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The map label for this gene is ffh [H]

Identifier: 57651806

GI number: 57651806

Start: 1261699

End: 1263066

Strand: Direct

Name: ffh [H]

Synonym: SACOL1253

Alternate gene names: 57651806

Gene position: 1261699-1263066 (Clockwise)

Preceding gene: 57651805

Following gene: 57651807

Centisome position: 44.91

GC content: 34.94

Gene sequence:

>1368_bases
ATGGCATTTGAAGGGTTATCAGAACGCTTGCAAGCGACGATGCAAAAAATGCGTGGTAAGGGTAAACTTACTGAAGCTGA
TATAAAGATAATGATGCGTGAAGTAAGATTAGCGTTACTTGAGGCTGACGTAAACTTTAAAGTGGTAAAAGAATTTATTA
AAACAGTATCAGAACGCGCATTAGGTTCCGATGTAATGCAATCATTAACACCAGGGCAACAAGTTATTAAAATAGTTCAA
GATGAATTAACGCAGTTGATGGGTGGAGAAAATACGTCGATTAATATGTCAAATAAACCACCTACTGTTGTTATGATGGT
TGGTTTACAAGGTGCTGGTAAAACAACAACTGCAGGTAAATTAGCATTATTGATGCGTAAAAAATACAACAAAAAACCTA
TGTTAGTTGCAGCAGATATTTATCGTCCAGCAGCGATAAATCAATTACAAACAGTAGGGAAACAAATTGATATTCCTGTA
TACAGTGAAGGAGATCAAGTAAAGCCACAACAAATTGTAACTAATGCATTAAAACATGCTAAAGAAGAACATTTAGACTT
TGTAATCATTGATACAGCAGGTCGATTACACATCGATGAAGCATTGATGAACGAATTAAAAGAAGTAAAAGACATTGCTA
AACCAAACGAAATTATGTTAGTTGTCGATTCAATGACGGGTCAAGATGCTGTCAATGTTGCAGAATCTTTTGACGATCAA
CTTGATGTCACAGGTGTTACCTTAACTAAATTAGATGGTGATACACGTGGTGGTGCAGCTTTATCTATTCGTTCGGTGAC
ACAAAAACCAATTAAATTTGTTGGTATGAGTGAAAAGTTAGATGGTTTAGAGCTATTCCATCCTGAACGTATGGCATCAC
GTATTTTAGGTATGGGTGATGTGTTAAGTTTAATTGAAAAAGCGCAACAAGATGTGGATCAAGAAAAAGCAAAAGATTTA
GAGAAAAAGATGCGTGAGTCATCGTTTACTTTAGATGATTTTTTAGAACAACTTGATCAGGTGAAAAATCTAGGACCACT
GGATGATATTATGAAAATGATTCCAGGTATGAATAAAATGAAAGGGCTAGATAAGCTTAATATGAGTGAAAAGCAAATTG
ATCATATTAAAGCGATTATCCAGTCAATGACGCCGGCTGAAAGAAACAATCCAGACACATTGAATGTATCACGTAAAAAG
CGTATTGCTAAAGGGTCTGGTCGTTCATTACAAGAAGTCAATCGTTTGATGAAACAATTTAACGATATGAAGAAAATGAT
GAAACAGTTCACTGGTGGCGGTAAAGGTAAAAAAGGTAAACGCAATCAAATGCAAAATATGTTAAAAGGTATGAATTTAC
CGTTTTAA

Upstream 100 bases:

>100_bases
GATGAAATGAAACAACATTTAAGTAATCCAGAACAAATACAACGTTATATTCAACAATTAGAAGACTTAGAATAGATATA
AATTGAGGGAGGACATCGAT

Downstream 100 bases:

>100_bases
TGTTTAATATAACACGCTGATTTTTGTTGCAATGAGATGTGCATCCCGAAAGTTATACTAAAGAATATAACTTTATGGGG
TGCATATTTTTAGATACACA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MAFEGLSERLQATMQKMRGKGKLTEADIKIMMREVRLALLEADVNFKVVKEFIKTVSERALGSDVMQSLTPGQQVIKIVQ
DELTQLMGGENTSINMSNKPPTVVMMVGLQGAGKTTTAGKLALLMRKKYNKKPMLVAADIYRPAAINQLQTVGKQIDIPV
YSEGDQVKPQQIVTNALKHAKEEHLDFVIIDTAGRLHIDEALMNELKEVKDIAKPNEIMLVVDSMTGQDAVNVAESFDDQ
LDVTGVTLTKLDGDTRGGAALSIRSVTQKPIKFVGMSEKLDGLELFHPERMASRILGMGDVLSLIEKAQQDVDQEKAKDL
EKKMRESSFTLDDFLEQLDQVKNLGPLDDIMKMIPGMNKMKGLDKLNMSEKQIDHIKAIIQSMTPAERNNPDTLNVSRKK
RIAKGSGRSLQEVNRLMKQFNDMKKMMKQFTGGGKGKKGKRNQMQNMLKGMNLPF

Sequences:

>Translated_455_residues
MAFEGLSERLQATMQKMRGKGKLTEADIKIMMREVRLALLEADVNFKVVKEFIKTVSERALGSDVMQSLTPGQQVIKIVQ
DELTQLMGGENTSINMSNKPPTVVMMVGLQGAGKTTTAGKLALLMRKKYNKKPMLVAADIYRPAAINQLQTVGKQIDIPV
YSEGDQVKPQQIVTNALKHAKEEHLDFVIIDTAGRLHIDEALMNELKEVKDIAKPNEIMLVVDSMTGQDAVNVAESFDDQ
LDVTGVTLTKLDGDTRGGAALSIRSVTQKPIKFVGMSEKLDGLELFHPERMASRILGMGDVLSLIEKAQQDVDQEKAKDL
EKKMRESSFTLDDFLEQLDQVKNLGPLDDIMKMIPGMNKMKGLDKLNMSEKQIDHIKAIIQSMTPAERNNPDTLNVSRKK
RIAKGSGRSLQEVNRLMKQFNDMKKMMKQFTGGGKGKKGKRNQMQNMLKGMNLPF
>Mature_454_residues
AFEGLSERLQATMQKMRGKGKLTEADIKIMMREVRLALLEADVNFKVVKEFIKTVSERALGSDVMQSLTPGQQVIKIVQD
ELTQLMGGENTSINMSNKPPTVVMMVGLQGAGKTTTAGKLALLMRKKYNKKPMLVAADIYRPAAINQLQTVGKQIDIPVY
SEGDQVKPQQIVTNALKHAKEEHLDFVIIDTAGRLHIDEALMNELKEVKDIAKPNEIMLVVDSMTGQDAVNVAESFDDQL
DVTGVTLTKLDGDTRGGAALSIRSVTQKPIKFVGMSEKLDGLELFHPERMASRILGMGDVLSLIEKAQQDVDQEKAKDLE
KKMRESSFTLDDFLEQLDQVKNLGPLDDIMKMIPGMNKMKGLDKLNMSEKQIDHIKAIIQSMTPAERNNPDTLNVSRKKR
IAKGSGRSLQEVNRLMKQFNDMKKMMKQFTGGGKGKKGKRNQMQNMLKGMNLPF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=460, Percent_Identity=31.7391304347826, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI226371618, Length=358, Percent_Identity=34.3575418994413, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI89061728, Length=150, Percent_Identity=36.6666666666667, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI23308697, Length=300, Percent_Identity=27, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI295424842, Length=300, Percent_Identity=27, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=51.8867924528302, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=34.6613545816733, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=461, Percent_Identity=30.3687635574837, Blast_Score=227, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI193206261, Length=302, Percent_Identity=29.1390728476821, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=441, Percent_Identity=32.6530612244898, Blast_Score=235, Evalue=9e-63,
Organism=Saccharomyces cerevisiae, GI6320498, Length=262, Percent_Identity=27.0992366412214, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17647949, Length=444, Percent_Identity=31.3063063063063, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24641198, Length=241, Percent_Identity=26.9709543568465, Blast_Score=93, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50706; Mature: 50575

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFEGLSERLQATMQKMRGKGKLTEADIKIMMREVRLALLEADVNFKVVKEFIKTVSERA
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LGSDVMQSLTPGQQVIKIVQDELTQLMGGENTSINMSNKPPTVVMMVGLQGAGKTTTAGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHH
LALLMRKKYNKKPMLVAADIYRPAAINQLQTVGKQIDIPVYSEGDQVKPQQIVTNALKHA
HHHHHHHHCCCCCCEEECCHHCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHH
KEEHLDFVIIDTAGRLHIDEALMNELKEVKDIAKPNEIMLVVDSMTGQDAVNVAESFDDQ
HHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCC
LDVTGVTLTKLDGDTRGGAALSIRSVTQKPIKFVGMSEKLDGLELFHPERMASRILGMGD
CCCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHCHHH
VLSLIEKAQQDVDQEKAKDLEKKMRESSFTLDDFLEQLDQVKNLGPLDDIMKMIPGMNKM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCHHH
KGLDKLNMSEKQIDHIKAIIQSMTPAERNNPDTLNVSRKKRIAKGSGRSLQEVNRLMKQF
CCCHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
NDMKKMMKQFTGGGKGKKGKRNQMQNMLKGMNLPF
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AFEGLSERLQATMQKMRGKGKLTEADIKIMMREVRLALLEADVNFKVVKEFIKTVSERA
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LGSDVMQSLTPGQQVIKIVQDELTQLMGGENTSINMSNKPPTVVMMVGLQGAGKTTTAGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHH
LALLMRKKYNKKPMLVAADIYRPAAINQLQTVGKQIDIPVYSEGDQVKPQQIVTNALKHA
HHHHHHHHCCCCCCEEECCHHCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHH
KEEHLDFVIIDTAGRLHIDEALMNELKEVKDIAKPNEIMLVVDSMTGQDAVNVAESFDDQ
HHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCC
LDVTGVTLTKLDGDTRGGAALSIRSVTQKPIKFVGMSEKLDGLELFHPERMASRILGMGD
CCCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHCHHH
VLSLIEKAQQDVDQEKAKDLEKKMRESSFTLDDFLEQLDQVKNLGPLDDIMKMIPGMNKM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCHHH
KGLDKLNMSEKQIDHIKAIIQSMTPAERNNPDTLNVSRKKRIAKGSGRSLQEVNRLMKQF
CCCHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
NDMKKMMKQFTGGGKGKKGKRNQMQNMLKGMNLPF
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]