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The map label for this gene is galM [H]

Identifier: 57650881

GI number: 57650881

Start: 2393840

End: 2394859

Strand: Reverse

Name: galM [H]

Synonym: SACOL2332

Alternate gene names: 57650881

Gene position: 2394859-2393840 (Counterclockwise)

Preceding gene: 57650882

Following gene: 57650880

Centisome position: 85.24

GC content: 31.37

Gene sequence:

>1020_bases
ATGATAGTTGAAGTTGAGCACCAAAGACAAGGTGTAGATTTAATCAAAATTGATAATGATGAAACTAAAATTATTTTTAC
GAATTATGGAGCAAGAGTAGTGTCTTGGAAATATCATGATAATAATATTGTTCTTGGAAATGTTGTTGAAGCGGATGAAT
TTTATCATAGTAATCCTTTTAAATTTGGTGCTTCTATAGGAAGATATAGCGGTAGAATTGATAATGCTAAATTTAAGTTG
AAAGGTAAAGAATATCAGTTAGAAAAAAACAACGGTGAACATCATTTACATGGTGGATGTCATGGTTTGGACAATAAGTT
ATTTGATTATGAAATTAGAAATGAAATTGCTCAAATTAAAGTTATATTTAAGACGGTGTTGAAATCAGCTGATGATCATT
TCCCGGGTGATATCGATGTGACGATTACACATATTTATGATGCGGATCACCAATGGTCGATTGAATACGAAGCAGTTGCA
TCAGAAGACACATTGTTTAGTCCTACGAATCATGTGTACTTCAATTTGAATCGAGATAATAATGTCGTTGATAATCATCG
CATTTCAAGTAATCAATTAGATATGTATGTATTAGATGAGCGAAATATTGTTACAGGTGATATTCTAGATTTACATGAAG
TGTTTGAAGATAACAAGATAAAATTGAGTGATATTTTTACATCACAACATGCGCAATTAAGCCAACAAATGACACGTTTT
GGTGGTCTCGATCACCCATTTACAGTTGGTGAACATAAAATGTATGTTGAAAATCATGAATTTATGTTAGAGGTCGATAC
AGATATGCCTCATGTTGTGTTCTTTACTTTTAACCAGCCTGATGAGTGGGATAGTCCATTTAATATTTATAAACCACATT
CTGGCTTTACATTAGAAACACAATTTTTACCAAATGATATTAATTTATATGGTGAAAAAGCACCGTCAATTTTAAAAGCT
GGTGAAGTGTTCAATTCGAAAACAAGTTTCCGTATCGAAGAAAAAGTAGAAAATGATTAA

Upstream 100 bases:

>100_bases
AATATGATGTTATCGGTGCAATCATTTGTATTGTAGGTGTTTTAGTAATGTTGCTACCCAGCAGAGCTTGAACACTTGTG
GTTAGAAGGGAGAAGTAAAA

Downstream 100 bases:

>100_bases
AAGTATCGGCATTTATATAATATTTATGTTATTTGGCGGAATTTTGAATAGGTTATCAAGAATCGTATCAAATGAAGTGA
CATCATTAATATACAGTTTG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MIVEVEHQRQGVDLIKIDNDETKIIFTNYGARVVSWKYHDNNIVLGNVVEADEFYHSNPFKFGASIGRYSGRIDNAKFKL
KGKEYQLEKNNGEHHLHGGCHGLDNKLFDYEIRNEIAQIKVIFKTVLKSADDHFPGDIDVTITHIYDADHQWSIEYEAVA
SEDTLFSPTNHVYFNLNRDNNVVDNHRISSNQLDMYVLDERNIVTGDILDLHEVFEDNKIKLSDIFTSQHAQLSQQMTRF
GGLDHPFTVGEHKMYVENHEFMLEVDTDMPHVVFFTFNQPDEWDSPFNIYKPHSGFTLETQFLPNDINLYGEKAPSILKA
GEVFNSKTSFRIEEKVEND

Sequences:

>Translated_339_residues
MIVEVEHQRQGVDLIKIDNDETKIIFTNYGARVVSWKYHDNNIVLGNVVEADEFYHSNPFKFGASIGRYSGRIDNAKFKL
KGKEYQLEKNNGEHHLHGGCHGLDNKLFDYEIRNEIAQIKVIFKTVLKSADDHFPGDIDVTITHIYDADHQWSIEYEAVA
SEDTLFSPTNHVYFNLNRDNNVVDNHRISSNQLDMYVLDERNIVTGDILDLHEVFEDNKIKLSDIFTSQHAQLSQQMTRF
GGLDHPFTVGEHKMYVENHEFMLEVDTDMPHVVFFTFNQPDEWDSPFNIYKPHSGFTLETQFLPNDINLYGEKAPSILKA
GEVFNSKTSFRIEEKVEND
>Mature_339_residues
MIVEVEHQRQGVDLIKIDNDETKIIFTNYGARVVSWKYHDNNIVLGNVVEADEFYHSNPFKFGASIGRYSGRIDNAKFKL
KGKEYQLEKNNGEHHLHGGCHGLDNKLFDYEIRNEIAQIKVIFKTVLKSADDHFPGDIDVTITHIYDADHQWSIEYEAVA
SEDTLFSPTNHVYFNLNRDNNVVDNHRISSNQLDMYVLDERNIVTGDILDLHEVFEDNKIKLSDIFTSQHAQLSQQMTRF
GGLDHPFTVGEHKMYVENHEFMLEVDTDMPHVVFFTFNQPDEWDSPFNIYKPHSGFTLETQFLPNDINLYGEKAPSILKA
GEVFNSKTSFRIEEKVEND

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=337, Percent_Identity=27.5964391691395, Blast_Score=111, Evalue=9e-25,
Organism=Escherichia coli, GI1786971, Length=349, Percent_Identity=26.3610315186246, Blast_Score=104, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17557428, Length=161, Percent_Identity=31.6770186335404, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI115533334, Length=161, Percent_Identity=31.6770186335404, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322004, Length=339, Percent_Identity=25.6637168141593, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319493, Length=322, Percent_Identity=28.2608695652174, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324399, Length=339, Percent_Identity=26.2536873156342, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24659048, Length=324, Percent_Identity=28.3950617283951, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583720, Length=269, Percent_Identity=24.1635687732342, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24668278, Length=269, Percent_Identity=23.7918215613383, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24668282, Length=328, Percent_Identity=25, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 39280; Mature: 39280

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVEVEHQRQGVDLIKIDNDETKIIFTNYGARVVSWKYHDNNIVLGNVVEADEFYHSNPF
CEEEEECHHCCCEEEEECCCCEEEEEEECCCEEEEEEEECCCEEEEEEEEHHHHHCCCCC
KFGASIGRYSGRIDNAKFKLKGKEYQLEKNNGEHHLHGGCHGLDNKLFDYEIRNEIAQIK
EECCCHHHCCCCCCCCEEEEECCEEEEECCCCCEEECCCCCCCCCCEECHHHHHHHHHHH
VIFKTVLKSADDHFPGDIDVTITHIYDADHQWSIEYEAVASEDTLFSPTNHVYFNLNRDN
HHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEEEEECCCCCEECCCCEEEEEECCCC
NVVDNHRISSNQLDMYVLDERNIVTGDILDLHEVFEDNKIKLSDIFTSQHAQLSQQMTRF
CCCCCCCCCCCCEEEEEECCCCEEECCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHH
GGLDHPFTVGEHKMYVENHEFMLEVDTDMPHVVFFTFNQPDEWDSPFNIYKPHSGFTLET
CCCCCCEECCCEEEEEECCEEEEEECCCCCEEEEEECCCCCCCCCCCEEECCCCCCEEEE
QFLPNDINLYGEKAPSILKAGEVFNSKTSFRIEEKVEND
EECCCCCEECCCCCCCHHHHHHHHCCCCCEEECCCCCCC
>Mature Secondary Structure
MIVEVEHQRQGVDLIKIDNDETKIIFTNYGARVVSWKYHDNNIVLGNVVEADEFYHSNPF
CEEEEECHHCCCEEEEECCCCEEEEEEECCCEEEEEEEECCCEEEEEEEEHHHHHCCCCC
KFGASIGRYSGRIDNAKFKLKGKEYQLEKNNGEHHLHGGCHGLDNKLFDYEIRNEIAQIK
EECCCHHHCCCCCCCCEEEEECCEEEEECCCCCEEECCCCCCCCCCEECHHHHHHHHHHH
VIFKTVLKSADDHFPGDIDVTITHIYDADHQWSIEYEAVASEDTLFSPTNHVYFNLNRDN
HHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEEEEECCCCCEECCCCEEEEEECCCC
NVVDNHRISSNQLDMYVLDERNIVTGDILDLHEVFEDNKIKLSDIFTSQHAQLSQQMTRF
CCCCCCCCCCCCEEEEEECCCCEEECCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHH
GGLDHPFTVGEHKMYVENHEFMLEVDTDMPHVVFFTFNQPDEWDSPFNIYKPHSGFTLET
CCCCCCEECCCEEEEEECCEEEEEECCCCCEEEEEECCCCCCCCCCCEEECCCCCCEEEE
QFLPNDINLYGEKAPSILKAGEVFNSKTSFRIEEKVEND
EECCCCCEECCCCCCCHHHHHHHHCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]