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The map label for this gene is lysA [H]

Identifier: 57651900

GI number: 57651900

Start: 1447587

End: 1448852

Strand: Direct

Name: lysA [H]

Synonym: SACOL1435

Alternate gene names: 57651900

Gene position: 1447587-1448852 (Clockwise)

Preceding gene: 57651899

Following gene: 57651904

Centisome position: 51.53

GC content: 33.57

Gene sequence:

>1266_bases
ATGACTGTTAAATATAATCAAAATGGCGAATTAACAATGGATGGTATTAGTTTAAAAACGATTGCACAAAGCTTTGGTAC
ACCTACCATTGTTTATGATGAACTACAAATTAGAGAACAGATGCGCCGTTACCATCGCGCATTTAAAGATAGTGGATTAA
AATACAATATTTCATACGCCTCAAAGGCATTTACTTGCATTCAAATGGTCAAACTTGTAGCTGAGGAAGATTTACAGTTA
GATGTTGTTTCTGAAGGTGAATTATATACAGCTTTAGAAGCAGGTTTTGAACCGAGTCGCATCCATTTCCATGGTAACAA
TAAAACGAAACATGAAATTAGGTATGCTTTAGAAAATAATATCGGTTATTTTGTTATAGATTCATTAGAAGAAATTGAAT
TAATAGACCGCTATGCTAATGATACGGTTCAAGTTGTATTACGAGTTAATCCAGGTGTTGAAGCACATACACACGAATTT
ATTCAAACTGGGCAAGAAGATAGTAAGTTTGGATTATCAATTCAATATGGCTTAGCTAAAAAAGCAATTGACAAAGTCCA
ACAATCTAAACACTTAAAATTAAAAGGTGTACATTGTCATATTGGTTCACAGATTGAAGGTACAGAAGCATTTATTGAAA
CTGCTAAAATTGTTTTACGTTGGCTTAAAGAGCAAGGCATTCAAGTTGAATTATTAAACCTTGGTGGTGGCTTTGGTATT
AAATATGTTGAAGGTGACGAAAGTTTCCCTATCGAAAGTGGTATTAAAGATATTACAGACGCAATAAAATCCGAAATTAA
AGTTCTAGGTATAGATGCACCAGAAATAGGTATTGAACCGGGACGATCAATTGTAGGTGAAGCTGGCGTTACTTTATATG
AAGTTGGAACCATTAAAGAAATTCCAGAGATTAATAAATATGTTTCAATCGATGGCGGTATGAGTGATCATATCAGAACT
GCACTTTATGACGCAAAGTATCAAGCATTGCTTGTTAATAGAAATGAAGAAGCAGATGACAGTGTAACTATAGCTGGAAA
ATTATGTGAGTCTGGTGATATCATTATTAAAGACGCTAAATTACCTTCATCAGTCAAACGTGGAGACTATCTTGCTATAT
TATCAACTGGTGCATATCATTACTCTATGGCATCCAATTACAATCAAATGCAAAAGCCTTCTGTGTTTTTCTTAAAAGAT
GGCAAAGCACGTGAAGTTATAAAGCGACAATCGTTAAGACAACTCATTATTAATGATACAAAATAA

Upstream 100 bases:

>100_bases
GATATCCGCATCGATGAATATACCTTTAAAGGTGTTGGTGCAAATTCTGAACAATTAAGTGCTATGAATCATGATTCTTT
AAAAAAGGAGTACATTTCAA

Downstream 100 bases:

>100_bases
AAATAAACAAAGTAATCCCCGAAGCACAGAAAATTATACTGTGACTCGGGGAATTTTTATGCATTATAGATGACTGTAGA
AAACATGCTTGGACATATAC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTVKYNQNGELTMDGISLKTIAQSFGTPTIVYDELQIREQMRRYHRAFKDSGLKYNISYASKAFTCIQMVKLVAEEDLQL
DVVSEGELYTALEAGFEPSRIHFHGNNKTKHEIRYALENNIGYFVIDSLEEIELIDRYANDTVQVVLRVNPGVEAHTHEF
IQTGQEDSKFGLSIQYGLAKKAIDKVQQSKHLKLKGVHCHIGSQIEGTEAFIETAKIVLRWLKEQGIQVELLNLGGGFGI
KYVEGDESFPIESGIKDITDAIKSEIKVLGIDAPEIGIEPGRSIVGEAGVTLYEVGTIKEIPEINKYVSIDGGMSDHIRT
ALYDAKYQALLVNRNEEADDSVTIAGKLCESGDIIIKDAKLPSSVKRGDYLAILSTGAYHYSMASNYNQMQKPSVFFLKD
GKAREVIKRQSLRQLIINDTK

Sequences:

>Translated_421_residues
MTVKYNQNGELTMDGISLKTIAQSFGTPTIVYDELQIREQMRRYHRAFKDSGLKYNISYASKAFTCIQMVKLVAEEDLQL
DVVSEGELYTALEAGFEPSRIHFHGNNKTKHEIRYALENNIGYFVIDSLEEIELIDRYANDTVQVVLRVNPGVEAHTHEF
IQTGQEDSKFGLSIQYGLAKKAIDKVQQSKHLKLKGVHCHIGSQIEGTEAFIETAKIVLRWLKEQGIQVELLNLGGGFGI
KYVEGDESFPIESGIKDITDAIKSEIKVLGIDAPEIGIEPGRSIVGEAGVTLYEVGTIKEIPEINKYVSIDGGMSDHIRT
ALYDAKYQALLVNRNEEADDSVTIAGKLCESGDIIIKDAKLPSSVKRGDYLAILSTGAYHYSMASNYNQMQKPSVFFLKD
GKAREVIKRQSLRQLIINDTK
>Mature_420_residues
TVKYNQNGELTMDGISLKTIAQSFGTPTIVYDELQIREQMRRYHRAFKDSGLKYNISYASKAFTCIQMVKLVAEEDLQLD
VVSEGELYTALEAGFEPSRIHFHGNNKTKHEIRYALENNIGYFVIDSLEEIELIDRYANDTVQVVLRVNPGVEAHTHEFI
QTGQEDSKFGLSIQYGLAKKAIDKVQQSKHLKLKGVHCHIGSQIEGTEAFIETAKIVLRWLKEQGIQVELLNLGGGFGIK
YVEGDESFPIESGIKDITDAIKSEIKVLGIDAPEIGIEPGRSIVGEAGVTLYEVGTIKEIPEINKYVSIDGGMSDHIRTA
LYDAKYQALLVNRNEEADDSVTIAGKLCESGDIIIKDAKLPSSVKRGDYLAILSTGAYHYSMASNYNQMQKPSVFFLKDG
KAREVIKRQSLRQLIINDTK

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=427, Percent_Identity=30.6791569086651, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322664, Length=366, Percent_Identity=24.3169398907104, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586472, Length=355, Percent_Identity=24.5070422535211, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47035; Mature: 46904

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKYNQNGELTMDGISLKTIAQSFGTPTIVYDELQIREQMRRYHRAFKDSGLKYNISYA
CEEEECCCCCEEECCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEHH
SKAFTCIQMVKLVAEEDLQLDVVSEGELYTALEAGFEPSRIHFHGNNKTKHEIRYALENN
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHCCCCCCEEEECCCCCCHHHHHHHHHCC
IGYFVIDSLEEIELIDRYANDTVQVVLRVNPGVEAHTHEFIQTGQEDSKFGLSIQYGLAK
CCEEEECCHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCEEEEHHHHH
KAIDKVQQSKHLKLKGVHCHIGSQIEGTEAFIETAKIVLRWLKEQGIQVELLNLGGGFGI
HHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEE
KYVEGDESFPIESGIKDITDAIKSEIKVLGIDAPEIGIEPGRSIVGEAGVTLYEVGTIKE
EEEECCCCCCHHCCHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHCCCCEEEEECCCCCC
IPEINKYVSIDGGMSDHIRTALYDAKYQALLVNRNEEADDSVTIAGKLCESGDIIIKDAK
CCCCCCEEEECCCCHHHHHHHHHHCCEEEEEEECCCCCCCCEEEEEEECCCCCEEEECCC
LPSSVKRGDYLAILSTGAYHYSMASNYNQMQKPSVFFLKDGKAREVIKRQSLRQLIINDT
CCCCCCCCCEEEEEECCCEEEEHHCCCCHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCC
K
C
>Mature Secondary Structure 
TVKYNQNGELTMDGISLKTIAQSFGTPTIVYDELQIREQMRRYHRAFKDSGLKYNISYA
EEEECCCCCEEECCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEHH
SKAFTCIQMVKLVAEEDLQLDVVSEGELYTALEAGFEPSRIHFHGNNKTKHEIRYALENN
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHCCCCCCEEEECCCCCCHHHHHHHHHCC
IGYFVIDSLEEIELIDRYANDTVQVVLRVNPGVEAHTHEFIQTGQEDSKFGLSIQYGLAK
CCEEEECCHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCEEEEHHHHH
KAIDKVQQSKHLKLKGVHCHIGSQIEGTEAFIETAKIVLRWLKEQGIQVELLNLGGGFGI
HHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEE
KYVEGDESFPIESGIKDITDAIKSEIKVLGIDAPEIGIEPGRSIVGEAGVTLYEVGTIKE
EEEECCCCCCHHCCHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHCCCCEEEEECCCCCC
IPEINKYVSIDGGMSDHIRTALYDAKYQALLVNRNEEADDSVTIAGKLCESGDIIIKDAK
CCCCCCEEEECCCCHHHHHHHHHHCCEEEEEEECCCCCCCCEEEEEEECCCCCEEEECCC
LPSSVKRGDYLAILSTGAYHYSMASNYNQMQKPSVFFLKDGKAREVIKRQSLRQLIINDT
CCCCCCCCCEEEEEECCCEEEEHHCCCCHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]