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The map label for this gene is ldhD

Identifier: 57651032

GI number: 57651032

Start: 2596114

End: 2597106

Strand: Direct

Name: ldhD

Synonym: SACOL2535

Alternate gene names: 57651032

Gene position: 2596114-2597106 (Clockwise)

Preceding gene: 57651030

Following gene: 57651034

Centisome position: 92.41

GC content: 34.54

Gene sequence:

>993_bases
ATGACAAAAATTATGTTCTTTGGTACGCGTGATTATGAGAAAGAGATGGCATTAAATTGGGGGAAAAAGAATAATGTCGA
AGTAACTACTTCTAAAGAGCTATTATCAAGTGCTACAGTCGATCAATTAAAAGATTACGATGGCGTAACTACAATGCAAT
TTGGTAAGTTAGAAAATGACGTTTATCCTAAATTAGAATCTTACGGTATTAAACAAATTGCACAACGTACTGCTGGATTT
GATATGTATGATTTAGATTTAGCTAAAAAACACAATATTGTGATATCTAACGTTCCTAGTTATTCACCTGAAACAATTGC
AGAGTATTCTGTTTCTATCGCCCTACAATTAGTGCGTCGCTTCCCAGATATTGAACGCCGTGTACAAGCACATGATTTTA
CTTGGCAAGCAGAAATCATGTCTAAACCAGTTAAAAATATGACTGTTGCAATTATTGGTACGGGTCGTATCGGTGCTGCT
ACAGCTAAAATATATGCAGGATTTGGTGCTACAATTACAGCTTATGACGCCTATCCTAATAAAGATTTAGACTTTTTAAC
TTATAAAGATAGTGTTAAAGAAGCTATTAAAGATGCCGATATTATTTCTTTACATGTTCCAGCGAACAAAGAAAGCTATC
ATTTATTCGATAAAGCAATGTTTGATCATGTGAAAAAAGGTGCAATCTTAGTTAACGCAGCACGTGGTGCAGTCATCAAT
ACACCTGATTTAATCGCTGCAGTGAACGATGGTACTTTGTTAGGTGCTGCGATTGATACTTATGAAAATGAAGCAGCATA
CTTCACAAATGACTGGACTAATAAAGACATTGACGATAAAACATTATTAGAGTTAATCGAACATGAAAGAATTTTAGTAA
CACCACATATTGCTTTCTTCTCTGATGAAGCAGTACAAAACCTTGTTGAAGGTGGTTTAAACGCAGCATTATCTGTCATT
AACACTGGTACATGTGAAACACGTTTAAATTAA

Upstream 100 bases:

>100_bases
GTGATATTTTTCACAATTAAATTGTGGCGTGATTTTAATGTGCATAATCTTTAATTTCACTCATTTACTTTTCAATCTTT
TAAAAGCGAGGTTTTTAATA

Downstream 100 bases:

>100_bases
TATATATATTTAAAAGCAAAGGCGCGCCATGTGCCTTTGCTTTTTATTTTGTATATCTGTATCAAAATCGATTTGATTAA
AATCCGCTTTATTTTATCAT

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: D-LDH; D-specific D-2-hydroxyacid dehydrogenase

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLENDVYPKLESYGIKQIAQRTAGF
DMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFPDIERRVQAHDFTWQAEIMSKPVKNMTVAIIGTGRIGAA
TAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKAMFDHVKKGAILVNAARGAVIN
TPDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDDKTLLELIEHERILVTPHIAFFSDEAVQNLVEGGLNAALSVI
NTGTCETRLN

Sequences:

>Translated_330_residues
MTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLENDVYPKLESYGIKQIAQRTAGF
DMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFPDIERRVQAHDFTWQAEIMSKPVKNMTVAIIGTGRIGAA
TAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKAMFDHVKKGAILVNAARGAVIN
TPDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDDKTLLELIEHERILVTPHIAFFSDEAVQNLVEGGLNAALSVI
NTGTCETRLN
>Mature_329_residues
TKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLENDVYPKLESYGIKQIAQRTAGFD
MYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFPDIERRVQAHDFTWQAEIMSKPVKNMTVAIIGTGRIGAAT
AKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKAMFDHVKKGAILVNAARGAVINT
PDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDDKTLLELIEHERILVTPHIAFFSDEAVQNLVEGGLNAALSVIN
TGTCETRLN

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family

Homologues:

Organism=Homo sapiens, GI23308577, Length=284, Percent_Identity=24.6478873239437, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4557497, Length=250, Percent_Identity=27.2, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI61743967, Length=250, Percent_Identity=27.2, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI145580578, Length=256, Percent_Identity=26.171875, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI4557499, Length=256, Percent_Identity=26.171875, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI145580575, Length=250, Percent_Identity=26, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI6912396, Length=200, Percent_Identity=29.5, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787645, Length=328, Percent_Identity=29.5731707317073, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789279, Length=243, Percent_Identity=29.6296296296296, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI87082289, Length=250, Percent_Identity=27.6, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87081824, Length=205, Percent_Identity=22.9268292682927, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788660, Length=229, Percent_Identity=26.6375545851528, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=326, Percent_Identity=26.3803680981595, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI25147481, Length=353, Percent_Identity=25.2124645892351, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320925, Length=266, Percent_Identity=27.8195488721804, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=227, Percent_Identity=29.9559471365639, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=258, Percent_Identity=27.5193798449612, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=304, Percent_Identity=24.6710526315789, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=180, Percent_Identity=25.5555555555556, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646446, Length=256, Percent_Identity=28.90625, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646448, Length=256, Percent_Identity=28.90625, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646452, Length=256, Percent_Identity=28.90625, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646450, Length=256, Percent_Identity=28.90625, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI62472511, Length=256, Percent_Identity=28.90625, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28574286, Length=238, Percent_Identity=23.9495798319328, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45552429, Length=296, Percent_Identity=23.3108108108108, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585514, Length=289, Percent_Identity=23.1833910034602, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574282, Length=289, Percent_Identity=23.1833910034602, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574284, Length=296, Percent_Identity=23.3108108108108, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921140, Length=286, Percent_Identity=23.0769230769231, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45551003, Length=296, Percent_Identity=23.3108108108108, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585516, Length=258, Percent_Identity=20.9302325581395, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LDHD_STAAC (Q5HD29)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_187328.1
- ProteinModelPortal:   Q5HD29
- SMR:   Q5HD29
- STRING:   Q5HD29
- EnsemblBacteria:   EBSTAT00000010156
- GeneID:   3238242
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL2535
- TIGR:   SACOL2535
- eggNOG:   COG1052
- GeneTree:   EBGT00050000024534
- HOGENOM:   HBG731446
- OMA:   MAGFGCQ
- ProtClustDB:   PRK12480
- BioCyc:   SAUR93062:SACOL2535-MONOMER
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C

EC number: =1.1.1.28

Molecular weight: Translated: 36682; Mature: 36551

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 235-235 ACT_SITE 264-264 ACT_SITE 296-296 BINDING 259-259

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLEND
CCEEEEECCCCHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
VYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRR
CCCCHHHCCHHHHHHHHCCCCEEECCHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
FPDIERRVQAHDFTWQAEIMSKPVKNMTVAIIGTGRIGAATAKIYAGFGATITAYDAYPN
CCCHHHHHHHCCCEEEHHHHHCCCCCEEEEEEECCCCCCHHEEEEECCCCEEEEEECCCC
KDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKAMFDHVKKGAILVNAARGAVIN
CCCEEEEEHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEC
TPDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDDKTLLELIEHERILVTPHIAFF
CCCEEEEECCCEEEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHHHCCEEEEECCCEEC
SDEAVQNLVEGGLNAALSVINTGTCETRLN
CHHHHHHHHHCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLEND
CEEEEECCCCHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
VYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRR
CCCCHHHCCHHHHHHHHCCCCEEECCHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
FPDIERRVQAHDFTWQAEIMSKPVKNMTVAIIGTGRIGAATAKIYAGFGATITAYDAYPN
CCCHHHHHHHCCCEEEHHHHHCCCCCEEEEEEECCCCCCHHEEEEECCCCEEEEEECCCC
KDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKAMFDHVKKGAILVNAARGAVIN
CCCEEEEEHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEC
TPDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDDKTLLELIEHERILVTPHIAFF
CCCEEEEECCCEEEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHHHCCEEEEECCCEEC
SDEAVQNLVEGGLNAALSVINTGTCETRLN
CHHHHHHHHHCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA