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The map label for this gene is dut [H]

Identifier: 57651284

GI number: 57651284

Start: 370986

End: 371528

Strand: Direct

Name: dut [H]

Synonym: SACOL0357

Alternate gene names: 57651284

Gene position: 370986-371528 (Clockwise)

Preceding gene: 57651283

Following gene: 57651285

Centisome position: 13.21

GC content: 37.75

Gene sequence:

>543_bases
ATGACTAACACATTACAAGTAAAACTATTATCAAAAAATGCTAGAATGCCCGAACGAAATCATAAGACGGATGCAGGTTA
TGACATATTCTCAGCTGAAACTGTCGTACTCGAACCACAAGAAAAAGCAGTGATCAAAACAGATGTAGCTGTGAGTATAC
CAGAGGGCTATGTCGGACTATTAACTAGTCGTAGTGGTGTAAGTAGTAAAACGTATTTAGTGATTGAAACAGGCAAGATA
GACGCGGGATATCATGGCAATTTAGGGATTAATATCAAGAATGATGAAGAACGTGATGGAATACCCTTTTTATATGATGA
TATAGACGCTGAATTAGAAGATGGATTAATAAGCATTTTAGATATAAAAGGTAACTATGTACAAGATGGAAGAGGCATAA
GAAGAGTTTACCAAATCAACAAAGGCGATAAACTAGCTCAATTGGTTATCGTGCCTATATGGACACCGGAACTAAAGCAA
GTGGAGGAATTCGAAAGTGTTTCAGAACGTGGAGCAAAAGGCTTCGGAAGTAGCGGAGTGTAA

Upstream 100 bases:

>100_bases
AATGCTATTCAACATTCAGTTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAA
ATATGAGGAGGAATAGGAAA

Downstream 100 bases:

>100_bases
AGACATCTTAGATCGAGTTAAGGAGGTTTTGGGGAAGTGACGCAATACTTAGTCACAACATTCAAAGATTCAACAGGACT
ACCACATGAACATATTACTG

Product: prophage L54a, deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MTNTLQVKLLSKNARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVSSKTYLVIETGKI
DAGYHGNLGINIKNDEERDGIPFLYDDIDAELEDGLISILDIKGNYVQDGRGIRRVYQINKGDKLAQLVIVPIWTPELKQ
VEEFESVSERGAKGFGSSGV

Sequences:

>Translated_180_residues
MTNTLQVKLLSKNARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVSSKTYLVIETGKI
DAGYHGNLGINIKNDEERDGIPFLYDDIDAELEDGLISILDIKGNYVQDGRGIRRVYQINKGDKLAQLVIVPIWTPELKQ
VEEFESVSERGAKGFGSSGV
>Mature_179_residues
TNTLQVKLLSKNARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVSSKTYLVIETGKID
AGYHGNLGINIKNDEERDGIPFLYDDIDAELEDGLISILDIKGNYVQDGRGIRRVYQINKGDKLAQLVIVPIWTPELKQV
EEFESVSERGAKGFGSSGV

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=175, Percent_Identity=30.2857142857143, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI4503423, Length=175, Percent_Identity=30.2857142857143, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI70906441, Length=175, Percent_Identity=30.2857142857143, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71988561, Length=176, Percent_Identity=29.5454545454545, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319729, Length=176, Percent_Identity=26.1363636363636, Blast_Score=71, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24583610, Length=179, Percent_Identity=31.2849162011173, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI19921126, Length=179, Percent_Identity=31.2849162011173, Blast_Score=91, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 19801; Mature: 19669

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTLQVKLLSKNARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGL
CCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCEEEECCCCCEEEEECEEEECCCCEEEE
LTSRSGVSSKTYLVIETGKIDAGYHGNLGINIKNDEERDGIPFLYDDIDAELEDGLISIL
EECCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCHHCCCEEEEE
DIKGNYVQDGRGIRRVYQINKGDKLAQLVIVPIWTPELKQVEEFESVSERGAKGFGSSGV
EECCCEEECCCCEEEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TNTLQVKLLSKNARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGL
CCEEEEEEECCCCCCCCCCCCCCCCEEEECCCEEEECCCCCEEEEECEEEECCCCEEEE
LTSRSGVSSKTYLVIETGKIDAGYHGNLGINIKNDEERDGIPFLYDDIDAELEDGLISIL
EECCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCHHCCCEEEEE
DIKGNYVQDGRGIRRVYQINKGDKLAQLVIVPIWTPELKQVEEFESVSERGAKGFGSSGV
EECCCEEECCCCEEEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174 [H]