Definition Staphylococcus aureus subsp. aureus COL chromosome, complete genome.
Accession NC_002951
Length 2,809,422

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The map label for this gene is mnhA [H]

Identifier: 57651643

GI number: 57651643

Start: 955163

End: 957568

Strand: Reverse

Name: mnhA [H]

Synonym: SACOL0955

Alternate gene names: 57651643

Gene position: 957568-955163 (Counterclockwise)

Preceding gene: 57651644

Following gene: 57651642

Centisome position: 34.08

GC content: 33.46

Gene sequence:

>2406_bases
GTGAGTTTGTTACATATTGCGGTGATATTACCGTTAATATTCGCACTCATTATTCCTATCCTGTATAGATTTTTTAAACG
TATACATTTAGGATGGTTCGTATTACCTGTCCCTATCGTCATATTTATTTATATGCTTACATTAATTAAAACGACGATGT
CAGGTAATACTGTAATGAAAACCTTAAATTGGATGCCTCATTTTGGTATGAACTTTGATTTATATCTTGATGGCTTAGGT
TTACTCTTTAGTTTGCTTATTTCAGGAATCGGCAGTTTAGTAGTATTATATTCAATCGGCTACTTAAGTAAGTCAGAACA
ACTAGGGAATTTTTATTGTTATTTATTACTATTTATGGGTGCAATGTTAGGTGTCGTACTTTCAGATAATGTTATTATTC
TATATTTATTCTGGGAGCTAACGTCATTTTCTAGTTTTTTACTTATTTCATTCTGGCGCGAACGACAAGCATCTATATAT
GGTGCTCAAAAATCGCTCATAATCACAGTATTTGGTGGTCTATCATTATTAGGTGGTATCATCTTACTCGCTATACCAAC
ACAATCATTTAGCATTCAGTACATGATTCAACATGCTTCTGAAATTCAAAATAGCCCATTCTTCATTTTTGCGATGATTT
TAATCATGATTGGTGCTTTTACAAAATCTGCTCAGTTTCCATTTTATATTTGGCTACCAGATGCAATGGAAGCACCTACA
CCAGTCAGTGCTTATCTTCATTCAGCAACAATGGTTAAAGCAGGGTTATATTTAATCGCTCGAATGACACCAATCTTCGC
AGCATCGCAAGGTTGGGTATGGACTGTCACACTCGTTGGTTTAATTACATTATTCTGGGCTTCGCTAAACGCAACAAAAC
AACAAGACTTGAAAGGTATACTGGCATTTTCAACAGTATCCCAATTAGGTATGATTATGGCGATGCTTGGAATCGGTGCC
ATTAGTTATCACTATCAAGGCGATGATAGCAAAATATATGCTGCTGCATTTACGGCTGCAATATTCCATTTAATCAACCA
TGCAACATTTAAAGGTGCCCTATTTATGATTACAGGTGCAGTGGATCATTCTACTGGTACACGTGATGTTAAGAAATTAG
GTGGCTTACTAACAATTATGCCTATTTCATTTACAATCACTGTTATTACAGCATTAAGTATGGCTGGTGTACCACCGTTC
AATGGTTTCTTATCAAAAGAATCATTTTTAGAAACAACATTTACAGCAAGCCAAGCAAATTTATTCAGTGTTGATACATT
AGGCTACCTATTCCCAATCATTGGTATAGTGGGCAGTGTCTTCACATTTGTATATTCAATTAAATTTATAATGCATATAT
TTTTCGGACAATATAAACCTGAACAATTACCTAAAAAAGCACACGAAGTATCAATATTAATGCTTTTATCACCAGCTATT
TTAGCTACATTAGTAATTGTATTTGGTTTATTCCCTGGCATTTTAACTAATTCGATTATTGAACCAGCTACATCTTCGAT
TAATCATACGGTAATTGATGATGTTGAATTCCATATGTTCCATGGATTAACGCCTGCCTTTTTATCAACATTAGTGATTT
ATATTTTAGGTATCTTACTAATTGTGACATTTAGTTATTGGGTGAAATTGTTGCAACGACAACCTGGTAAACTAACATTC
AATTATTGGTACAACAGAAGTGCAAATGTTATTCCAAACTACTCTGAAAAGATGACGAATAGCTATGTTACCGATTATTC
ACGTAATAATTTAGTTATCATTTTTGGTGCATTAATTTTATTAACATTTGTCACTATATTCTCAGTACCTTTCAACATTA
ATTTTAAAGACGTTAGTCCGATTAGAATTTTCGAAGTTTGTATCGTAATTTTATTATTAAGTGCTGCCTTTTTAATTCTT
TTCGCTAAATCAAGATTATTTAGCATCATTATGTTAAGTGCAGTTGGATATGCTGTGTCTGTATTGTTTATATTCTTTAA
AGCACCCGACTTAGCATTGACACAGTTTGTCGTTGAATCTATTTCAACAGCATTGTTCTTATTATGCTTCTACCACTTAC
CAAATTTAAATCGTTATAATGAAAAGCGCTCATTCCAGCTTACTAATGCTTTAATTGCTGGTGGTGTTGGTTTGTCCGTC
ATTATTATCGGTTTAATTGCATACGGAAATAGACATTTTGAATCGATATCTAAGTTTTATCAAGAGCACGTTTATGATTT
AGCTCACGGTAAAAACATGGTAAACGTCATACTTGTTGATTTCCGTGGTATGGATACTTTATTCGAGTCATCTGTGCTTG
GTATCGCAGGATTAGCTGTATATACAATGATTAAATTACGTAAAAAGCGTCAAACGCAAGGTAACGAGGTGAAAAATCAT
GAATAG

Upstream 100 bases:

>100_bases
TTCTGAAAATAAAGCACAACAAGGAGTGTGTACGTTTTTCAGAACTATATCATTCATGTATAATGAATAACATAAATATT
TTTTAAAGGAGGACAACATA

Downstream 100 bases:

>100_bases
ACAACAAAATGATCTAATTTTGCAATTTGCTGCAGTTATTATCTTTTTCATGGTAATGGTCTTTGGTTTTTCACTTTTCT
TAGCAGGACATTATACACCT

Product: monovalent cation/H+ antiporter subunit A

Products: NAD+; ubiquinol [C]

Alternate protein names: Mnh complex subunit A1 [H]

Number of amino acids: Translated: 801; Mature: 800

Protein sequence:

>801_residues
MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLG
LLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIY
GAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPT
PVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGA
ISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPF
NGFLSKESFLETTFTASQANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAI
LATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTF
NYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLIL
FAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSV
IIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNH
E

Sequences:

>Translated_801_residues
MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLG
LLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIY
GAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPT
PVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGA
ISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPF
NGFLSKESFLETTFTASQANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAI
LATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTF
NYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLIL
FAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSV
IIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNH
E
>Mature_800_residues
SLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLGL
LFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYG
AQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPTP
VSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGAI
SYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFN
GFLSKESFLETTFTASQANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAIL
ATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTFN
YWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILF
AKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSVI
IIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNHE

Specific function: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion [H]

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=473, Percent_Identity=29.8097251585624, Blast_Score=178, Evalue=2e-44,
Organism=Escherichia coli, GI1788614, Length=522, Percent_Identity=30.2681992337165, Blast_Score=206, Evalue=5e-54,
Organism=Escherichia coli, GI1788829, Length=477, Percent_Identity=32.4947589098532, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI1788831, Length=358, Percent_Identity=32.4022346368715, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI1788827, Length=445, Percent_Identity=26.7415730337079, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1788613, Length=466, Percent_Identity=25.9656652360515, Blast_Score=119, Evalue=9e-28,
Organism=Escherichia coli, GI2367154, Length=458, Percent_Identity=24.0174672489083, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005663
- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: 1.6.99.5 [C]

Molecular weight: Translated: 89398; Mature: 89266

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMG
HHHCCCCCCCCHHHEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGI
HHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
ILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPT
HEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC
PVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGI
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
LAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGA
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCEEEEEEEC
VDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQAN
CCCCCCHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCC
LFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHH
LATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
IVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALIL
HHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEHHHHHHH
LTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVS
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHH
IIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
YTMIKLRKKRQTQGNEVKNHE
HHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMG
HHHCCCCCCCCHHHEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGI
HHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
ILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPT
HEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC
PVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGI
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
LAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGA
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCEEEEEEEC
VDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQAN
CCCCCCHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCC
LFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHH
LATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
IVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALIL
HHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEHHHHHHH
LTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVS
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHH
IIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
YTMIKLRKKRQTQGNEVKNHE
HHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Iron [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; ubiquinone [C]

Specific reaction: NADH + ubiquinone = NAD+ + ubiquinol [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA