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The map label for this gene is ald2

Identifier: 57652007

GI number: 57652007

Start: 1797492

End: 1798610

Strand: Reverse

Name: ald2

Synonym: SACOL1758

Alternate gene names: 57652007

Gene position: 1798610-1797492 (Counterclockwise)

Preceding gene: 57652009

Following gene: 57652006

Centisome position: 64.02

GC content: 35.92

Gene sequence:

>1119_bases
ATGAAAATTGGTATACCAAGGGAGATTAAAAATAATGAAAATCGTGTTGGTTTATCACCAAGTGGTGTGCACGCTTTAGT
AGAAAGTGGGCATACTGTTTTAGTGGAAACAAATGCGGGTTCAGGATCATTCTTTGAAGATGTAGATTACAAAGAAGCAG
GTGCTGAGATTGTTGCTGAACAAGCAAAAGTTTGGGATGTGGATATGGTTATTAAAGTTAAAGAACCACTTGAATCTGAA
TATCCATATTTTAAAGAAGGGCTTGTATTATTCACTTATCTTCATTTAGCAAATGAAGAAAAATTAACACAAGCTTTGAT
AGATAGAAAAGTAATTAGTATTGCATATGAGACTGTGCAGTTACCAGACCGATCTTTACCATTGTTATCACCAATGAGTG
AGGTAGCAGGAAGAATGTCAGCTCAAGTTGGCGCAGAGTTCCTACAAAAACTTAATGGTGGTATGGGAATTCTACTAGGT
GGTGTCCCAGGAGTACCTAAGGGTAAAGTAACTATTATCGGTGGTGGTCAAGCAGGAACAAATGCAGCTAAAATTGCACT
AGGACTAGGTGCAGATGTTACGATTTTAGATGTTAATCCAAAGCGTTTACAACAATTAGATGATTTATTCGGTGGACGTG
TACATACAATTATGTCAAATCCGTTGAATATTGAGTTGTATGTTAAACAAAGTGATTTAGTAATAGGTGCAGTTTTAATT
CCAGGTGCTAAAGCGCCAAGACTTGTAACAGAAGACATGATTAAACAAATGAAAAATGGGTCAGTTATTATTGACATTGC
TATTGATCAAGGCGGTATTTTTGAAACAACTGATAAAATTACGACACATGATGATCCTACATATATTAAGCATGGTGTGG
TTCATTATGCAGTTGCAAATATGCCAGGTGCAGTACCGCGTACTTCGACGTTAGCTTTAAATAATGCTACGCTACCTTAT
GCGCTCATGCTAGCTAATAAAGGGTATAGAGAAGCATTTAAATCAAATCAACCATTATCATTAGGTTTAAATACTTACAA
AGGTCACGTAACCAATAAAGGCGTTGCAGAGGCATTTGAAATGGAATATAAATCTGTAGAAGAAGCATTACAATTATAA

Upstream 100 bases:

>100_bases
CAATTTTCGGAAAAGTCAGTGTAATAACCTTTACAATTTTGTGGATTTTTGATTGCGCTTTCAAAATGTTCGCGTTAAGA
TGATTATGGAGGTGGATGGT

Downstream 100 bases:

>100_bases
TTTGAATTTGATGAAAAGGGAATGGATTACAGCGTACTAAAGAATGACGTTATCATCTCCTTGGTTATTAAAATTAAATA
ATGATAAATTAAAGCTAGAA

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESE
YPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLG
GVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLI
PGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPY
ALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL

Sequences:

>Translated_372_residues
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESE
YPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLG
GVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLI
PGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPY
ALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
>Mature_372_residues
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESE
YPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLG
GVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLI
PGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPY
ALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family

Homologues:

Organism=Homo sapiens, GI122939155, Length=348, Percent_Identity=32.183908045977, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI122939153, Length=348, Percent_Identity=32.183908045977, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1787887, Length=336, Percent_Identity=33.6309523809524, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17550456, Length=347, Percent_Identity=31.4121037463977, Blast_Score=153, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHA2_STAA3 (Q2FG29)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_494349.1
- ProteinModelPortal:   Q2FG29
- SMR:   Q2FG29
- STRING:   Q2FG29
- EnsemblBacteria:   EBSTAT00000036533
- GeneID:   3914161
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_1655
- eggNOG:   COG0686
- GeneTree:   EBGT00050000024386
- HOGENOM:   HBG289735
- OMA:   VAHGHEV
- ProtClustDB:   CLSK885510
- GO:   GO:0005488
- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141
- PIRSF:   PIRSF000183
- TIGRFAMs:   TIGR00518

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N

EC number: =1.4.1.1

Molecular weight: Translated: 40106; Mature: 40106

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00836 ALADH_PNT_1; PS00837 ALADH_PNT_2

Important sites: ACT_SITE 95-95

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAE
CCCCCCCHHCCCCCEECCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
QAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQ
HHHEECEEEEEEECCCCCCCCCHHHCCHHEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
LPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCCC
NAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLI
CCEEEEEECCCCEEEEECCHHHHHHHHHHHCCEEEEEECCCCEEEEEEEECCEEEEEEEE
PGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVAN
CCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHEEHHHC
MPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFE
CCCCCCCCEEEEECCCCCCEEEEECCCCHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHH
MEYKSVEEALQL
HHHHHHHHHHCC
>Mature Secondary Structure
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAE
CCCCCCCHHCCCCCEECCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
QAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQ
HHHEECEEEEEEECCCCCCCCCHHHCCHHEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
LPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCCC
NAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLI
CCEEEEEECCCCEEEEECCHHHHHHHHHHHCCEEEEEECCCCEEEEEEEECCEEEEEEEE
PGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVAN
CCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHEEHHHC
MPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFE
CCCCCCCCEEEEECCCCCCEEEEECCCCHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHH
MEYKSVEEALQL
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA