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The map label for this gene is holB [H]

Identifier: 57651365

GI number: 57651365

Start: 537584

End: 538510

Strand: Direct

Name: holB [H]

Synonym: SACOL0526

Alternate gene names: 57651365

Gene position: 537584-538510 (Clockwise)

Preceding gene: 57651364

Following gene: 57651366

Centisome position: 19.14

GC content: 30.64

Gene sequence:

>927_bases
ATGGATGAACAGCAACAATTGACGAATGCATATCATTCAAATAAATTATCGCATGCCTATTTATTTGAAGGTGATGATGC
ACAAACGATGAAACAAGTTGCGATTAATTTTGCAAAGCTTATTTTATGTCAAACAGATAGTCAATGTGAAACAAAGGTTA
GTACATATAATCATCCAGACTTTATGTATATATCAACAACTGAGAATGCAATTAAGAAAGAACAAGTTGAACAACTTGTG
CGTCATATGAATCAACTTCCTATAGAAAGCACAAATAAAGTGTACATCATTGAAGACTTTGAAAAGTTAACTGTTCAAGG
GGAAAACAGTATCTTGAAATTTCTTGAAGAACCACCGGACAATACGATTGCTATTTTATTGTCTACAAAACCTGAGCAAA
TTTTAGACACAATCCATTCAAGGTGTCAGCATGTATATTTCAAGCCTATTGATAAAGAAAAGTTTATAAATAGATTAGTT
GAACAAAACATGTCTAAGCCAGTAGCTGAAATGATTAGTACTTATACTACGCAAATAGATAATGCAATGGCTTTAAATGA
AGAATTTGATTTATTAGCATTAAGGAAATCAGTTATACGTTGGTGTGAATTGTTGCTTACTAATAAGCCAATGGCACTTA
TAGGTATTATTGATTTATTGAAACAGGCTAAAAATAAAAAACTGCAATCTTTAACTATTGCAGCTGTGAATGGTTTCTTC
GAAGATATCATACATACAAAGGTAAATGTAGAGGATAAACAAATATATAGTGATTTAAAAAATGATATTGATCAATATGC
GCAAAAGTTGTCGTTTAATCAATTAATTTTGATGTTTGATCAACTGACGGAAGCACATAAGAAATTGAATCAAAATGTAA
ATCCAACGCTTGTATTTGAACAAATCGTAATTAAGGGTGTGAGTTAG

Upstream 100 bases:

>100_bases
TGGTTCTAAAAATAATCACAAATCATGGTCGCTATTGTTGCAGTAATTAGTTGCTCTTTGGCAACCTTTTTATATAAAAG
CAAAAGGGAGTTTGTAATGA

Downstream 100 bases:

>100_bases
ATGCCAAATGTAATAGGTGTTCAGTTTCAAAAAGCGGGAAAATTAGAATATTATACACCTAATGATATACAAGTAGATAT
AGAAGACTGGGTAGTTGTCG

Product: DNA polymerase III subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MDEQQQLTNAYHSNKLSHAYLFEGDDAQTMKQVAINFAKLILCQTDSQCETKVSTYNHPDFMYISTTENAIKKEQVEQLV
RHMNQLPIESTNKVYIIEDFEKLTVQGENSILKFLEEPPDNTIAILLSTKPEQILDTIHSRCQHVYFKPIDKEKFINRLV
EQNMSKPVAEMISTYTTQIDNAMALNEEFDLLALRKSVIRWCELLLTNKPMALIGIIDLLKQAKNKKLQSLTIAAVNGFF
EDIIHTKVNVEDKQIYSDLKNDIDQYAQKLSFNQLILMFDQLTEAHKKLNQNVNPTLVFEQIVIKGVS

Sequences:

>Translated_308_residues
MDEQQQLTNAYHSNKLSHAYLFEGDDAQTMKQVAINFAKLILCQTDSQCETKVSTYNHPDFMYISTTENAIKKEQVEQLV
RHMNQLPIESTNKVYIIEDFEKLTVQGENSILKFLEEPPDNTIAILLSTKPEQILDTIHSRCQHVYFKPIDKEKFINRLV
EQNMSKPVAEMISTYTTQIDNAMALNEEFDLLALRKSVIRWCELLLTNKPMALIGIIDLLKQAKNKKLQSLTIAAVNGFF
EDIIHTKVNVEDKQIYSDLKNDIDQYAQKLSFNQLILMFDQLTEAHKKLNQNVNPTLVFEQIVIKGVS
>Mature_308_residues
MDEQQQLTNAYHSNKLSHAYLFEGDDAQTMKQVAINFAKLILCQTDSQCETKVSTYNHPDFMYISTTENAIKKEQVEQLV
RHMNQLPIESTNKVYIIEDFEKLTVQGENSILKFLEEPPDNTIAILLSTKPEQILDTIHSRCQHVYFKPIDKEKFINRLV
EQNMSKPVAEMISTYTTQIDNAMALNEEFDLLALRKSVIRWCELLLTNKPMALIGIIDLLKQAKNKKLQSLTIAAVNGFF
EDIIHTKVNVEDKQIYSDLKNDIDQYAQKLSFNQLILMFDQLTEAHKKLNQNVNPTLVFEQIVIKGVS

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=161, Percent_Identity=27.9503105590062, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004622 [H]

Pfam domain/function: NA

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 35516; Mature: 35516

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQQQLTNAYHSNKLSHAYLFEGDDAQTMKQVAINFAKLILCQTDSQCETKVSTYNHPD
CCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHEECCCCHHHHHHHCCCCCC
FMYISTTENAIKKEQVEQLVRHMNQLPIESTNKVYIIEDFEKLTVQGENSILKFLEEPPD
EEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHEECCCHHHHHHHHCCCC
NTIAILLSTKPEQILDTIHSRCQHVYFKPIDKEKFINRLVEQNMSKPVAEMISTYTTQID
CEEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
NAMALNEEFDLLALRKSVIRWCELLLTNKPMALIGIIDLLKQAKNKKLQSLTIAAVNGFF
CHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
EDIIHTKVNVEDKQIYSDLKNDIDQYAQKLSFNQLILMFDQLTEAHKKLNQNVNPTLVFE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
QIVIKGVS
HHHHHCCC
>Mature Secondary Structure
MDEQQQLTNAYHSNKLSHAYLFEGDDAQTMKQVAINFAKLILCQTDSQCETKVSTYNHPD
CCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHEECCCCHHHHHHHCCCCCC
FMYISTTENAIKKEQVEQLVRHMNQLPIESTNKVYIIEDFEKLTVQGENSILKFLEEPPD
EEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHEECCCHHHHHHHHCCCC
NTIAILLSTKPEQILDTIHSRCQHVYFKPIDKEKFINRLVEQNMSKPVAEMISTYTTQID
CEEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
NAMALNEEFDLLALRKSVIRWCELLLTNKPMALIGIIDLLKQAKNKKLQSLTIAAVNGFF
CHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
EDIIHTKVNVEDKQIYSDLKNDIDQYAQKLSFNQLILMFDQLTEAHKKLNQNVNPTLVFE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
QIVIKGVS
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]