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The map label for this gene is hssS [H]

Identifier: 57650906

GI number: 57650906

Start: 2417990

End: 2419363

Strand: Direct

Name: hssS [H]

Synonym: SACOL2359

Alternate gene names: 57650906

Gene position: 2417990-2419363 (Clockwise)

Preceding gene: 57650905

Following gene: 57650907

Centisome position: 86.07

GC content: 31.37

Gene sequence:

>1374_bases
ATGTTTAAAACACTCTATGCTAGAATTGCGATTTATTCCATTACGGTTATTTTATTTAGTGCATTAATAAGTTTTGTATT
AACAAATGTTTACTATCATTATAATTTAAAAGCATCTAATGACGCGAAAATCATGAAGACGCTTAAAGAAGCAAGACAAT
ATGAACAATCAGCTAAACCAACGCACATTCAACAATATTTCAAACATTTAGGGCAAATGAATTACCAAATAATGACCATT
GATCAAAAAGGTCATAAGACATTTTATGGGGAGCCATTTAGAGAAGATACTTTATCACAAAATGCTATTAACAACGTATT
AAATAATCAAGATTACCATGGTATTAAAGATAAACCATTCGCATTATTCGTAACTGGATTTTTCGACAATGTAACAGATA
ATACTGTTGGTATTAACTTTAAGACAAAAGACGGTTCAATAGCAGTATTTATGCGTCCAGATATTGGAGAAACATTTAGC
GAGTTTAGAACATTCTTAGCCGTCTTGTTAATGTTGTTATTATTTATCTCGATTTCATTAGTTATCGCATCAACCTATTC
AATCATTCGTCCAGTAAAAAAGTTAAAGCTAGCGACCGAACGCTTAATTGATGGTGATTTTGAAACACCTATCAAACAAA
CACGCAAAGATGAAATTGGAACATTACAGTATCACTTTAATAAGATGAGAGAGTCATTGGGACAAGTTGATCAAATGAGG
CAGCATTTTGTACAAAATGTATCTCATGAAATCAAAACACCATTAACACATATTCATCATTTATTAAGCGAGTTACAACA
AACTTCTGATAAAACATTAAGACAACAATATATAAATGATATCTATACCATTACAACGCAGCTGAGCGGATTAACAACTG
AATTGTTGCTCTTATCCGAATTAGATAATCACCAACATTTATTATTCGATGATAAGATTCAAGTCAATCAACTCATTAAA
GATATCATTCGACATGAACAATTTGCTGCTGATGAAAAGTCGTTAATCATTTTAGCTGACCTAGAATCAATCAATTTCCT
AGGAAATCAACGTTTGTTACATCAAGCATTGAGTAATTTATTAATAAATGCTATTAAGTATACAGATGTTGGTGGTGCCA
TTGACATCGCTTTGCAACATAGTCACAACAATATCATTTTCACAATAAGTAATGATGGTTCACCAATTAGTCCACAAGCT
GAAGCACGTTTATTTGAACGTTTTTATAAAGTGAGCAAACATGATAATAGCAATGGTTTAGGTCTTGCAATTACAAAATC
CATCATTGAATTGCATCATGGTACAATCCAATTCACACAAAGTAACGAGTATGTAACCACCTTTACTATTACACTGCCAA
ATAATTCACTTTAA

Upstream 100 bases:

>100_bases
GTTGACGTTCATATTAAGCGACTACGCCAAAGATTAAAAAAATTAAATGCCACACTTACAATTGAAACAGTAAGAGGACA
AGGCTATAAGGTGGAGAATC

Downstream 100 bases:

>100_bases
TCTCTACCTCCTGAAAAAACATTTCTGTTTTTATTTCAGGAGGTATCTTTTATATTGATTAGCGCTTTCTAGCCACTTAA
CATTTAATTTCTACCATTCA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKPTHIQQYFKHLGQMNYQIMTI
DQKGHKTFYGEPFREDTLSQNAINNVLNNQDYHGIKDKPFALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFS
EFRTFLAVLLMLLLFISISLVIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKIQVNQLIK
DIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQA
EARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSL

Sequences:

>Translated_457_residues
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKPTHIQQYFKHLGQMNYQIMTI
DQKGHKTFYGEPFREDTLSQNAINNVLNNQDYHGIKDKPFALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFS
EFRTFLAVLLMLLLFISISLVIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKIQVNQLIK
DIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQA
EARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSL
>Mature_457_residues
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKPTHIQQYFKHLGQMNYQIMTI
DQKGHKTFYGEPFREDTLSQNAINNVLNNQDYHGIKDKPFALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFS
EFRTFLAVLLMLLLFISISLVIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKIQVNQLIK
DIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQA
EARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSL

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=284, Percent_Identity=30.9859154929577, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1786783, Length=296, Percent_Identity=27.7027027027027, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790346, Length=294, Percent_Identity=25.8503401360544, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790861, Length=288, Percent_Identity=25.6944444444444, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788279, Length=296, Percent_Identity=27.3648648648649, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787894, Length=294, Percent_Identity=26.1904761904762, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87081816, Length=336, Percent_Identity=23.2142857142857, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789403, Length=358, Percent_Identity=26.536312849162, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789808, Length=298, Percent_Identity=23.8255033557047, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=26.4840182648402, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI87082128, Length=294, Percent_Identity=23.8095238095238, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=28.8537549407115, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=24.7967479674797, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789149, Length=393, Percent_Identity=20.6106870229008, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=24.3362831858407, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52376; Mature: 52376

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCC
THIQQYFKHLGQMNYQIMTIDQKGHKTFYGEPFREDTLSQNAINNVLNNQDYHGIKDKPF
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCE
ALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFSEFRTFLAVLLMLLLFISISL
EEEEEEHHCCCCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSE
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LDNHQHLLFDDKIQVNQLIKDIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNL
CCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCHHHHHHHHHHH
LINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSNGL
HHHHHHHCCCCCEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
GLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSL
CHHHHHHHHHHHCCEEEEEECCCEEEEEEEECCCCCC
>Mature Secondary Structure
MFKTLYARIAIYSITVILFSALISFVLTNVYYHYNLKASNDAKIMKTLKEARQYEQSAKP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCC
THIQQYFKHLGQMNYQIMTIDQKGHKTFYGEPFREDTLSQNAINNVLNNQDYHGIKDKPF
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCE
ALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFSEFRTFLAVLLMLLLFISISL
EEEEEEHHCCCCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSE
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LDNHQHLLFDDKIQVNQLIKDIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNL
CCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCHHHHHHHHHHH
LINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSNGL
HHHHHHHCCCCCEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
GLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSL
CHHHHHHHHHHHCCEEEEEECCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA