.6243093922652, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786991, Length=381, Percent_Identity=26.509186351706, Blast_Score=92, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=335, Percent_Identity=30.1492537313433, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71992977, Length=345, Percent_Identity=27.2463768115942, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI32564660, Length=330, Percent_Identity=29.0909090909091, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=177, Percent_Identity=32.2033898305085, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=387, Percent_Identity=26.8733850129199, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324432, Length=328, Percent_Identity=25.3048780487805, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21357415, Length=321, Percent_Identity=29.595015576324, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI161085790, Length=357, Percent_Identity=27.1708683473389, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI28574759, Length=357, Percent_Identity=27.1708683473389, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI21356575, Length=370, Percent_Identity=27.5675675675676, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46757; Mature: 46757

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFSESERLQQLSNEYILGGVNSPSRSYKAVGGGAPVVMKEGHGAYLYDVDGNKFIDYLQ
CCCCHHHHHHHHCCCEEEECCCCCCCCCEECCCCCCEEEECCCCEEEEECCCHHHHHHHH
AYGPIITGHAHPHITKAIQEQAAKGVLFGTPTELEIEFSKKLRDAIPSLEKIRFVNSGTE
HHCCEEECCCCHHHHHHHHHHHHCCCEECCCCCEEEHHHHHHHHHCCCHHHHHHHCCCHH
AVMTTIRVARAYTKRNKIIKFAGSYHGHSDLVLVAAGSGPSQLGSPDSAGVPESVAREVI
HHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCHHCCCCCCCCCCHHHHHHEE
TVPFNDINAYKEAIEFWGDEIAAVLVEPIVGNFGMVMPQPGFLEEVNEISHNNGTLVIYD
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEEH
EVITAFRFHYGAAQDLLGVIPDLTAFGKIVGGGLPIGGYGGRQDIMEQVAPLGPAYQAGT
HHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
MAGNPLSMKAGIALLEVLEQDGVYEKLDSLGQQLEEGLLKLIEKHNITATINRIYGSLTL
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCEEEE
YFTDEKVTHYDQVEHSDGEAFGKFFKLMLNQGINLAPSKFEAWFLTTEHTEEDIKQTLKA
EEECCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
ADYAFSQMK
HHHHHHHCC
>Mature Secondary Structure
MNFSESERLQQLSNEYILGGVNSPSRSYKAVGGGAPVVMKEGHGAYLYDVDGNKFIDYLQ
CCCCHHHHHHHHCCCEEEECCCCCCCCCEECCCCCCEEEECCCCEEEEECCCHHHHHHHH
AYGPIITGHAHPHITKAIQEQAAKGVLFGTPTELEIEFSKKLRDAIPSLEKIRFVNSGTE
HHCCEEECCCCHHHHHHHHHHHHCCCEECCCCCEEEHHHHHHHHHCCCHHHHHHHCCCHH
AVMTTIRVARAYTKRNKIIKFAGSYHGHSDLVLVAAGSGPSQLGSPDSAGVPESVAREVI
HHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCHHCCCCCCCCCCHHHHHHEE
TVPFNDINAYKEAIEFWGDEIAAVLVEPIVGNFGMVMPQPGFLEEVNEISHNNGTLVIYD
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEEH
EVITAFRFHYGAAQDLLGVIPDLTAFGKIVGGGLPIGGYGGRQDIMEQVAPLGPAYQAGT
HHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
MAGNPLSMKAGIALLEVLEQDGVYEKLDSLGQQLEEGLLKLIEKHNITATINRIYGSLTL
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCEEEE
YFTDEKVTHYDQVEHSDGEAFGKFFKLMLNQGINLAPSKFEAWFLTTEHTEEDIKQTLKA
EEECCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
ADYAFSQMK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA