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The map label for this gene is gpxA1

Identifier: 57651874

GI number: 57651874

Start: 1342869

End: 1343345

Strand: Reverse

Name: gpxA1

Synonym: SACOL1325

Alternate gene names: 57651874

Gene position: 1343345-1342869 (Counterclockwise)

Preceding gene: 57650318

Following gene: 57651857

Centisome position: 47.82

GC content: 33.54

Gene sequence:

>477_bases
ATGGAGACAATTTATGATTTTGTAGTAGAAACAAATAAAGGTGTTACTTACAAATTAGATGCATATAAGGGTGACGTTAT
GCTAATTGTTAATACAGCTAGCGAATGTGGCTTTACTTCACAATTTGAAGGTTTGCAATCATTATACGAGAAATACAAAG
ATCAAGGGTTTGTAATTCTAGGTTTCCCTTGTAATCAATTTGGTGGCCAAGAACCTGGTTCAGGCGAAGAAGCAGCTCAA
AACTGTAAATTAAACTATGGTGTTACCTTCCCTATGCATCAAAAAATAGACGTAAAAGGGGAACATCAATTACCTTTATT
TAGATATTTGACTGCGGCACAACACGGATTCTTTAATGAGAAAATCAAATGGAATTTCACTAAGTTTTTAGTGGATCGCG
AAGGTAACGTTGTTAAACGATTTGCACCTCAAAAAAAACCTGTTCAAATCGAAAGAGAAATAGAAAAATTATTATAA

Upstream 100 bases:

>100_bases
CCTTAATAAAATCCTACTCAAAGTATTCTATCATAGAGTTTTAGTAAAGACTATTACACGATTTTGTGGTACATTTTAAG
TAAATCGAAAGGATGATACA

Downstream 100 bases:

>100_bases
AATATACTAGCTCATAGCAAATAAAACGCTTCATATAAAGTCGTATCATATATTGACTCGACCTTTATATGAAGCGTTTT
TATTACAAACATTCCTCTAT

Product: glutathione peroxidase

Products: glutathione disulfide; H2O

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
METIYDFVVETNKGVTYKLDAYKGDVMLIVNTASECGFTSQFEGLQSLYEKYKDQGFVILGFPCNQFGGQEPGSGEEAAQ
NCKLNYGVTFPMHQKIDVKGEHQLPLFRYLTAAQHGFFNEKIKWNFTKFLVDREGNVVKRFAPQKKPVQIEREIEKLL

Sequences:

>Translated_158_residues
METIYDFVVETNKGVTYKLDAYKGDVMLIVNTASECGFTSQFEGLQSLYEKYKDQGFVILGFPCNQFGGQEPGSGEEAAQ
NCKLNYGVTFPMHQKIDVKGEHQLPLFRYLTAAQHGFFNEKIKWNFTKFLVDREGNVVKRFAPQKKPVQIEREIEKLL
>Mature_158_residues
METIYDFVVETNKGVTYKLDAYKGDVMLIVNTASECGFTSQFEGLQSLYEKYKDQGFVILGFPCNQFGGQEPGSGEEAAQ
NCKLNYGVTFPMHQKIDVKGEHQLPLFRYLTAAQHGFFNEKIKWNFTKFLVDREGNVVKRFAPQKKPVQIEREIEKLL

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family

Homologues:

Organism=Homo sapiens, GI192455698, Length=153, Percent_Identity=39.8692810457516, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI75709200, Length=156, Percent_Identity=39.7435897435897, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI90903240, Length=156, Percent_Identity=39.7435897435897, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI15618997, Length=155, Percent_Identity=39.3548387096774, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI4557629, Length=173, Percent_Identity=34.6820809248555, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI90903238, Length=131, Percent_Identity=38.9312977099237, Blast_Score=90, Evalue=7e-19,
Organism=Homo sapiens, GI6006001, Length=173, Percent_Identity=32.9479768786127, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI32967607, Length=182, Percent_Identity=29.6703296703297, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI33186887, Length=177, Percent_Identity=31.0734463276836, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI41406084, Length=183, Percent_Identity=29.5081967213115, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1788003, Length=166, Percent_Identity=42.7710843373494, Blast_Score=139, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17506887, Length=159, Percent_Identity=42.7672955974843, Blast_Score=139, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17535473, Length=159, Percent_Identity=40.8805031446541, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193210707, Length=163, Percent_Identity=46.0122699386503, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71993584, Length=157, Percent_Identity=36.3057324840764, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI193209493, Length=164, Percent_Identity=36.5853658536585, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17550320, Length=164, Percent_Identity=35.3658536585366, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71999642, Length=76, Percent_Identity=43.421052631579, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193210709, Length=72, Percent_Identity=51.3888888888889, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319721, Length=157, Percent_Identity=53.5031847133758, Blast_Score=176, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322228, Length=159, Percent_Identity=50.9433962264151, Blast_Score=171, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6322826, Length=159, Percent_Identity=44.0251572327044, Blast_Score=134, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24656772, Length=161, Percent_Identity=46.583850931677, Blast_Score=146, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24656777, Length=161, Percent_Identity=46.583850931677, Blast_Score=145, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24656767, Length=161, Percent_Identity=46.583850931677, Blast_Score=145, Evalue=1e-35,
Organism=Drosophila melanogaster, GI85726443, Length=158, Percent_Identity=46.8354430379747, Blast_Score=135, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BSAA_STAAC (Q5HGC7)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_186180.1
- ProteinModelPortal:   Q5HGC7
- SMR:   Q5HGC7
- STRING:   Q5HGC7
- EnsemblBacteria:   EBSTAT00000009412
- GeneID:   3236399
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1325
- TIGR:   SACOL1325
- eggNOG:   COG0386
- GeneTree:   EBGT00050000024122
- HOGENOM:   HBG648990
- OMA:   FLVDPAS
- ProtClustDB:   CLSK885262
- BioCyc:   SAUR93062:SACOL1325-MONOMER
- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR11592
- PIRSF:   PIRSF000303
- PRINTS:   PR01011

Pfam domain/function: PF00255 GSHPx; SSF52833 Thiordxn-like_fd

EC number: 1.11.1.9

Molecular weight: Translated: 18118; Mature: 18118

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1; PS00763 GLUTATHIONE_PEROXID_2; PS51355 GLUTATHIONE_PEROXID_3

Important sites: ACT_SITE 36-36

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIYDFVVETNKGVTYKLDAYKGDVMLIVNTASECGFTSQFEGLQSLYEKYKDQGFVIL
CCCCEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEE
GFPCNQFGGQEPGSGEEAAQNCKLNYGVTFPMHQKIDVKGEHQLPLFRYLTAAQHGFFNE
ECCHHHCCCCCCCCCHHHHHCCEEECCEECCCCCEECCCCCCCCHHHHHHHHHHCCCCCC
KIKWNFTKFLVDREGNVVKRFAPQKKPVQIEREIEKLL
EEEEEEEEEEEECCCCEEECCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
METIYDFVVETNKGVTYKLDAYKGDVMLIVNTASECGFTSQFEGLQSLYEKYKDQGFVIL
CCCCEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEE
GFPCNQFGGQEPGSGEEAAQNCKLNYGVTFPMHQKIDVKGEHQLPLFRYLTAAQHGFFNE
ECCHHHCCCCCCCCCHHHHHCCEEECCEECCCCCEECCCCCCCCHHHHHHHHHHCCCCCC
KIKWNFTKFLVDREGNVVKRFAPQKKPVQIEREIEKLL
EEEEEEEEEEEECCCCEEECCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutathione; H2O2

Specific reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA