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The map label for this gene is mutL [H]

Identifier: 57651866

GI number: 57651866

Start: 1333086

End: 1335095

Strand: Direct

Name: mutL [H]

Synonym: SACOL1316

Alternate gene names: 57651866

Gene position: 1333086-1335095 (Clockwise)

Preceding gene: 57651865

Following gene: 57651867

Centisome position: 47.45

GC content: 31.39

Gene sequence:

>2010_bases
ATGGGGAAAATTAAAGAACTCCAAACCTCATTAGCAAATAAAATCGCAGCAGGTGAAGTAGTTGAAAGACCGAGTTCTGT
TGTGAAAGAACTGTTGGAAAATGCTATAGATGCAGGCGCTACAGAAATAAGCATTGAAGTAGAGGAATCTGGCGTCCAAT
CTATTCGCGTAGTCGATAATGGAAGCGGAATTGAAGCGGAAGACTTAGGATTAGTATTTCATAGACATGCGACTAGTAAA
TTAGATCAAGATGAAGATTTATTTCATATTAGGACATTAGGATTCCGTGGTGAAGCACTAGCCAGTATTTCATCAGTTGC
TAAAGTAACATTGAAGACTTGCACGGATAATGCTAATGGAAATGAAATATATGTAGAAAATGGTGAAATATTAAATCATA
AGCCTGCAAAAGCGAAAAAAGGAACAGATATACTTGTAGAATCATTATTTTATAATACACCAGCACGTTTAAAATATATT
AAAAGTTTATACACTGAACTAGGTAAAATAACAGATATTGTCAACAGAATGGCAATGAGCCATCCGGACATTCGAATAGC
ACTCATTTCAGATGGCAAAACAATGTTAAGTACAAATGGTTCAGGACGAACTAATGAAGTGATGGCAGAGATTTATGGGA
TGAAAGTTGCACGAGATTTAGTACATATATCTGGAGATACAAGTGATTATCACATTGAAGGTTTTGTTGCAAAGCCTGAA
CATTCTAGAAGTAATAAGCACTATATTTCTATTTTTATTAATGGACGATACATTAAAAACTTTATGCTAAATAAAGCGAT
TTTAGAAGGCTATCATACACTCTTAACAATAGGTAGGTTCCCGATTTGTTATATTAATATTGAAATGGATCCAATCTTAG
TAGACGTAAATGTTCATCCAACAAAACTAGAAGTGCGTTTATCAAAAGAAGAGCAACTATACCAATTGATTGTGAGCAAA
ATACAAGAAGCATTTAAAGACCGTATATTAATTCCTAAAAATAACTTGGATTATGTGCCAAAAAAAAATAAAGTATTACA
TTCATTCGAACAACAAAAAATCGAATTTGAACAAAGACAAAACACAGAGAATAACCAAGAGAAGACGTTTTCATCTGAAG
AAAGTAACAGTAAGCCATTTATGGAAGAAAATCAAAACGATGAGATAGTTATAAAAGAAGATTCATATAATCCATTCGTA
ACGAAAACATCTGAAAGTTTAATAGCTGATGATGAATCTTCTGGTTATAATAATACACGTGAAAAAGATGAAGACTACTT
CAAAAAACAACAAGAAATTTTACAAGAAATGGATCAAACATTTGATTCAAATGATGGTACAACTGTGCAAAATTATGAGA
ATAAAGCGTCTGATGATTATTATGATGTAAACGATATTAAAGGAACAAAAAGTAAAGACCCTAAACGAAGAATTCCATAT
ATGGAAATTGTTGGACAAGTACATGGAACGTATATTATTGCTCAAAATGAATTTGGCATGTACATGATTGACCAGCATGC
AGCTCAAGAAAGAATAAAATATGAATATTTTCGAGATAAAATAGGTGAGGTTACCAATGAAGTACAAGATTTATTAATCC
CGTTAACATTTCATTTTTCAAAAGATGAACAATTAGTCATTGATCAATATAAAAATGAGCTTCAACAAGTAGGTATCATG
TTAGAACATTTTGGTGGTCATGATTATATTGTAAGTAGCTATCCAGTTTGGTTCCCTAAAGATGAAGTAGAAGAAATTAT
TAAAGATATGATTGAGCTAATTTTGGAAGAGAAAAAAGTAGATATCAAAAAATTACGTGAAGATGTAGCAATCATGATGT
CATGTAAAAAATCCATTAAAGCGAATCATTATTTACAAAAACATGAAATGTCTGATTTAATTGATCAATTAAGAGAAGCG
GAAGATCCATTTACATGTCCACATGGTCGTCCAATAATCATTAATTTTTCAAAATACGAATTAGAAAAATTATTTAAGCG
TGTGATGTAG

Upstream 100 bases:

>100_bases
ACTACAAATTAAAAATTTGAATTTATCTAATATGACACCAATTGAGGCATTGGTGAAGTTAAGTGAATTACAAAATCAAT
TAAAATAGAGGTGTTGCAAA

Downstream 100 bases:

>100_bases
AGAGGATGAATCAAGTGAATAACAACATATTGCCTGCTATAAGAAACATTAAAGATTTAGAGAAACTGATTAAAACAGAC
TATAAAATGTGTGTGCTTCT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 669; Mature: 668

Protein sequence:

>669_residues
MGKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDNGSGIEAEDLGLVFHRHATSK
LDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANGNEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYI
KSLYTELGKITDIVNRMAMSHPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPE
HSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHPTKLEVRLSKEEQLYQLIVSK
IQEAFKDRILIPKNNLDYVPKKNKVLHSFEQQKIEFEQRQNTENNQEKTFSSEESNSKPFMEENQNDEIVIKEDSYNPFV
TKTSESLIADDESSGYNNTREKDEDYFKKQQEILQEMDQTFDSNDGTTVQNYENKASDDYYDVNDIKGTKSKDPKRRIPY
MEIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFSKDEQLVIDQYKNELQQVGIM
LEHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKVDIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREA
EDPFTCPHGRPIIINFSKYELEKLFKRVM

Sequences:

>Translated_669_residues
MGKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDNGSGIEAEDLGLVFHRHATSK
LDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANGNEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYI
KSLYTELGKITDIVNRMAMSHPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPE
HSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHPTKLEVRLSKEEQLYQLIVSK
IQEAFKDRILIPKNNLDYVPKKNKVLHSFEQQKIEFEQRQNTENNQEKTFSSEESNSKPFMEENQNDEIVIKEDSYNPFV
TKTSESLIADDESSGYNNTREKDEDYFKKQQEILQEMDQTFDSNDGTTVQNYENKASDDYYDVNDIKGTKSKDPKRRIPY
MEIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFSKDEQLVIDQYKNELQQVGIM
LEHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKVDIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREA
EDPFTCPHGRPIIINFSKYELEKLFKRVM
>Mature_668_residues
GKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDNGSGIEAEDLGLVFHRHATSKL
DQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANGNEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYIK
SLYTELGKITDIVNRMAMSHPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPEH
SRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHPTKLEVRLSKEEQLYQLIVSKI
QEAFKDRILIPKNNLDYVPKKNKVLHSFEQQKIEFEQRQNTENNQEKTFSSEESNSKPFMEENQNDEIVIKEDSYNPFVT
KTSESLIADDESSGYNNTREKDEDYFKKQQEILQEMDQTFDSNDGTTVQNYENKASDDYYDVNDIKGTKSKDPKRRIPYM
EIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFSKDEQLVIDQYKNELQQVGIML
EHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKVDIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREAE
DPFTCPHGRPIIINFSKYELEKLFKRVM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=337, Percent_Identity=38.2789317507418, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI310128478, Length=350, Percent_Identity=29.7142857142857, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI4505913, Length=350, Percent_Identity=29.7142857142857, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI4505911, Length=405, Percent_Identity=27.1604938271605, Blast_Score=146, Evalue=7e-35,
Organism=Homo sapiens, GI189458898, Length=405, Percent_Identity=27.1604938271605, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI189458896, Length=398, Percent_Identity=27.3869346733668, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI310128480, Length=299, Percent_Identity=28.0936454849498, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI263191589, Length=241, Percent_Identity=34.0248962655602, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI91992160, Length=271, Percent_Identity=28.4132841328413, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI91992162, Length=271, Percent_Identity=28.4132841328413, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI310128482, Length=245, Percent_Identity=24.4897959183673, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI310128484, Length=261, Percent_Identity=23.7547892720307, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1790612, Length=604, Percent_Identity=28.1456953642384, Blast_Score=226, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI71991825, Length=319, Percent_Identity=36.3636363636364, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17562796, Length=359, Percent_Identity=30.9192200557103, Blast_Score=149, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6323819, Length=333, Percent_Identity=39.3393393393393, Blast_Score=212, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324247, Length=368, Percent_Identity=27.445652173913, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325093, Length=286, Percent_Identity=24.4755244755245, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323063, Length=362, Percent_Identity=26.7955801104972, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136968, Length=335, Percent_Identity=35.2238805970149, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17136970, Length=359, Percent_Identity=29.5264623955432, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 76856; Mature: 76725

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDN
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEC
GSGIEAEDLGLVFHRHATSKLDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANG
CCCCCHHHHHHHEEHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCC
NEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYIKSLYTELGKITDIVNRMAMS
CEEEEECCCEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPE
CCCEEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEECCC
HSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHP
CCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECEEEEEEECCC
TKLEVRLSKEEQLYQLIVSKIQEAFKDRILIPKNNLDYVPKKNKVLHSFEQQKIEFEQRQ
CEEEEEECCHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
NTENNQEKTFSSEESNSKPFMEENQNDEIVIKEDSYNPFVTKTSESLIADDESSGYNNTR
CCCCCHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEECCCCHHCCCCCCCCCCCCC
EKDEDYFKKQQEILQEMDQTFDSNDGTTVQNYENKASDDYYDVNDIKGTKSKDPKRRIPY
CCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHCCCH
MEIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFS
HHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEC
KDEQLVIDQYKNELQQVGIMLEHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKV
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC
DIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREAEDPFTCPHGRPIIINFSKYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHH
LEKLFKRVM
HHHHHHHCC
>Mature Secondary Structure 
GKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDN
CCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEC
GSGIEAEDLGLVFHRHATSKLDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANG
CCCCCHHHHHHHEEHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCC
NEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYIKSLYTELGKITDIVNRMAMS
CEEEEECCCEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPE
CCCEEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEECCC
HSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHP
CCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECEEEEEEECCC
TKLEVRLSKEEQLYQLIVSKIQEAFKDRILIPKNNLDYVPKKNKVLHSFEQQKIEFEQRQ
CEEEEEECCHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
NTENNQEKTFSSEESNSKPFMEENQNDEIVIKEDSYNPFVTKTSESLIADDESSGYNNTR
CCCCCHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEECCCCHHCCCCCCCCCCCCC
EKDEDYFKKQQEILQEMDQTFDSNDGTTVQNYENKASDDYYDVNDIKGTKSKDPKRRIPY
CCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHCCCH
MEIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFS
HHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEC
KDEQLVIDQYKNELQQVGIMLEHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKV
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC
DIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREAEDPFTCPHGRPIIINFSKYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHH
LEKLFKRVM
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA