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The map label for this gene is pncB [H]

Identifier: 57650665

GI number: 57650665

Start: 2037975

End: 2039444

Strand: Reverse

Name: pncB [H]

Synonym: SACOL1975

Alternate gene names: 57650665

Gene position: 2039444-2037975 (Counterclockwise)

Preceding gene: 57650668

Following gene: 57650664

Centisome position: 72.59

GC content: 33.4

Gene sequence:

>1470_bases
GTGTACCAATTAGAAGACGACAGTTTAATGTTACATAATGACTTATATCAAATAAATATGGCTGAAAGTTATTGGAATGA
TAATATTCATGAAAAAATGGCTGTATTTGATTTGTATTTTAGAAAAATGCCATTTAATAGTGGCTATGCTGTTTTTAATG
GTTTAAAACGCGTCATTGATTTTATAGAACATTTTGGATTTTCAGAATCTGATTTGGAATATTTAAAGTCTATTGGCTAC
AAGGATGATTTCTTATCATATTTAAAAGATTTAAAATTCACAGGCAGCATCCGTTCGATGCAAGAAGGCGAATTATGCTT
TGGTAACGAACCATTGTTACGCGTAGAAGCACCATTGATTCAAGCGCAATTAATAGAAACAATTTTATTAAACATTGTAA
ATTTCCATACATTAATTACAACAAAGGCTAGCAGAATTCGTCAAATTGCATCAAATGATAAATTAATGGAGTTTGGTACA
CGTCGTGCGCAAGAAATTGATGCAGCATTGTGGGGCGCTAGAGCTGCTTACATCGGGGGCTTTGATTCTACAAGTAATGT
TAGGGCGGGGAAATTATTTGGTATACCTGTGTCTGGTACACATGCACATGCATTTGTCCAAACTTATGGAGACGAATATG
TTGCCTTCAAAAAATATGCTGAAAGACATAAAAATTGTGTGTTCCTAGTAGATACATTCCATACTTTAAAATCTGGCGTG
CCAAATGCAATAAAAGTTGCAAAAGAATTAGGTGACAAAATTAACTTTGTAGGTATTCGATTAGATTCTGGAGATATCGC
TTATTTATCTAAAGAGGCAAGACGTATGCTTGATGAAGCAGGATTTACTGAAACTAAAATTATCGCGTCTAATGATTTGG
ATGAAGAAACGATTACGAGTTTGAAAGCACAAGGTGCAAAAGTAGATTCTTGGGGCGTTGGTACAAAGCTGATTACAGGA
TACGATCAACCAGCATTAGGTGCAGTATATAAACTTGTAGCTATTGAAAATGAAGATGGTTCATATAGTGATCGTATTAA
ATTATCAAATAACGCTGAAAAGGTTACGACGCCAGGTAAGAAAAATGTATATCGCATTATAAACAAGAAAACAGGTAAGG
CAGAAGGCGATTATATTACTTTGGAAAATGAAAATCCATACGATGAACAACCTTTAAAATTATTCCATCCAGTGCATACT
TATAAAATGAAATTTATAAAATCTTTCGAAGCCATTGATTTGCATCATAATATTTATGAAAATGGTAAATTAGTATATCA
AATGCCAACAGAAGATGAATCACGTGAATATTTAGCACTAGGATTACAATCTATTTGGGATGAAAATAAGCGTTTCCTGA
ATCCACAAGAATATCCAGTCGATTTAAGCAAGGCATGTTGGGATAATAAACATAAACGTATTTTTGAAGTTGCGGAACAC
GTTAAGGAGATGGAAGAAGATAATGAGTAA

Upstream 100 bases:

>100_bases
TTTTAATTAAAAGTATGGAAATTAAGGGGCTCTTATGTATATAAAAAAATGAATTATGATAAAATGTAAGAAAATATTTA
GGTCGATTGGAGAGATACAA

Downstream 100 bases:

>100_bases
ATTACAAGACGTTATTGTACAAGAAATGAAAGTGAAAAAGCGTATCGATAGTGCTGAAGAAATTATGGAATTAAAGCAAT
TTATAAAAAATTATGTACAA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MYQLEDDSLMLHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSIGY
KDDFLSYLKDLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGT
RRAQEIDAALWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERHKNCVFLVDTFHTLKSGV
PNAIKVAKELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLITG
YDQPALGAVYKLVAIENEDGSYSDRIKLSNNAEKVTTPGKKNVYRIINKKTGKAEGDYITLENENPYDEQPLKLFHPVHT
YKMKFIKSFEAIDLHHNIYENGKLVYQMPTEDESREYLALGLQSIWDENKRFLNPQEYPVDLSKACWDNKHKRIFEVAEH
VKEMEEDNE

Sequences:

>Translated_489_residues
MYQLEDDSLMLHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSIGY
KDDFLSYLKDLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGT
RRAQEIDAALWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERHKNCVFLVDTFHTLKSGV
PNAIKVAKELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLITG
YDQPALGAVYKLVAIENEDGSYSDRIKLSNNAEKVTTPGKKNVYRIINKKTGKAEGDYITLENENPYDEQPLKLFHPVHT
YKMKFIKSFEAIDLHHNIYENGKLVYQMPTEDESREYLALGLQSIWDENKRFLNPQEYPVDLSKACWDNKHKRIFEVAEH
VKEMEEDNE
>Mature_489_residues
MYQLEDDSLMLHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVIDFIEHFGFSESDLEYLKSIGY
KDDFLSYLKDLKFTGSIRSMQEGELCFGNEPLLRVEAPLIQAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGT
RRAQEIDAALWGARAAYIGGFDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERHKNCVFLVDTFHTLKSGV
PNAIKVAKELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITSLKAQGAKVDSWGVGTKLITG
YDQPALGAVYKLVAIENEDGSYSDRIKLSNNAEKVTTPGKKNVYRIINKKTGKAEGDYITLENENPYDEQPLKLFHPVHT
YKMKFIKSFEAIDLHHNIYENGKLVYQMPTEDESREYLALGLQSIWDENKRFLNPQEYPVDLSKACWDNKHKRIFEVAEH
VKEMEEDNE

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=515, Percent_Identity=32.621359223301, Blast_Score=273, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI71997947, Length=532, Percent_Identity=36.6541353383459, Blast_Score=314, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI71997952, Length=532, Percent_Identity=36.6541353383459, Blast_Score=314, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI71997955, Length=211, Percent_Identity=45.0236966824645, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24581587, Length=521, Percent_Identity=37.0441458733205, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI161076680, Length=204, Percent_Identity=45.0980392156863, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24581595, Length=204, Percent_Identity=45.0980392156863, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI28574709, Length=204, Percent_Identity=45.0980392156863, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24581593, Length=204, Percent_Identity=45.0980392156863, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24581591, Length=204, Percent_Identity=45.0980392156863, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 55893; Mature: 55893

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQLEDDSLMLHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVID
CCCCCCCCEEEECCEEEEEEHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FIEHFGFSESDLEYLKSIGYKDDFLSYLKDLKFTGSIRSMQEGELCFGNEPLLRVEAPLI
HHHHCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCEEECCHHH
QAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGTRRAQEIDAALWGARAAYIGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHEECC
FDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERHKNCVFLVDTFHTLKSGV
CCCCCCCCCCEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECHHHHHHCC
PNAIKVAKELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITS
CHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
LKAQGAKVDSWGVGTKLITGYDQPALGAVYKLVAIENEDGSYSDRIKLSNNAEKVTTPGK
HHHCCCCCCCCCCCCEEEECCCCCHHHHHEEEEEEECCCCCCCCEEEECCCCCCCCCCCH
KNVYRIINKKTGKAEGDYITLENENPYDEQPLKLFHPVHTYKMKFIKSFEAIDLHHNIYE
HHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NGKLVYQMPTEDESREYLALGLQSIWDENKRFLNPQEYPVDLSKACWDNKHKRIFEVAEH
CCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
VKEMEEDNE
HHHHHCCCC
>Mature Secondary Structure
MYQLEDDSLMLHNDLYQINMAESYWNDNIHEKMAVFDLYFRKMPFNSGYAVFNGLKRVID
CCCCCCCCEEEECCEEEEEEHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
FIEHFGFSESDLEYLKSIGYKDDFLSYLKDLKFTGSIRSMQEGELCFGNEPLLRVEAPLI
HHHHCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCEEECCHHH
QAQLIETILLNIVNFHTLITTKASRIRQIASNDKLMEFGTRRAQEIDAALWGARAAYIGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHEECC
FDSTSNVRAGKLFGIPVSGTHAHAFVQTYGDEYVAFKKYAERHKNCVFLVDTFHTLKSGV
CCCCCCCCCCEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECHHHHHHCC
PNAIKVAKELGDKINFVGIRLDSGDIAYLSKEARRMLDEAGFTETKIIASNDLDEETITS
CHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
LKAQGAKVDSWGVGTKLITGYDQPALGAVYKLVAIENEDGSYSDRIKLSNNAEKVTTPGK
HHHCCCCCCCCCCCCEEEECCCCCHHHHHEEEEEEECCCCCCCCEEEECCCCCCCCCCCH
KNVYRIINKKTGKAEGDYITLENENPYDEQPLKLFHPVHTYKMKFIKSFEAIDLHHNIYE
HHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NGKLVYQMPTEDESREYLALGLQSIWDENKRFLNPQEYPVDLSKACWDNKHKRIFEVAEH
CCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
VKEMEEDNE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]